Mechanistic understanding of the toxic effects of arsenic and warfare arsenicals on human health and environment

Association of urinary arsenic with insulin resistance: Cross-sectional analysis of the National Health and Nutrition Examination Survey, 2015–2016

(2022) Meiling Zhou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Arsenic: A Global Environmental Challenge

(2021) Qiao Yi Chen et al.   Annual Review of Pharmacology and Toxicology

MicroRNA-191 blocking the translocation of GLUT4 is involved in arsenite-induced hepatic insulin resistance through inhibiting the IRS1/AKT pathway

(2021) Wenqi Li et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management

(2021) Md. Shiblur Rahaman et al.   ENVIRONMENTAL POLLUTION

The association of arsenic exposure with hypertension and blood pressure: A systematic review and dose–response meta-analysis

(2021) Jiaxin Zhao et al.   ENVIRONMENTAL POLLUTION

Arsenic in the geo-environment: A review of sources, geochemical processes, toxicity and removal technologies

(2021) N. Janardhana Raju   ENVIRONMENTAL RESEARCH

Polymorphisms in arsenic (+ 3 oxidation state) methyltransferase (AS3MT) predict the occurrence of hyperleukocytosis and arsenic metabolism in APL patients treated with As2O3

(2020) Wen-Sheng Liu et al.   ARCHIVES OF TOXICOLOGY

Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Re-epithelialization and immune cell behaviour in an ex vivo human skin model

(2020) Ana Rakita et al.   Scientific Reports

4PBA Restores Signalling of a Cysteine-substituted Mutant BMPR2 Receptor Found in Patients with PAH

(2020) Benjamin J Dunmore et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Arsenite Binds to ZNF598 to Perturb Ribosome-Associated Protein Quality Control

(2020) Lok Ming Tam et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Assessing potential mechanisms of arsenic-induced skin lesions and cancers: Human and in vitro evidence

(2020) Qibing Zeng et al.   ENVIRONMENTAL POLLUTION

Mottled pigmentation, palmar keratosis & chronic arsenic poisoning

(2020) Yashdeep Singh Pathania   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Global threat of arsenic in groundwater

(2020) Joel Podgorski et al.   SCIENCE

Investigating arsenic impact of ACC treated timbers in compost production (A case study in Christchurch, New Zealand)

(2020) Majeed Safa et al.   ENVIRONMENTAL POLLUTION

Studying the metabolism of toxic chemical warfare agent-related phenylarsenic chemicals in vitro in cod liver

(2020) Hanna Niemikoski et al.   JOURNAL OF HAZARDOUS MATERIALS

Global impact of atmospheric arsenic on health risk: 2005 to 2015

(2020) Lei Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protective role of HO‐1 against acute kidney injury caused by cutaneous exposure to arsenicals

(2020) Ritesh K. Srivastava et al.   ANNALS OF THE NEW YORK ACADEMY OF SCIENCES

Arsenic exposure increased expression of HOTAIR and LincRNA-p21 in vivo and vitro

(2020) Jingwen Tan et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Arsenic induces dose-dependent structural and ultrastructural pathological remodeling in the heart of Wistar rats

(2020) Ana Cláudia Ferreira Souza et al.   LIFE SCIENCES

Mechanisms underlying the protective effect of tannic acid against arsenic trioxide‑induced cardiotoxicity in rats: Potential involvement of mitochondrial apoptosis

(2020) Yucong Xue et al.   Molecular Medicine Reports

Arsenic contamination of groundwater: A global synopsis with focus on the Indian Peninsula

(2020) E. Shaji et al.   Geoscience Frontiers

LncRNA H19-mediated M2 polarization of macrophages promotes myofibroblast differentiation in pulmonary fibrosis induced by arsenic exposure

(2020) Tian Xiao et al.   ENVIRONMENTAL POLLUTION

Gestational arsenic exposure and paternal intergenerational epigenetic inheritance

(2020) Keiko Nohara et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

An Overview on Arsenic Trioxide-Induced Cardiotoxicity

(2019) Vadavanath Prabhakaran Vineetha et al.   Cardiovascular Toxicology

Inorganic arsenic induces pyroptosis and pancreatic β cells dysfunction through stimulating the IRE1α/TNF-α pathway and protective effect of taurine

(2019) Pei Pei et al.   FOOD AND CHEMICAL TOXICOLOGY

Nrf2 deficiency aggravates the increase in osteoclastogenesis and bone loss induced by inorganic arsenic

(2019) Zhiyuan Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Targeted Degradation of Glucose Transporters Protects Against Arsenic Toxicity

(2019) Marco Jochem et al.   MOLECULAR AND CELLULAR BIOLOGY

Toxic effects of chemical warfare agent mixtures on the mussel Mytilus trossulus in the Baltic Sea: A laboratory exposure study

(2019) Nicole Höher et al.   MARINE ENVIRONMENTAL RESEARCH

Arsenic-induced neoplastic transformation involves epithelial-mesenchymal transition and activation of β-catenin/c-Myc pathway in human kidney epithelial cells

(2019) Yu-Wei Chang et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Pathways of arsenic uptake and efflux

(2019) Luis D. Garbinski et al.   ENVIRONMENT INTERNATIONAL

Metabolic and epigenetic reprogramming in the arsenic-induced cancer stem cells

(2019) Lingzhi Li et al.   SEMINARS IN CANCER BIOLOGY

Arsenic Neurotoxicity in Humans

(2019) Hitoshi Mochizuki   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genome-wide CRISPR screen identifies suppressors of endoplasmic reticulum stress-induced apoptosis

(2019) Ronald A. Panganiban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher risk of hyperglycemia with greater susceptibility in females in chronic arsenic-exposed individuals in Bangladesh

(2019) Sudip Kumar Paul et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Arsenic-Induced Carcinogenesis and Immune Dysregulation

(2019) Hsin-Wei Huang et al.   International Journal of Environmental Research and Public Health

Arsenic is more potent than cadmium or manganese in disrupting the INS-1 beta cell microRNA landscape

(2019) Rowan Beck et al.   ARCHIVES OF TOXICOLOGY

Pathogenesis of atherosclerosis in the tunica intima, media, and adventitia of coronary arteries: An updated review

(2019) Aleksandra Milutinović et al.   Bosnian Journal of Basic Medical Sciences

Arsenic induces human chondrocyte senescence and accelerates rat articular cartilage aging

(2019) Yao-Pang Chung et al.   ARCHIVES OF TOXICOLOGY

Epigenetic regulations in alternative telomere lengthening: Understanding the mechanistic insight in arsenic-induced skin cancer patients

(2019) Pritha Bhattacharjee et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Rice production threatened by coupled stresses of climate and soil arsenic

(2019) E. Marie Muehe et al.   Nature Communications

Arsenic induces pancreatic dysfunction and ferroptosis via mitochondrial ROS-autophagy-lysosomal pathway

(2019) Sen Wei et al.   JOURNAL OF HAZARDOUS MATERIALS

Neuroprotective mechanisms of selenium against arsenic-induced behavioral impairments in rats

(2019) Isaac A. Adedara et al.   NEUROTOXICOLOGY

Arsenic exposure: A public health problem leading to several cancers

(2019) I. Palma-Lara et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Multi-generational impacts of arsenic exposure on genome-wide DNA methylation and the implications for arsenic-induced skin lesions

(2018) Xiaojuan Guo et al.   ENVIRONMENT INTERNATIONAL

Arsenic exposure, diabetes-related genes and diabetes prevalence in a general population from Spain

(2018) Maria Grau-Perez et al.   ENVIRONMENTAL POLLUTION

Telomeres: Implications for Cancer Development

(2018) Aina Bernal et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cyclin D1 promoter -56 and -54 bp CpG un-methylation predicts invasive progression in arsenic-induced Bowen’s disease

(2018) Wei-Ting Liao et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Chemical characteristics and source apportionment of PM 2.5 between heavily polluted days and other days in Zhengzhou, China

(2018) Nan Jiang et al.   JOURNAL OF ENVIRONMENTAL SCIENCES

Ethnic, geographic and dietary differences in arsenic exposure in the multi-ethnic study of atherosclerosis (MESA)

