Melatonin MT 1 and MT 2 receptor ERK signaling is differentially dependent on G i/o and G q/11 proteins

Differential Function of Melatonin MT1 and MT2 Receptors in REM and NREM Sleep

(2019) Gabriella Gobbi et al.   Frontiers in Endocrinology

New perspectives on the role of melatonin in human sleep, circadian rhythms and their regulation

(2018) Nava Zisapel   BRITISH JOURNAL OF PHARMACOLOGY

Heteromeric MT 1 /MT 2 melatonin receptors modulate the scotopic electroretinogram via PKCζ in mice

(2018) Ilaria Piano et al.   EXPERIMENTAL EYE RESEARCH

Manifold roles of β-arrestins in GPCR signaling elucidated with siRNA and CRISPR/Cas9

(2018) Louis M. Luttrell et al.   Science Signaling

Type 2 diabetes–associated variants of the MT2melatonin receptor affect distinct modes of signaling

(2018) Angeliki Karamitri et al.   Science Signaling

Melatonin in type 2 diabetes mellitus and obesity

(2018) Angeliki Karamitri et al.   Nature Reviews Endocrinology

Targeting Melatonin MT2 Receptors: A Novel Pharmacological Avenue for Inflammatory and Neuropathic Pain

(2017) Luca Posa et al.   CURRENT MEDICINAL CHEMISTRY

MT1and MT2Melatonin Receptors: A Therapeutic Perspective

(2016) Jiabei Liu et al.   Annual Review of Pharmacology and Toxicology

Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice

(2016) Sa-Ik Hong et al.   Biomolecules & Therapeutics

Update on melatonin receptors: IUPHAR Review 20

(2016) Ralf Jockers et al.   BRITISH JOURNAL OF PHARMACOLOGY

The dynamic subcellular localization of ERK: mechanisms of translocation and role in various organelles

(2016) Ehud Wainstein et al.   CURRENT OPINION IN CELL BIOLOGY

IGFBP3 and MAPK/ERK signaling mediates melatonin-induced antitumor activity in prostate cancer

(2016) Juan C. Mayo et al.   JOURNAL OF PINEAL RESEARCH

Melatonin Represses Metastasis in Her2-Postive Human Breast Cancer Cells by Suppressing RSK2 Expression

(2016) L. Mao et al.   MOLECULAR CANCER RESEARCH

Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia

(2016) José L. Moreno et al.   Science Signaling

Allosteric signaling through an mGlu2 and 5-HT2Aheteromeric receptor complex and its potential contribution to schizophrenia

(2016) José L. Moreno et al.   Science Signaling

Melatonin controls experimental autoimmune encephalomyelitis by altering the T effector/regulatory balance

(2015) Nuria Álvarez-Sánchez et al.   BRAIN BEHAVIOR AND IMMUNITY

Melatonin Contributes to the Seasonality of Multiple Sclerosis Relapses

(2015) Mauricio F. Farez et al.   CELL

Amyloid β peptide directly impairs pineal gland melatonin synthesis and melatonin receptor signaling through the ERK pathway

(2015) Erika Cecon et al.   FASEB JOURNAL

Convergence of Melatonin and Serotonin (5-HT) Signaling at MT2/5-HT2CReceptor Heteromers

(2015) Maud Kamal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exogenous melatonin inhibits neutrophil migration through suppression of ERK activation

(2015) Da-Long Ren et al.   JOURNAL OF ENDOCRINOLOGY

Highly Potent and Selective MT2 Melatonin Receptor Full Agonists from Conformational Analysis of 1-Benzyl-2-acylaminomethyl-tetrahydroquinolines

(2015) Gilberto Spadoni et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein interactome mining defines melatonin MT1receptors as integral component of presynaptic protein complexes of neurons

(2015) Abla Benleulmi-Chaachoua et al.   JOURNAL OF PINEAL RESEARCH

The experimental power of FR900359 to study Gq-regulated biological processes

(2015) Ramona Schrage et al.   Nature Communications

Melatonin Receptor Type 1 Signals to Extracellular Signal-Regulated Kinase 1 and 2 via Gi and Gs Dually Coupled Pathways in HEK-293 Cells

(2014) Linjie Chen et al.   BIOCHEMISTRY

Understanding melatonin receptor pharmacology: Latest insights from mouse models, and their relevance to human disease

(2014) Gianluca Tosini et al.   BIOESSAYS

Melatonin alleviates myosin light chain kinase expression and activity via the mitogen-activated protein kinase pathway during atherosclerosis in rabbits

(2014) XIAOWEN CHENG et al.   Molecular Medicine Reports

Melatonin enhances adult rat hippocampal progenitor cell proliferation via ERK signaling pathway through melatonin receptor

(2014) C. Tocharus et al.   NEUROSCIENCE

Alterations of melatonin receptors MT1 and MT2 in the hypothalamic suprachiasmatic nucleus during depression

(2013) Ying-Hui Wu et al.   JOURNAL OF AFFECTIVE DISORDERS

Heteromeric MT1/MT2 Melatonin Receptors Modulate Photoreceptor Function

(2013) K. Baba et al.   Science Signaling

Melatonin: An underappreciated player in retinal physiology and pathophysiology

(2012) Gianluca Tosini et al.   EXPERIMENTAL EYE RESEARCH

Melatonin receptor agonist-induced reduction of SNP-released nitric oxide and cGMP production in isolated human non-pigmented ciliary epithelial cells

(2012) Juanita Dortch-Carnes et al.   EXPERIMENTAL EYE RESEARCH

Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes

(2012) Amélie Bonnefond et al.   NATURE GENETICS

ERK1/2 MAP kinases: Structure, function, and regulation

(2012) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins

(2011) Evelyne Lima-Fernandes et al.   EMBO JOURNAL

Removal of melatonin receptor type 1 increases intraocular pressure and retinal ganglion cells death in the mouse

(2011) Susana Alcantara-Contreras et al.   NEUROSCIENCE LETTERS

Localization of Melatonin Receptor 1 in Mouse Retina and Its Role in the Circadian Regulation of the Electroretinogram and Dopamine Levels

(2011) Anamika Sengupta et al.   PLoS One

Determination of the minimal melatonin exposure required to induce osteoblast differentiation from human mesenchymal stem cells and these effects on downstream signaling pathways

(2010) Shalini Sethi et al.   JOURNAL OF PINEAL RESEARCH

International Union of Basic and Clinical Pharmacology. LXXV. Nomenclature, Classification, and Pharmacology of G Protein-Coupled Melatonin Receptors

(2010) M. L. Dubocovich et al.   PHARMACOLOGICAL REVIEWS

Structural basis for the specific inhibition of heterotrimeric Gq protein by a small molecule

(2010) A. Nishimura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration

(2009) Marie-Laure Rives et al.   EMBO JOURNAL

Melatonin modulates visual function and cell viability in the mouse retina via the MT1 melatonin receptor

(2009) K. Baba et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA