Heavy metal and metalloid - induced reproductive toxicity

Mechanisms underlying reproductive toxicity induced by nickel nanoparticles identified by comprehensive gene expression analysis in GC-1 spg cells

(2021) Lu Kong et al.   ENVIRONMENTAL POLLUTION

Zinc transporters and their functional integration in mammalian cells

(2021) Taiho Kambe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A hybrid machine learning approach in modeling the impact of chromium concentration in blood and gonads on the concentration of the reproductive hormones of Urva auropunctatus

(2021) Shaista Andleeb et al.   MEASUREMENT

Cadmium induces apoptosis of pig lymph nodes by regulating the PI3K/AKT/HIF-1α pathway

(2021) Lu Yiming et al.   TOXICOLOGY

Molecular mechanism of heavy metals (Lead, Chromium, Arsenic, Mercury, Nickel and Cadmium) - induced hepatotoxicity – A review

(2021) Kaviyarasi Renu et al.   CHEMOSPHERE

Zinc Nanoparticles Ameliorate the Reproductive Toxicity Induced by Silver Nanoparticles in Male Rats

(2021) Asmaa M Shehata et al.   International Journal of Nanomedicine

Vitellogenesis in the Patagonian toothfish (Dissostichus eleginoides) conditioned to a recirculating aquaculture system

(2021) Rodolfo Amthauer et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Assessment of Ovarian Function in Phase III (Neo)Adjuvant Breast Cancer Clinical Trials: A Systematic Evaluation

(2021) Wanyuan Cui et al.   JNCI-Journal of the National Cancer Institute

Arsenic: an emerging role in adipose tissue dysfunction and muscle toxicity

(2021) Kaviyarasi Renu et al.   Toxin Reviews

Uranium in drinking water: a public health threat

(2020) Geir Bjørklund et al.   ARCHIVES OF TOXICOLOGY

Advances of Zinc Signaling Studies in Prostate Cancer

(2020) Dangdang Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Melatonin MT 1 and MT 2 receptor ERK signaling is differentially dependent on G i/o and G q/11 proteins

(2020) Min Chen et al.   JOURNAL OF PINEAL RESEARCH

Nickel: Human Health and Environmental Toxicology

(2020) Giuseppe Genchi et al.   International Journal of Environmental Research and Public Health

Heavy metal removal by N-acetylcysteine-functionalized cryogels

(2020) Sinem Evli et al.   BULLETIN OF MATERIALS SCIENCE

Melatonin modulates proliferation of pancreatic stellate cells through caspase-3 activation and changes in cyclin A and D expression

(2020) Matias Estaras et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Protective role of wogonin against cadmium induced testicular toxicity: Involvement of antioxidant, anti-inflammatory and anti-apoptotic pathways

(2020) Wen Yu et al.   LIFE SCIENCES

Coronaviruses pathogenesis, comorbidities and multi-organ damage – A review

(2020) Kaviyarasi Renu et al.   LIFE SCIENCES

Two neuroendocrine G protein‐coupled receptor molecules, somatostatin and melatonin: Physiology of signal transduction and therapeutic perspectives

(2020) Eva Costanzi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alpha-lipoic acid improves sperm motility in infertile men after varicocelectomy: a triple-blind randomized controlled trial

(2020) Behzad Abbasi et al.   REPRODUCTIVE BIOMEDICINE ONLINE

Chronic exposure to multi-metals on testicular toxicity in rats

(2020) Amit Gupta et al.   TOXICOLOGY MECHANISMS AND METHODS

Chlorogenic acid abates male reproductive dysfunction in arsenic-exposed mice via attenuation of testicular oxido-inflammatory stress and apoptotic responses

(2020) Manal F. El-Khadragy et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Suppression and recovery of reproductive behavior induced by early life exposure to mercury in zebrafish

(2020) Qiliang Chen et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Lead exposure activates the Nrf2/Keap1 pathway, aggravates oxidative stress, and induces reproductive damage in female mice

(2020) Xianlei Jiang et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki

(2020) Zili Chai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Chronic oral depleted uranium leads to reproductive damage in male rats through the ROS-hnRNP A2/B1-COX-2 signaling pathway

(2020) Binghui Lu et al.   TOXICOLOGY

Environmental doses of arsenic exposure are associated with increased reproductive-age male urinary hormone excretion and in vitro Leydig cell steroidogenesis

(2020) Meiping Tian et al.   JOURNAL OF HAZARDOUS MATERIALS

Deciphering the molecular mechanism during doxorubicin-mediated oxidative stress, apoptosis through Nrf2 and PGC-1α in a rat testicular milieu

