PAAN/MIF nuclease inhibition prevents neurodegeneration in Parkinson’s disease

Perampanel Inhibits α‐Synuclein Transmission in Parkinson's Disease Models

(2021) Jun Ueda et al.   MOVEMENT DISORDERS

PARkinson's: From cellular mechanisms to potential therapeutics

(2021) Zsofia Lengyel-Zhand et al.   PHARMACOLOGY & THERAPEUTICS

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

(2021) Laura N. Puentes et al.   Frontiers in Aging Neuroscience

Knockdown of macrophage migration inhibitory factor (MIF), a novel target to protect neurons from parthanatos induced by simulated post-spinal cord injury oxidative stress

(2020) Dongfang Yang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells

(2020) Hongge Wang et al.   ONCOGENE

Structural basis for allosteric PARP-1 retention on DNA breaks

(2020) Levani Zandarashvili et al.   SCIENCE

Parthanatos in the pathogenesis of nervous system diseases

(2020) Xuanzhong Wang et al.   NEUROSCIENCE

Parthanatos and its associated components: Promising therapeutic targets for cancer

(2020) Yunxiang Zhou et al.   PHARMACOLOGICAL RESEARCH

FK506 Induces Ligand-Independent Activation of the Bone Morphogenetic Protein Pathway and Osteogenesis

(2019) Sreedhara Sangadala et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

α-Synuclein pathology in Parkinson’s disease and related α-synucleinopathies

(2019) Michael X. Henderson et al.   NEUROSCIENCE LETTERS

Poly(ADP-Ribosylation) in Age-Related Neurological Disease

(2019) Leeanne McGurk et al.   TRENDS IN GENETICS

Small-molecule inhibitor targeting the Hsp90-Cdc37 protein-protein interaction in colorectal cancer

(2019) Lei Wang et al.   Science Advances

Discovery of a Potent GLUT Inhibitor from a Library of Rapafucins by Using 3D Microarrays

(2019) Zufeng Guo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Extracellular α-synuclein levels are regulated by neuronal activity

(2018) Kaoru Yamada et al.   Molecular Neurodegeneration

Parkin and PINK1 mitigate STING-induced inflammation

(2018) Danielle A. Sliter et al.   NATURE

Rapamycin-inspired macrocycles with new target specificity

(2018) Zufeng Guo et al.   Nature Chemistry

Poly(ADP-ribose) drives pathologic α-synuclein neurodegeneration in Parkinson’s disease

(2018) Tae-In Kam et al.   SCIENCE

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development

(2016) Joshua Bloom et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

(2016) Y. Wang et al.   SCIENCE

Cultured networks of excitatory projection neurons and inhibitory interneurons for studying human cortical neurotoxicity

(2016) Jin-Chong Xu et al.   Science Translational Medicine

FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model

(2016) Tae-In Kam et al.   eLife

Biology of Poly(ADP-Ribose) Polymerases: The Factotums of Cell Maintenance

(2015) Peter Bai   MOLECULAR CELL

The c-Abl inhibitor, Nilotinib, protects dopaminergic neurons in a preclinical animal model of Parkinson's disease

(2014) Senthilkumar S. Karuppagounder et al.   Scientific Reports

Parthanatos: mitochondrial-linked mechanisms and therapeutic opportunities

(2013) Amos A Fatokun et al.   BRITISH JOURNAL OF PHARMACOLOGY

rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration

(2013) Marusela Oliveras-Salvá et al.   Molecular Neurodegeneration

A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)

(2012) Fengwei Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

(2011) M. Merk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Poly(ADP-Ribose) (PAR) Binding to Apoptosis-Inducing Factor Is Critical for PAR Polymerase-1-Dependent Cell Death (Parthanatos)

(2011) Y. Wang et al.   Science Signaling

A simple and efficient route to the FKBP-binding domain from rapamycin

(2011) Wei Li et al.   TETRAHEDRON LETTERS

Behavioral phenotyping of mouse models of Parkinson's disease

(2010) Tonya N. Taylor et al.   BEHAVIOURAL BRAIN RESEARCH

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

(2010) Y. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Tautomerase-Null Macrophage Migration-Inhibitory Factor (MIF) Gene Knock-In Mouse Model Reveals That Protein Interactions and Not Enzymatic Activity Mediate MIF-Dependent Growth Regulation

(2009) G. Fingerle-Rowson et al.   MOLECULAR AND CELLULAR BIOLOGY