Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

Treatment Options for MODY Patients: A Systematic Review of Literature

(2020) Maurizio Delvecchio et al.   Diabetes Therapy

Evinacumab for Homozygous Familial Hypercholesterolemia

(2020) Frederick J. Raal et al.   NEW ENGLAND JOURNAL OF MEDICINE

Statin therapy reduces plasma angiopoietin-like 3 (ANGPTL3) concentrations in hypercholesterolemic patients via reduced liver X receptor (LXR) activation

(2020) Laurens F. Reeskamp et al.   ATHEROSCLEROSIS

ANGPTL3: a Novel Biomarker and Promising Therapeutic Target

(2019) Shuang Jiang et al.   JOURNAL OF DRUG TARGETING

23,24-Dihydrocucurbitacin B promotes lipid clearance by dual transcriptional regulation of LDLR and PCSK9

(2019) Hui-hui Li et al.   ACTA PHARMACOLOGICA SINICA

Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia

(2019) Chenglin Wu et al.   Acta Pharmaceutica Sinica B

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

(2019) Daehwan Kim et al.   NATURE BIOTECHNOLOGY

Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5 H -thieno[3′,2′:3,4]pyrido[1,2- b ]isoquinoline and 5,8,12,12a-tetrahydro-6 H -thieno[2′,3′:4,5]pyrido[2,1- a ]isoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK)

(2018) Zhanni Gu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Small molecule modulators of PCSK9 – A literature and patent overview

(2018) Daniel Pettersen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

PCSK9

(2018) Michael D. Shapiro et al.   CIRCULATION RESEARCH

Small Molecule Inhibitors of the PCSK9·LDLR Interaction

(2018) Jaru Taechalertpaisarn et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Small molecules as inhibitors of PCSK9: Current status and future challenges

(2018) Shengtao Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PCSK9 inhibitors: clinical evidence and implementation

(2018) Marc S. Sabatine   Nature Reviews Cardiology

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5 H -thieno[3′,2’:3,4]pyrido[1,2- b ]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes

(2017) Shengbin Zhou et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Angiopoietin-like 3 in lipoprotein metabolism

(2017) Sander Kersten   Nature Reviews Endocrinology

Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease

(2017) Frederick E. Dewey et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design, Synthesis, and Biological Evaluation of Novel Tetrahydroprotoberberine Derivatives (THPBs) as Selective α1A-Adrenoceptor Antagonists

(2016) Diliang Guo et al.   JOURNAL OF MEDICINAL CHEMISTRY

The harmonizome: a collection of processed datasets gathered to serve and mine knowledge about genes and proteins

(2016) Andrew D. Rouillard et al.   Database-The Journal of Biological Databases and Curation

MG132, a proteasome inhibitor, enhances LDL uptake in HepG2 cells in vitro by regulating LDLR and PCSK9 expression

(2014) Hong Yan et al.   ACTA PHARMACOLOGICA SINICA

Physiological regulation of lipoprotein lipase

(2014) Sander Kersten   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles

(2014) Zeng Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition ofPCSK9Transcription by Berberine Involves Down-regulation of Hepatic HNF1α Protein Expression through the Ubiquitin-Proteasome Degradation Pathway

(2014) Bin Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

(2013) Y. Liao et al.   BIOINFORMATICS

Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity

(2013) Pelagia Foka et al.   JOURNAL OF HEPATOLOGY

Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor

(2012) Wangke Qian et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile

(2012) Haifeng Sun et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A Two-step Binding Model of PCSK9 Interaction with the Low Density Lipoprotein Receptor

(2010) Taichi Yamamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-dose atorvastatin causes a rapid sustained increase in human serum PCSK9 and disrupts its correlation with LDL cholesterol

(2010) Greg Welder et al.   JOURNAL OF LIPID RESEARCH

Exome Sequencing,ANGPTL3Mutations, and Familial Combined Hypolipidemia

(2010) Kiran Musunuru et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

edgeR: a Bioconductor package for differential expression analysis of digital gene expression data

(2009) M. D. Robinson et al.   BIOINFORMATICS

Identification of a New Functional Domain in Angiopoietin-like 3 (ANGPTL3) and Angiopoietin-like 4 (ANGPTL4) Involved in Binding and Inhibition of Lipoprotein Lipase (LPL)

(2009) E-Chiang Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte Nuclear Factor 1α Plays a Critical Role inPCSK9Gene Transcription and Regulation by the Natural Hypocholesterolemic Compound Berberine

(2009) Hai Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Angiopoietin-like Proteins ANGPTL3 and ANGPTL4 Inhibit Lipoprotein Lipase Activity through Distinct Mechanisms

(2008) Lu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY