Current state in the development of candidate therapeutic HPV vaccines

HPV-Associated Head and Neck Cancer: Unique Features of Epidemiology and Clinical Management

(2016) Jessica H. Maxwell et al.   Annual Review of Medicine

An HPV-E6/E7 immunotherapy plus PD-1 checkpoint inhibition results in tumor regression and reduction in PD-L1 expression

(2015) A E Rice et al.   CANCER GENE THERAPY

The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor-β receptor on dendritic cells potentiates tumour antigen-specific CD8+T cell immunity

(2015) Y.-H. Ahn et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Intravaginal HPV DNA vaccination with electroporation induces local CD8+ T-cell immune responses and antitumor effects against cervicovaginal tumors

(2015) Y Sun et al.   GENE THERAPY

Antigen design enhances the immunogenicity of Semliki Forest virus-based therapeutic human papillomavirus vaccines

(2015) P P Ip et al.   GENE THERAPY

A novel RNA-based adjuvant combines strong immunostimulatory capacities with a favorable safety profile

(2015) Regina Heidenreich et al.   INTERNATIONAL JOURNAL OF CANCER

Model systems of human papillomavirus-associated disease

(2015) John Doorbar   JOURNAL OF PATHOLOGY

Identification of human papillomavirus-16 E6 variation in cervical cancer and their impact on T and B cell epitopes

(2015) Anoop Kumar et al.   JOURNAL OF VIROLOGICAL METHODS

Ubiquitin-like Molecule ISG15 Acts as an Immune Adjuvant to Enhance Antigen-specific CD8 T-cell Tumor Immunity

(2015) Daniel O Villarreal et al.   MOLECULAR THERAPY

Vaccines, adjuvants and autoimmunity

(2015) Luísa Eça Guimarães et al.   PHARMACOLOGICAL RESEARCH

Unique potential of 4-1BB agonist antibody to promote durable regression of HPV+tumors when combined with an E6/E7 peptide vaccine

(2015) Todd Bartkowiak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local administration of granulocyte macrophage colony-stimulating factor induces local accumulation of dendritic cells and antigen-specific CD8+ T cells and enhances dendritic cell cross-presentation

(2015) Sung-Jong Lee et al.   VACCINE

Co-administration with DNA encoding papillomavirus capsid proteins enhances the antitumor effects generated by therapeutic HPV DNA vaccination

(2015) Benjamin Yang et al.   Cell and Bioscience

Safety and Efficacy Data on Vaccines and Immunization to Human Papillomavirus

(2015) Natalie Kash et al.   Journal of Clinical Medicine

Sequential Cisplatin Therapy and Vaccination with HPV16 E6E7L2 Fusion Protein in Saponin Adjuvant GPI-0100 for the Treatment of a Model HPV16+ Cancer

(2015) Shiwen Peng et al.   PLoS One

Development and Clinical Evaluation of Dendritic Cell Vaccines for HPV Related Cervical Cancer - a Feasibility Study

(2014) Priya Ramanathan et al.   Asian Pacific Journal of Cancer Prevention

Phase Ib study evaluating a self-adjuvanted mRNA cancer vaccine (RNActive®) combined with local radiation as consolidation and maintenance treatment for patients with stage IV non-small cell lung cancer

(2014) Martin Sebastian et al.   BMC CANCER

A phase I dose escalation trial of MAGE-A3- and HPV16-specific peptide immunomodulatory vaccines in patients with recurrent/metastatic (RM) squamous cell carcinoma of the head and neck (SCCHN)

(2014) Dan P. Zandberg et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Toll-like Receptor Agonist Imiquimod Facilitates Antigen-Specific CD8+ T-cell Accumulation in the Genital Tract Leading to Tumor Control through IFN 

(2014) R.-S. Soong et al.   CLINICAL CANCER RESEARCH

Regression of Human Papillomavirus Intraepithelial Lesions Is Induced by MVA E2 Therapeutic Vaccine

(2014) Ricardo Rosales et al.   HUMAN GENE THERAPY

Treatment of Tumors with Vitamin E Suppresses Myeloid Derived Suppressor Cells and Enhances CD8+ T Cell-Mediated Antitumor Effects

