Keap1-Nrf2 pathway up-regulation via hydrogen sulfide mitigates polystyrene microplastics induced-hepatotoxic effects

Polyvinyl chloride microplastics induce growth inhibition and oxidative stress in Cyprinus carpio var. larvae

(2020) Xiaohua Xia et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Exogenous hydrogen sulfide donor NaHS alleviates nickel-induced epithelial-mesenchymal transition and the migration of A549 cells by regulating TGF-β1/Smad2/Smad3 signaling

(2020) Mengjuan Ye et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Microplastics induce intestinal inflammation, oxidative stress, and disorders of metabolome and microbiome in zebrafish

(2019) Ruxia Qiao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

H2S promotes a glycometabolism disorder by disturbing the Th1/Th2 balance during LPS-induced inflammation in the skeletal muscles of chickens

(2019) Hongyuan Jing et al.   CHEMOSPHERE

Nrf2 protects against diverse PM2.5 components-induced mitochondrial oxidative damage in lung cells

(2019) Michal Pardo et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Di (2-ethyl hexyl) phthalate (DEHP)-induced spleen toxicity in quail (Coturnix japonica) via disturbing Nrf2-mediated defense response

(2019) Lei Yu et al.   ENVIRONMENTAL POLLUTION

Hepatocellular HO-1 mediated iNOS-induced hepatoprotection against liver ischemia reperfusion injury

(2019) Yingli Qiao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Polystyrene microplastics cause tissue damages, sex-specific reproductive disruption and transgenerational effects in marine medaka (Oryzias melastigma)

(2019) Jun Wang et al.   ENVIRONMENTAL POLLUTION

Nrf2/HO-1 signaling pathway participated in the protection of hydrogen sulfide on neuropathic pain in rats

(2019) Hongguang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Protective effect of hydrogen sulfide on experimental testicular ischemia reperfusion in rats

(2019) M. Bozkurt et al.   Journal of Pediatric Urology

Exposure to polystyrene microplastics causes reproductive toxicity through oxidative stress and activation of the p38 MAPK signaling pathway

(2019) Xiaoman Xie et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish

(2019) Yao Zhao et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Accumulation of polystyrene microplastics in juvenile Eriocheir sinensis and oxidative stress effects in the liver

(2018) Ping Yu et al.   AQUATIC TOXICOLOGY

Gasotransmitter hydrogen sulfide signaling in neuronal health and disease

(2018) Bindu D. Paul et al.   BIOCHEMICAL PHARMACOLOGY

Nrf2-Keap1 signaling in oxidative and reductive stress

(2018) Ilaria Bellezza et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Sulfite protects neurons from oxidative stress

(2018) Yuka Kimura et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice

(2018) Zhenyu Shen et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Copper (II) and/or arsenite-induced oxidative stress cascades apoptosis and autophagy in the skeletal muscles of chicken

(2018) Yu Wang et al.   CHEMOSPHERE

Oxidative stress-induced skeletal muscle injury involves in NF-κB/p53-activated immunosuppression and apoptosis response in copper (II) or/and arsenite-exposed chicken

(2018) Hongjing Zhao et al.   CHEMOSPHERE

Grape seed procyanidin extract ameliorates lead-induced liver injury via miRNA153 and AKT/GSK-3β/Fyn-mediated Nrf2 activation

(2018) Biying Liu et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Corporate social responsibility in marine plastic debris governance

(2018) Micah Landon-Lane   MARINE POLLUTION BULLETIN

Polystyrene microplastics alter the behavior, energy reserve and nutritional composition of marine jacopever (Sebastes schlegelii)

(2018) Liyun Yin et al.   JOURNAL OF HAZARDOUS MATERIALS

Hyperactivation of Nrf2 increases stress tolerance at the cost of aging acceleration due to metabolic deregulation

(2018) Eleni N. Tsakiri et al.   AGING CELL

Biodegradation of polyethylene microplastics by the marine fungus Zalerion maritimum

(2017) Ana Paço et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Brg1-mediated Nrf2/HO-1 pathway activation alleviates hepatic ischemia–reperfusion injury

(2017) Mian Ge et al.   Cell Death & Disease

Adverse effects of microplastics and oxidative stress-induced MAPK/Nrf2 pathway-mediated defense mechanisms in the marine copepod Paracyclopina nana

(2017) Chang-Bum Jeong et al.   Scientific Reports

Tissue accumulation of microplastics in mice and biomarker responses suggest widespread health risks of exposure

(2017) Yongfeng Deng et al.   Scientific Reports

Hydrogen sulfide protects against TNF-α induced neuronal cell apoptosis through miR-485-5p/TRADD signaling

(2016) Zhiqiang Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

GST-TAT-SOD: Cell Permeable Bifunctional Antioxidant Enzyme—A Potential Selective Radioprotector

(2016) Jianru Pan et al.   Oxidative Medicine and Cellular Longevity

Quercetin protects mouse liver against nickel-induced DNA methylation and inflammation associated with the Nrf2/HO-1 and p38/STAT1/NF-κB pathway

(2015) Chan-Min Liu et al.   FOOD AND CHEMICAL TOXICOLOGY

Reduction of DNA damage induced by titanium dioxide nanoparticles through Nrf2 in vitro and in vivo

(2015) Zhiqin Shi et al.   JOURNAL OF HAZARDOUS MATERIALS

Hydrogen sulfide protects against apoptosis under oxidative stress through SIRT1 pathway in H9c2 cardiomyocytes

(2015) Dan Wu et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Tu2049 Hydrogen Sulfide (H2S) Regulates Liver Development and Protects From Acetaminophen (APAP)-Induced Liver Injury in Zebrafish

(2015) Alexander R. Cohen et al.   GASTROENTEROLOGY

Hydrogen sulfide protected gastric epithelial cell from ischemia/reperfusion injury by Keap1 s-sulfhydration, MAPK dependent anti-apoptosis and NF-κB dependent anti-inflammation pathway

(2014) Cheng Guo et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Microplastics in the seas

(2014) K. L. Law et al.   SCIENCE

Activated Nrf2 impairs liver regeneration in mice by activation of genes involved in cell-cycle control and apoptosis

(2013) Ulrike A. Köhler et al.   HEPATOLOGY

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

(2012) M. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous hydrogen sulfide formation mediates the liver damage in endotoxemic rats

(2012) Yulin Yan et al.   RESEARCH IN VETERINARY SCIENCE

Redox Biochemistry of Hydrogen Sulfide

(2010) Omer Kabil et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nrf2 the rescue: Effects of the antioxidative/electrophilic response on the liver

(2010) Curtis D. Klaassen et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Accumulation and fragmentation of plastic debris in global environments

(2009) D. K. A. Barnes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling