Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia

Low-dose decitabine priming endows CAR T cells with enhanced and persistent antitumour potential via epigenetic reprogramming

(2021) Yao Wang et al.   Nature Communications

Shaping Functional Avidity of CAR-T Cells: Affinity, Avidity and Antigen Density that Regulate Response

(2021) Raanan Greenman et al.   MOLECULAR CANCER THERAPEUTICS

T cell circuits that sense antigen density with an ultrasensitive threshold

(2021) Rogelio A. Hernandez-Lopez et al.   SCIENCE

CD70-specific CAR T-cells have potent activity against Acute Myeloid Leukemia (AML) without HSC toxicity

(2021) Tim Sauer et al.   BLOOD

Single Chain Variable Fragment Linker Length Regulates CAR Biology and T Cell Efficacy

(2020) Nathan Singh et al.   BLOOD

Safety and feasibility of anti-CD19 CAR T cells with fully human binding domains in patients with B-cell lymphoma

(2020) Jennifer N. Brudno et al.   NATURE MEDICINE

Impaired death receptor signaling in leukemia causes antigen-independent resistance by inducing CAR T cell dysfunction

(2020) Nathan Singh et al.   Cancer Discovery

KTE-X19 CAR T-Cell Therapy in Relapsed or Refractory Mantle-Cell Lymphoma

(2020) Michael Wang et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tuning the Antigen Density Requirement for CAR T-cell Activity

(2020) Robbie G. Majzner et al.   Cancer Discovery

A Distinct Transcriptional Program in Human CAR T Cells Bearing the 4-1BB Signaling Domain Revealed by scRNA-Seq

(2020) Angela C. Boroughs et al.   MOLECULAR THERAPY

Targeting CD70 with cusatuzumab eliminates acute myeloid leukemia stem cells in patients treated with hypomethylating agents

(2020) Carsten Riether et al.   NATURE MEDICINE

A rational mouse model to detect on-target, off-tumor CAR T cell toxicity

(2020) Mauro Castellarin et al.   JCI Insight

Lisocabtagene maraleucel for patients with relapsed or refractory large B-cell lymphomas (TRANSCEND NHL 001): a multicentre seamless design study

(2020) Jeremy S Abramson et al.   LANCET

CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape

(2019) Mohamad Hamieh et al.   NATURE

Hypomethylating agent alters the immune microenvironment in acute myeloid leukaemia (AML) and enhances the immunogenicity of a dendritic cell/AML vaccine

(2019) Myrna R. Nahas et al.   BRITISH JOURNAL OF HAEMATOLOGY

Modulation of Target Antigen Density Improves CAR T Cell Functionality and Persistence

(2019) Sneha Ramakrishna et al.   CLINICAL CANCER RESEARCH

γ-secretase inhibition increases efficacy of BCMA-specific chimeric antigen receptor T cells in multiple myeloma

(2019) Margot J. Pont et al.   BLOOD

Screening a Broad Range of Solid and Haematological Tumour Types for CD70 Expression Using a Uniform IHC Methodology as Potential Patient Stratification Method

(2019) Tal Flieswasser et al.   Cancers

c-Jun overexpression in CAR T cells induces exhaustion resistance

(2019) Rachel C. Lynn et al.   NATURE

CD19 and CD70 Dual-Target Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Relapsed and Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma

(2019) Sanfang Tu et al.   Frontiers in Oncology

Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia

(2018) Miriam Y. Kim et al.   CELL

CAR T-cells targeting FLT3 have potent activity against FLT3−ITD+ AML and act synergistically with the FLT3-inhibitor crenolanib

(2018) Hardikkumar Jetani et al.   LEUKEMIA

Compound CAR T-cells as a double-pronged approach for treating acute myeloid leukemia

(2018) Jessica C. Petrov et al.   LEUKEMIA

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia

(2018) Joseph A. Fraietta et al.   NATURE MEDICINE

CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma

(2018) Yuk Pheel Park et al.   ORAL ONCOLOGY

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

CARs versus BiTEs: A Comparison between T Cell–Redirection Strategies for Cancer Treatment

(2018) Clare Y. Slaney et al.   Cancer Discovery

Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells

(2018) Shojiro Kitajima et al.   Oncotarget

Structural principles of tumor necrosis factor superfamily signaling

(2018) Éva S. Vanamee et al.   Science Signaling

Disruption of TET2 promotes the therapeutic efficacy of CD19-targeted T cells

(2018) Joseph A. Fraietta et al.   NATURE

Multiomics of azacitidine-treated AML cells reveals variable and convergent targets that remodel the cell-surface proteome

(2018) Kevin K. Leung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two-Dimensional Regulation of CAR-T Therapy with Orthogonal Switches