(2018) Miranda R. Jones et al.   Journal of Exposure Science and Environmental Epidemiology

Association of H3K79 monomethylation (an epigenetic signature) with arsenic-induced skin lesions

(2018) Pritha Bhattacharjee et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Deep sea habitats in the chemical warfare dumping areas of the Baltic Sea

(2018) Michał Czub et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Effect of air temperature after heading of rice on the arsenic concentration of grain

(2018) Tomohito Arao et al.   SOIL SCIENCE AND PLANT NUTRITION

Mapping dynamic histone modification patterns during arsenic-induced malignant transformation of human bladder cells

(2018) Yichen Ge et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Long-term neurological and neuropsychological complications of sulfur mustard and Lewisite mixture poisoning in Chinese victims exposed to chemical warfare agents abandoned at the end of WWII

(2018) O. Isono et al.   TOXICOLOGY LETTERS

Arsenic induces fibrogenic changes in human kidney epithelial cells potentially through epigenetic alterations in DNA methylation

(2018) Yu-Wei Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Immunological dysfunction in chronic arsenic exposure: From subclinical condition to skin cancer

(2018) Sebastian Yu et al.   JOURNAL OF DERMATOLOGY

miRNA expression profiles of premalignant and malignant arsenic-induced skin lesions

(2018) Laila Al-Eryani et al.   PLoS One

Circulating miRNAs Associated with Arsenic Exposure

(2018) Rowan Beck et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

State of the science review of the health effects of inorganic arsenic: Perspectives for future research

(2018) Paul B. Tchounwou et al.   ENVIRONMENTAL TOXICOLOGY

Hsp90 and Hsp70 chaperones: Collaborators in protein remodeling

(2018) Olivier Genest et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Arsenic Exposure, Assessment, Toxicity, Diagnosis, and Management

(2018) Beth A. Baker et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Field testing of over 30,000 wells for arsenic across 400 villages of the Punjab plains of Pakistan and India: Implications for prioritizing mitigation

(2018) Alexander van Geen et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Effects of arsenic toxicity beyond epigenetic modifications

(2017) Geir Bjørklund et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

The Association of Arsenic Metabolism with Cancer, Cardiovascular Disease, and Diabetes: A Systematic Review of the Epidemiological Evidence

(2017) Chin-Chi Kuo et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Effects of Inorganic Arsenic, Methylated Arsenicals, and Arsenobetaine on Atherosclerosis in the apoE−/− Mouse Model and the Role of As3mt-Mediated Methylation

(2017) Luis Fernando Negro Silva et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Estimating the High-Arsenic Domestic-Well Population in the Conterminous United States

(2017) Joseph D. Ayotte et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Determination of total arsenic content and arsenic speciation in different types of rice

(2017) Sang Ryun Yim et al.   FOOD SCIENCE AND BIOTECHNOLOGY

An Interaction between Arsenic-Induced Epigenetic Modification and Inflammatory Promotion in a Skin Equivalent during Arsenic Carcinogenesis

(2017) Wei-Ting Liao et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Assessment of human dietary exposure to arsenic through rice

(2017) Matthew A. Davis et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Increased microRNA 21 expression contributes to arsenic induced skin lesions, skin cancers and respiratory distress in chronically exposed individuals

(2017) Nilanjana Banerjee et al.   TOXICOLOGY

Metabolism, toxicity and anticancer activities of arsenic compounds

(2017) Islam Khairul et al.   Oncotarget

Epigenomic reprogramming in inorganic arsenic-mediated gene expression patterns during carcinogenesis

(2017) Meredith Eckstein et al.   REVIEWS ON ENVIRONMENTAL HEALTH

Pharmacological Chaperones: Design and Development of New Therapeutic Strategies for the Treatment of Conformational Diseases

(2016) Marino Convertino et al.   ACS Chemical Biology

Molecular Mechanism Underlying Pathogenesis of Lewisite-Induced Cutaneous Blistering and Inflammation

(2016) Changzhao Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Corneal toxicity induced by vesicating agents and effective treatment options

(2016) Dinesh G. Goswami et al.   Annals of the New York Academy of Sciences

ATF4 regulates arsenic trioxide-mediated NADPH oxidase, ER-mitochondrial crosstalk and apoptosis

(2016) Ritesh K. Srivastava et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Arsenic alters global histone modifications in lymphocytes in vitro and in vivo

(2016) Angeliki Pournara et al.   CELL BIOLOGY AND TOXICOLOGY

Arsenic-induced mitochondrial oxidative damage is mediated by decreased PGC-1α expression and its downstream targets in rat brain

(2016) Chandra Prakash et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Distribution of chemical warfare agent, energetics, and metals in sediments at a deep-water discarded military munitions site

(2016) Christian Briggs et al.   DEEP-SEA RESEARCH PART II-TOPICAL STUDIES IN OCEANOGRAPHY

Risk assessment for arsenic-contaminated groundwater along River Indus in Pakistan

(2016) Unaib Rabbani et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1

(2016) M. Cárdenas-González et al.   ENVIRONMENTAL RESEARCH

Osteoblasts activate the Nrf2 signalling pathway in response to arsenic trioxide treatment

(2016) Pu-Rong Chiu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Arsenic levels in cutaneous appendicular organs are correlated with digitally evaluated hyperpigmented skin of the forehead but not the sole in Bangladesh residents

(2016) Ichiro Yajima et al.   Journal of Exposure Science and Environmental Epidemiology

In Bangladesh, arsenic poisoning is a neglected issue

(2016) Sam Loewenberg   LANCET

Arsenic trioxide mediates HAPI microglia inflammatory response and subsequent neuron apoptosis through p38/JNK MAPK/STAT3 pathway

(2016) Jiamin Mao et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

AIM2 inflammasome mediates Arsenic-induced secretion of IL-1 β and IL-18

(2016) Mingfang Zhang et al.   OncoImmunology

Early-life arsenic exposure significantly increased the risk of cardiovascular disease

(2015) F. Hsieh et al.   ATHEROSCLEROSIS

Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic

(2015) Hai-nan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-423-5p targets O-GlcNAc transferase to induce apoptosis in cardiomyocytes

(2015) PENG LUO et al.   Molecular Medicine Reports

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

(2014) Simone G. J. van Breda et al.   ARCHIVES OF TOXICOLOGY

Arsine toxicity is induced by inhalation but not by percutaneous exposure in hairless mice

(2014) Koichi Kato et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Arsenite Selectively Inhibits Mouse Bone Marrow Lymphoid Progenitor Cell Development In Vivo and In Vitro and Suppresses Humoral Immunity In Vivo

(2014) Peace C. Ezeh et al.   PLoS One

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

Association of Low to Moderate Levels of Arsenic Exposure With Risk of Type 2 Diabetes in Bangladesh

(2013) Wen-Chi Pan et al.   AMERICAN JOURNAL OF EPIDEMIOLOGY

Arsenic trioxide induces unfolded protein response in vascular endothelial cells

(2013) Ching-Yi Weng et al.   ARCHIVES OF TOXICOLOGY

Arsenic Binding to Proteins

(2013) Shengwen Shen et al.   CHEMICAL REVIEWS

Arsenic-Based Warfare Agents: Production, Use, and Destruction

(2013) Barbara Radke et al.   CRITICAL REVIEWS IN ENVIRONMENTAL SCIENCE AND TECHNOLOGY

Arsenic immunotoxicity: a review

(2013) Nygerma L Dangleben et al.   Environmental Health

Differential DNA Methylation in Umbilical Cord Blood of Infants Exposed to Low Levels of Arsenic in Utero

(2013) Devin C. Koestler et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Cardiovascular effects of arsenic: clinical and epidemiological findings

(2013) Francesco Stea et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Rapid Analysis of Lewisite Metabolites in Urine by High-Performance Liquid Chromatography-Inductively Coupled Plasma-Mass Spectrometry

(2013) R. D. Stanelle et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

A Computational Study of Detoxification of Lewisite Warfare Agents by British Anti-lewisite: Catalytic Effects of Water and Ammonia on Reaction Mechanism and Kinetics

