The importance of the nitric oxide‐cGMP pathway in age‐related cardiovascular disease: Focus on phosphodiesterase‐1 and soluble guanylate cyclase

Lifetime risk and multimorbidity of non-communicable diseases and disease-free life expectancy in the general population: A population-based cohort study

(2019) Silvan Licher et al.   PLOS MEDICINE

p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia

(2019) Masataka Yokoyama et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

PDE1 inhibition facilitates proteasomal degradation of misfolded proteins and protects against cardiac proteinopathy

(2019) Hanming Zhang et al.   Science Advances

Multiple common comorbidities produce left ventricular diastolic dysfunction associated with coronary microvascular dysfunction, oxidative stress, and myocardial stiffening

(2018) Oana Sorop et al.   CARDIOVASCULAR RESEARCH

A Multi-Protein Complex with TRPC, PDE1C, and A2R Plays a Critical Role in Regulating Cardiomyocyte cAMP and Survival

(2018) Yishuai Zhang et al.   CIRCULATION

Acute Enhancement of Cardiac Function by Phosphodiesterase Type 1 Inhibition: A Translational Study in the Dog and Rabbit

(2018) Toru Hashimoto et al.   CIRCULATION

Exploring New Cardiovascular Pathways

(2018) Marek Michalak et al.   Circulation-Heart Failure

Endothelium-Dependent Hyperpolarization (EDH) in Hypertension: The Role of Endothelial Ion Channels

(2018) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pharmacological Characterization of IW-1973, a Novel Soluble Guanylate Cyclase Stimulator with Extensive Tissue Distribution, Antihypertensive, Anti-Inflammatory, and Antifibrotic Effects in Preclinical Models of Disease

(2018) Jenny V. Tobin et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation

(2018) Ariane Migliato Martinelli et al.   JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES

Physiological activation and deactivation of soluble guanylate cyclase

(2018) Benjamin G. Horst et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mechanisms of Dysfunction in the Aging Vasculature and Role in Age-Related Disease

(2018) Anthony J. Donato et al.   CIRCULATION RESEARCH

Potential pitfalls in analyzing structural uncoupling of eNOS: aging is not associated with increased enzyme monomerization

(2018) Fumin Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

PDE3 inhibition by C-type natriuretic peptide-induced cGMP enhances cAMP-mediated signaling in both non-failing and failing hearts

(2017) Silja Meier et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Anti-fibrotic effects of soluble guanylate cyclase stimulators and activators: A review of the preclinical evidence

(2017) Peter Sandner et al.   RESPIRATORY MEDICINE

Sildenafil ameliorates left ventricular T-tubule remodeling in a pressure overload-induced murine heart failure model

(2016) Chun-kai Huang et al.   ACTA PHARMACOLOGICA SINICA

EDH: endothelium-dependent hyperpolarization and microvascular signalling

(2016) C. J. Garland et al.   Acta Physiologica

P66Shc-Induced MicroRNA-34a Causes Diabetic Endothelial Dysfunction by Downregulating Sirtuin1Highlights

(2016) Qiuxia Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-serine 239 phosphorylation

(2016) Andrew W. Holt et al.   CELLULAR SIGNALLING

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

Effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing and health-related quality of life measures in heart failure patients with preserved ejection fraction and pulmonary hypertension

(2016) Licette C.Y. Liu et al.   EUROPEAN JOURNAL OF HEART FAILURE

The Potential of sGC Modulators for the Treatment of Age-Related Fibrosis: A Mini-Review

(2016) Peter Sandner et al.   GERONTOLOGY

Restricted diet delays accelerated ageing and genomic stress in DNA-repair-deficient mice

(2016) W. P. Vermeij et al.   NATURE

Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?

(2016) Subrata Kumar Biswas   Oxidative Medicine and Cellular Longevity

PDE1C deficiency antagonizes pathological cardiac remodeling and dysfunction

(2016) Walter E. Knight et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical profile of ITI-214, an inhibitor of phosphodiesterase 1, for enhancement of memory performance in rats

(2016) Gretchen L. Snyder et al.   PSYCHOPHARMACOLOGY

PDE 5 inhibition with udenafil improves left ventricular systolic/diastolic functions and exercise capacity in patients with chronic heart failure with reduced ejection fraction; A 12-week, randomized, double-blind, placebo-controlled trial

(2015) Kyung-Hee Kim et al.   AMERICAN HEART JOURNAL

Correlates of Segmental Pulse Wave Velocity in Older Adults: The Atherosclerosis Risk in Communities (ARIC) Study

(2015) Michelle L. Meyer et al.   AMERICAN JOURNAL OF HYPERTENSION

The soluble guanylate cyclase activator cinaciguat prevents cardiac dysfunction in a rat model of type-1 diabetes mellitus

(2015) Csaba Mátyás et al.   Cardiovascular Diabetology

Role of cAMP-Phosphodiesterase 1C Signaling in Regulating Growth Factor Receptor Stability, Vascular Smooth Muscle Cell Growth, Migration, and Neointimal HyperplasiaNovelty and Significance

(2015) Yujun Cai et al.   CIRCULATION RESEARCH

Cyclic nucleotide phosphodiesterase 1 and vascular aging

(2015) C. Yan   CLINICAL SCIENCE

Phosphodiesterase 1 regulation is a key mechanism in vascular aging

(2015) P. K. B. Nino et al.   CLINICAL SCIENCE

Effects of sildenafil on invasive haemodynamics and exercise capacity in heart failure patients with preserved ejection fraction and pulmonary hypertension: a randomized controlled trial

(2015) Elke S. Hoendermis et al.   EUROPEAN HEART JOURNAL

The global impact of non-communicable diseases on healthcare spending and national income: a systematic review

(2015) Taulant Muka et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Vascular biology of ageing—Implications in hypertension

(2015) Adam Harvey et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Cellular and molecular biology of aging endothelial cells

(2015) Anthony J. Donato et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Vascular nitric oxide: Beyond eNOS

(2015) Yingzi Zhao et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Effect of soluble guanylyl cyclase activator and stimulator therapy on nitroglycerin-induced nitrate tolerance in rats

(2015) A. Jabs et al.   VASCULAR PHARMACOLOGY

Soluble guanylyl cyclase activation improves progressive cardiac remodeling and failure after myocardial infarction. Cardioprotection over ACE inhibition

(2014) Daniela Fraccarollo et al.   BASIC RESEARCH IN CARDIOLOGY

Is chronic inhibition of phosphodiesterase type 5 cardioprotective and safe? A meta-analysis of randomized controlled trials

(2014) Elisa Giannetta et al.   BMC Medicine

Clinical and Molecular Genetics of the Phosphodiesterases (PDEs)

(2014) Monalisa F. Azevedo et al.   ENDOCRINE REVIEWS

Cyclic Nucleotide Phosphodiesterases: important signaling modulators and therapeutic targets

(2014) F Ahmad et al.   ORAL DISEASES

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Inhibition of Phosphodiesterase-1 Attenuates Cold-Induced Pulmonary Hypertension

(2013) Patrick Crosswhite et al.   HYPERTENSION

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

Dysfunctional nitric oxide signalling increases risk of myocardial infarction

(2013) Jeanette Erdmann et al.   NATURE

The cGMP Signaling Pathway as a Therapeutic Target in Heart Failure With Preserved Ejection Fraction

(2013) Stephen J. Greene et al.   Journal of the American Heart Association

Smooth muscle cells and vascular diseases

(2012) J.-B. Michel et al.   CARDIOVASCULAR RESEARCH

Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction

(2012) Matej Durik et al.   CIRCULATION

Low-grade chronic inflammation and superoxide anion production by NADPH oxidase are the main determinants of physical frailty in older adults

(2012) Gregory Baptista et al.   FREE RADICAL RESEARCH

The Soluble Guanylyl Cyclase Activator Bay 58-2667 Selectively Limits Cardiomyocyte Hypertrophy

(2012) Jennifer C. Irvine et al.   PLoS One

Functional alterations in endothelial NO, PGI2 and EDHF pathways in aorta in ApoE/LDLR−/− mice

(2012) Gábor Csányi et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Phosphodiesterases Regulate BAY 41-2272-Induced VASP Phosphorylation in Vascular Smooth Muscle Cells

(2012) Shaquria P. Adderley et al.   Frontiers in Pharmacology

Comparison of Soluble Guanylate Cyclase Stimulators and Activators in Models of Cardiovascular Disease Associated with Oxidative Stress

(2012) Melissa H. Costell et al.   Frontiers in Pharmacology

Vascular Aging: Facts and Factors

(2012) Ana P. Dantas et al.   Frontiers in Physiology

IgG from patients with pulmonary arterial hypertension and/or systemic sclerosis binds to vascular smooth muscle cells and induces cell contraction

(2011) Guillaume Bussone et al.   ANNALS OF THE RHEUMATIC DISEASES

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

(2011) Clint L. Miller et al.   BASIC RESEARCH IN CARDIOLOGY

Long-term Treatment With Sildenafil Citrate in Pulmonary Arterial Hypertension

(2011) Lewis J. Rubin et al.   CHEST

Aging and vascular endothelial function in humans

(2011) Douglas R. Seals et al.   CLINICAL SCIENCE

PDE inhibitors: a new approach to treat metabolic syndrome?

(2011) Claire Lugnier   CURRENT OPINION IN PHARMACOLOGY

PDE1 isozymes, key regulators of pathological vascular remodeling

(2011) Stefan Chan et al.   CURRENT OPINION IN PHARMACOLOGY

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency

(2011) Mark J. Crabtree et al.   FREE RADICAL BIOLOGY AND MEDICINE

Decreased cGMP Level Contributes to Increased Contraction in Arteries From Hypertensive Rats

(2011) Fernanda R. Giachini et al.   HYPERTENSION

SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans

(2011) Anthony J. Donato et al.   JOURNAL OF PHYSIOLOGY-LONDON

Age-Related Changes in the Elastic Tissue of the Human Aorta

(2011) Olaf Fritze et al.   JOURNAL OF VASCULAR RESEARCH

Deteriorated function of cutaneous microcirculation in chronic congestive heart failure

(2011) Edvinsson Marie-Louise et al.   Journal of Geriatric Cardiology

Mthfr deficiency induces endothelial progenitor cell senescence via uncoupling of eNOS and downregulation of SIRT1

(2010) Catherine A. Lemarié et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells

(2010) Yujun Cai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Heme-Dependent and Independent Soluble Guanylate Cyclase Activators and Vasodilation

(2010) Fernanda B M Priviero et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure

(2010) Andreas Schäfer et al.   PHARMACOLOGICAL RESEARCH

eNOS uncoupling and endothelial dysfunction in aged vessels

(2009) Yang-Ming Yang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tadalafil Therapy for Pulmonary Arterial Hypertension

(2009) Nazzareno Galiè et al.   CIRCULATION

PDEs1-5 activity and expression in tissues of cirrhotic rats reveal a role for aortic PDE3 in NO desensitization

(2009) Rima Tahseldar-Roumieh et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Metabolic reprogramming, caloric restriction and aging

(2009) Rozalyn M. Anderson et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress

(2008) Zongmin Zhou et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

α1 Soluble Guanylyl Cyclase (sGC) Splice Forms as Potential Regulators of Human sGC Activity

(2008) Iraida G. Sharina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the expression of soluble guanylyl cyclase by reactive oxygen species

(2007) C Gerassimou et al.   BRITISH JOURNAL OF PHARMACOLOGY