Endogenous hydrogen sulfide counteracts polystyrene nanoplastics-induced mitochondrial apoptosis and excessive autophagy via regulating Nrf2 and PGC-1α signaling pathway in mouse spermatocyte-derived GC-2spd(ts) cells

DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells

(2021) Huan Liu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polystyrene microplastics trigger hepatocyte apoptosis and abnormal glycolytic flux via ROS-driven calcium overload

(2021) Siwen Li et al.   JOURNAL OF HAZARDOUS MATERIALS

A comparative review of microplastics and nanoplastics: Toxicity hazards on digestive, reproductive and nervous system

(2021) Kai Yin et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen

(2021) Guifang Zhao et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Increased m6A RNA modification is related to the inhibition of the Nrf2-mediated antioxidant response in di-(2-ethylhexyl) phthalate-induced prepubertal testicular injury

(2020) Tian-Xin Zhao et al.   ENVIRONMENTAL POLLUTION

Hydrogen sulfide alleviates liver injury via S-sulfhydrated-Keap1/Nrf2/LRP1 pathway

(2020) Shuang Zhao et al.   HEPATOLOGY

The emerging risk of exposure to nano(micro)plastics on endocrine disturbance and reproductive toxicity: From a hypothetical scenario to a global public health challenge

(2020) Fatemeh Amereh et al.   ENVIRONMENTAL POLLUTION

Polystyrene microplastics cause cardiac fibrosis by activating Wnt/β-catenin signaling pathway and promoting cardiomyocyte apoptosis in rats

(2020) Zekang Li et al.   ENVIRONMENTAL POLLUTION

Reproductive toxicity of polystyrene microplastics: In vivo experimental study on testicular toxicity in mice

(2020) Baolian Hou et al.   JOURNAL OF HAZARDOUS MATERIALS

Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects

(2020) Siwen Li et al.   JOURNAL OF HAZARDOUS MATERIALS

Polystyrene microplastics induced male reproductive toxicity in mice

(2020) Haibo Jin et al.   JOURNAL OF HAZARDOUS MATERIALS

Enhanced reproductive toxicities induced by phthalates contaminated microplastics in male mice (Mus musculus)

(2020) Yongfeng Deng et al.   JOURNAL OF HAZARDOUS MATERIALS

Potential human health risks due to environmental exposure to nano- and microplastics and knowledge gaps: A scoping review

(2020) Arifur Rahman et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu

(2019) Kaviyarasi Renu et al.   Reproductive Biology

MitoQ ameliorates testis injury from oxidative attack by repairing mitochondria and promoting the Keap1-Nrf2 pathway

(2019) Jie Zhang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

BPDE and B[a]P induce mitochondrial compromise by ROS-mediated suppression of the SIRT1/TERT/PGC-1α pathway in spermatogenic cells both in vitro and in vivo

(2019) Wang Yang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silica nanoparticles induce spermatocyte cell autophagy through microRNA-494 targeting AKT in GC-2spd cells

(2019) Lihua Ren et al.   ENVIRONMENTAL POLLUTION

Plastic and Human Health: A Micro Issue?

(2017) Stephanie L. Wright et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Carnitine-mediated antioxidant enzyme activity and Bcl2 expression involves peroxisome proliferator-activated receptor-γ coactivator-1α in mouse testis

(2017) Vikas Kumar Roy et al.   REPRODUCTION FERTILITY AND DEVELOPMENT

Production, use, and fate of all plastics ever made

(2017) Roland Geyer et al.   Science Advances

Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

(2017) Yongfeng Deng et al.   Scientific Reports

Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway

(2016) Jiaqi Liu et al.   Cell and Bioscience

A global inventory of small floating plastic debris

(2015) Erik van Sebille et al.   Environmental Research Letters

The protective effects of endogenous hydrogen sulfide modulator, S-propargyl-cysteine, on high glucose-induced apoptosis in cardiomyocytes: A novel mechanism mediated by the activation of Nrf2

(2015) Hebei Yang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pre-diabetes alters testicular PGC1-α/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress

(2013) Luís Rato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Regulation of mitochondrial biogenesis and PGC-1α under cellular stress

(2013) Tina Wenz   MITOCHONDRION

Hydrogen Sulfide Protects Against Cellular Senescence via S-Sulfhydration of Keap1 and Activation of Nrf2

(2012) Guangdong Yang et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity

(2012) Stephan T Stern et al.   Particle and Fibre Toxicology

Gold Nanoparticles Induce Autophagosome Accumulation through Size-Dependent Nanoparticle Uptake and Lysosome Impairment

(2011) Xiaowei Ma et al.   ACS Nano

Hydrogen Sulfide Increases Glutathione Production and Suppresses Oxidative Stress in Mitochondria

(2009) Yuka Kimura et al.   ANTIOXIDANTS & REDOX SIGNALING

Mono-(2-ethylhexyl) Phthalate Increases Spermatocyte Mitochondrial Peroxiredoxin 3 and Cyclooxygenase 2

(2008) T. M. Onorato et al.   JOURNAL OF ANDROLOGY