Mechanistic role of HPV-associated early proteins in cervical cancer: Molecular pathways and targeted therapeutic strategies

Structural and biochemical analysis of the PTPN4 PDZ domain bound to the C-terminal tail of the human papillomavirus E6 oncoprotein

(2022) Hye Seon Lee et al.   JOURNAL OF MICROBIOLOGY

Loss of the E6AP ubiquitin ligase induces p53-dependent phosphorylation of HPV-18 E6 in cells derived from cervical cancer

(2022) Arushi Vats et al.   JOURNAL OF VIROLOGY

Targeted Disruption of E6/p53 Binding Exerts Broad Activity and Synergism with Paclitaxel and Topotecan against HPV-Transformed Cancer Cells

(2022) Marta Celegato et al.   Cancers

Dynamic crosstalk within the tumor microenvironment of uterine cervical carcinoma: baseline network, iatrogenic alterations, and translational implications

(2021) Rosalba De Nola et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Human papillomavirus E6 and E7: What remains?

(2021) Arushi Vats et al.   Tumour Virus Research

Gene knock-out chain reaction enables high disruption efficiency of HPV18 E6/E7 genes in cervical cancer cells

(2021) Rui Tian et al.   Molecular Therapy-Oncolytics

Human Papillomavirus E6 and E7: The Cervical Cancer Hallmarks and Targets for Therapy

(2020) Asmita Pal et al.   Frontiers in Microbiology

Long noncoding RNAs (lncRNAs) in cervical carcinogenesis: New molecular targets, current prospects

(2020) Maria Luiza Tabosa de Carvalho Galvão et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Gynecologic cancers and non-coding RNAs: Epigenetic regulators with emerging roles

(2020) Zahra Sadat Razavi et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Molecular landscape of recurrent cervical cancer

(2020) Divya Adiga et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Biological activities of Ficus carica latex for potential therapeutics in Human Papillomavirus (HPV) related cervical cancers

(2019) Arshia Ghanbari et al.   Scientific Reports

Correlation of human papillomavirus 16 and 18 with cervical cancer and their diagnosis methods in Iranian women: A systematic review and meta-analysis

(2019) Mona Fani et al.   CURRENT PROBLEMS IN CANCER

The Human Papillomavirus (HPV) E1 protein regulates the expression of cellular genes involved in immune response

(2019) Leonardo Josué Castro-Muñoz et al.   Scientific Reports

Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis

(2019) Marc Arbyn et al.   Lancet Global Health

Epidemiology and burden of HPV-related disease

(2018) Beatriz Serrano et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

HPV: Molecular pathways and targets

(2018) Shilpi Gupta et al.   CURRENT PROBLEMS IN CANCER

Human Papillomavirus Types 16 and 18 Early-expressed Proteins Differentially Modulate the Cellular Redox State and DNA Damage

(2018) Alfredo Cruz-Gregorio et al.   International Journal of Biological Sciences

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Integrated genomic and molecular characterization of cervical cancer

(2017)   NATURE

The human papillomavirus DNA helicase E1 binds, stimulates, and confers processivity to cellular DNA polymerase epsilon

(2017) Michaelle Chojnacki et al.   NUCLEIC ACIDS RESEARCH

The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor

(2017) Toni M. Brand et al.   Science Signaling

Human papillomavirus vaccines: WHO position paper, May 2017–Recommendations

(2017)   VACCINE

The human papillomavirus E7 oncoprotein as a regulator of transcription

(2017) William K. Songock et al.   VIRUS RESEARCH

Roles of APOBEC3A and APOBEC3B in Human Papillomavirus Infection and Disease Progression

(2017) Cody Warren et al.   Viruses-Basel

Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation

(2017) Yiyu Zhang et al.   Oncotarget

The receptor tyrosine kinase AXL mediates nuclear translocation of the epidermal growth factor receptor

(2017) Toni M. Brand et al.   Science Signaling

High Resolution Spatial Mapping of Human Footprint across Antarctica and Its Implications for the Strategic Conservation of Avifauna

(2017) Luis R. Pertierra et al.   PLoS One

Biology and Applications of CRISPR Systems: Harnessing Nature’s Toolbox for Genome Engineering

(2016) Addison V. Wright et al.   CELL

Current state in the development of candidate therapeutic HPV vaccines

(2016) Andrew Yang et al.   Expert Review of Vaccines

Structure of the E6/E6AP/p53 complex required for HPV-mediated degradation of p53

(2016) Denise Martinez-Zapien et al.   NATURE

Tempo and mode of genome evolution in a 50,000-generation experiment

(2016) Olivier Tenaillon et al.   NATURE

ERK Signaling Pathway Is Involved in HPV-16 E6 but not E7 Oncoprotein-Induced HIF-1α Protein Accumulation in NSCLC Cells

(2016) Fei Liu et al.   ONCOLOGY RESEARCH

Complete Regression of Metastatic Cervical Cancer After Treatment With Human Papillomavirus–Targeted Tumor-Infiltrating T Cells

(2015) Sanja Stevanović et al.   JOURNAL OF CLINICAL ONCOLOGY

Safety, efficacy, and immunogenicity of VGX-3100, a therapeutic synthetic DNA vaccine targeting human papillomavirus 16 and 18 E6 and E7 proteins for cervical intraepithelial neoplasia 2/3: a randomised, double-blind, placebo-controlled phase 2b trial

(2015) Cornelia L Trimble et al.   LANCET

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy

(2015) Ketaki Ganti et al.   Viruses-Basel

HER2 as a novel therapeutic target for cervical cancer

(2015) Doo-Yi Oh et al.   Oncotarget

In silico mechanistic analysis of IRF3 inactivation and high-risk HPV E6 species-dependent drug response

(2015) Masaud Shah et al.   Scientific Reports

The Role of Signaling Pathways in Cervical Cancer and Molecular Therapeutic Targets

(2014) Joaquín Manzo-Merino et al.   ARCHIVES OF MEDICAL RESEARCH

Paxillin promotes tumor progression and predicts survival and relapse in oral cavity squamous cell carcinoma by microRNA-218 targeting

(2014) De-Wei Wu et al.   CARCINOGENESIS

Development and Applications of CRISPR-Cas9 for Genome Engineering

(2014) Patrick D. Hsu et al.   CELL

Inactivation of the Human Papillomavirus E6 or E7 Gene in Cervical Carcinoma Cells by Using a Bacterial CRISPR/Cas RNA-Guided Endonuclease

(2014) E. M. Kennedy et al.   JOURNAL OF VIROLOGY

Human Papillomavirus E7 Oncoprotein Increases Production of the Anti-Inflammatory Interleukin-18 Binding Protein in Keratinocytes

(2014) K. H. Richards et al.   JOURNAL OF VIROLOGY

Human Papillomavirus E6 Triggers Upregulation of the Antiviral and Cancer Genomic DNA Deaminase APOBEC3B

(2014) Valdimara C. Vieira et al.   mBio

APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

(2014) Stephen Henderson et al.   Cell Reports

Expression of Suppressor of Cytokine Signaling 1 (SOCS1) Impairs Viral Clearance and Exacerbates Lung Injury during Influenza Infection

(2014) Keer Sun et al.   PLoS Pathogens

A novel function of HPV16-E6/E7 in epithelial–mesenchymal transition

(2013) Young-Suk Jung et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of interleukin-6/signal transducer and activator of transcription 3 by human papillomavirus early proteins 6 induces fibroblast senescence to promote cervical tumourigenesis through autocrine and paracrine pathways in tumour microenvironment

(2013) Chunxia Ren et al.   EUROPEAN JOURNAL OF CANCER

Review of the current knowledge on the epidemiology, pathogenesis, and prevention of human papillomavirus infection

(2013) Asia Asiaf et al.   EUROPEAN JOURNAL OF CANCER PREVENTION

Immune alterations and immunotherapy prospects in head and neck cancer

(2013) Vincent Varilla et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

(2013) K. Akagi et al.   GENOME RESEARCH

The Human papillomavirus type 16 E7 oncoprotein induces a transcriptional repressor complex on the Toll-like receptor 9 promoter

