Article
Cell Biology
Carla Budrow, Kayla Elder, Michael Coyle, Ashley Centner, Natalie Lipari, Sophie Cohen, John Glinski, N'Senga Kinzonzi, Emily Wheelis, Grace McManus, Fredric Manfredsson, Christopher Bishop
Summary: Parkinson's Disease (PD) is a neurodegenerative disorder characterized by motor symptoms caused by the loss of dopamine cells. Recent studies have shown that neuroplasticity in the serotonin system plays a role in the development and severity of drug-induced side effects in PD patients. Through experiments on sub-chronic vortioxetine treatment, we found that the dopamine transporter modulates the anti-dyskinetic effects of vortioxetine by regulating 5-HT1A/1B receptors.
Article
Chemistry, Analytical
Jing Chen, Shuying Li, Ying Chen, Jiao Yang, Jianbin Dong, Xiaoquan Lu
Summary: The study successfully detected 5-HT using the Tri-AgNP/L-Cys/MXene electrochemical sensor, with a wide detection range and low detection limit. The sensor showed a good performance in detecting 5-HT in actual serum samples, with high recovery rate and low relative standard deviation.
ANALYTICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kathryn Lanza, Christopher Bishop
Summary: Parkinson's Disease (PD) and long-term L-DOPA treatment induce plasticity that contributes to L-DOPA-induced dyskinesia (LID), with the dopamine D3 receptor (D3R) emerging as a promising target in LID management due to its upregulation in LID. D3R undergoes dynamic changes in both PD and LID, and recent genetic and pharmacologic tools have helped clarify its role in LID.
Review
Immunology
Tiziana Carandini, Mara Cercignani, Daniela Galimberti, Elio Scarpini, Marco Bozzali
Summary: Dopamine, noradrenaline, and serotonin play crucial roles in the interaction between the nervous and immune systems by binding to cell-receptors and regulating their function. Dysregulation of monoamines may contribute to fatigue and depression in Multiple Sclerosis, with potential for targeted drug treatments.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Gastroenterology & Hepatology
Maria Arnoriaga-Rodriguez, Jordi Mayneris-Perxachs, Oren Contreras-Rodriguez, Aurelijus Burokas, Juan-Antonio Ortega-Sanchez, Gerard Blasco, Claudia Coll, Carles Biarnes, Anna Castells-Nobau, Josep Puig, Josep Garre-Olmo, Rafel Ramos, Salvador Pedraza, Ramon Brugada, Joan C. Vilanova, Joaquin Serena, Jordi Barretina, Jordi Gich, Vicente Perez-Brocal, Andres Moya, Xavier Fernandez-Real, Lluis Ramio-Torrenta, Reinald Pamplona, Joaquim Sol, Mariona Jove, Wifredo Ricart, Manuel Portero-Otin, Rafael Maldonado, Jose Manuel Fernandez-Real
Summary: The study revealed the relationship between inhibitory control and obesity, as well as the interactions between gut microbiota, metabolomics, and brain structure. Metabolic pathway alterations associated with obesity were found to be linked to inhibitory control, and results were validated in mice through fecal microbiota transplantation.
Article
Cell Biology
Nawal A. Yahya, Janelle K. Lanham, Daniel J. Sprague, Oleg Palygin, John D. McCorvy, Jonathan S. Marchant
Summary: The anthelmintic drug praziquantel (PZQ) causes contraction of parasitic schistosomes and blood vessels. PZQ's action on the vasculature is mediated by the activation of host serotonergic 5-HT2B receptors. The molecular basis for PZQ interaction with these receptors and their location in the vessel wall have not been experimentally defined.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Multidisciplinary Sciences
Yoon-Sang Oh, Sang-Won Yoo, Chul Hyoung Lyoo, Joong-Seok Kim
Summary: Drug-induced parkinsonism (DIP) is a major cause of misdiagnosis of Parkinson's disease (PD) and is characterized by a dopamine receptor blockade. This study found that monoamine availability in the thalamus was lower in DIP patients compared to healthy controls and similar to that of early PD patients, suggesting that this could be an imaging biomarker of DIP.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Aki Takahashi, Romain Durand-de Cuttoli, Meghan E. Flanigan, Emi Hasegawa, Tomomi Tsunematsu, Hossein Aleyasin, Yoan Cherasse, Ken Miya, Takuya Okada, Kazuko Keino-Masu, Koshiro Mitsui, Long Li, Vishwendra Patel, Robert D. Blitzer, Michael Lazarus, Kenji F. Tanaka, Akihiro Yamanaka, Takeshi Sakurai, Sonoko Ogawa, Scott J. Russo
Summary: The glutamatergic projections from the lateral habenula (LHb) to the dorsal raphe nucleus (DRN) modulate male mice's aggressive behavior. Inhibition of LHb-DRN projection blocks the increase in aggression after social instigation. The activity of this pathway is not necessary for the expression of species-typical aggressive behavior but essential for the increase in aggression resulting from social instigation.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Daniel J. Christoffel, Jessica J. Walsh, Paul Hoerbelt, Boris D. Heifets, Pierre Llorach, Ricardo C. Lopez, Charu Ramakrishnan, Karl Deisseroth, Robert C. Malenka
Summary: The study reveals that dopamine and serotonin modulate excitatory synaptic transmission in the nucleus accumbens in input-specific ways, influencing motivated behaviors differently. Endogenous release of DA and 5-HT, as well as optogenetic inhibition, alter the behavioral effects of drugs in distinct manners.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Multidisciplinary Sciences
Maxemiliano V. Vargas, Lee E. Dunlap, Chunyang Dong, Samuel J. Carter, Robert J. Tombari, Shekib A. Jami, Lindsay P. Cameron, Seona D. Patel, Joseph J. Hennessey, Hannah N. Saeger, John D. McCorvy, John A. Gray, Lin Tian, David E. Olson
Summary: Decreased dendritic spine density in the cortex is a common feature of neuropsychiatric diseases, and psychedelics have been found to promote cortical neuron growth. This study shows that intracellular 5-HT2A receptors mediate the plasticity-promoting effects of psychedelics, providing insight into the mechanisms behind their therapeutic effects. The findings suggest that targeting intracellular 5-HT2A receptors could be a potential therapeutic approach.
Review
Biochemistry & Molecular Biology
Yaeko Hashimoto, Takuji Suzuki, Kenji Hashimoto
Summary: The ongoing COVID-19 pandemic has sparked interest in drug repurposing, particularly in the use of antidepressants. Clinical data suggest that early-stage COVID-19 patients who take antidepressants may have a lower risk of intubation or death. Fluvoxamine, among antidepressants, is the most attractive drug for mild to moderate COVID-19 cases. Additionally, there may be a possible link between maternal COVID-19 infection and a risk for neuropsychiatric disorders in offspring, such as autism spectrum disorder and schizophrenia.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Weiyuan Huang, Wanhong Zuo, Lixin Chen, Liwei Wang, George Tewfik, Rao Fu, Jiayi Zheng, Ding Li, Jiang-Hong Ye
Summary: Acetaldehyde exerts its aversive property by exciting LHb neurons via multiple cellular mechanisms and inducing conditioned place aversion. New treatments targeting LHb may be beneficial for alcoholism management.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Changliang Liu, Xintong Cai, Andreas Ritzau-Jost, Paul F. Kramer, Yulong Li, Zayd M. Khaliq, Stefan Hallermann, Pascal S. Kaeser
Summary: Information flow in neurons involves integration of inputs in dendrites, generation of action potentials near the soma, and release of neurotransmitters from nerve terminals in the axon. A study found that acetylcholine-releasing neurons in the striatum can induce action potential firing in distal dopamine axons. This mechanism segregates the control of dopamine signaling between axons and somata.
Article
Neurosciences
Lise Guilhemsang, Amaia Gutierrez-Ceballos, Mario Antonazzo, Nicolas P. Mallet, Luisa Ugedo, Teresa Morera-Herreras
Summary: This study investigated the modulatory effects of 5-HT2A receptor stimulation on the basal ganglia circuitry, specifically targeting the mPF information processing through trans-striatal pathways. The results showed that the 5-HT2A agonist TCB-2 increased the firing rate and inhibitory response of medial SNr neurons, while the 5-HT2A receptor antagonist MDL11939 blocked these effects. Overall, these findings suggest a preferential modulatory action of 5-HT2A receptors on the dynamic regulation of basal ganglia circuitry.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Biology
Laifu Li, Li-Zi Zhang, Zhi-Xiong He, Huan Ma, Yu-Ting Zhang, Yu-Feng Xun, Wei Yuan, Wen-Juan Hou, Yi-Tong Li, Zi-Jian Lv, Rui Jia, Fa-Dao Tai
Summary: This study using socially monogamous mandarin voles found that neural circuits involving 5-HTergic neurons in the dorsal raphe nucleus and serotonin terminals in the anterior cingulate cortex play a crucial role in consolation-like behaviors and sociability. The release of 5-HT in the ACC and activity of DR neurons were significantly increased during comforting behaviors and social interactions. Activation of 5-HT1A receptors in the ACC was able to reverse deficits in consolation and sociability induced by inhibition of 5-HTergic neurons in the DR.