(2014) Tae Heung Kang et al.   PLoS One

Intramuscular Therapeutic Vaccination Targeting HPV16 Induces T Cell Responses That Localize in Mucosal Lesions

(2014) L. Maldonado et al.   Science Translational Medicine

Oral vaccination against HPV E7 for treatment of cervical intraepithelial neoplasia grade 3 (CIN3) elicits E7-specific mucosal immunity in the cervix of CIN3 patients

(2014) Kei Kawana et al.   VACCINE

The Burden of HPV-Associated Anogenital Cancers

(2014) Katie Wakeham et al.   Current Oncology Reports

Clearance of persistent HPV infection and cervical lesion by therapeutic DNA vaccine in CIN3 patients

(2014) Tae Jin Kim et al.   Nature Communications

Episomal Expression of Truncated Listeriolysin O in LmddA-LLO-E7 Vaccine Enhances Antitumor Efficacy by Preferentially Inducing Expansions of CD4+FoxP3- and CD8+ T Cells

(2014) Z. Chen et al.   Cancer Immunology Research

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

(2014) L. Jeanbart et al.   Cancer Immunology Research

Intratumoral injection of therapeutic HPV vaccinia vaccine following cisplatin enhances HPV-specific antitumor effects

(2013) Sung Yong Lee et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

The long-term immune response after HPV16 peptide vaccination in women with low-grade pre-malignant disorders of the uterine cervix: a placebo-controlled phase II study

(2013) Peggy J. de Vos van Steenwijk et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Enhanced Cancer Radiotherapy through Immunosuppressive Stromal Cell Destruction in Tumors

(2013) Chao-Yi Wu et al.   CLINICAL CANCER RESEARCH

Histone deacetylase inhibitor AR-42 enhances E7-specific CD8+ T cell-mediated antitumor immunity induced by therapeutic HPV DNA vaccination

(2013) Sung Yong Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

HPV16 synthetic long peptide (HPV16-SLP) vaccination therapy of patients with advanced or recurrent HPV16-induced gynecological carcinoma, a phase II trial

(2013) Mariette I E van Poelgeest et al.   Journal of Translational Medicine

HPV-16 E6 and E7 protein T cell epitopes prediction analysis based on distributions of HLA-A loci across populations: An in silico approach

(2013) Yufeng Yao et al.   VACCINE

Low-dose cyclophosphamide administered as daily or single dose enhances the antitumor effects of a therapeutic HPV vaccine

(2012) Shiwen Peng et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

A placebo-controlled randomized HPV16 synthetic long-peptide vaccination study in women with high-grade cervical squamous intraepithelial lesions

(2012) Peggy J. de Vos van Steenwijk et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Emerging human papillomavirus vaccines

(2012) Barbara Ma et al.   EXPERT OPINION ON EMERGING DRUGS

Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer-systematic review and meta-analysis of trends by time and region

(2012) Hisham Mehanna et al.   HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

Successful therapeutic vaccination with integrase defective lentiviral vector expressing nononcogenic human papillomavirus E7 protein

(2012) Felicia Grasso et al.   INTERNATIONAL JOURNAL OF CANCER

Immunotherapy Against HPV16/18 Generates Potent TH1 and Cytotoxic Cellular Immune Responses

(2012) M. L. Bagarazzi et al.   Science Translational Medicine

Global Burden of Human Papillomavirus and Related Diseases

(2012) David Forman et al.   VACCINE

Regression of high-grade cervical intraepithelial neoplasia with TG4001 targeted immunotherapy

(2011) Jean-Luc Brun et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Role of regulatory T-cells in immunization strategies involving a recombinant alphavirus vector system

(2011) Mateusz Walczak et al.   ANTIVIRAL THERAPY

New Approaches to Immunotherapy for HPV Associated Cancers

(2011) Anne-Sophie Bergot et al.   Cancers

Immunotherapy for Cervical Cancer

(2010) Jun-Han Su et al.   BIODRUGS

Phase II trial of imiquimod and HPV therapeutic vaccination in patients with vulval intraepithelial neoplasia

