Dendritic Cells and Their Role in Immunotherapy

Dendritic Cell Paucity Leads to Dysfunctional Immune Surveillance in Pancreatic Cancer

(2020) Samarth Hegde et al.   CANCER CELL

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

(2019) Mikhail Binnewies et al.   CELL

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Targeting Tumor-Associated Macrophages in Cancer

(2019) Paulina Pathria et al.   TRENDS IN IMMUNOLOGY

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

(2019) Stefanie K. Wculek et al.   Journal for ImmunoTherapy of Cancer

Dendritic Cell Metabolism and Function in Tumors

(2019) Paolo Giovanelli et al.   TRENDS IN IMMUNOLOGY

Sequential Anti-PD1 Therapy Following Dendritic Cell Vaccination Improves Survival in a HER2 Mammary Carcinoma Model and Identifies a Critical Role for CD4 T Cells in Mediating the Response

(2019) Krithika N. Kodumudi et al.   Frontiers in Immunology

Transcriptional Basis of Mouse and Human Dendritic Cell Heterogeneity

(2019) Chrysothemis C. Brown et al.   CELL

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

(2019) Qiming Zhang et al.   CELL

Engineering dendritic cell vaccines to improve cancer immunotherapy

(2019) Caleb R. Perez et al.   Nature Communications

CXCR3 enables recruitment and site-specific bystander activation of memory CD8+ T cells

(2019) Nicholas J. Maurice et al.   Nature Communications

The Cytosolic DNA-Sensing cGAS–STING Pathway in Cancer

(2019) John Kwon et al.   Cancer Discovery

TIM-3 Regulates CD103 + Dendritic Cell Function and Response to Chemotherapy in Breast Cancer

(2018) Álvaro de Mingo Pulido et al.   CANCER CELL

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Activation of p53 in Immature Myeloid Precursor Cells Controls Differentiation into Ly6c + CD103 + Monocytic Antigen-Presenting Cells in Tumors

(2018) Madhav D. Sharma et al.   IMMUNITY

Human dendritic cell subsets: an update

(2018) Matthew Collin et al.   IMMUNOLOGY

Modulation of the tumor microenvironment by intratumoral administration of IMO-2125, a novel TLR9 agonist, for cancer immunotherapy

(2018) Daqing Wang et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Clec9A+Dendritic Cells Are Not Essential for Antitumor CD8+T Cell Responses Induced by Poly I:C Immunotherapy

(2018) Connie B. Gilfillan et al.   JOURNAL OF IMMUNOLOGY

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

(2018) Linda M. Liau et al.   Journal of Translational Medicine

Distinct progenitor lineages contribute to the heterogeneity of plasmacytoid dendritic cells

(2018) Patrick Fernandes Rodrigues et al.   NATURE IMMUNOLOGY

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Eradication of spontaneous malignancy by local immunotherapy

(2018) Idit Sagiv-Barfi et al.   Science Translational Medicine

Defining the role of the tumor vasculature in antitumor immunity and immunotherapy

(2018) Marco B. Schaaf et al.   Cell Death & Disease

A phase-1/2 study of adenovirus-p53 transduced dendritic cell vaccine in combination with indoximod in metastatic solid tumors and invasive breast cancer

(2018) Hatem Soliman et al.   Oncotarget

An autologous dendritic cell vaccine polarizes a Th-1 response which is tumoricidal to patient-derived breast cancer cells

(2018) Michele Tomasicchio et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

In vivo cancer vaccination: Which dendritic cells to target and how?

