Ginsenoside Rf inhibits human tau proteotoxicity and causes specific LncRNA, miRNA and mRNA expression changes in Caenorhabditis elegans model of tauopathy

A SIRT1 Activator, Ginsenoside Rc, Promotes Energy Metabolism in Cardiomyocytes and Neurons

(2021) Qingxia Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

TPM, FPKM, or Normalized Counts? A Comparative Study of Quantification Measures for the Analysis of RNA-seq Data from the NCI Patient-Derived Models Repository

(2021) Yingdong Zhao et al.   Journal of Translational Medicine

Polystyrene nanoparticles induced neurodevelopmental toxicity in Caenorhabditis elegans through regulation of dpy-5 and rol-6

(2021) Yu Shang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

FOXO and related transcription factors binding elements in the regulation of neurodegenerative disorders

(2021) Vaibhav Oli et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Increased miR‐34c mediates synaptic deficits by targeting synaptotagmin 1 through ROS‐JNK‐p53 pathway in Alzheimer’s Disease

(2020) Zhongli Shi et al.   AGING CELL

Identifying lncRNA–miRNA–mRNA networks to investigate Alzheimer’s disease pathogenesis and therapy strategy

(2020) Nana Ma et al.   Aging-US

Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells

(2020) Wenqi Jin et al.   LIFE SCIENCES

Integrated bioinformatics analysis for the screening of hub genes and therapeutic drugs in ovarian cancer

(2020) Dan Yang et al.   Journal of Ovarian Research

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

(2020) Jack M. Webster et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ginsenosides attenuate bioenergetics and morphology of mitochondria in cultured PC12 cells under the insult of amyloid beta-peptide

(2020) Kenneth Kin Leung Kwan et al.   Journal of Ginseng Research

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

(2019) Evandro F. Fang et al.   NATURE NEUROSCIENCE

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

(2019) Anju Singh et al.   MOLECULES

Natural occurring polysaccharides from Panax ginseng C. A. Meyer: A review of isolation, structures, and bioactivities

(2019) Bin Zhao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Antidepressant effects of ginsenoside Rf on behavioral change in the glial degeneration model of depression by reversing glial loss

(2019) Yunna Kim et al.   Journal of Ginseng Research

Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau

(2019) Sarah M. Waldherr et al.   Nature Communications

Human amyloid β peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans

(2018) Chenyin Wang et al.   NEUROBIOLOGY OF DISEASE

Muscle-Specific Histone H3K36 Dimethyltransferase SET-18 Shortens Lifespan of Caenorhabditis elegans by Repressing daf-16a Expression

(2018) Liangping Su et al.   Cell Reports

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Disease‐associated tau impairs mitophagy by inhibiting Parkin translocation to mitochondria

(2018) Nadia Cummins et al.   EMBO JOURNAL

Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau

(2018) Rebecca Freilich et al.   Nature Communications

Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease

(2017) Eric Tönnies et al.   JOURNAL OF ALZHEIMERS DISEASE

Hydralazine induces stress resistance and extends C. elegans lifespan by activating the NRF2/SKN-1 signalling pathway

(2017) Esmaeil Dehghan et al.   Nature Communications

Larval crowding accelerates C. elegans development and reduces lifespan

(2017) Andreas H. Ludewig et al.   PLoS Genetics

O-GlcNAcylation of SKN-1 modulates the lifespan and oxidative stress resistance in Caenorhabditis elegans

(2017) Hongyuan Li et al.   Scientific Reports

Ginsenoside Re Attenuates Neuroinflammation in a Symptomatic ALS Animal Model

(2016) Mudan Cai et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Ginsenosides attenuate d-galactose- and AlCl3-inducedspatial memory impairment by restoring the dysfunction of the neurotransmitter systems in the rat model of Alzheimer's disease

(2016) Yan Zhang et al.   JOURNAL OF ETHNOPHARMACOLOGY

MicroRNA mir-34 provides robustness to environmental stress response via the DAF-16 network in C. elegans

(2016) Meltem Isik et al.   Scientific Reports

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo

(2016) Marianna Karina Gorsky et al.   Scientific Reports

Worming forward: amyotrophic lateral sclerosis toxicity mechanisms and genetic interactions in Caenorhabditis elegans

(2014) Martine Therrien et al.   Frontiers in Genetics

Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases

(2014) Adanna G. Alexander et al.   Frontiers in Genetics

Inhibition of tau aggregation in a novel Caenorhabditis elegans model of tauopathy mitigates proteotoxicity

(2012) Chronis Fatouros et al.   HUMAN MOLECULAR GENETICS

MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9

(2011) Jurong Yang et al.   AGE

Tau-Induced Defects in Synaptic Plasticity, Learning, and Memory Are Reversible in Transgenic Mice after Switching Off the Toxic Tau Mutant

(2011) A. Sydow et al.   JOURNAL OF NEUROSCIENCE

Non-coding RNAs in human disease

(2011) Manel Esteller   NATURE REVIEWS GENETICS

Tau Mediated Neurodegeneration: An Insight into Alzheimer’s Disease Pathology

(2011) M. Obulesu et al.   NEUROCHEMICAL RESEARCH

The Many Faces of Tau

(2011) Meaghan Morris et al.   NEURON

Alzheimer's disease neurofibrillary degeneration: pivotal and multifactorial: Figure 1

(2010) Khalid Iqbal et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration

(2010) Sébastien S. Hébert et al.   HUMAN MOLECULAR GENETICS

Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation

(2010) Cole Trapnell et al.   NATURE BIOTECHNOLOGY

Neurobiology of cognitive disorders

(2009) Alexander Kurz et al.   CURRENT OPINION IN PSYCHIATRY

Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

(2009) Yipeng Wang et al.   HUMAN MOLECULAR GENETICS

Intracellular amyloid formation in muscle cells of Aβ-transgenic Caenorhabditis elegans: determinants and physiological role in copper detoxification

(2009) Alicia N Minniti et al.   Molecular Neurodegeneration

A synaptic DEG/ENaC ion channel mediates learning in C. elegans by facilitating dopamine signalling

(2008) Giannis Voglis et al.   EMBO JOURNAL

RNA-Seq: a revolutionary tool for transcriptomics

(2008) Zhong Wang et al.   NATURE REVIEWS GENETICS