(2013) Chandan Sahu et al.   JOURNAL OF PHYSICAL CHEMISTRY A

In vitro toxicological characterization of two arsenosugars and their metabolites

(2013) Larissa Leffers et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Activation of the Nrf2 Pathway by Inorganic Arsenic in Human Hepatocytes and the Role of Transcriptional Repressor Bach1

(2013) Dan Liu et al.   Oxidative Medicine and Cellular Longevity

Groundwater Arsenic Contamination Throughout China

(2013) L. Rodriguez-Lado et al.   SCIENCE

Unfolded protein response (UPR) signaling regulates arsenic trioxide-mediated macrophage innate immune function disruption

(2013) Ritesh K. Srivastava et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Arsenic modulates heme oxygenase-1, interleukin-6, and vascular endothelial growth factor expression in endothelial cells: roles of ROS, NF-κB, and MAPK pathways

(2012) Lisu Wang et al.   ARCHIVES OF TOXICOLOGY

Arsenic-Mediated Activation of the Nrf2-Keap1 Antioxidant Pathway

(2012) Alexandria Lau et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis

(2012) Suryakant K. Niture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pharmacological Enhancement of α-Glucosidase by the Allosteric Chaperone N-acetylcysteine

(2012) Caterina Porto et al.   MOLECULAR THERAPY

Inorganic arsenic impairs proliferation and cytokine expression in human primary T lymphocytes

(2012) Claudie Morzadec et al.   TOXICOLOGY

Unfolded Protein Response Signaling and MAP Kinase Pathways Underlie Pathogenesis of Arsenic-Induced Cutaneous Inflammation

(2011) C. Li et al.   Cancer Prevention Research

Arsenic increases lipopolysaccharide-dependent expression of interleukin-8 gene by stimulating a redox-sensitive pathway that strengthens p38-kinase activation

(2011) Emilie Bourdonnay et al.   MOLECULAR IMMUNOLOGY

Phloem transport of arsenic species from flag leaf to grain during grain filling

(2011) Anne-Marie Carey et al.   NEW PHYTOLOGIST

The Arsenic Exposure Hypothesis for Alzheimer Disease

(2010) Gordon Gong et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Arsenic-related DNA copy-number alterations in lung squamous cell carcinomas

(2010) V D Martinez et al.   BRITISH JOURNAL OF CANCER

Arsenic species in seafood: Origin and human health implications

(2010) Kevin A. Francesconi   PURE AND APPLIED CHEMISTRY

Effects of arsenic exposure on DNA methylation and epigenetic gene regulation

(2010) John F Reichard et al.   Epigenomics

Lung Cancer in a U.S. Population with Low to Moderate Arsenic Exposure

(2009) Julia E. Heck et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Arsenic Exposure Transforms Human Epithelial Stem/Progenitor Cells into a Cancer Stem-like Phenotype

(2009) Erik J. Tokar et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Requirement of Arsenic Biomethylation for Oxidative DNA Damage

(2009) Chikara Kojima et al.   JNCI-Journal of the National Cancer Institute

Resveratrol protects against arsenic trioxide-induced cardiotoxicityin vitroandin vivo

(2008) X-Y Zhao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Arsenic Exposure In utero Exacerbates Skin Cancer Response in Adulthood with Contemporaneous Distortion of Tumor Stem Cell Dynamics

(2008) M. P. Waalkes et al.   CANCER RESEARCH

Human health risk screening due to consumption of fish contaminated with chemical warfare agents in the Baltic Sea

(2008) Hans Sanderson et al.   JOURNAL OF HAZARDOUS MATERIALS

Inhibition by methylated organoarsenicals of the respiratory 2-oxo-acid dehydrogenases

(2008) Erik R. Bergquist et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

Lung cancer and exposure to arsenic in rural Bangladesh

(2008) M G Mostafa et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Transporters of arsenite in rice and their role in arsenic accumulation in rice grain

(2008) J. F. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Speciation and enrichment of arsenic in strongly reducing shallow aquifers at western Hetao Plain, northern China

(2008) Yamin Deng et al.   Environmental geology.