The importance of sulfur-containing motifs in drug design and discovery
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The importance of sulfur-containing motifs in drug design and discovery
Authors
Keywords
-
Journal
Expert Opinion on Drug Discovery
Volume 17, Issue 5, Pages 501-512
Publisher
Informa UK Limited
Online
2022-02-23
DOI
10.1080/17460441.2022.2044783
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Prospects and Challenges in Organosulfur Chemistry
- (2022) Ming Wang et al. ACS Sustainable Chemistry & Engineering
- Sulfur-containing therapeutics in the treatment of Alzheimer’s disease
- (2021) Haizhou Zhu et al. MEDICINAL CHEMISTRY RESEARCH
- Covalent Inhibition of Wild-Type HIV-1 Reverse Transcriptase Using a Fluorosulfate Warhead
- (2021) Joseph A. Ippolito et al. ACS Medicinal Chemistry Letters
- Eat Your Broccoli: Oxidative Stress, NRF2, and Sulforaphane in Chronic Kidney Disease
- (2021) Scott E. Liebman et al. Nutrients
- Imipenem/Cilastatin/Relebactam: A Review in Gram-Negative Bacterial Infections
- (2021) Young-A. Heo DRUGS
- An update on the emerging approaches for histone deacetylase (HDAC) inhibitor drug discovery and future perspectives
- (2021) Ma Su et al. Expert Opinion on Drug Discovery
- The active form of the influenza cap-snatching endonuclease inhibitor baloxavir marboxil is a tight binding inhibitor
- (2021) Brendan Todd et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Discovery of TAK-981, a First-in-Class Inhibitor of SUMO-Activating Enzyme for the Treatment of Cancer
- (2021) Steven P. Langston et al. JOURNAL OF MEDICINAL CHEMISTRY
- NITD-688, a pan-serotype inhibitor of the dengue virus NS4B protein, shows favorable pharmacokinetics and efficacy in preclinical animal models
- (2021) Stephanie A. Moquin et al. Science Translational Medicine
- Steroid sulfatase inhibitors: the current landscape
- (2021) Hanan S. Anbar et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Design, Synthesis, and Structural Characterization of Lysine Covalent BH3 Peptides Targeting Mcl-1
- (2021) Luca Gambini et al. JOURNAL OF MEDICINAL CHEMISTRY
- Steroid Sulphatase and Its Inhibitors: Past, Present, and Future
- (2021) Paul A. Foster MOLECULES
- P-287 Preclinical evaluation of alpelisib (PI3K inhibitor) and its synergistic effect in combination with ribociclib (CDK 4/6 inhibitor) in colorectal cancer
- (2021) R. Aslam et al. ANNALS OF ONCOLOGY
- Translational and pharmacokinetic‐pharmacodynamic application for the clinical development of GDC‐0334, a novel TRPA1 inhibitor
- (2021) Phyllis Chan et al. CTS-Clinical and Translational Science
- Odevixibat: First Approval
- (2021) Emma D. Deeks DRUGS
- How do we address neglected sulfur pharmacophores in drug discovery?
- (2021) Michael J. Tilby et al. Expert Opinion on Drug Discovery
- Discovery of LYC-55716: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor-γ (RORγ) Agonist for Use in Treating Cancer
- (2021) Thomas D. Aicher et al. JOURNAL OF MEDICINAL CHEMISTRY
- Repositioning of the Anthelmintic Drugs Bithionol and Triclabendazole as Transthyretin Amyloidogenesis Inhibitors
- (2021) Takeshi Yokoyama et al. JOURNAL OF MEDICINAL CHEMISTRY
- JNJ-67569762, A 2-Aminotetrahydropyridine-Based Selective BACE1 Inhibitor Targeting the S3 Pocket: From Discovery to Clinical Candidate
- (2021) Frederik J. R. Rombouts et al. JOURNAL OF MEDICINAL CHEMISTRY
- 3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents
- (2021) Sho Konno et al. JOURNAL OF MEDICINAL CHEMISTRY
- Clinical Utility of Fedratinib in Myelofibrosis
- (2021) Julian A Waksal et al. OncoTargets and Therapy
- Oral fexinidazole for stage 1 or early stage 2 African Trypanosoma brucei gambiense trypanosomiasis: a prospective, multicentre, open-label, cohort study
- (2021) Victor Kande Betu Ku Mesu et al. Lancet Global Health
- Full-Spectrum Fluoromethyl Sulfonation via Modularized Multicomponent Coupling
- (2021) Kejie Li et al. CCS Chemistry
- Effects of Lusutrombopag on Post-invasive Procedural Bleeding in Thrombocytopenic Patients with Chronic Liver Disease
- (2021) Manami Yoshida et al. ADVANCES IN THERAPY
- Maralixibat: First Approval
- (2021) Matt Shirley DRUGS
- Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation
- (2021) Yichao Wan et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Selective SIRT2 inhibitors as promising anticancer therapeutics: An update from 2016 to 2020
- (2021) Eslam Roshdy et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles
- (2021) Muhamad Mustafa et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Medicinal chemistry updates of novel HDACs inhibitors (2020 to present)
- (2021) Xingrui He et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Carbonic anhydrase inhibitors: an update on experimental agents for the treatment and imaging of hypoxic tumors
- (2021) Claudiu T. Supuran EXPERT OPINION ON INVESTIGATIONAL DRUGS
- Lysine Covalent Antagonists of Melanoma Inhibitors of Apoptosis Protein
- (2021) Parima Udompholkul et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Cysteine-targeting Covalent Protein Kinase Inhibitors
- (2021) Xiaoyun Lu et al. JOURNAL OF MEDICINAL CHEMISTRY
- Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells
- (2021) Brenda Medellin et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery of Chromane-6-Sulfonamide Derivative as a Potent, Selective, and Orally Available Novel Retinoic Acid Receptor-Related Orphan Receptor γt Inverse Agonist
- (2021) Lei Chen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Drugs That Changed Society: History and Current Status of the Early Antibiotics: Salvarsan, Sulfonamides, and β-Lactams
- (2021) Søren Brøgger Christensen MOLECULES
- Belzutifan for Renal Cell Carcinoma in von Hippel–Lindau Disease
- (2021) Eric Jonasch et al. NEW ENGLAND JOURNAL OF MEDICINE
- Properties of FDA-approved small molecule protein kinase inhibitors: A 2022 update
- (2021) Robert Roskoski Jr. PHARMACOLOGICAL RESEARCH
- Novel Treatments from Inhibition of the Intestinal Sodium–Hydrogen Exchanger 3
- (2021) Csaba P Kovesdy et al. International Journal of Nephrology and Renovascular Disease
- A Phase 1 Study of SLC-0111, a Novel Inhibitor of Carbonic Anhydrase IX, in Patients With Advanced Solid Tumors
- (2020) Paul C. McDonald et al. AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
- Sodium Dithionite‐Mediated Decarboxylative Sulfonylation: Facile Access to Tertiary Sulfones
- (2020) Yaping Li et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Thioproline Serves as an Efficient Antioxidant Protecting Human Cells from Oxidative Stress and Improves Cell Viability
- (2020) Yat-Hing Ham et al. CHEMICAL RESEARCH IN TOXICOLOGY
- SuFEx Activation with Ca(NTf2)2: A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
- (2020) Subham Mahapatra et al. ORGANIC LETTERS
- Chiral Analogues of PFI-1 as BET Inhibitors and Their Functional Role in Myeloid Malignancies
- (2020) Bianca Altenburg et al. ACS Medicinal Chemistry Letters
- Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface
- (2020) Mingxing Teng et al. ACS Medicinal Chemistry Letters
- Design and Synthesis of 5‐Morpholino‐Thiophene‐Indole/ Oxindole Hybrids as Cytotoxic Agents
- (2020) Upasana Yadav et al. ChemistrySelect
- Clinical Utility of Lefamulin: If Not Now, When?
- (2020) Nicholas J. Mercuro et al. Current Infectious Disease Reports
- Sulfoximines as Rising Stars in Modern Drug Discovery? Current Status and Perspective on an Emerging Functional Group in Medicinal Chemistry
- (2020) Patrick Mäder et al. JOURNAL OF MEDICINAL CHEMISTRY
- Thiadiazole derivatives as anticancer agents
- (2020) Monika Szeliga Pharmacological Reports
- Carbonic Anhydrase Inhibitors Targeting Metabolism and Tumor Microenvironment
- (2020) Andrea Angeli et al. Metabolites
- A Broad‐Spectrum, Catalytic Amidation of Sulfonyl Fluorides and Fluorosulfates
- (2020) Mingjie Wei et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- FDA Approval Summary: Lurbinectedin for the Treatment of Metastatic Small Cell Lung Cancer
- (2020) Sonia Singh et al. CLINICAL CANCER RESEARCH
- PROTACs to address the challenges facing small molecule inhibitors
- (2020) Pedro Martín-Acosta et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Application of sulfoximines in medicinal chemistry from 2013 to 2020
- (2020) Yu Han et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- PROTACs– a game-changing technology
- (2019) Markella Konstantinidou et al. Expert Opinion on Drug Discovery
- Cefiderocol: Discovery, Chemistry, and In Vivo Profiles of a Novel Siderophore Cephalosporin
- (2019) Takafumi Sato et al. CLINICAL INFECTIOUS DISEASES
- Sulfamates in drug design and discovery: Pre-clinical and clinical investigations
- (2019) Seyed-Omar Zaraei et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Role of sulphur-heterocycles in medicinal chemistry: An update
- (2019) Shelly Pathania et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy
- (2019) Carlo Baggio et al. JOURNAL OF MEDICINAL CHEMISTRY
- Medicinal Thiols: Current Status and New Perspectives
- (2019) Annalise R. Pfaff et al. MINI-REVIEWS IN MEDICINAL CHEMISTRY
- Covalent Small Molecules as Enabling Platforms for Drug Discovery
- (2019) Samuel E. Dalton et al. CHEMBIOCHEM
- New thiazole-2(3H)-thiones containing 4-(3,4,5-trimethoxyphenyl) moiety as anticancer agents
- (2019) Mahsa Ansari et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Thiazole-containing compounds as therapeutic targets for cancer therapy
- (2019) Prabodh Chander Sharma et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Preclinical Evaluation of Ureidosulfamate Carbonic Anhydrase IX/XII Inhibitors in the Treatment of Cancers
- (2019) Kaye J. Williams et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- A phase I randomized controlled trial to evaluate safety and clinical effect of topically applied GSK2981278 ointment in a psoriasis plaque test
- (2018) E.G. Kang et al. BRITISH JOURNAL OF DERMATOLOGY
- Enzyme structures of the bacterial peptidoglycan and wall teichoic acid biogenesis pathways
- (2018) Nathanael A Caveney et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- SULFATION PATHWAYS: Steroid sulphatase inhibition via aryl sulphamates: clinical progress, mechanism and future prospects
- (2018) Barry V L Potter JOURNAL OF MOLECULAR ENDOCRINOLOGY
- Genetically Encoding Fluorosulfate-l-tyrosine To React with Lysine, Histidine, and Tyrosine via SuFEx in Proteins in Vivo
- (2018) Nanxi Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Characterization of influenza virus variants induced by treatment with the endonuclease inhibitor baloxavir marboxil
- (2018) Shinya Omoto et al. Scientific Reports
- Analysis of US FDA-Approved Drugs Containing Sulfur Atoms
- (2018) Kevin A. Scott et al. Topics in Current Chemistry
- Sulfonimidamides: Synthesis and Applications in Preparative Organic Chemistry
- (2018) Ganesh Chandra Nandi et al. ADVANCED SYNTHESIS & CATALYSIS
- Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review
- (2018) Chuang Zhao et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Emerging and Re-Emerging Warheads for Targeted Covalent Inhibitors: Applications in Medicinal Chemistry and Chemical Biology
- (2018) Matthias Gehringer et al. JOURNAL OF MEDICINAL CHEMISTRY
- Discovery and Characterization of AZD6738, a Potent Inhibitor of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Kinase with Application as an Anticancer Agent
- (2018) Kevin M. Foote et al. JOURNAL OF MEDICINAL CHEMISTRY
- Synthesis, biological evaluation and molecular docking study of N -(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists
- (2017) Meng Zhou et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Sulfoximines from a Medicinal Chemist's Perspective: Physicochemical and in vitro Parameters Relevant for Drug Discovery
- (2017) Marcus Frings et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Novel carbonic anhydrase IX-targeted therapy enhances the anti-tumour effects of cisplatin in small cell lung cancer
- (2017) Jennifer L Bryant et al. INTERNATIONAL JOURNAL OF CANCER
- The most appropriate therapeutic strategy for acute lower respiratory tract infections: a Delphi-based approach
- (2017) Francesco Blasi et al. JOURNAL OF CHEMOTHERAPY
- Sulfur Containing Scaffolds in Drugs: Synthesis and Application in Medicinal Chemistry
- (2016) Minghao Feng et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Thiazolo[4,5-d]pyrimidines as a privileged scaffold in drug discovery
- (2016) Bhimanna Kuppast et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- A novel pleuromutilin antibacterial compound, its binding mode and selectivity mechanism
- (2016) Zohar Eyal et al. Scientific Reports
- Discovery and Development of the Aryl O-Sulfamate Pharmacophore for Oncology and Women’s Health
- (2015) Mark P. Thomas et al. JOURNAL OF MEDICINAL CHEMISTRY
- The β-Lactams Strike Back: Ceftazidime-Avibactam
- (2015) Evan J. Zasowski et al. PHARMACOTHERAPY
- Kinetic and Structural Requirements for Carbapenemase Activity in GES-Type β-Lactamases
- (2014) Nichole K. Stewart et al. BIOCHEMISTRY
- Sulfoximines: A Neglected Opportunity in Medicinal Chemistry
- (2013) Ulrich Lücking ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Data-Mining for Sulfur and Fluorine: An Evaluation of Pharmaceuticals To Reveal Opportunities for Drug Design and Discovery
- (2013) Elizabeth A. Ilardi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Antitrypanosomal Activity of Fexinidazole, a New Oral Nitroimidazole Drug Candidate for Treatment of Sleeping Sickness
- (2011) Marcel Kaiser et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- The role of sulfamide derivatives in medicinal chemistry: a patent review (2006 – 2008)
- (2009) Allen B Reitz et al. EXPERT OPINION ON THERAPEUTIC PATENTS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search