Article
Chemistry, Multidisciplinary
Chen-hong Guo, Ting Cao, Long-tai Zheng, John L. Waddington, Xue-chu Zhen
ACTA PHARMACOLOGICA SINICA
(2020)
Editorial Material
Chemistry, Multidisciplinary
Xue-chu Zhen, Hong-Yuan Chu
ACTA PHARMACOLOGICA SINICA
(2020)
Article
Immunology
Chaojun Han, Pengju Yan, Tao He, Junjie Cheng, Wenhua Zheng, Long-Tai Zheng, Xuechu Zhen
BRAIN BEHAVIOR AND IMMUNITY
(2020)
Article
Cell Biology
Wu Jing, Yang Huicui, Cheng Junjie, Zhang Li, Ke Youliang, Zhu Yi, Wang Cheng, Zhang Xiaohu, Zhen Xuechu, Zheng Long Tai
JOURNAL OF CELLULAR PHYSIOLOGY
(2020)
Article
Cell Biology
Xia Zhao, Linlin Liu, Yizhou Jiang, Marta Silva, Xuechu Zhen, Wenhua Zheng
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Review
Neurosciences
Ming-ming Xu, Mao-tian Zhou, Shu-wei Li, Xue-chu Zhen, Shuang Yang
Summary: Neurodegenerative diseases such as Alzheimer's and Parkinson's are incurable and progressively debilitating conditions that mainly affect the elderly. Research has found that protein glycosylation plays a crucial role in these diseases, with abnormal changes indicating altered biological pathways in disease progression. Early detection of neurodegenerative diseases is being explored through the use of specific glycosylation changes in cerebrospinal fluid, blood, and urine as potential biomarkers.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Yu Zhang, Lei Xu, Yao Zhang, Jie Pan, Pu-qing Wang, Sheng Tian, Huan-ting Li, Bo-wen Gao, Ting-jun Hou, Xue-chu Zhen, Long-Tai Zheng
Summary: This study identified 12 compounds with better bioactivity than ISO-1 as MIF inhibitors, with compound 11 showing marked anti-inflammatory efficacy in LPS-activated BV-2 microglial cells by suppressing NF-κB and MAPKs activation. These findings suggest that small-molecule MIF inhibitors could be promising therapeutic agents for neuroinflammatory diseases.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Immunology
Long-Tai Zheng, Jiaojiao Chen, Li Zhang, Yu Zhang, Lei Xu, Tingjun Hou, Xuechu Zhen, Qijun Dai, Hua Liu
Summary: This study demonstrated that the MIF inhibitor Z-312 possesses significant anti-inflammatory effects in LPS-induced neuroinflammation by reducing proinflammatory cytokine production and modulating NF-κB and MAPK signaling pathways. Furthermore, in a PD mouse model, Z-312 markedly ameliorated microglial activation and subsequent DA neuron loss. The findings suggest that Z-312 may be a promising neuroprotective agent for the treatment of neuroinflammation-mediated neurological diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Junjie Cheng, Rong Zhang, Zhirou Xu, Youliang Ke, Renjuan Sun, Huicui Yang, Xiaohu Zhang, Xuechu Zhen, Long-Tai Zheng
Summary: The study suggests that glycolysis plays a crucial role in microglial activation and inhibiting glycolysis can attenuate neuroinflammatory diseases associated with microglial activation.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Mingmei Wang, Chunlei Wan, Tao He, Chaojun Han, Kailian Zhu, John L. Waddington, Xuechu Zhen
Summary: Mitochondria play a crucial role in Parkinson's disease, and mitophagy is essential for the survival of DA neurons. The sigma-1 receptor modulates mitophagy, providing protection for DA neurons in a PD-like mouse model.
Article
Chemistry, Multidisciplinary
Peng-ju Yan, Zhao-xiang Ren, Zhi-feng Shi, Chun-lei Wan, Chao-jun Han, Liu-shuai Zhu, Ning-ning Li, John L. Waddington, Xue-chu Zhen
Summary: This study reveals that deficiency of Clk1 suppresses METH-induced conditioned place preference (CPP) and increases DAT expression on the cell membrane of striatum and hippocampus. The decrease in iron content in the brain regions is due to elevated expression of iron exporter ferroportin 1 (FPN1) associated with increased expression of hypoxia-inducible factor-1 alpha (HIF-1 alpha) in response to Clk1 deficiency. Iron plays a critical role in mediating Clk1 deficiency-induced alterations in DAT expression via upstream HIF-1 alpha.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Neurosciences
Tao He, Chaojun Han, Chun Liu, Jiaojiao Chen, Huicui Yang, Longtai Zheng, John L. Waddington, Xuechu Zhen
Summary: This study found that methamphetamine abuse can lead to damage of dopaminergic neurons, and revealed the important role of D1 receptors in this damage. The study also found that the AMPK/FOXO3A pathway mediates the activation of autophagy mediated by D1 receptors.
PSYCHOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Zheng Ying, Na Ye, Qilian Ma, Fan Chen, Ningning Li, Xuechu Zhen
Summary: Significant evidences show that sub-cellular organelle dynamics play a critical role in physiological and pathological events, making them attractive drug targets. However, drug development in this field is still limited despite extensive studies on the biological mechanisms. This review explores the potential of targeting organelle dynamics in the central nervous system, specifically mitochondrial dynamics and ER-organelle membrane contact dynamics, for treating neurodegenerative diseases.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Chemistry, Medicinal
Na Ye, Wangzhi Qin, Sheng Tian, Qingfeng Xu, Eric A. Wold, Jia Zhou, Xue-Chu Zhen
JOURNAL OF MEDICINAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Fengxia Yan, Rikang Wang, Shuai Li, Xia Zhao, Yizhou Jiang, Linlin Liu, Jiankang Fang, Xuechu Zhen, Philip Lazarovici, Wenhua Zheng
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2020)
