Article
Biotechnology & Applied Microbiology
Fenting Lei, Fancai Zeng, Xin Yu, Yiping Deng, Zongquan Zhang, Maochang Xu, Nianhui Ding, Ji Tian, Chunhong Li
Summary: Due to the failure of oral nano-delivery systems to target the colon and achieve controlled drug release in the treatment of inflammatory bowel disease (IBD), there is an urgent need to develop a microenvironment responsive drug delivery system. In this study, a pH-responsive hydrogel-coated nanoemulsion was successfully developed for the co-delivery of curcumin and emodin. The prepared system showed promising therapeutic effects in IBD by alleviating inflammation, repairing mucosal damage, and clearing reactive oxygen species.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xiaoxue Wang, Jingjie Qi, Wenjie Zhang, Yajie Pu, Rong Yang, Penghui Wang, Shuai Liu, Xiaoyan Tan, Bo Chi
Summary: A novel printable bionic hydrogel with antibacterial and antioxidant properties was developed to effectively treat large and irregular-shaped wounds by inhibiting inflammation and accelerating wound healing. The hydrogels showed excellent properties such as high compression modulus, stable rheological properties, effective antibacterial effects, and the ability to remove excessive reactive oxygen species. In comparison to commercial dressings, these hydrogels demonstrated better expression of VEGF and CD31, accelerated granulation tissue regeneration, and promoted wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Bian-Xia Xue, Tian-Tian Yang, Ru-Shang He, Wen-Ke Gao, Jia-Xin Lai, Si-Xia Liu, Cong-Yan Duan, Shao-Xia Wang, Hui-Juan Yu, Wen-Zhi Yang, Li-Hua Zhang, Qi-Long Wang, Hong-Hua Wu
Summary: This study provided insights into the degradation products and stability of Nardosinone, a bioactive compound found in Nardostachys jatamansi DC, and offered guidance for the quality control and application of Nardosinone-related products.
Article
Polymer Science
Kun Cai, Yang Liu, Yan Yue, Yuancheng Liu, Fengbiao Guo
Summary: Optimized eucalyptus essential oil nanoemulsions (EEO NEs) were combined with a hydrogel matrix to prepare eucalyptus essential oil nanoemulsion hydrogels (CBM/CMC/EEO NE). CBM/CMC/EEO NE exhibited high anti-biofilm activity against S. aureus in vitro and effectively treated infected wounds in vivo. This may be a new clinical alternative for healing infected wounds in the future.
Article
Chemistry, Applied
Kai Huang, Runan Liu, Ying Zhang, Xiao Guan
Summary: The study indicates that the prepared cedarwood essential oil nanoemulsion has smaller particle size and higher zeta potential value compared to the Pickering emulsion, with better stability. Both nanoemulsion and Pickering emulsion show higher antioxidant, iron reducing, and antibacterial activities than the cedarwood essential oil itself.
Review
Biochemistry & Molecular Biology
Zhongming Cao, Yue Luo, Zhaoyang Li, Lei Tan, Xiangmei Liu, Changyi Li, Yufeng Zheng, Zhenduo Cui, Kelvin Wai Kwok Yeung, Yanqin Liang, Shengli Zhu, Shuilin Wu
Summary: This review summarizes the recent progress of antibacterial hydrogels, including their fabrication methodologies, performances, antibacterial mechanisms, and applications, as well as current challenges and future perspectives in this field.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Chemistry, Applied
Yu Fu, Jianhua Zhang, Yilin Wang, Jie Li, Jianxu Bao, Xu Xu, Chaoqun Zhang, Yiwen Li, Haoxing Wu, Zhipeng Gu
Summary: Hydrogels with antioxidative and antibacterial properties, incorporating reduced polydopamine nanoparticles, have been designed for accelerated wound healing. The hydrogels exhibited excellent antioxidative properties and antibacterial activity, protecting cells from oxidative stress and preventing infections. Both in vitro and in vivo studies confirmed the effectiveness of these hydrogels as dressings for accelerated wound healing.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Applied
Yajie Zhong, Farzad Seidi, Yilin Wang, Ling Zheng, Yongcan Jin, Huining Xiao
Summary: An injectable self-healing hydrogel with inherent antibacterial activity was developed by forming dynamic covalent bonds between boronic acid and catechol groups in quaternized chitosan, along with encapsulating EGCG. The hydrogels showed excellent dual functions of antibacterial and antioxidant properties, and demonstrated good biocompatibility and contact-active antibacterial activity. In vivo evaluation showed the hydrogels' regenerative wound healing performance, highlighting their potential as novel wound dressings for wound management.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Zhendong Guo, Lisi Yan, Bo Zhou, Peiwen Zhao, Wenyuan Wang, Siyan Dong, Bo Cheng, Jing Yang, Xinyu Wang, Binbin Li
Summary: Bacterial infection and excessive reactive oxygen species (ROS) in diabetic wounds can lead to chronic wounds. A hydrogel was developed by combining methacrylated silk fibroin (SFMA) with ε-polylysine (EPL) and manganese dioxide nanoparticles (BMNPs) to improve the wound microenvironment. The hydrogel showed antibacterial and antioxidant properties. In vivo experiments demonstrated that the hydrogel had better antibacterial effects and reduced ROS levels in diabetic wounds infected with Staphylococcus aureus (S. aureus). The hydrogel also promoted wound healing and tissue regeneration.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Yikun Ren, Shanshan Ma, Dan Zhang, Shen Guo, Rong Chang, Yuanmeng He, Minghao Yao, Fangxia Guan
Summary: An injectable hyaluronic acid hydrogel with antioxidative and photothermal antibacterial activity has been developed as a functional dressing for infected wounds. This hydrogel demonstrates good stability, biocompatibility, and effective prevention of early infection and acceleration of wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Yarong Lv, Zhongxun Yu, Chenxi Li, Jianwei Zhou, Xujin Lv, Jia Chen, Ming Wei, Jun Liu, Xiaomin Yu, Ce Wang, Ping Hu, Yong Liu
Summary: A series of gelatin-based nanofiber membranes with different curcumin contents were fabricated, showing excellent properties in physical, mechanical, and biocompatibility aspects, indicating the ability to inhibit bacteria and eliminate free radicals, making them promising materials for treating infected wounds.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Jiaxin Li, Yachao Yan, Yingzhi Chen, Qinglin Fang, Muhammad Irfan Hussain, Lu-Ning Wang
Summary: In this study, a flexible hydrogel composed of sodium alginate and curcumin-loaded metal-organic frameworks was created for long-term drug release and antibacterial activity, offering a new management system for chronic wound dressings.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Engineering, Chemical
Seong Hwan Yu, Do-Yeong Kim, Youjin Baek, Hyeon Gyu Lee
Summary: This study investigated the effects of nanoencapsulation and gel incorporation on the antioxidant activity, stability, and release profile of curcumin. The results showed that CUR-loaded nanoparticles and CUR NPs-filled gelatin-genipin gels had significantly higher antioxidant activity, stability, and in vitro release profile compared to free CUR. The GL/GP-CUR NPs exhibited the highest antioxidant activity and increased stability, while the CUR NPs had a faster release rate. These findings suggest that GL/GP-CUR NPs have potential as an effective delivery system for CUR in the food industry.
JOURNAL OF FOOD ENGINEERING
(2024)
Article
Chemistry, Multidisciplinary
Yike Li, Huiyu Zheng, Yaxian Liang, Ming Xuan, Guiting Liu, Huixu Xie
Summary: This study developed a novel hydrogel (HAMA/PHMB-Ms) with excellent antibacterial properties and wound healing effects, showing promising clinical potential for the treatment of diabetic wounds.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Physical
Zejun Xu, Guiting Liu, Li Zheng, Jun Wu
Summary: A hydrogel with enhanced antimicrobial and antioxidant properties (CMGFC) was developed to accelerate diabetic wound healing. The CMGFC hydrogel showed high antibacterial efficiency and strong ROS scavenging ability, protecting cells from oxidative stress. In vivo results demonstrated reduced inflammatory responses, enhanced angiogenesis, and improved wound healing with the CMGFC hydrogel.