(2013) Uzma A. Hasan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Landscape of genomic alterations in cervical carcinomas

(2013) Akinyemi I. Ojesina et al.   NATURE

Structure Based Identification and Characterization of Flavonoids That Disrupt Human Papillomavirus-16 E6 Function

(2013) Jonathan J. Cherry et al.   PLoS One

The E4 protein; structure, function and patterns of expression

(2013) John Doorbar   VIROLOGY

The E5 proteins

(2013) Daniel DiMaio et al.   VIROLOGY

The E1 proteins

(2013) Monika Bergvall et al.   VIROLOGY

Ruthenium oligonucleotides, targeting HPV16 E6 oncogene, inhibit the growth of cervical cancer cells under illumination by a mechanism involving p53

(2012) A Reschner et al.   GENE THERAPY

HPV16 Oncoproteins Induce MMPs/RECK-TIMP-2 Imbalance in Primary Keratinocytes: Possible Implications in Cervical Carcinogenesis

(2012) Laura Beatriz da Silva Cardeal et al.   PLoS One

Influence of HPV16 E6/7 on the Expression of FGF2 and FGFR Type B in Cervical Carcinogenesis

(2012) Ya-Min Cheng et al.   Reproductive Sciences

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

(2012) M. L. Bagarazzi et al.   Science Translational Medicine

Solution Structure Analysis of the HPV16 E6 Oncoprotein Reveals a Self-Association Mechanism Required for E6-Mediated Degradation of p53

(2012) Katia Zanier et al.   STRUCTURE

Human papillomavirus-16 E5 protein: oncogenic role and therapeutic value

(2012) Niladri Ganguly   CELLULAR ONCOLOGY

Construction of a Full Transcription Map of Human Papillomavirus Type 18 during Productive Viral Infection

(2011) X. Wang et al.   JOURNAL OF VIROLOGY

Role of Calpain in the Formation of Human Papillomavirus Type 16 E1^E4 Amyloid Fibers and Reorganization of the Keratin Network

(2011) J. Khan et al.   JOURNAL OF VIROLOGY

Wnt inhibitory factor 1 induces apoptosis and inhibits cervical cancer growth, invasion and angiogenesis in vivo

(2011) I Ramachandran et al.   ONCOGENE

HPV-DNA integration and carcinogenesis: putative roles for inflammation and oxidative stress

(2010) Vonetta M Williams et al.   Future Virology

Beyond Cervical Cancer: Burden of Other HPV-Related Cancers Among Men and Women

(2010) Anil K. Chaturvedi   JOURNAL OF ADOLESCENT HEALTH

E1^E4-mediated keratin phosphorylation and ubiquitylation: a mechanism for keratin depletion in HPV16-infected epithelium

(2010) P. B. McIntosh et al.   JOURNAL OF CELL SCIENCE

Effects of chromium picolinate supplementation on the growth, carcass quality and gene expression of beef during the finishing period

(2010) Liu Guifen et al.   MOLECULAR BIOLOGY REPORTS

Low- and high-risk human papillomavirus E7 proteins regulate p130 differently

(2010) Lisa Barrow-Laing et al.   VIROLOGY

Selective targeting of HPV-16 E6/E7 in cervical cancer cells with a potent oncolytic adenovirus and its enhanced effect with radiotherapy in vitro and vivo

(2009) Wei Wang et al.   CANCER LETTERS

Involvement of NF- B and AP-1 in COX-2 upregulation by human papillomavirus 16 E5 oncoprotein

(2009) S.-H. Kim et al.   CARCINOGENESIS

Phosphorylation of the Human Papillomavirus Type 16 E1^E4 Protein at T57 by ERK Triggers a Structural Change That Enhances Keratin Binding and Protein Stability

(2009) Q. Wang et al.   JOURNAL OF VIROLOGY

Bap31 Is a Novel Target of the Human Papillomavirus E5 Protein

(2008) J. A. Regan et al.   JOURNAL OF VIROLOGY