(2019) Kaviyarasi Renu et al.   Reproductive Biology

Exposure to mercury and human reproductive health: A systematic review

(2019) Magda Carvalho Henriques et al.   REPRODUCTIVE TOXICOLOGY

Cadmium toxicity: effects on human reproduction and fertility

(2019) Sunil Kumar et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Study on the damage of sperm induced by nickel nanoparticle exposure

(2019) Wangcheng Hu et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Proposed Key Characteristics of Female Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Data in Hazard Assessment

(2019) Ulrike Luderer et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Proposed Key Characteristics of Male Reproductive Toxicants as an Approach for Organizing and Evaluating Mechanistic Evidence in Human Health Hazard Assessments

(2019) Xabier Arzuaga et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview

(2019) Zeeshanur Rahman et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Biomarkers of metal toxicity in embryos in the general population

(2019) Ou Jie et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Heavy metal toxicity: An update of chelating therapeutic strategies

(2019) Jong-Joo Kim et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

A Review of Uranium-Induced Reproductive Toxicity

(2019) Shuang Wang et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Nickel toxicology with reference to male molecular reproductive physiology

(2019) Asim Rizvi et al.   Reproductive Biology

Heavy metal exposure, oxidative stress and semen quality: Exploring associations and mediation effects in reproductive-aged men

(2019) Yinni He et al.   CHEMOSPHERE

Multiple Mechanisms of Zinc-Mediated Inhibition for the Apoptotic Caspases-3, -6, -7, and -8

(2018) Scott J. Eron et al.   ACS Chemical Biology

A comparative study of edetate calcium disodium and dimercaptosuccinic acid in the treatment of lead poisoning in adults

(2018) Kirushanthi Sakthithasan et al.   CLINICAL TOXICOLOGY

Hexavalent chromium induces testicular dysfunction in small Indian mongoose ( Herpestes javanicus ) inhabiting tanneries area of Kasur District, Pakistan

(2018) Shaista Andleeb et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Infectious, inflammatory and ‘autoimmune’ male factor infertility: how do rodent models inform clinical practice?

(2018) Monika Fijak et al.   HUMAN REPRODUCTION UPDATE

Melatonin Regulates the Synthesis of Steroid Hormones on Male Reproduction: A Review

(2018) Kun Yu et al.   MOLECULES

Melatonin promotes sheep Leydig cell testosterone secretion in a co-culture with Sertoli cells

(2018) Shou-Long Deng et al.   THERIOGENOLOGY

LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress

(2018) Ming Gao et al.   TOXICOLOGY LETTERS

DNA methylation and potential multigenerational epigenetic effects linked to uranium chronic low-dose exposure in gonads of males and females rats

(2018) G. Elmhiri et al.   TOXICOLOGY LETTERS

The trafficking of metal ion transporters of the Zrt- and Irt-like protein (ZIP) family

(2018) Katherine Bowers et al.   TRAFFIC

The toxicological mechanisms and detoxification of depleted uranium exposure

(2018) Yong-Chao Yue et al.   Environmental Health and Preventive Medicine

Sulphur dioxide and arsenic affect male reproduction via interfering with spermatogenesis in mice

(2018) Xiujuan Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Review on molecular and biochemical insights of arsenic-mediated male reproductive toxicity

(2018) Kaviyarasi Renu et al.   LIFE SCIENCES

Co-exposure to metals and polycyclic aromatic hydrocarbons, microRNA expression, and early health damage in coke oven workers

(2018) Qifei Deng et al.   ENVIRONMENT INTERNATIONAL

Melatonin Improves Oocyte Maturation and Mitochondrial Functions by Reducing Bisphenol A-Derived Superoxide in Porcine Oocytes In Vitro

(2018) Hyo-Jin Park et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Electrochemically-mediated selective capture of heavy metal chromium and arsenic oxyanions from water

(2018) Xiao Su et al.   Nature Communications

The toxicology of mercury: Current research and emerging trends

(2017) Geir Bjørklund et al.   ENVIRONMENTAL RESEARCH

Efficacy of α-lipoic acid against cadmium toxicity on metal ion and oxidative imbalance, and expression of metallothionein and antioxidant genes in rabbit brain

(2017) Hamida M. Saleh et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Involvement of testicular DAAM1 expression in zinc protection against cadmium-induced male rat reproductive toxicity

(2017) Marouane Chemek et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Chelation therapy: The interaction of British Anti-Lewisite (BAL) with some heavy metal cations of p and d blocks

(2017) Panayiotis V. Ioannou et al.   MAIN GROUP CHEMISTRY

Zebrafish exposure to environmentally relevant concentration of depleted uranium impairs progeny development at the molecular and histological levels

(2017) Olivier Armant et al.   PLoS One

Derivation of an oral toxicity reference value for nickel

(2017) Lynne T. Haber et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Spermatozoa Expression of piR-31704, piR-39888, and piR-40349 and Their Correlation to Sperm Concentration and Fertilization Rate After ICSI

(2017) Long Cui et al.   Reproductive Sciences

The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

(2017) Cristina de Angelis et al.   REPRODUCTIVE TOXICOLOGY

Male reproductive toxicity of CrVI: In-utero exposure to CrVI at the critical window of testis differentiation represses the expression of Sertoli cell tight junction proteins and hormone receptors in adult F 1 progeny rats

(2017) Kathiresh M. Kumar et al.   REPRODUCTIVE TOXICOLOGY

A review of reproductive and developmental toxicity of silver nanoparticles in laboratory animals

(2017) Makoto Ema et al.   REPRODUCTIVE TOXICOLOGY

Steroidogenesis: Unanswered Questions

(2017) Walter L. Miller   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Transplacental Nutrient Transport Mechanisms of Intrauterine Growth Restriction in Rodent Models and Humans

(2017) Elke Winterhager et al.   Frontiers in Physiology

Oral administration ofMoringa oleiferaoil but not coconut oil prevents mercury-induced testicular toxicity in rats

(2016) S. O. Abarikwu et al.   ANDROLOGIA

Downregulation of steroid hormone receptor expression and activation of cell signal transduction pathways induced by a chiral nonylphenol isomer in mouse sertoli TM4 cells

(2016) Xiaozhen Liu et al.   ENVIRONMENTAL TOXICOLOGY

The mechanisms of cyclophosphamide-induced testicular toxicity and the protective agents

(2016) Emad Ghobadi et al.   Expert Opinion on Drug Metabolism & Toxicology

Therapeutic effect of spermatogonial stem cell on testicular damage caused by lead in rats

(2016) Heba F. Pasha et al.   GENE

The protective effects of zinc in lead-induced testicular and epididymal toxicity in Wistar rats

(2016) M Reshma Anjum et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Hsa-miR-137, hsa-miR-520e and hsa-miR-590-3p perform crucial roles in Lynch syndrome

(2016) Changyu Zhou et al.   Oncology Letters

Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

(2016) Maria Elena Ferrero   Biomed Research International

Nickel Release, ROS Generation and Toxicity of Ni and NiO Micro- and Nanoparticles

(2016) Siiri Latvala et al.   PLoS One

Suppressing male spermatogenesis-associated protein 5-like gene expression reduces vitellogenin gene expression and fecundity in Nilaparvata lugens Stål

(2016) Lin-Quan Ge et al.   Scientific Reports

Determinants and Consequences of Arsenic Metabolism Efficiency among 4,794 Individuals: Demographics, Lifestyle, Genetics, and Toxicity

(2015) R. J. Jansen et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Melatonin and male reproduction

(2015) Chunjin Li et al.   CLINICA CHIMICA ACTA

Epigenetic alterations in sperm associated with male infertility

(2015) Akane Kitamura et al.   CONGENITAL ANOMALIES

Associations of lead and cadmium with sex hormones in adult males

(2015) Jacob K. Kresovich et al.   ENVIRONMENTAL RESEARCH

Effects of bleomycin, etoposide and cisplatin treatment on Leydig cell structure and transcription of steroidogenic enzymes in rat testis

(2015) Maie Al-Bader et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Sertoli cell as a model in male reproductive toxicology: Advantages and disadvantages

(2015) Mariana M. S. Reis et al.   JOURNAL OF APPLIED TOXICOLOGY

Impact of sperm DNA chromatin in the clinic

(2015) Dimitrios Ioannou et al.   JOURNAL OF ASSISTED REPRODUCTION AND GENETICS

Toxicity assessment due to sub-chronic exposure to individual and mixtures of four toxic heavy metals

(2015) Samuel J. Cobbina et al.   JOURNAL OF HAZARDOUS MATERIALS

Piccolo Directs Activity Dependent F-Actin Assembly from Presynaptic Active Zones via Daam1

(2015) Dhananjay Wagh et al.   PLoS One

Epigenetic alterations in sperm associated with male infertility

(2015) Akane Kitamura et al.   CONGENITAL ANOMALIES

Protective effect of alpha glucosyl hesperidin (G-hesperidin) on chronic vanadium induced testicular toxicity and sperm nuclear DNA damage in male Sprague Dawley rats

(2014) B. Vijaya Bharathi et al.   ANDROLOGIA

Perspectives in Endocrine Toxicity of Heavy Metals—A Review

(2014) S. V. S. Rana   BIOLOGICAL TRACE ELEMENT RESEARCH

Direct action of endocrine disrupting chemicals on human sperm

(2014) C. Schiffer et al.   EMBO REPORTS

Betaine supplementation protects against renal injury induced by cadmium intoxication in rats: Role of oxidative stress and caspase-3

(2014) Hanan Hagar et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Metals and female reproductive toxicity

(2014) P Sengupta et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Nickel Nanoparticles Exposure and Reproductive Toxicity in Healthy Adult Rats

(2014) Lu Kong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transcriptional Regulation of Programmed Hypertension by Melatonin: An Epigenetic Perspective

(2014) You-Lin Tain et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Binding Mode Investigations on the Interaction of Lead(II) Acetate with Human Chorionic Gonadotropin

(2014) Hao Zhang et al.   JOURNAL OF PHYSICAL CHEMISTRY B

The hypothalamic–pituitary–gonadal axis is target of cadmium toxicity. An update of recent studies and potential therapeutic approaches

(2013) Anunciación Lafuente   FOOD AND CHEMICAL TOXICOLOGY

Mercuric chloride-induced testicular toxicity in rats and the protective role of sodium selenite and vitamin E

(2013) Suna Kalender et al.   FOOD AND CHEMICAL TOXICOLOGY

Potential for genotoxic and reprotoxic effects of vanadium compounds due to occupational and environmental exposures: An article based on a presentation at the 8th International Symposium on Vanadium Chemistry, Biological Chemistry, and Toxicology, Washington DC, August 15–18, 2012

(2013) M. A. Altamirano-Lozano et al.   Journal of Immunotoxicology

The SLC39 family of zinc transporters

(2013) Jeeyon Jeong et al.   MOLECULAR ASPECTS OF MEDICINE

Inward-facing conformation of the zinc transporter YiiP revealed by cryoelectron microscopy

(2013) N. Coudray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oral toxicity of silver ions, silver nanoparticles and colloidal silver – A review

(2013) Niels Hadrup et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Associations between microRNA (miR-21, 126, 155 and 221), albuminuria and heavy metals in Hong Kong Chinese adolescents

(2012) Alice P.S. Kong et al.   CLINICA CHIMICA ACTA

Environmental and occupational exposure of metals and their role in male reproductive functions

(2012) Pallav Sengupta   DRUG AND CHEMICAL TOXICOLOGY

Types, Causes, Detection and Repair of DNA Fragmentation in Animal and Human Sperm Cells

(2012) Clara González-Marín et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Effect of Restraint Stress on Lead-Induced Male Reproductive Toxicity in Rats

(2012) P. HARI PRIYA et al.   Journal of Experimental Zoology Part A-Ecological Genetics and Physiology

Effects of hexavalent chromium on reproductive functions of male adult rats

(2012) Neila Marouani et al.   Reproductive Biology

Protective role of pectin against cadmium-induced testicular toxicity and oxidative stress in rats

(2012) Khaled M. M. Koriem et al.   TOXICOLOGY MECHANISMS AND METHODS

Co-administration of meso 2,3-dimercaptosuccinic acid monoesters reduces arsenic concentration and oxidative stress in gallium arsenide exposed rats

(2011) Swaran JS Flora et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Altered Profile of Seminal Plasma MicroRNAs in the Molecular Diagnosis of Male Infertility

(2011) C. Wang et al.   CLINICAL CHEMISTRY

Cadmium, Lead, and Mercury in Relation to Reproductive Hormones and Anovulation in Premenopausal Women

(2011) Anna Z. Pollack et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

A survey of small RNAs in human sperm

(2011) Stephen A. Krawetz et al.   HUMAN REPRODUCTION

Neurotoxic Effects and Biomarkers of Lead Exposure: A Review

(2011) T. Sanders et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Cytotoxicity and genotoxicity of silver nanoparticles in the human lung cancer cell line, A549

(2010) Rasmus Foldbjerg et al.   ARCHIVES OF TOXICOLOGY

Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A—induced damages on testes in mature rats

(2010) Hassan Malekinejad et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding

(2010) Vibe G. Frokjaer et al.   PSYCHONEUROENDOCRINOLOGY

Accumulation of Mercury in Ovaries of Mice After the Application of Skin-lightening Creams

(2009) Iman Al-Saleh et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The Two Faces of Estradiol: Effects on the Developing Brain

(2009) Margaret M. McCarthy   NEUROSCIENTIST

Pediatric fatality secondary to EDTA chelation

(2008) Arla J. Baxter et al.   CLINICAL TOXICOLOGY

Effect of smoking on blood lead levels in workers and role of reactive oxygen species in lead-induced sperm chromatin DNA damage

(2008) Ping-Chi Hsu et al.   FERTILITY AND STERILITY

Semen characteristics and inflammatory mediators in infertile men with different clinical diagnoses

(2008) E. Moretti et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice

(2008) Q. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro toxic effects of metal compounds on kinetic traits and ultrastructure of rabbit spermatozoa

(2008) Cesare Castellini et al.   REPRODUCTIVE TOXICOLOGY