(2018) MyLinh T. Duong et al.   Molecular Therapy-Oncolytics

Function of Novel Anti-CD19 Chimeric Antigen Receptors with Human Variable Regions Is Affected by Hinge and Transmembrane Domains

(2017) Leah Alabanza et al.   MOLECULAR THERAPY

Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection

(2017) Justin Eyquem et al.   NATURE

CD22-targeted CAR T cells induce remission in B-ALL that is naive or resistant to CD19-targeted CAR immunotherapy

(2017) Terry J Fry et al.   NATURE MEDICINE

CD70, a novel target of CAR T-cell therapy for gliomas

(2017) Linchun Jin et al.   NEURO-ONCOLOGY

Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas

(2017) Stephen J. Schuster et al.   NEW ENGLAND JOURNAL OF MEDICINE

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

(2017) Sattva S. Neelapu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Crystal structure of CD27 in complex with a neutralizing noncompeting antibody

(2017) Alexey Teplyakov et al.   Acta Crystallographica Section F-Structural Biology Communications

The Public Repository of Xenografts Enables Discovery and Randomized Phase II-like Trials in Mice

(2016) Elizabeth C. Townsend et al.   CANCER CELL

Preclinical Evaluation of Chimeric Antigen Receptors Targeting CD70-Expressing Cancers

(2016) Qiong J. Wang et al.   CLINICAL CANCER RESEARCH

CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia

(2016) Carsten Riether et al.   JOURNAL OF EXPERIMENTAL MEDICINE

DNMT3A mutation leads to leukemic extramedullary infiltration mediated by TWIST1

(2016) Jie Xu et al.   Journal of Hematology & Oncology

CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia

(2016) Challice L Bonifant et al.   MOLECULAR THERAPY

Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9

(2016) John G Doench et al.   NATURE BIOTECHNOLOGY

Construction of a linker library with widely controllable flexibility for fusion protein design

(2015) Gang Li et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Affinity-Tuned ErbB2 or EGFR Chimeric Antigen Receptor T Cells Exhibit an Increased Therapeutic Index against Tumors in Mice

(2015) X. Liu et al.   CANCER RESEARCH

pVHL/HIF-Regulated CD70 Expression Is Associated with Infiltration of CD27+ Lymphocytes and Increased Serum Levels of Soluble CD27 in Clear Cell Renal Cell Carcinoma

(2015) M. Ruf et al.   CLINICAL CANCER RESEARCH

T cells compete by cleaving cell surface CD27 and blocking access to CD70-bearing APCs

(2015) Matthew A. Burchill et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treatment of CD33-directed Chimeric Antigen Receptor-modified T Cells in One Patient With Relapsed and Refractory Acute Myeloid Leukemia

(2015) Quan-shun Wang et al.   MOLECULAR THERAPY

4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors

(2015) Adrienne H Long et al.   NATURE MEDICINE

The Phyre2 web portal for protein modeling, prediction and analysis

(2015) Lawrence A Kelley et al.   Nature Protocols

Acute Myeloid Leukemia

(2015) Hartmut Döhner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

(2015) M. J. Frigault et al.   Cancer Immunology Research

How I treat the older patient with acute myeloid leukemia

(2014) G. Ossenkoppele et al.   BLOOD

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

(2013) A. Mardiros et al.   BLOOD

Matrix Metalloproteinase-8 Is Overexpressed in Waldenström's Macroglobulinemia Cells, and Specific Inhibition of this Metalloproteinase Blocks Release of Soluble CD27

(2012) Yangsheng Zhou et al.   Clinical Lymphoma Myeloma & Leukemia

The Tumor Necrosis Factor Receptor Stalk Regions Define Responsiveness to Soluble versus Membrane-Bound Ligand

(2012) C. Richter et al.   MOLECULAR AND CELLULAR BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

T cells redirected against CD70 for the immunotherapy of CD70-positive malignancies

(2011) D. R. Shaffer et al.   BLOOD

SPICE: Exploration and analysis of post-cytometric complex multivariate datasets

(2011) Mario Roederer et al.   CYTOMETRY PART A

Kit inhibitor APcK110 extends survival in an AML xenograft mouse model

(2010) Stefan Faderl et al.   INVESTIGATIONAL NEW DRUGS

Timing and tuning of CD27-CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology

(2009) Martijn A. Nolte et al.   IMMUNOLOGICAL REVIEWS

Trimer Stabilization, Oligomerization, and Antibody-Mediated Cell Surface Immobilization Improve the Activity of Soluble Trimers of CD27L, CD40L, 41BBL, and Glucocorticoid-Induced TNF Receptor Ligand

(2009) A. Wyzgol et al.   JOURNAL OF IMMUNOLOGY