Silencing of amygdala circuits during sepsis prevents the development of anxiety-related behaviours

The advent of fear conditioning as an animal model of post-traumatic stress disorder: Learning from the past to shape the future of PTSD research

(2021) Thomas C.M. Bienvenu et al.   NEURON

Mesenchymal Stromal Cells Protect the Blood-Brain Barrier, Reduce Astrogliosis, and Prevent Cognitive and Behavioral Alterations in Surviving Septic Mice

(2020) Adriano Y. O. Silva et al.   CRITICAL CARE MEDICINE

Sickness Behavior Score Is Associated with Neuroinflammation and Late Behavioral Changes in Polymicrobial Sepsis Animal Model

(2020) Mariana Pereira de Souza Goldim et al.   INFLAMMATION

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

(2020) Kristina E Rudd et al.   LANCET

Mitochondrial Transplantation Attenuates Brain Dysfunction in Sepsis by Driving Microglial M2 Polarization

(2020) Chaoying Yan et al.   MOLECULAR NEUROBIOLOGY

Sepsis survivor mice exhibit a behavioral endocrine syndrome with ventral hippocampal dysfunction

(2020) Joanna L. Spencer-Segal et al.   PSYCHONEUROENDOCRINOLOGY

What animal models can tell us about long-term cognitive dysfunction following sepsis: A systematic review

(2020) Felipe Figueredo Savi et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Levetiracetam optimal dose-finding as first-line treatment for neonatal seizures occurring in the context of hypoxic-ischaemic encephalopathy (LEVNEONAT-1): study protocol of a phase II trial

(2019) Geraldine Favrais et al.   BMJ Open

Continuous EEG Monitoring in a Consecutive Patient Cohort with Sepsis and Delirium

(2019) Rikke M. Nielsen et al.   Neurocritical Care

Effects of MFHAS1 on cognitive impairment and dendritic pathology in the hippocampus of septic rats

(2019) Jing Zhong et al.   LIFE SCIENCES

Dynamic remodeling of a basolateral-to-central amygdala glutamatergic circuit across fear states

(2019) Nolan D. Hartley et al.   NATURE NEUROSCIENCE

Current Status of Animal Models of Posttraumatic Stress Disorder: Behavioral and Biological Phenotypes, and Future Challenges in Improving Translation

(2018) Jessica Deslauriers et al.   BIOLOGICAL PSYCHIATRY

New perspectives on central amygdala function

(2018) Jonathan P Fadok et al.   CURRENT OPINION IN NEUROBIOLOGY

Long-Term Cognitive Outcomes After Sepsis: a Translational Systematic Review

(2018) Tatiana Barichello et al.   MOLECULAR NEUROBIOLOGY

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

(2018) Robert J. Fenster et al.   NATURE REVIEWS NEUROSCIENCE

Minimum Quality Threshold in Pre-Clinical Sepsis Studies (Mqtipss)

(2018) Marcin F. Osuchowski et al.   SHOCK

NLRP3/Caspase-1 Pathway-Induced Pyroptosis Mediated Cognitive Deficits in a Mouse Model of Sepsis-Associated Encephalopathy

(2018) Qun Fu et al.   INFLAMMATION

Reconsolidation/destabilization, extinction and forgetting of fear memory as therapeutic targets for PTSD

(2018) Satoshi Kida   PSYCHOPHARMACOLOGY

Synaptic encoding of fear memories in the amygdala

(2018) Reed L Ressler et al.   CURRENT OPINION IN NEUROBIOLOGY

Inhibition of indoleamine 2,3-dioxygenase 1/2 prevented cognitive impairment and energetic metabolism changes in the hippocampus of adult rats subjected to polymicrobial sepsis

(2017) Clarissa M. Comim et al.   JOURNAL OF NEUROIMMUNOLOGY

The central amygdala controls learning in the lateral amygdala

(2017) Kai Yu et al.   NATURE NEUROSCIENCE

Targeting Neural Hyperactivity as a Treatment to Stem Progression of Late-Onset Alzheimer’s Disease

(2017) Rebecca P. Haberman et al.   Neurotherapeutics

Recognizing Sepsis as a Global Health Priority — A WHO Resolution

(2017) Konrad Reinhart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Post-Traumatic Stress Disorder

(2017) Arieh Shalev et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Central Amygdala-Substantia Innominata Neural Circuitry Encodes Aversive Reinforcement Signals

(2017) Yuting Cui et al.   Cell Reports

Unraveling cognitive traits using the Morris water maze unbiased strategy classification (MUST-C) algorithm

(2016) Tomer Illouz et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroanatomy and Physiology of Brain Dysfunction in Sepsis

(2016) Aurelien Mazeraud et al.   CLINICS IN CHEST MEDICINE

Effect of a Primary Care Management Intervention on Mental Health–Related Quality of Life Among Survivors of Sepsis

(2016) Konrad Schmidt et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)

(2016) Mervyn Singer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Preclinical Models of Overwhelming Sepsis Implicate the Neural System that Encodes Contextual Fear Memory

(2016) Patricio T Huerta et al.   MOLECULAR MEDICINE

Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders

(2016) M A Lebow et al.   MOLECULAR PSYCHIATRY

Vagal neurocircuitry and its influence on gastric motility

(2016) R. Alberto Travagli et al.   Nature Reviews Gastroenterology & Hepatology

Cecal Ligation and Puncture Results in Long-Term Central Nervous System Myeloid Inflammation

(2016) Benjamin H. Singer et al.   PLoS One

Neuronal Circuits for Fear Expression and Recovery: Recent Advances and Potential Therapeutic Strategies

(2015) Cyril Dejean et al.   BIOLOGICAL PSYCHIATRY

Central Cholinergic Neurons Are Rapidly Recruited by Reinforcement Feedback

(2015) Balázs Hangya et al.   CELL

Elucidating an Affective Pain Circuit that Creates a Threat Memory

(2015) Sung Han et al.   CELL

Validation of the 6Hz refractory seizure mouse model for intracerebroventricularly administered compounds

(2015) Laura Walrave et al.   EPILEPSY RESEARCH

Disrupted Tryptophan Metabolism Induced Cognitive Impairment in a Mouse Model of Sepsis-associated Encephalopathy

(2015) Rong Gao et al.   INFLAMMATION

Systemic Lipopolysaccharide Administration-Induced Cognitive Impairments are Reversed by Erythropoietin Treatment in Mice

(2015) Rong Gao et al.   INFLAMMATION

Sepsis-induced selective parvalbumin interneuron phenotype loss and cognitive impairments may be mediated by NADPH oxidase 2 activation in mice

(2015) Mu-Huo Ji et al.   Journal of Neuroinflammation

Viral-genetic tracing of the input–output organization of a central noradrenaline circuit

(2015) Lindsay A. Schwarz et al.   NATURE

Basomedial amygdala mediates top-down control of anxiety and fear

(2015) Avishek Adhikari et al.   NATURE

Regulating anxiety with extrasynaptic inhibition

(2015) Paolo Botta et al.   NATURE NEUROSCIENCE

Neuronal circuits for fear and anxiety

(2015) Philip Tovote et al.   NATURE REVIEWS NEUROSCIENCE

The Human BNST: Functional Role in Anxiety and Addiction

(2015) S N Avery et al.   NEUROPSYCHOPHARMACOLOGY

Early Standard Electroencephalogram Abnormalities Predict Mortality in Septic Intensive Care Unit Patients

(2015) Eric Azabou et al.   PLoS One

Cognitive decline after sepsis

(2015) Djillali Annane et al.   Lancet Respiratory Medicine

From non-pharmacological treatments for post-traumatic stress disorder to novel therapeutic targets

(2014) Hendrikus Hendriksen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pathological circuit function underlying addiction and anxiety disorders

(2014) Andreas Lüthi et al.   NATURE NEUROSCIENCE

Central amygdala PKC-δ+ neurons mediate the influence of multiple anorexigenic signals

(2014) Haijiang Cai et al.   NATURE NEUROSCIENCE

Chemogenetic Synaptic Silencing of Neural Circuits Localizes a Hypothalamus→Midbrain Pathway for Feeding Behavior

(2014) Tevye J. Stachniak et al.   NEURON

Distributed circuits underlying anxiety

(2014) Avishek Adhikari   Frontiers in Behavioral Neuroscience

Motivational Salience Signal in the Basal Forebrain Is Coupled with Faster and More Precise Decision Speed

(2014) Irene Avila et al.   PLOS BIOLOGY

Assessment of Plasma C-Reactive Protein as a Biomarker of Posttraumatic Stress Disorder Risk

(2014) Satish A. Eraly et al.   JAMA Psychiatry

Experience-dependent modification of a central amygdala fear circuit

(2013) Haohong Li et al.   NATURE NEUROSCIENCE

Implications of memory modulation for post-traumatic stress and fear disorders

(2013) Ryan G Parsons et al.   NATURE NEUROSCIENCE

Molecular mechanisms of dendrite stability

(2013) Anthony J. Koleske   NATURE REVIEWS NEUROSCIENCE

Permanent Genetic Access to Transiently Active Neurons via TRAP: Targeted Recombination in Active Populations

(2013) Casey J. Guenthner et al.   NEURON

Animal models of post-traumatic stress disorder: face validity

(2013) Sonal Goswami et al.   Frontiers in Neuroscience

Levetiracetam Use in the Critical Care Setting

(2013) Jennifer L. DeWolfe et al.   Frontiers in Neurology

Levetiracetam has an activity-dependent effect on inhibitory transmission

(2012) Anna L. Meehan et al.   EPILEPSIA

The dendritic tree and brain disorders

(2012) Vaishali A. Kulkarni et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Unknown

(2012) Sangeeta Chavan et al.   MOLECULAR MEDICINE

Levetiracetam inhibits neurotransmitter release associated with CICR

(2012) Kouji Fukuyama et al.   NEUROSCIENCE LETTERS

Late Anxiety-Like Behavior and Neuroinflammation in Mice Subjected to Sublethal Polymicrobial Sepsis

(2012) Allan C. Calsavara et al.   NEUROTOXICITY RESEARCH

Glucocorticoids Can Induce PTSD-Like Memory Impairments in Mice

(2012) N. Kaouane et al.   SCIENCE

Effect of levetiracetam monotherapy on background EEG activity and cognition in drug-naïve epilepsy patients

(2011) Jounhong Ryan Cho et al.   CLINICAL NEUROPHYSIOLOGY

Leptin Action on GABAergic Neurons Prevents Obesity and Reduces Inhibitory Tone to POMC Neurons

(2011) Linh Vong et al.   NEURON

Cecal ligation and puncture: the gold standard model for polymicrobial sepsis?

(2011) Lien Dejager et al.   TRENDS IN MICROBIOLOGY

Long-term Cognitive Impairment and Functional Disability Among Survivors of Severe Sepsis

(2010) Theodore J. Iwashyna et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Genetic dissection of an amygdala microcircuit that gates conditioned fear

(2010) Wulf Haubensak et al.   NATURE

Immunodesign of experimental sepsis by cecal ligation and puncture

(2009) Daniel Rittirsch et al.   Nature Protocols

Factors associated with posttraumatic stress symptoms in a prospective cohort of patients after abdominal sepsis: a nomogram

(2008) Kimberly R. Boer et al.   INTENSIVE CARE MEDICINE

Sepsis causes neuroinflammation and concomitant decrease of cerebral metabolism

(2008) Alexander Semmler et al.   Journal of Neuroinflammation

Neuronal Ensemble Bursting in the Basal Forebrain Encodes Salience Irrespective of Valence

(2008) Shih-Chieh Lin et al.   NEURON

Evidence for a cytokine model of cognitive function

(2008) J. McAfoose et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

From inflammation to sickness and depression: when the immune system subjugates the brain

(2007) Robert Dantzer et al.   NATURE REVIEWS NEUROSCIENCE