(2010) S Daayana et al.   BRITISH JOURNAL OF CANCER

In vitro Progression of Human Papillomavirus 16 Episome-Associated Cervical Neoplasia Displays Fundamental Similarities to Integrant-Associated Carcinogenesis

(2010) E. Gray et al.   CANCER RESEARCH

A Conserved E7-derived Cytotoxic T Lymphocyte Epitope Expressed on HumanPapillomavirus16-transformed HLA-A2+Epithelial Cancers

(2010) Angelika B. Riemer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perspectives for Preventive and Therapeutic HPV Vaccines

(2010) Ken Lin et al.   JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION

Oral immunization with a Lactobacillus casei vaccine expressing human papillomavirus (HPV) type 16 E7 is an effective strategy to induce mucosal cytotoxic lymphocytes against HPV16 E7

(2010) Katsuyuki Adachi et al.   VACCINE

Currently approved prophylactic HPV vaccines

(2009) Diane M Harper   Expert Review of Vaccines

Enhancement of dendritic cell-based vaccine potency by anti-apoptotic siRNAs targeting key pro-apoptotic proteins in cytotoxic CD8+ T cell-mediated cell death

(2009) Jin Hee Kim et al.   IMMUNOLOGY LETTERS

Treatment With Cyclooxygenase-2 Inhibitors Enables Repeated Administration of Vaccinia Virus for Control of Ovarian Cancer

(2009) Chih-Long Chang et al.   MOLECULAR THERAPY

Vaccination against HPV-16 Oncoproteins for Vulvar Intraepithelial Neoplasia

(2009) Gemma G. Kenter et al.   NEW ENGLAND JOURNAL OF MEDICINE

The first clinical use of a live-attenuated Listeria monocytogenes vaccine: A Phase I safety study of Lm-LLO-E7 in patients with advanced carcinoma of the cervix

(2009) Paulo Cesar Maciag et al.   VACCINE

Treatment with demethylating agent, 5-aza-2′-deoxycytidine enhances therapeutic HPV DNA vaccine potency

(2009) Dan Lu et al.   VACCINE

Administration of HPV DNA vaccine via electroporation elicits the strongest CD8+ T cell immune responses compared to intramuscular injection and intradermal gene gun delivery

(2009) Simon R. Best et al.   VACCINE

Low-dose radiation enhances therapeutic HPV DNA vaccination in tumor-bearing hosts

(2008) Chih-Wen Tseng et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Therapeutic human papillomavirus vaccines: current clinical trials and future directions

(2008) Chien-Fu Hung et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Treatment with proteasome inhibitor bortezomib enhances antigen-specific CD8+ T-cell-mediated antitumor immunity induced by DNA vaccination

(2008) Chih-Wen Tseng et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Whole tumor antigen vaccination using dendritic cells: Comparison of RNA electroporation and pulsing with UV-irradiated tumor cells

(2008) Fabian Benencia et al.   Journal of Translational Medicine

Combination of treatment with death receptor 5-specific antibody with therapeutic HPV DNA vaccination generates enhanced therapeutic anti-tumor effects

(2008) Chih Wen Tseng et al.   VACCINE

Cellular immunity induced by a novel HPV18 DNA vaccine encoding an E6/E7 fusion consensus protein in mice and rhesus macaques

(2008) Jian Yan et al.   VACCINE

Listeria-based HPV-16 E7 vaccines limit autochthonous tumor growth in a transgenic mouse model for HPV-16 transformed tumors

(2008) Duane A. Sewell et al.   VACCINE

Augmentation of alphavirus vector-induced human papilloma virus-specific immune and anti-tumour responses by co-expression of interleukin-12

(2008) Annelies Riezebos-Brilman et al.   VACCINE

Induction of antitumor immunity in vivo following delivery of a novel HPV-16 DNA vaccine encoding an E6/E7 fusion antigen

(2008) Jian Yan et al.   VACCINE

Enhancing therapeutic HPV DNA vaccine potency through depletion of CD4+CD25+ T regulatory cells

(2008) Chi-Mu Chuang et al.   VACCINE