Pancreatic alpha cells and glucagon secretion: Novel functions and targets in glucose homeostasis

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state

(2022) Xiao-Qing Dai et al.   Cell Metabolism

Dasiglucagon: A Next-Generation Glucagon Analog for Rapid and Effective Treatment of Severe Hypoglycemia Results of Phase 3 Randomized Double-Blind Clinical Trial

(2021) Thomas R. Pieber et al.   DIABETES CARE

Pharmacokinetics, safety, tolerability and efficacy of cotadutide, a glucagon‐like peptide‐1 and glucagon receptor dual agonist, in phase 1 and 2 trials in overweight or obese participants of A sian descent with or without type 2 diabetes

(2021) Michiko Asano et al.   DIABETES OBESITY & METABOLISM

KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin

(2021) Bilal Singh et al.   Molecular Metabolism

Pancreatic α-cells – The unsung heroes in islet function

(2020) Anna Wendt et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Inpatient hypoglycaemia: understanding who is at risk

(2020) Yue Ruan et al.   DIABETOLOGIA

A method for the generation of human stem cell-derived alpha cells

(2020) Quinn P. Peterson et al.   Nature Communications

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high fat diet

(2020) Joely A. Kellard et al.   Molecular Metabolism

Small molecule glucagon receptor antagonists: an updated patent review (2015–2019)

(2020) Chen Cheng et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

‘Resistance is futile?’ – paradoxical inhibitory effects of K ATP channel closure in glucagon‐secreting α‐cells

(2020) Quan Zhang et al.   JOURNAL OF PHYSIOLOGY-LONDON

SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

(2020) Heeyoung Chae et al.   Molecular Metabolism

miR-132-3p is a positive regulator of alpha-cell mass and is downregulated in obese hyperglycemic mice

(2019) Rodolphe Dusaulcy et al.   Molecular Metabolism

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells

(2019) Kenichiro Furuyama et al.   NATURE

The liver-alpha cell axis and type 2 diabetes

(2019) Nicolai J Wewer Albrechtsen et al.   ENDOCRINE REVIEWS

Micro(RNA) Management and Mismanagement of the Islet

(2019) Lena Eliasson et al.   JOURNAL OF MOLECULAR BIOLOGY

The Long Noncoding RNA Paupar Modulates PAX6 Regulatory Activities to Promote Alpha Cell Development and Function

(2019) Ruth A. Singer et al.   Cell Metabolism

Paracrine Interactions within the Pancreatic Islet Determine the Glycemic Set Point

(2018) Rayner Rodriguez-Diaz et al.   Cell Metabolism

Endogenous Reprogramming of Alpha Cells into Beta Cells, Induced by Viral Gene Therapy, Reverses Autoimmune Diabetes

(2018) Xiangwei Xiao et al.   Cell Stem Cell

Intranasal glucagon for hypoglycaemia in diabetic patients. An old dream is becoming reality?

(2018) Antonio E. Pontiroli et al.   DIABETES OBESITY & METABOLISM

Problem or solution: The strange story of glucagon

(2018) R.V. Scott et al.   PEPTIDES

Islet microRNAs in health and type-2 diabetes

(2018) Anna Wendt et al.   CURRENT OPINION IN PHARMACOLOGY

A novel dual glucagon-like peptide and glucagon receptor agonist SAR425899: Results of randomized, placebo-controlled first-in-human and first-in-patient trials

(2018) Joachim Tillner et al.   DIABETES OBESITY & METABOLISM

Islet prohormone processing in health and disease

(2018) Yi-Chun Chen et al.   DIABETES OBESITY & METABOLISM

Dysregulation of Glucagon Secretion by Hyperglycemia-Induced Sodium-Dependent Reduction of ATP Production

(2018) Jakob G. Knudsen et al.   Cell Metabolism

Insulin Secretion Depends on Intra-islet Glucagon Signaling

(2018) Berit Svendsen et al.   Cell Reports

The New Biology and Pharmacology of Glucagon

(2017) T. D. Müller et al.   PHYSIOLOGICAL REVIEWS

CFTR is involved in the regulation of glucagon secretion in human and rodent alpha cells

(2017) Anna Edlund et al.   Scientific Reports

Impact of MicroRNA Levels, Target-Site Complementarity, and Cooperativity on Competing Endogenous RNA-Regulated Gene Expression

(2016) Rémy Denzler et al.   MOLECULAR CELL

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist

(2016) Nicolas Damond et al.   eLife

Evaluation of Efficacy and Safety of the Glucagon Receptor Antagonist LY2409021 in Patients With Type 2 Diabetes: 12- and 24-Week Phase 2 Studies

(2015) Christof M. Kazda et al.   DIABETES CARE

Short-term administration of the glucagon receptor antagonist LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes

(2015) R. P. Kelly et al.   DIABETES OBESITY & METABOLISM

Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

(2015) V. Salem et al.   DIABETES OBESITY & METABOLISM

Glucagon receptor antagonism induces increased cholesterol absorption

(2015) Hong-Ping Guan et al.   JOURNAL OF LIPID RESEARCH

A Randomized, Controlled Trial of 3.0 mg of Liraglutide in Weight Management

(2015) Xavier Pi-Sunyer et al.   NEW ENGLAND JOURNAL OF MEDICINE

MiR-375 Promotes Redifferentiation of Adult Human β Cells Expanded In Vitro

(2015) Gili Nathan et al.   PLoS One

Coinfusion of Low-Dose GLP-1 and Glucagon in Man Results in a Reduction in Food Intake

(2014) Jaimini Cegla et al.   DIABETES

A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents

(2014) Brian Finan et al.   NATURE MEDICINE

Role of KATP Channels in Glucose-Regulated Glucagon Secretion and Impaired Counterregulation in Type 2 Diabetes

(2013) Quan Zhang et al.   Cell Metabolism

Glucagon and GLP-1 inhibit food intake and increase c-fos expression in similar appetite regulating centres in the brainstem and amygdala

(2013) J A Parker et al.   INTERNATIONAL JOURNAL OF OBESITY

Glucagon Receptor Knockout Prevents Insulin-Deficient Type 1 Diabetes in Mice

(2011) Y. Lee et al.   DIABETES

GLP-1 Inhibits and Adrenaline Stimulates Glucagon Release by Differential Modulation of N- and L-Type Ca2+ Channel-Dependent Exocytosis

(2010) Yang Z. De Marinis et al.   Cell Metabolism

Conversion of adult pancreatic α-cells to β-cells after extreme β-cell loss

(2010) Fabrizio Thorel et al.   NATURE

Paracrinology of islets and the paracrinopathy of diabetes

(2010) R. H. Unger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miR-375 maintains normal pancreatic  - and  -cell mass

(2009) M. N. Poy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physiology of the pancreatic α-cell and glucagon secretion: role in glucose homeostasis and diabetes

(2008) Ivan Quesada et al.   JOURNAL OF ENDOCRINOLOGY