Naringenin promoted spinal microglia M2 polarization in rat model of cancer-induced bone pain via regulating AMPK/PGC-1α signaling axis

Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK/PGC-1α-mediated mitochondrial biogenesis and suppression of neuroinflammation

(2022) Jia Sun et al.   BRAIN BEHAVIOR AND IMMUNITY

β2-adrenoreceptor agonist ameliorates mechanical allodynia in paclitaxel-induced neuropathic pain via induction of mitochondrial biogenesis

(2021) Nan Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

Spinal HSP27 participates in PDGFRβ‐mediated morphine tolerance through PI3K/Akt and p38 MAPK signaling pathways

(2020) Zheng Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Microglia induce the transformation of A1/A2 reactive astrocytes via the CXCR7/PI3K/Akt pathway in chronic post-surgical pain

(2020) Ting Li et al.   Journal of Neuroinflammation

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

(2020) Mar Puigdellívol et al.   Frontiers in Cellular Neuroscience

Effects of Mitochondrial Dysfunction via AMPK/PGC-1α Signal Pathway on Pathogenic Mechanism of Diabetic Peripheral Neuropathy and the Protective Effects of Chinese Medicine

(2019) Qian Zhang et al.   Chinese Journal of Integrative Medicine

Targeting MAPK Pathways by Naringenin Modulates Microglia M1/M2 Polarization in Lipopolysaccharide-Stimulated Cultures

(2019) Bei Zhang et al.   Frontiers in Cellular Neuroscience

AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression

(2019) Hong-Chun Xiang et al.   Journal of Neuroinflammation

Berberine Facilitates Angiogenesis Against Ischemic Stroke Through Modulating Microglial Polarization via AMPK Signaling

(2019) Junrong Zhu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Hydrogen-rich saline promotes microglia M2 polarization and complement-mediated synapse loss to restore behavioral deficits following hypoxia-ischemic in neonatal mice via AMPK activation

(2019) Xili Chu et al.   Journal of Neuroinflammation

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The therapeutic potential of GABA in neuron-glia interactions of cancer-induced bone pain

(2019) Meng-Meng Ge et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain

(2019) Shu-Ping Chen et al.   PHARMACOLOGICAL RESEARCH

Isovitexin-Mediated Regulation of Microglial Polarization in Lipopolysaccharide-Induced Neuroinflammation via Activation of the CaMKKβ/AMPK-PGC-1α Signaling Axis

(2019) Bingrun Liu et al.   Frontiers in Immunology

A Dual AMPK/Nrf2 Activator Reduces Brain Inflammation After Stroke by Enhancing Microglia M2 Polarization

(2018) Yunjie Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha as a Novel Target for Bipolar Disorder and Other Neuropsychiatric Disorders

(2018) Andrew A. Nierenberg et al.   BIOLOGICAL PSYCHIATRY

IDH2 Deficiency in Microglia Decreases the Pro-inflammatory Response via the ERK and NF-κB Pathways

(2018) Unbin Chae et al.   INFLAMMATION

Novel Allosteric Activators for Ferroptosis Regulator Glutathione Peroxidase 4

(2018) Cong Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction

(2018) Su Liu et al.   JOURNAL OF PAIN

Dehydrocorydaline attenuates bone cancer pain by shifting microglial M1/M2 polarization toward the M2 phenotype

(2018) Wenwen Huo et al.   Molecular Pain

Microglia in neuropathic pain: cellular and molecular mechanisms and therapeutic potential

(2018) Kazuhide Inoue et al.   NATURE REVIEWS NEUROSCIENCE

Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain

(2018) Ya-Qun Zhou et al.   Redox Biology

Roles of inflammation, neurogenic inflammation, and neuroinflammation in pain

(2018) Megumi Matsuda et al.   Journal of Anesthesia

Pharmacokinetic, pharmacodynamic and formulations aspects of Naringenin: An update

(2018) Ruthvika Joshi et al.   LIFE SCIENCES

SIRT1 activation by SRT1720 attenuates bone cancer pain via preventing Drp1-mediated mitochondrial fission

(2018) Ming-Yue Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

High-fat diet inhibits PGC-1α suppressive effect on NFκB signaling in hepatocytes

(2017) Wermerson Assunção Barroso et al.   EUROPEAN JOURNAL OF NUTRITION

Erythropoietin ameliorates early brain injury after subarachnoid haemorrhage by modulating microglia polarization via the EPOR/JAK2-STAT3 pathway

(2017) Shanwu Wei et al.   EXPERIMENTAL CELL RESEARCH

The Role of Spinal GABAB Receptors in Cancer-Induced Bone Pain in Rats

(2017) Ya-Qun Zhou et al.   JOURNAL OF PAIN

Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes: a possible mechanism underlying its beneficial effect on exercise endurance

(2017) Jihang Chen et al.   Food & Function

The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-κB activation

(2016) Felipe A. Pinho-Ribeiro et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Maraviroc reduces neuropathic pain through polarization of microglia and astroglia – Evidence from in vivo and in vitro studies

(2016) Anna Piotrowska et al.   NEUROPHARMACOLOGY

Naringenin reduces inflammatory pain in mice

(2016) Felipe A. Pinho-Ribeiro et al.   NEUROPHARMACOLOGY

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

(2016) Xiao-Yi Xiong et al.   PROGRESS IN NEUROBIOLOGY

Activation of Adenosine Monophosphate–activated Protein Kinase Suppresses Neuroinflammation and Ameliorates Bone Cancer Pain

(2015) Huayuan Song et al.   ANESTHESIOLOGY

The PGC-1 coactivators promote an anti-inflammatory environment in skeletal muscle in vivo

(2015) Petra Sabine Eisele et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intrathecal Injection of JWH-015 Attenuates Bone Cancer Pain Via Time-Dependent Modification of Pro-inflammatory Cytokines Expression and Astrocytes Activity in Spinal Cord

(2015) Cui’e Lu et al.   INFLAMMATION

Naringenin Suppresses Neuroinflammatory Responses Through Inducing Suppressor of Cytokine Signaling 3 Expression

(2015) Ling-Hsuan Wu et al.   MOLECULAR NEUROBIOLOGY

Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases

(2015) Yu Tang et al.   MOLECULAR NEUROBIOLOGY

Naringenin neutralises oxidative stress and nerve growth factor discrepancy in experimental diabetic neuropathy

(2015) Salim S. Al-Rejaie et al.   NEUROLOGICAL RESEARCH

M1 and M2 immune activation in Parkinson’s Disease: Foe and ally?

(2015) M.S. Moehle et al.   NEUROSCIENCE

Parthenolide Relieves Pain and Promotes M2 Microglia/Macrophage Polarization in Rat Model of Neuropathy

(2015) Katarzyna Popiolek-Barczyk et al.   NEURAL PLASTICITY

Role of naringenin in protection against diabetic hyperalgesia and tactile allodynia in male Wistar rats

(2014) Parisa Hasanein et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Bone cancer pain

(2014) Patrick W. Mantyh   Current Opinion in Supportive and Palliative Care

Spinal IFN-γ-induced protein-10 (CXCL10) mediates metastatic breast cancer-induced bone pain by activation of microglia in rat models

(2013) Huilian Bu et al.   BREAST CANCER RESEARCH AND TREATMENT

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue

(2013) Zhongxiao Wan et al.   Obesity

Functional crosstalk of PGC-1 coactivators and inflammation in skeletal muscle pathophysiology

(2013) Petra S. Eisele et al.   Seminars in Immunopathology

Neuroprotective effect of naringenin is mediated through suppression of NF-κB signaling pathway in experimental stroke

(2012) S.S. Raza et al.   NEUROSCIENCE

The Role of Galectin-3/MAC-2 in the Activation of the Innate-Immune Function of Phagocytosis in Microglia in Injury and Disease

(2009) Shlomo Rotshenker   JOURNAL OF MOLECULAR NEUROSCIENCE