MIF, a controversial cytokine: a review of structural features, challenges, and opportunities for drug development

Overview of fusion tags for recombinant proteins

(2016) E. N. Kosobokova et al.   BIOCHEMISTRY-MOSCOW

Macrophage Migration Inhibitory Factor-CXCR4 Receptor Interactions

(2016) Deepa Rajasekaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Analysis of MIF Structural Features that Control Functional Activation of CD74

(2015) Georgios Pantouris et al.   CHEMISTRY & BIOLOGY

MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis

(2015) Setareh Alampour-Rajabi et al.   FASEB JOURNAL

Macrophage migration inhibitory factor (MIF) is rendered enzymatically inactive by myeloperoxidase-derived oxidants but retains its immunomodulatory function

(2015) Nina Dickerhof et al.   FREE RADICAL BIOLOGY AND MEDICINE

Age-dependent alterations in the inflammatory response to pulmonary challenge

(2015) Helena M. Linge et al.   IMMUNOLOGIC RESEARCH

Selective Targeting of a Disease-Related Conformational Isoform of Macrophage Migration Inhibitory Factor Ameliorates Inflammatory Conditions

(2015) Michael Thiele et al.   JOURNAL OF IMMUNOLOGY

Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation

(2015) Yanhua Zheng et al.   NATURE CELL BIOLOGY

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Macrophage Migration Inhibitory Factor as a Chaperone Inhibiting Accumulation of Misfolded SOD1

(2015) Adrian Israelson et al.   NEURON

Exploring the binding mechanisms of MIF to CXCR2 using theoretical approaches

(2015) Lei Xu et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine

(2015) L. Qin et al.   SCIENCE

Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4–CXCR7

(2015) M Chatterjee et al.   Cell Death & Disease

Role of Macrophage Migration Inhibitory Factor in Obesity, Insulin Resistance, Type 2 Diabetes, and Associated Hepatic Co-Morbidities: A Comprehensive Review of Human and Rodent Studies

(2015) Martine C. Morrison et al.   Frontiers in Immunology

The critical role of macrophage migration inhibitory factor in insulin activity

(2014) Milica Vujicic et al.   CYTOKINE

A Leishmania Ortholog of Macrophage Migration Inhibitory Factor Modulates Host Macrophage Responses

(2014) D. Kamir et al.   JOURNAL OF IMMUNOLOGY

MIF: Mood Improving/Inhibiting Factor?

(2014) Joshua Bloom et al.   Journal of Neuroinflammation

Phase I, multicentre, dose-escalation trial of monotherapy with milatuzumab (humanized anti-CD74 monoclonal antibody) in relapsed or refractory multiple myeloma

(2013) Jonathan L. Kaufman et al.   BRITISH JOURNAL OF HAEMATOLOGY

Homotrimeric Macrophage Migration Inhibitory Factor (MIF) Drives Inflammatory Responses in the Corneal Epithelium by Promoting Caveolin-rich Platform Assembly in Response to Infection

(2013) Thomas Reidy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing the Effects of Cysteine Residues on Protein Adsorption onto Gold Nanoparticles Using Wild-Type and Mutated GB3 Proteins

(2013) Kumudu Siriwardana et al.   LANGMUIR

MIF intersubunit disulfide mutant antagonist supports activation of CD74 by endogenous MIF trimer at physiologic concentrations

(2013) C. Fan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Small molecular modulation of macrophage migration inhibitory factor in the hyperoxia-induced mouse model of bronchopulmonary dysplasia

(2013) Huanxing Sun et al.   RESPIRATORY RESEARCH

Dehalogenation of an Anthropogenic Compound by an Engineered Variant of the Mouse Cytokine Macrophage Migration Inhibitory Factor

(2012) Anna A. Wasiel et al.   CHEMBIOCHEM

Neutralization of Macrophage Migration Inhibitory Factor (MIF) by Fully Human Antibodies Correlates with Their Specificity for the β-Sheet Structure of MIF

(2012) Randolf J. Kerschbaumer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Allosteric Inhibitor of Macrophage Migration Inhibitory Factor (MIF)

(2012) Fengwei Bai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Characterization of Molecular Determinants of the Conformational Stability of Macrophage Migration Inhibitory Factor: Leucine 46 Hydrophobic Pocket

(2012) Farah El-Turk et al.   PLoS One

Inactivation of Tautomerase Activity of Macrophage Migration Inhibitory Factor by Sulforaphane: a Potential Biomarker for Anti-inflammatory Intervention

(2011) Z. R. Healy et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

A role for macrophage migration inhibitory factor in protective immunity against Aspergillus fumigatus

(2011) Ivana Stojanovic et al.   IMMUNOBIOLOGY

Thyroxine is a potential endogenous antagonist of macrophage migration inhibitory factor (MIF) activity