Article
Immunology
Zubaid-ul-khazir, Gulam N. Yatoo, Humara Wani, Shakeel A. Shah, Mohammad I. Zargar, Manzoor A. Rather, Javid A. Banday
Summary: The essential oil from the leaves of Abies pindrow in Kashmir, India, was found to be rich in monoterpene hydrocarbons, with limonene and alpha-pinene as major constituents. It exhibited significant antibacterial activity against various bacteria, with the strongest inhibition seen against E. Coli. Additionally, the oil showed cytotoxic activity against different cancer cell lines, with the highest sensitivity observed in human ductal breast epithelial tumor cells.
MICROBIAL PATHOGENESIS
(2021)
Article
Chemistry, Physical
Hina Kouser Qadri, Arjumund Shaheen, Showkat Rashid, Imtiyaz Ahmad Bhat, Ghulam Mohammad Rather, Aijaz Ahmad Dar
Summary: In this study, the mixed micelle and monolayer formation of a biocompatible and cleavable gemini surfactant 16-E1-16 with the copolymer P123 were investigated. Strong interaction between P123 and 16-E1-16 was observed, resulting in the formation of small mixed micelles with similar composition and thermodynamically stable mixed monolayers. The formulations of binary mixtures of P123 and 16-E1-16 showed better injectable properties and faster drug release rate, making them potential candidates for injectable drug delivery systems.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Review
Biochemistry & Molecular Biology
Shahid Ud Din Wani, Mohammed Iqbal Zargar, Mubashir Hussain Masoodi, Sultan Alshehri, Prawez Alam, Mohammed M. Ghoneim, Areej Alshlowi, H. G. Shivakumar, Mohammad Ali, Faiyaz Shakeel
Summary: Silk fibroin, derived from silkworm cocoons, is widely used in biomedicine due to its superior biocompatibility and controllable degradation. It is employed in drug delivery systems to extend drug shelf life, control release, and provide new possibilities for treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Haamid Rasool Bhat, Malay Kumar Rana, Aijaz Ahmad Dar
Summary: The study investigates the capability of the Cucurbit [n]uril molecule family to capture and sense toxic chemical warfare agents using density functional theory and time-dependent density functional theory. The results demonstrate that CB[6] has good binding stability with the nerve agent cyclosarin, but the stability decreases with an increase in the number of cyclosarin guests. Infrared spectroscopic vibrational signatures and fluorescence spectra analysis confirm the stability of the inclusion complexes and the importance of the NBD fluorophore.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Rohi Masrat, Aijaz Ahmad Dar
Summary: The rheological behavior of aqueous solutions of biocompatible polymer HPC in the presence of cationic CTAB and nonionic Tween 40 has been investigated. Steady-state bulk experiments show two distinct regions in the rheogram, while dynamic experiments indicate a decrease in the stability of HPC hydrogels with increasing surfactant concentration. Interfacial shear tests reveal a non-Newtonian dilatant behavior at the solution-air interface and two distinct dilatant regions separated by a Newtonian region at the solution-soya oil interface. The strength of films formed at the two interfaces decreases with the increase of surfactant concentration, indicating stronger interaction between HPC and CTAB than Tween 40.
Article
Chemistry, Multidisciplinary
Masrat Bashir, Aijaz A. Dar, Imtiyaz Yousuf
Summary: This study synthesized and characterized Mn(II)- and Zn(II)-based complexes 1 and 2 derived from the aroyl-hydrazone Schiff base ligand (L1). The compounds were fully characterized using various analytical techniques. In vitro interaction studies with ct-DNA and bovine serum albumin (BSA) showed that complex 2 exhibited stronger binding than complex 1 and L1. The Mn(II) complex demonstrated better antioxidant ability, while complex 2 showed more effective bactericidal activity against Gram-positive bacteria. In terms of cytotoxicity, the polymeric Zn(II) complex exhibited better and selective cytotoxicity against the A549 cancer cell line.
Article
Biochemistry & Molecular Biology
Umar Nabi Tak, Showkat Rashid, Pawandeep Kour, Nighat Nazir, Mohammed Iqbal Zargar, Aijaz Ahmad Dar
Summary: An ultra-stretchable, quickly self-healable adhesive hydrogel loaded with Bergenia stracheyi extract demonstrates potential for use as wound dressing material. The hydrogel, synthesized using biocompatible and biodegradable polymers and the plant extract, exhibits excellent tissue adhesion, stretchability, mechanical strength, anti-bacterial capability, and anti-oxidant properties. These properties make the hydrogel suitable for biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Pawandeep Kour, Aijaz Ahmad Dar
Summary: The development of hybrid formulations incorporating hydrogels, antioxidants, and nanoemulsions containing polyunsaturated fatty acids is in high demand. In this study, we formulated quercetin-loaded oil-in-water nanoemulsions using surfactants such as Tween 20 (nonionic), sodium lauroyl sarcosine (anionic), and 3-(N,N-dimethylmyristylammonio)-propanesulfonate (zwitterionic) to control autoxidative degradation of linoleic acid. The nanoemulsions with anionic and zwitterionic surfactants exhibited better control of lipid peroxidation at 37 degrees C, with droplet sizes less than 200 nm. The hybrid alginate capsules derived from these formulations showed good release of quercetin and scavenging activity against DPPH radicals, making them robust and suitable for applications in the food and pharmaceutical industries.
ACS FOOD SCIENCE & TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Masrat Bashir, Aijaz A. Dar, Imtiyaz Yousuf
Summary: This work focuses on the synthesis, characterization, and biological profile of Mn(II)- and Zn(II)-based complexes derived from a specific ligand. The structural and electronic properties were studied, and the stability of crystal lattice structures was investigated. The complexes showed avid binding to DNA and exhibited antioxidant and antibacterial activities. Furthermore, the polymeric Zn(II) complex exhibited selective cytotoxicity against a lung cancer cell line.
Article
Nanoscience & Nanotechnology
Nirbhai Singh, Shikha Aery, Smayira Juneja, Laxmi Kumari, Mohd Sajid Lone, Aijaz Ahmad Dar, Sandip Pawar, Surinder K. Mehta, Abhijit Dan
Summary: This study presents a promising strategy for drug delivery using chitosan hydrogels and dual-responsive microgels. The composite materials showed controllable release of the drug and excellent biocompatibility.
ACS APPLIED BIO MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Nirbhai Singh, Shikha Aery, Smayira Juneja, Laxmi Kumari, Mohd Sajid Lone, Aijaz Ahmad Dar, Sandip V. Pawar, Surinder K. Mehta, Abhijit Dan
Summary: A promising strategy based on chitosan hydrogels and dual temperature- and pH-responsive microgels was reported for the release of a model drug, moxifloxacin. The microgels were incorporated inside the hydrogel matrix, resulting in a double barrier system that significantly reduced the drug release rate and prolonged the delivery time. The release of moxifloxacin could be controlled by regulating the temperature and pH of the delivery medium.
ACS APPLIED BIO MATERIALS
(2022)
Article
Veterinary Sciences
Mujeeb Ur Rehman Fazili, Aijaz Ahmad Dar, Akeel Bashir Beigh, Anees Ahmad Shah, Rameez Ali Dar
Summary: The study concludes that the modified intralingual suture technique is minimally invasive, cost-effective, suitable for field application, and more acceptable to farmers/animal owners for treating cross-sucking in heifers.
ACTA VETERINARIA EURASIA
(2022)
Article
Chemistry, Organic
Mohmad Muzafar Wani, Aijaz Ahmad Dar, Bilal A. Bhat
Summary: This study presents a novel Morita-Baylis-Hillman reaction utilizing electron-deficient alkenes in micellar media for the synthesis of a wide range of aryl and aliphatic ketones. The reaction takes place in water under mild conditions within the confined environment of micelles, aligning with the principles of sustainable and green chemistry. Detailed proton NMR studies establish the site of the reaction in the palisade region of the micellar assembly, suggesting the potential of employing micellar catalysis for energetically less favorable chemical transformations.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