(2018) Cheryl Lai-Lai Chiang et al.   CANCER TREATMENT REVIEWS

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Tumor-Derived cGAMP Triggers a STING-Mediated Interferon Response in Non-tumor Cells to Activate the NK Cell Response

(2018) Assaf Marcus et al.   IMMUNITY

Design of amidobenzimidazole STING receptor agonists with systemic activity

(2018) Joshi M. Ramanjulu et al.   NATURE

WDFY4 is required for cross-presentation in response to viral and tumor antigens

(2018) Derek J. Theisen et al.   SCIENCE

Inhibition of Human Dendritic Cell ER Stress Response Reduces T Cell Alloreactivity Yet Spares Donor Anti-tumor Immunity

(2018) Brian C. Betts et al.   Frontiers in Immunology

Dendritic Cells Display Subset and Tissue-Specific Maturation Dynamics over Human Life

(2017) Tomer Granot et al.   IMMUNITY

Dendritic Cells but Not Macrophages Sense Tumor Mitochondrial DNA for Cross-priming through Signal Regulatory Protein α Signaling

(2017) Meng Michelle Xu et al.   IMMUNITY

High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization

(2017) Marcela Alcántara-Hernández et al.   IMMUNITY

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

An immunogenic personal neoantigen vaccine for patients with melanoma

(2017) Patrick A. Ott et al.   NATURE

Mapping the human DC lineage through the integration of high-dimensional techniques

(2017) Peter See et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Lipid bodies containing oxidatively truncated lipids block antigen cross-presentation by dendritic cells in cancer

(2017) Filippo Veglia et al.   Nature Communications

Interleukin-12 from CD103 + Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis

(2017) Deepak Mittal et al.   Cancer Immunology Research

Granulocytes: New Members of the Antigen-Presenting Cell Family

(2017) Ang Lin et al.   Frontiers in Immunology

Topical Imiquimod Plus Nab-paclitaxel for Breast Cancer Cutaneous Metastases

(2017) Lupe G. Salazar et al.   JAMA Oncology

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

T Cell Cancer Therapy Requires CD40-CD40L Activation of Tumor Necrosis Factor and Inducible Nitric-Oxide-Synthase-Producing Dendritic Cells

(2016) Ilaria Marigo et al.   CANCER CELL

Abstract 4908: Cancer immunotherapy with immunomodulatory anti-CD137 and anti-PD-1 monoclonal antibodies requires Batf3-dependent dendritic cells

(2016) Alfonso R. Sánchez-Paulete et al.   CANCER RESEARCH

Dendritic cell-based immunotherapy

(2016) Rachel L Sabado et al.   CELL RESEARCH

Phase Ib Trial of the Toll-like Receptor 8 Agonist, Motolimod (VTX-2337), Combined with Cetuximab in Patients with Recurrent or Metastatic SCCHN

(2016) Laura Q.M. Chow et al.   CLINICAL CANCER RESEARCH

Dendritic Cell-Based Immunotherapy: State of the Art and Beyond

(2016) K. F. Bol et al.   CLINICAL CANCER RESEARCH

Unsupervised High-Dimensional Analysis Aligns Dendritic Cells across Tissues and Species

(2016) Martin Guilliams et al.   IMMUNITY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

A Comparative Study of the T Cell Stimulatory and Polarizing Capacity of Human Primary Blood Dendritic Cell Subsets

(2016) Simone P. Sittig et al.   MEDIATORS OF INFLAMMATION

Systemic RNA delivery to dendritic cells exploits antiviral defence for cancer immunotherapy

(2016) Lena M. Kranz et al.   NATURE

Individualized vaccination of AML patients in remission is associated with induction of antileukemia immunity and prolonged remissions

(2016) J. Rosenblatt et al.   Science Translational Medicine

Dendritic Cells and Cancer Immunity

(2016) Alycia Gardner et al.   TRENDS IN IMMUNOLOGY

IDO in the Tumor Microenvironment: Inflammation, Counter-Regulation, and Tolerance

(2016) David H. Munn et al.   TRENDS IN IMMUNOLOGY

Differential Intrasplenic Migration of Dendritic Cell Subsets Tailors Adaptive Immunity

(2016) Samuele Calabro et al.   Cell Reports

Macrophages and Therapeutic Resistance in Cancer

(2015) Brian Ruffell et al.   CANCER CELL

Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors

(2015) J. R. Baird et al.   CANCER RESEARCH

ER Stress Sensor XBP1 Controls Anti-tumor Immunity by Disrupting Dendritic Cell Homeostasis

(2015) Juan R. Cubillos-Ruiz et al.   CELL

Tapping CD4 T Cells for Cancer Immunotherapy: The Choice of Personalized Genomics

(2015) Maurizio Zanetti   JOURNAL OF IMMUNOLOGY

Different maturation cocktails provide dendritic cells with different chemoattractive properties

(2015) Chiara Massa et al.   Journal of Translational Medicine

Tetanus toxoid and CCL3 improve dendritic cell vaccines in mice and glioblastoma patients

(2015) Duane A. Mitchell et al.   NATURE

Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity

(2015) Stefani Spranger et al.   NATURE

Diverse roles of STING-dependent signaling on the development of cancer

(2015) J Ahn et al.   ONCOGENE

Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity

(2015) Leticia Corrales et al.   Cell Reports

Antigen Presentation by MHC-Dressed Cells

(2015) Masafumi Nakayama   Frontiers in Immunology

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Dissecting the Tumor Myeloid Compartment Reveals Rare Activating Antigen-Presenting Cells Critical for T Cell Immunity

(2014) Miranda L. Broz et al.   CANCER CELL

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Immunization of Malignant Melanoma Patients with Full-Length NY-ESO-1 Protein Using TLR7 Agonist Imiquimod as Vaccine Adjuvant

(2014) S. Adams et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

(2014) Qifan Zhu et al.   JOURNAL OF IMMUNOLOGY

Perivascular leukocyte clusters are essential for efficient activation of effector T cells in the skin

(2014) Yohei Natsuaki et al.   NATURE IMMUNOLOGY

Induction of Antigen-Specific Immunity with a Vaccine Targeting NY-ESO-1 to the Dendritic Cell Receptor DEC-205

(2014) M. V. Dhodapkar et al.   Science Translational Medicine

Tumor Promotion by Intratumoral Plasmacytoid Dendritic Cells Is Reversed by TLR7 Ligand Treatment

(2013) I. Le Mercier et al.   CANCER RESEARCH

Dual Blockade of PD-1 and CTLA-4 Combined with Tumor Vaccine Effectively Restores T-Cell Rejection Function in Tumors

(2013) J. Duraiswamy et al.   CANCER RESEARCH

Targeting of 111In-Labeled Dendritic Cell Human Vaccines Improved by Reducing Number of Cells

(2013) E. H. J. G. Aarntzen et al.   CLINICAL CANCER RESEARCH

Oncology Meets Immunology: The Cancer-Immunity Cycle

(2013) Daniel S. Chen et al.   IMMUNITY

Fast Dendritic Cells Stimulated with Alternative Maturation Mixtures Induce Polyfunctional and Long-Lasting Activation of Innate and Adaptive Effector Cells with Tumor-Killing Capabilities

(2013) C. Massa et al.   JOURNAL OF IMMUNOLOGY

Transcriptional programming of dendritic cells for enhanced MHC class II antigen presentation

(2013) Bryan Vander Lugt et al.   NATURE IMMUNOLOGY

An interleukin-17–mediated paracrine network promotes tumor resistance to anti-angiogenic therapy

(2013) Alicia S Chung et al.   NATURE MEDICINE

Topical TLR7 Agonist Imiquimod Can Induce Immune-Mediated Rejection of Skin Metastases in Patients with Breast Cancer

(2012) S. Adams et al.   CLINICAL CANCER RESEARCH

Human Tissues Contain CD141hi Cross-Presenting Dendritic Cells with Functional Homology to Mouse CD103+ Nonlymphoid Dendritic Cells

(2012) Muzlifah Haniffa et al.   IMMUNITY

Tumor-infiltrating DCs suppress nucleic acid–mediated innate immune responses through interactions between the receptor TIM-3 and the alarmin HMGB1

(2012) Shigeki Chiba et al.   NATURE IMMUNOLOGY

Anti-TIM3 Antibody Promotes T Cell IFN- -Mediated Antitumor Immunity and Suppresses Established Tumors

(2011) S. F. Ngiow et al.   CANCER RESEARCH

VTX-2337 Is a Novel TLR8 Agonist That Activates NK Cells and Augments ADCC

(2011) H. Lu et al.   CLINICAL CANCER RESEARCH

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Type I interferon is selectively required by dendritic cells for immune rejection of tumors

(2011) Mark S. Diamond et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Synthetic double-stranded RNA induces innate immune responses similar to a live viral vaccine in humans

(2011) Marina Caskey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Exploiting the Role of Endogenous Lymphoid-Resident Dendritic Cells in the Priming of NKT Cells and CD8+ T Cells to Dendritic Cell-Based Vaccines

(2011) Troels R. Petersen et al.   PLoS One

Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation

(2010) K. Birkholz et al.   BLOOD

Gene Expression Profile Correlates with T-Cell Infiltration and Relative Survival in Glioblastoma Patients Vaccinated with Dendritic Cell Immunotherapy

(2010) Robert M. Prins et al.   CLINICAL CANCER RESEARCH

Efficient and versatile manipulation of the peripheral CD4+ T-cell compartment by antigen targeting to DNGR-1/CLEC9A

(2010) Olivier P. Joffre et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction

(2010) G. Matteoli et al.   GUT

Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation

(2010) Pilar M. Domínguez et al.   IMMUNOLOGICAL REVIEWS

Human CD141+(BDCA-3)+dendritic cells (DCs) represent a unique myeloid DC subset that cross-presents necrotic cell antigens

(2010) Sarah L. Jongbloed et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Superior antigen cross-presentation and XCR1 expression define human CD11c+CD141+cells as homologues of mouse CD8+dendritic cells

(2010) Annabell Bachem et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Peripheral CD103+dendritic cells form a unified subset developmentally related to CD8α+conventional dendritic cells

(2010) Brian T. Edelson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity

(2010) Kaori Sakuishi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Antibody-Targeted NY-ESO-1 to Mannose Receptor or DEC-205 In Vitro Elicits Dual Human CD8+ and CD4+ T Cell Responses with Broad Antigen Specificity

(2010) T. Tsuji et al.   JOURNAL OF IMMUNOLOGY

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer

(2010) Philip W. Kantoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

CD8+ T Cell Priming by Dendritic Cell Vaccines Requires Antigen Transfer to Endogenous Antigen Presenting Cells

(2010) Alice W. Yewdall et al.   PLoS One

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influence of bevacizumab, sunitinib and sorafenib as single agents or in combination on the inhibitory effects of VEGF on human dendritic cell differentiation from monocytes

(2009) C Alfaro et al.   BRITISH JOURNAL OF CANCER

The effect of anti-VEGF therapy on immature myeloid cell and dendritic cells in cancer patients

(2008) Takuya Osada et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Antigen-Presentation Properties of Plasmacytoid Dendritic Cells

(2008) José A. Villadangos et al.   IMMUNITY

Monocyte-derived dendritic cells in innate and adaptive immunity

(2008) Beatriz León et al.   IMMUNOLOGY AND CELL BIOLOGY

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin

(2008) David Sancho et al.   JOURNAL OF CLINICAL INVESTIGATION

Batf3 Deficiency Reveals a Critical Role for CD8 + Dendritic Cells in Cytotoxic T Cell Immunity

(2008) K. Hildner et al.   SCIENCE

A clinical grade poly I:C-analogue (Ampligen®) promotes optimal DC maturation and Th1-type T cell responses of healthy donors and cancer patients in vitro

(2008) H. Navabi et al.   VACCINE