Corneal toxicity induced by vesicating agents and effective treatment options

Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization

(2016) Dinesh G. Goswami et al.   CORNEA

Clinical progression of ocular injury following arsenical vesicant lewisite exposure

(2016) Neera Tewari-Singh et al.   Cutaneous and Ocular Toxicology

Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye

(2016) Fang Bian et al.   Ocular Surface

Rabbit as an animal model for intravitreal pharmacokinetics: Clinical predictability and quality of the published data

(2015) Eva M. del Amo et al.   EXPERIMENTAL EYE RESEARCH

Flavanone silibinin treatment attenuates nitrogen mustard-induced toxic effects in mouse skin

(2015) Anil K. Jain et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Nitrogen mustard exposure of murine skin induces DNA damage, oxidative stress and activation of MAPK/Akt-AP1 pathway leading to induction of inflammatory and proteolytic mediators

(2015) Dileep Kumar et al.   TOXICOLOGY LETTERS

The Beneficial Effects of Doxycycline, An Inhibitor of Matrix Metalloproteinases, on Sulfur Mustard-Induced Ocular Pathologies Depend on the Injury Stage

(2014) Vered Horwitz et al.   CURRENT EYE RESEARCH

Molecular Mechanisms of Silibinin-Mediated Cancer Chemoprevention with Major Emphasis on Prostate Cancer

(2013) Harold Ting et al.   AAPS Journal

Historical perspective on effects and treatment of sulfur mustard injuries

(2013) John S. Graham et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Targeting Tumor Microenvironment with Silibinin: Promise and Potential for a Translational Cancer Chemopreventive Strategy

(2013) Gagan Deep et al.   CURRENT CANCER DRUG TARGETS

Anti-VEGF Therapy (Bevacizumab) for Sulfur Mustard-Induced Corneal Neovascularization Associated with Delayed Limbal Stem Cell Deficiency in Rabbits

(2013) Tamar Kadar et al.   CURRENT EYE RESEARCH

A Computational Study of Detoxification of Lewisite Warfare Agents by British Anti-lewisite: Catalytic Effects of Water and Ammonia on Reaction Mechanism and Kinetics

(2013) Chandan Sahu et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Topical efficacy of dimercapto-chelating agents against lewisite-induced skin lesions in SKH-1 hairless mice

(2013) Stéphane Mouret et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The generation of 4-hydroxynonenal, an electrophilic lipid peroxidation end product, in rabbit cornea organ cultures treated with UVB light and nitrogen mustard

(2013) Ruijin Zheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Silibinin – A Promising New Treatment for Cancer

(2012) Catherine Wing Ying Cheung et al.   Anti-Cancer Agents in Medicinal Chemistry

Pathogenesis of Acute and Delayed Corneal Lesions After Ocular Exposure to Sulfur Mustard Vapor

(2012) Patrick McNutt et al.   CORNEA

Delayed Loss of Corneal Epithelial Stem Cells in a Chemical Injury Model Associated with Limbal Stem Cell Deficiency in Rabbits

(2012) Tamar Kadar et al.   CURRENT EYE RESEARCH

Endothelial cell damage following sulfur mustard exposure in rabbits and its association with the delayed-onset ocular lesions

(2012) Tamar Kadar et al.   Cutaneous and Ocular Toxicology

Development of a mouse model for sulfur mustard-induced ocular injury and long-term clinical analysis of injury progression

(2012) Albert Leonard Ruff et al.   Cutaneous and Ocular Toxicology

Silibinin Attenuates Sulfur Mustard Analog-Induced Skin Injury by Targeting Multiple Pathways Connecting Oxidative Stress and Inflammation

(2012) Neera Tewari-Singh et al.   PLoS One

Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries

(2012) Neera Tewari-Singh et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

A review on delayed toxic effects of sulfur mustard in Iranian veterans

(2012) Seyed mansour Razavi et al.   DARU-Journal of Pharmaceutical Sciences

Structural changes in the skin of hairless mice following exposure to sulfur mustard correlate with inflammation and DNA damage

(2011) Laurie B. Joseph et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Protective effect of dexamethasone against hypoxia-induced disruption of barrier function in human corneal epithelial cells

(2011) Kazuhiro Kimura et al.   EXPERIMENTAL EYE RESEARCH

Mechanisms of sulfur mustard analog 2-chloroethyl ethyl sulfide-induced DNA damage in skin epidermal cells and fibroblasts

(2011) Swetha Inturi et al.   FREE RADICAL BIOLOGY AND MEDICINE

2-Chloroethyl ethyl sulfide causes microvesication and inflammation-related histopathological changes in male hairless mouse skin

(2011) Anil K. Jain et al.   TOXICOLOGY

Sulfur mustard analog, 2-chloroethyl ethyl sulfide-induced skin injury involves DNA damage and induction of inflammatory mediators, in part via oxidative stress, in SKH-1 hairless mouse skin

(2011) Anil K. Jain et al.   TOXICOLOGY LETTERS

Progression of ocular sulfur mustard injury: development of a model system

(2010) Denise Milhorn et al.   Annals of the New York Academy of Sciences

Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer

(2010) Gagan Deep et al.   CANCER AND METASTASIS REVIEWS

Biological and Molecular Mechanisms of Sulfur Mustard Analogue-Induced Toxicity in JB6 and HaCaT Cells: Possible Role of Ataxia Telangiectasia-Mutated/Ataxia Telangiectasia-Rad3-Related Cell Cycle Checkpoint Pathway

(2010) Neera Tewari-Singh et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Sulfur mustard induced cytokine production and cell death: Investigating the potential roles of the p38, p53, and NF-κB signaling pathways with RNA interference

(2010) Albert L. Ruff et al.   JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY

Doxycycline Hydrogels as a Potential Therapy for Ocular Vesicant Injury

(2010) Marion K. Gordon et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Expression of proliferative and inflammatory markers in a full-thickness human skin equivalent following exposure to the model sulfur mustard vesicant, 2-chloroethyl ethyl sulfide

(2010) Adrienne T. Black et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds

(2009) SivaNaga S. Anumolu et al.   BIOMATERIALS

Long-term ocular consequences of sulfur mustard in seriously eye-injured war veterans

(2009) Hassan Ghasemi et al.   Cutaneous and Ocular Toxicology

Mechanisms Mediating the Vesicant Actions of Sulfur Mustard after Cutaneous Exposure

(2009) Michael P. Shakarjian et al.   TOXICOLOGICAL SCIENCES

The chronic effects of sulfur mustard exposure

(2009) Mike Rowell et al.   TOXICOLOGY

Molecular toxicology of sulfur mustard-induced cutaneous inflammation and blistering

(2009) K. Kehe et al.   TOXICOLOGY

Mustard Gas: Imminent Danger or Eminent Threat?

(2008) Matthew J Geraci   ANNALS OF PHARMACOTHERAPY

Ocular injuries following sulfur mustard exposure—Pathological mechanism and potential therapy

(2008) Tamar Kadar et al.   TOXICOLOGY