Synthesis of heterocyclic ring-fused analogs of HMG499 as novel degraders of HMG-CoA reductase that lower cholesterol

How I treat statin-associated side effects in an outpatient setting

(2021) Vishnu Priya Pulipati et al.   Future Cardiology

Degradation versus Inhibition: Development of Proteolysis-Targeting Chimeras for Overcoming Statin-Induced Compensatory Upregulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

(2020) Mei-Xin Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Anti-DENV And Anti-Dengue Vector Activity of Some Heterocyclic Scaffolds

(2020) Deepika Purohit et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Statin Treatment-Induced Development of Type 2 Diabetes: From Clinical Evidence to Mechanistic Insights

(2020) Unai Galicia-Garcia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Power of Plasticity—Metabolic Regulation of Hepatic Stellate Cells

(2020) Parth Trivedi et al.   Cell Metabolism

Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo

(2020) Guoshun Luo et al.   Acta Pharmaceutica Sinica B

A Structured Literature Review of the Epidemiology and Disease Burden of Non-Alcoholic Steatohepatitis (NASH)

(2019) Manca Povsic et al.   ADVANCES IN THERAPY

Schnyder corneal dystrophy-associated UBIAD1 mutations cause corneal cholesterol accumulation by stabilizing HMG-CoA reductase

(2019) Shi-You Jiang et al.   PLoS Genetics

Synthesis and biological evaluation of methylpyrimidine-fused tricyclic diterpene analogs as novel oral anti-late-onset hypogonadism agents

(2019) Jie Bai et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The importance of the nitric oxide‐cGMP pathway in age‐related cardiovascular disease: Focus on phosphodiesterase‐1 and soluble guanylate cyclase

(2019) Keivan Golshiri et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Deciphering the Role of Lipid Droplets in Cardiovascular Disease

(2018) Ira J. Goldberg et al.   CIRCULATION

Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann–Pick C1 mutant cell via lysosome-associated membrane protein 1

(2018) Ashutosh Singhal et al.   Cell Death & Disease

Discovery of a potent HMG-CoA reductase degrader that eliminates statin-induced reductase accumulation and lowers cholesterol

(2018) Shi-You Jiang et al.   Nature Communications

Synthesis of heterocyclic ring-fused tricyclic diterpene analogs as novel inhibitors of RANKL-induced osteoclastogenesis and bone resorption

(2017) Gao Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Regression of Liver Fibrosis

(2017) John Iredale et al.   SEMINARS IN LIVER DISEASE

Intracellular Cholesterol Trafficking and Impact in Neurodegeneration

(2017) Fabian Arenas et al.   Frontiers in Molecular Neuroscience

Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection

(2016) Xin Gong et al.   CELL

The Role of Cholesterol in the Pathogenesis of NASH

(2016) George N. Ioannou   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis

(2016) Hans-Theo Schon et al.   Frontiers in Pharmacology

The synthesis and antibacterial activity of pyrazole-fused tricyclic diterpene derivatives

(2015) Li-Gang Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Statin use and non-alcoholic steatohepatitis in at risk individuals

(2015) Paola Dongiovanni et al.   JOURNAL OF HEPATOLOGY

Structure–Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer’s Disease Brains

(2015) Kenji Matsumura et al.   JOURNAL OF MEDICINAL CHEMISTRY

An assessment by the Statin Diabetes Safety Task Force: 2014 update

(2014) Kevin C. Maki et al.   Journal of Clinical Lipidology

Design, Synthesis, and Structure–Activity Relationship Studies of Novel Fused Heterocycles-Linked Triazoles with Good Activity and Water Solubility

(2014) Xufeng Cao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Free cholesterol accumulation in hepatic stellate cells: Mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice

(2013) Kengo Tomita et al.   HEPATOLOGY

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

Synthesis and Biological Evaluation of Heterocyclic Ring-Fused Betulinic Acid Derivatives as Novel Inhibitors of Osteoclast Differentiation and Bone Resorption

(2012) Jun Xu et al.   JOURNAL OF MEDICINAL CHEMISTRY

A High-Cholesterol Diet Exacerbates Liver Fibrosis in Mice via Accumulation of Free Cholesterol in Hepatic Stellate Cells

(2011) Toshiaki Teratani et al.   GASTROENTEROLOGY

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY