Journal
CLINICAL TOXICOLOGY
Volume 56, Issue 11, Pages 1143-1149Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/15563650.2018.1478424
Keywords
CaNa(2)EDTA; DMSA; succimer; lead; lead poisoning; edetate calcium disodium
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Background: We evaluated the efficacy of two antidotes, edetate calcium disodium (CaNa(2)EDTA) and dimercaptosuccinic acid (DMSA), for the treatment of lead poisoning in adults. Methods: Thirty-seven patients with blood lead concentrations >40 mu g/dL and positive CaNa(2)EDTA lead mobilization were randomized to receive 1050 mg/m(2)/day of oral DMSA (n = 21) or 500 mg/m(2)/day of intravenous CaNa(2)EDTA (n = 16) over two five-day courses separated by a 10-day rest period. Efficacy of treatment was evaluated by blood lead assays on the first day of the two courses and 14 days after the end of treatment and baseline CaNa(2)EDTA lead mobilization test and 14 days after the end of treatment. Results and conclusion: Both treatments significantly reduced the prevalence of clinical symptoms, blood lead levels and CaNa(2)EDTA lead mobilization and were well tolerated. DMSA had a greater impact on reducing blood lead concentrations (p = .005) and CaNa(2)EDTA on lead mobilization (p = .04). Comparison of equimolar doses showed that CaNa(2)EDTA was more effective than DMSA (p < .001).
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