Human papillomavirus E6 and E7: What remains?

Decades of research on the human papillomavirus oncogenes, E6 and E7, have given us huge amounts of data on their expression, functions and structures. We know much about the very many cellular proteins and pathways that they influence in one way or another. However, much of this information is quite discrete, referring to one activity examined under one condition. It is now time to join the dots to try to understand a larger picture: how, where and when do all these interactions occur... and why? Examining these questions will also show how many of the yet obscure cellular processes work together for cellular and tissue homeostasis in health and disease.

Automated summary

Decades of research on the human papillomavirus oncogenes E6 and E7 have provided a wealth of data on their expression, functions, and structures, as well as the cellular proteins and pathways they influence. It is important to connect the existing discrete information to understand the bigger picture of how and why these interactions occur, shedding light on cellular and tissue homeostasis in health and disease.