(2011) Y. Al-Abed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The D-dopachrome tautomerase (DDT) gene product is a cytokine and functional homolog of macrophage migration inhibitory factor (MIF)

(2011) M. Merk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fragment screening of inhibitors for MIF tautomerase reveals a cryptic surface binding site

(2010) Larry R. McLean et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Receptor agonists of macrophage migration inhibitory factor

(2010) William L. Jorgensen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)

(2010) Alissa A. Hare et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activation of the JNK signalling pathway by macrophage migration inhibitory factor (MIF) and dependence on CXCR4 and CD74

(2010) Hongqi Lue et al.   CELLULAR SIGNALLING

A small-molecule inhibitor of macrophage migration inhibitory factor for the treatment of inflammatory disease

(2010) Aaron P. Kithcart et al.   FASEB JOURNAL

Macrophage migration inhibitory factor-knockout mice are long lived and respond to caloric restriction

(2010) James M. Harper et al.   FASEB JOURNAL

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

(2010) Sandra Kraemer et al.   FASEB JOURNAL

MIF as a disease target: ISO-1 as a proof-of-concept therapeutic

(2010) Yousef Al-Abed et al.   Future Medicinal Chemistry

Identification and Characterization of Novel Classes of Macrophage Migration Inhibitory Factor (MIF) Inhibitors with Distinct Mechanisms of Action

(2010) Hajer Ouertatani-Sakouhi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Small-Molecule Macrophage Migration Inhibitory Factor Antagonist Protects against Glomerulonephritis in Lupus-Prone NZB/NZW F1 and MRL/lpr Mice

(2010) L. Leng et al.   JOURNAL OF IMMUNOLOGY

Macrophage Migration Inhibitory Factor Is Secreted by Rhabdomyosarcoma Cells, Modulates Tumor Metastasis by Binding to CXCR4 and CXCR7 Receptors and Inhibits Recruitment of Cancer-Associated Fibroblasts

(2010) Maciej Tarnowski et al.   MOLECULAR CANCER RESEARCH

Macrophage migration inhibitory factor is critically involved in basal and fluoxetine-stimulated adult hippocampal cell proliferation and in anxiety, depression and memory-related behaviors

(2010) L Conboy et al.   MOLECULAR PSYCHIATRY

Allosteric inhibition of macrophage migration inhibitory factor revealed by ibudilast

(2010) Y. Cho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MIF proteins are not glutathione transferase homologs

(2010) William R. Pearson   PROTEIN SCIENCE

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Chemokine receptor oligomerization: functional considerations

(2009) Marcus Thelen et al.   CURRENT OPINION IN PHARMACOLOGY

Milatuzumab – a promising new immunotherapeutic agent

(2009) Zuzana Berkova et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A functional heteromeric MIF receptor formed by CD74 and CXCR4

(2009) Verena Schwartz et al.   FEBS LETTERS

Ribosomal Protein S19 Interacts with Macrophage Migration Inhibitory Factor and Attenuates Its Pro-inflammatory Function

(2009) Ana-Maria Filip et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Golgi-Associated Protein p115 Mediates the Secretion of Macrophage Migration Inhibitory Factor

(2009) M. Merk et al.   JOURNAL OF IMMUNOLOGY

A Tautomerase-Null Macrophage Migration-Inhibitory Factor (MIF) Gene Knock-In Mouse Model Reveals That Protein Interactions and Not Enzymatic Activity Mediate MIF-Dependent Growth Regulation

(2009) G. Fingerle-Rowson et al.   MOLECULAR AND CELLULAR BIOLOGY

The crystal structures of macrophage migration inhibitory factor fromPlasmodium falciparumandPlasmodium berghei

(2009) Sarah E. Dobson et al.   PROTEIN SCIENCE

MIF in autoimmunity and novel therapeutic approaches

(2008) Stanislava Stosic-Grujicic et al.   AUTOIMMUNITY REVIEWS

The Conformational Flexibility of the Carboxy Terminal Residues 105−114 Is a Key Modulator of the Catalytic Activity and Stability of Macrophage Migration Inhibitory Factor†

(2008) Farah El-Turk et al.   BIOCHEMISTRY

A Novel, Macrophage Migration Inhibitory Factor Suicide Substrate Inhibits Motility and Growth of Lung Cancer Cells

(2008) M. Winner et al.   CANCER RESEARCH

The role of macrophage migration inhibitory factor on glucose metabolism and diabetes

(2008) C. Toso et al.   DIABETOLOGIA

Discovery of Human Macrophage Migration Inhibitory Factor (MIF)-CD74 Antagonists via Virtual Screening

(2008) Zoe Cournia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

(2008) C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA