Emerging photodynamic nanotherapeutics for inducing immunogenic cell death and potentiating cancer immunotherapy

Regulating Glucose Metabolism with Prodrug Nanoparticles for Promoting Photoimmunotherapy of Pancreatic Cancer

(2021) Fang Sun et al.   Advanced Science

Noninvasively immunogenic sonodynamic therapy with manganese protoporphyrin liposomes against triple-negative breast cancer

(2021) Huaqing Chen et al.   BIOMATERIALS

Natural Melanin-Based Nanoparticles With Combined Chemo/Photothermal/Photodynamic Effect Induce Immunogenic Cell Death (ICD) on Tumor

(2021) Ding Liu et al.   Frontiers in Bioengineering and Biotechnology

Functionalized Scintillating Nanotubes for Simultaneous Radio- and Photodynamic Therapy of Cancer

(2021) Irene Villa et al.   ACS Applied Materials & Interfaces

Phototherapy together with it triggered immunological response for Anti-HPV treatment of oropharyngeal cancer: Removing tumor and pathogenic virus simultaneously

(2021) Zhao Liu et al.   BIOMATERIALS

Recent Advancements in Nanomedicine for ‘Cold’ Tumor Immunotherapy

(2021) Qinjun Chen et al.   Nano-Micro Letters

Immune/Hypoxic Tumor Microenvironment Regulation-Enhanced Photodynamic Treatment Realized by pH-Responsive Phase Transition-Targeting Nanobubbles

(2021) Meng Zhao et al.   ACS Applied Materials & Interfaces

A Biomimetic Aggregation‐Induced Emission Photosensitizer with Antigen‐Presenting and Hitchhiking Function for Lipid Droplet Targeted Photodynamic Immunotherapy

(2021) Xiuli Xu et al.   ADVANCED MATERIALS

Ferroptosis-apoptosis combined anti-melanoma immunotherapy with a NIR-responsive upconverting mSiO2 photodynamic platform

(2021) Danqi Li et al.   CHEMICAL ENGINEERING JOURNAL

Combined OX40 Agonist and PD-1 Inhibitor Immunotherapy Improves the Efficacy of Vascular Targeted Photodynamic Therapy in a Urothelial Tumor Model

(2021) Ricardo G. Alvim et al.   MOLECULES

Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

(2021) Yanjuan Huang et al.   Nature Communications

Protonated 2D carbon nitride sensitized with Ce6 as a smart metal-free nanoplatform for boosted acute multimodal photo-sono tumor inactivation and long-term cancer immunotherapy

(2021) Mengya Chen et al.   CHEMICAL ENGINEERING JOURNAL

Applying nanotechnology to boost cancer immunotherapy by promoting immunogenic cell death

(2021) Lvqin Fu et al.   CHINESE CHEMICAL LETTERS

Photodynamic therapy synergizes with PD-L1 checkpoint blockade for immunotherapy of CRC by multifunctional nanoparticles

(2021) Zeting Yuan et al.   MOLECULAR THERAPY

Tumor-targeted nanoplatform for in situ oxygenation-boosted immunogenic phototherapy of colorectal cancer

(2020) Huamei He et al.   Acta Biomaterialia

Colorectal cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Immune biological rationales for the design of combined radio- and immunotherapies

(2020) Michael Hader et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Engineering of Upconverted Metal–Organic Frameworks for Near-Infrared Light-Triggered Combinational Photodynamic/Chemo-/Immunotherapy against Hypoxic Tumors

(2020) Yulei Shao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Endoplasmic Reticulum Targeting to Amplify Immunogenic Cell Death for Cancer Immunotherapy

(2020) Hongzhang Deng et al.   NANO LETTERS

Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

(2020) Nan Yang et al.   Nano-Micro Letters

Supramolecular Photothermal Nanomedicine Mediated Distant Tumor Inhibition via PD-1 and TIM-3 Blockage

(2020) Tong-Yi Huang et al.   Frontiers in Chemistry

Photodynamic therapy produces enhanced efficacy of antitumor immunotherapy by simultaneously inducing intratumoral release of sorafenib

(2020) Xu Sun et al.   BIOMATERIALS

Macrophage-mimic shape changeable nanomedicine retained in tumor for multimodal therapy of breast cancer

(2020) Rui Liu et al.   JOURNAL OF CONTROLLED RELEASE

Accurate and Real-Time Temperature Monitoring during MR Imaging Guided PTT

(2020) Xianfu Meng et al.   NANO LETTERS

Prodrug‐Based Versatile Nanomedicine for Enhancing Cancer Immunotherapy by Increasing Immunogenic Cell Death

(2020) Shuang Bai et al.   Small

Artificial Nanoscale Erythrocytes from Clinically Relevant Compounds for Enhancing Cancer Immunotherapy

(2020) Wenquan Ou et al.   Nano-Micro Letters

Ultrasound and Near-Infrared Light Dual-Triggered Upconversion Zeolite-Based Nanocomposite for Hyperthermia-Enhanced Multimodal Melanoma Therapy via a Precise Apoptotic Mechanism

(2020) Lulu Zheng et al.   ACS Applied Materials & Interfaces

Cancer nanomedicine meets immunotherapy: opportunities and challenges

(2020) Qingxue Sun et al.   ACTA PHARMACOLOGICA SINICA

Engineering antigen as photosensitiser nanocarrier to facilitate ROS triggered immune cascade for photodynamic immunotherapy

(2020) Huaiji Wang et al.   BIOMATERIALS

Dendritic cell vaccine for the effective immunotherapy of breast cancer

(2020) Jiang Ni et al.   BIOMEDICINE & PHARMACOTHERAPY

Ferroptosis, necroptosis, and pyroptosis in anticancer immunity

(2020) Rong Tang et al.   Journal of Hematology & Oncology

Nanoscale Metal–Organic Framework Co-delivers TLR-7 Agonists and Anti-CD47 Antibodies to Modulate Macrophages and Orchestrate Cancer Immunotherapy

(2020) Kaiyuan Ni et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Emerging graphitic carbon nitride-based materials for biomedical applications

(2020) Guangfu Liao et al.   PROGRESS IN MATERIALS SCIENCE

Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer

(2020) Yanlei Liu et al.   Nano-Micro Letters

Biodegradable Poly(γ-glutamic acid)@glucose oxidase@carbon dot nanoparticles for simultaneous multimodal imaging and synergetic cancer therapy

(2020) Ming Zhang et al.   BIOMATERIALS

Fucoidan-based, tumor-activated nanoplatform for overcoming hypoxia and enhancing photodynamic therapy and antitumor immunity

(2020) Chu-Hung Chung et al.   BIOMATERIALS

Sonodynamic therapy-derived multimodal synergistic cancer therapy

(2020) Mimi Xu et al.   CANCER LETTERS

MnO 2 Nanoflowers Induce Immunogenic Cell Death under Nutrient Deprivation: Enabling an Orchestrated Cancer Starvation‐Immunotherapy

(2020) Yannan Yang et al.   Advanced Science

Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma

(2020) Yifei Yin et al.   Nano Today

A targeting black phosphorus nanoparticle based immune cells nano-regulator for photodynamic/photothermal and photo-immunotherapy

(2020) Xiaoge Zhang et al.   Bioactive Materials

NIR-Triggered Phototherapy and Immunotherapy via an Antigen-Capturing Nanoplatform for Metastatic Cancer Treatment

(2019) Meng Wang et al.   Advanced Science

Ferroptosis is a type of autophagy-dependent cell death

(2019) Borong Zhou et al.   SEMINARS IN CANCER BIOLOGY

Expandable Immunotherapeutic Nanoplatforms Engineered from Cytomembranes of Hybrid Cells Derived from Cancer and Dendritic Cells

(2019) Wen‐Long Liu et al.   ADVANCED MATERIALS

In Situ Dendritic Cell Vaccine for Effective Cancer Immunotherapy

(2019) Weijing Yang et al.   ACS Nano

Light-Enhanced O2-Evolving Nanoparticles Boost Photodynamic Therapy To Elicit Antitumor Immunity

(2019) Tingting Wang et al.   ACS Applied Materials & Interfaces

Hyaluronidase with pH‐responsive Dextran Modification as an Adjuvant Nanomedicine for Enhanced Photodynamic‐Immunotherapy of Cancer

(2019) Hairong Wang et al.   ADVANCED FUNCTIONAL MATERIALS

CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy

(2019) Weimin Wang et al.   NATURE

Immunogenic cell death in cancer therapy: Present and emerging inducers

(2019) Jingyi Zhou et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Immunomodulatory Lipocomplex Functionalized with Photosensitizer-Embedded Cancer Cell Membrane Inhibits Tumor Growth and Metastasis

(2019) Han Young Kim et al.   NANO LETTERS

Adverse Events Following Cancer Immunotherapy: Obstacles and Opportunities

(2019) Kristen E. Pauken et al.   TRENDS IN IMMUNOLOGY

Targeting photodynamic and photothermal therapy to the endoplasmic reticulum enhances immunogenic cancer cell death

(2019) Wei Li et al.   Nature Communications

Artificial Cell-Mediated Photodynamic Therapy Enhanced Anticancer Efficacy through Combination of Tumor Disruption and Immune Response Stimulation

(2019) Jiang Ni et al.   ACS Omega

High Affinity of Chlorin e6 to Immunoglobulin G for Intraoperative Fluorescence Image-Guided Cancer Photodynamic and Checkpoint Blockade Therapy

(2019) Jiaojiao Xu et al.   ACS Nano

Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy

(2019) Yinchu Ma et al.   ACS Nano

Positron Emission Tomography-Guided Photodynamic Therapy with Biodegradable Mesoporous Silica Nanoparticles for Personalized Cancer Immunotherapy

(2019) Cheng Xu et al.   ACS Nano

Self‐Amplified Drug Delivery with Light‐Inducible Nanocargoes to Enhance Cancer Immunotherapy

(2019) Bing Feng et al.   ADVANCED MATERIALS

Activating Antitumor Immunity and Antimetastatic Effect Through Polydopamine‐Encapsulated Core–Shell Upconversion Nanoparticles

(2019) Shuangqian Yan et al.   ADVANCED MATERIALS

A Three-in-One Immunotherapy Nanoweapon via Cascade-Amplifying Cancer-Immunity Cycle against Tumor Metastasis, Relapse, and Postsurgical Regrowth

(2019) Qian Li et al.   NANO LETTERS

Redox-Activated Porphyrin-Based Liposome Remote-Loaded with Indoleamine 2,3-Dioxygenase (IDO) Inhibitor for Synergistic Photoimmunotherapy through Induction of Immunogenic Cell Death and Blockage of IDO Pathway

(2019) Dechun Liu et al.   NANO LETTERS

Inorganic Nanozyme with Combined Self-Oxygenation/Degradable Capabilities for Sensitized Cancer Immunochemotherapy

(2019) Jie Wang et al.   Nano-Micro Letters

Janus Nanobullets Combine Photodynamic Therapy and Magnetic Hyperthermia to Potentiate Synergetic Anti‐Metastatic Immunotherapy

(2019) Zheng Wang et al.   Advanced Science

Low Photosensitizer Dose and Early Radiotherapy Enhance Antitumor Immune Response of Photodynamic Therapy-Based Dendritic Cell Vaccination

(2019) Bastien Doix et al.   Frontiers in Oncology

Co-delivery of Bee Venom Melittin and a Photosensitizer with an Organic–Inorganic Hybrid Nanocarrier for Photodynamic Therapy and Immunotherapy

(2019) Haojie Liu et al.   ACS Nano

Tumor‐Targeted Drug and CpG Delivery System for Phototherapy and Docetaxel‐Enhanced Immunotherapy with Polarization toward M1‐Type Macrophages on Triple Negative Breast Cancers

(2019) Lv Chen et al.   ADVANCED MATERIALS

Multifunctional nanocapsules on a seesaw balancing sonodynamic and photodynamic therapies against superficial malignant tumors by effective immune-enhancement

(2019) Zhe Liu et al.   BIOMATERIALS

Immune Checkpoint Blockade Mediated by a Small‐Molecule Nanoinhibitor Targeting the PD‐1/PD‐L1 Pathway Synergizes with Photodynamic Therapy to Elicit Antitumor Immunity and Antimetastatic Effects on Breast Cancer

(2019) Rui Zhang et al.   Small

Photodynamic Therapy Combined with Antihypoxic Signaling and CpG Adjuvant as an In Situ Tumor Vaccine Based on Metal–Organic Framework Nanoparticles to Boost Cancer Immunotherapy

(2019) Zhixiong Cai et al.   Advanced Healthcare Materials

Smart Nanovesicle-Mediated Immunogenic Cell Death through Tumor Microenvironment Modulation for Effective Photodynamic Immunotherapy

(2019) Weijing Yang et al.   ACS Nano

Integration of immunogenic activation and immunosuppressive reversion using mitochondrial-respiration-inhibited platelet-mimicking nanoparticles

(2019) Xiaoli Mai et al.   BIOMATERIALS

The potentiated checkpoint blockade immunotherapy by ROS-responsive nanocarrier-mediated cascade chemo-photodynamic therapy

(2019) Liqin Hu et al.   BIOMATERIALS

Defeating relapsed and refractory malignancies through a nano-enabled mitochondria-mediated respiratory inhibition and damage pathway

(2019) Zhengyang Yang et al.   BIOMATERIALS

Medium dose intermittent cyclophosphamide induces immunogenic cell death and cancer cell autonomous type I interferon production in glioma models

(2019) Bin Du et al.   CANCER LETTERS

Enhanced Immunotherapy Based on Photodynamic Therapy for Both Primary and Lung Metastasis Tumor Eradication

(2018) Wen Song et al.   ACS Nano

Bioinspired Hybrid Protein Oxygen Nanocarrier Amplified Photodynamic Therapy for Eliciting Anti-tumor Immunity and Abscopal Effect

(2018) Zhikuan Chen et al.   ACS Nano

Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases

(2018) Ruijing Liang et al.   BIOMATERIALS

Necroptotic cancer cells-mimicry nanovaccine boosts anti-tumor immunity with tailored immune-stimulatory modality

(2018) Ting Kang et al.   BIOMATERIALS

Sonodynamic therapy-assisted immunotherapy: A novel modality for cancer treatment

(2018) Qianyu Zhang et al.   CANCER SCIENCE

Nanoscale Metal–Organic Framework Overcomes Hypoxia for Photodynamic Therapy Primed Cancer Immunotherapy

(2018) Guangxu Lan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

(2018) Guangbao Yang et al.   NANO LETTERS

Low-dose X-ray radiotherapy–radiodynamic therapy via nanoscale metal–organic frameworks enhances checkpoint blockade immunotherapy

(2018) Kuangda Lu et al.   Nature Biomedical Engineering

Combined local immunostimulatory radioisotope therapy and systemic immune checkpoint blockade imparts potent antitumour responses

(2018) Yu Chao et al.   Nature Biomedical Engineering

Emerging strategies for combination checkpoint modulators in cancer immunotherapy

(2018) Aleksandra Popovic et al.   JOURNAL OF CLINICAL INVESTIGATION

Scintillator-Based Nanohybrids with Sacrificial Electron Prodrug for Enhanced X-ray-Induced Photodynamic Therapy

(2018) Han Wang et al.   NANO LETTERS

Combination of NIR therapy and regulatory T cell modulation using layer-by-layer hybrid nanoparticles for effective cancer photoimmunotherapy

(2018) Wenquan Ou et al.   Theranostics

Cell-Membrane Immunotherapy Based on Natural Killer Cell Membrane Coated Nanoparticles for the Effective Inhibition of Primary and Abscopal Tumor Growth

(2018) Guanjun Deng et al.   ACS Nano

Hypoxia-Triggered Transforming Immunomodulator for Cancer Immunotherapy via Photodynamically Enhanced Antigen Presentation of Dendritic Cell

(2018) Sooseok Im et al.   ACS Nano

An emerging role for nanomaterials in increasing immunogenicity of cancer cell death

(2018) Tatiana Mishchenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

A Self-Delivery Chimeric Peptide for Photodynamic Therapy Amplified Immunotherapy

(2018) Hong Cheng et al.   MACROMOLECULAR BIOSCIENCE

Biochemical Aspects of PD-L1 Regulation in Cancer Immunotherapy

(2018) Jinfang Zhang et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ganoderma: A Cancer Immunotherapy Review

(2018) Yu Cao et al.   Frontiers in Pharmacology

Combination Therapy with Anti-PD-1, Anti-TIM-3, and Focal Radiation Results in Regression of Murine Gliomas

(2016) Jennifer E. Kim et al.   CLINICAL CANCER RESEARCH

Immunotherapy to Treat Cancer

(2016) JS McCune   CLINICAL PHARMACOLOGY & THERAPEUTICS

Photodynamic Therapy Mediated by Nontoxic Core–Shell Nanoparticles Synergizes with Immune Checkpoint Blockade To Elicit Antitumor Immunity and Antimetastatic Effect on Breast Cancer

(2016) Xiaopin Duan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chlorin-Based Nanoscale Metal–Organic Framework Systemically Rejects Colorectal Cancers via Synergistic Photodynamic Therapy and Checkpoint Blockade Immunotherapy

(2016) Kuangda Lu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Acid-Activatable Versatile Micelleplexes for PD-L1 Blockade-Enhanced Cancer Photodynamic Immunotherapy

(2016) Dangge Wang et al.   NANO LETTERS

Checkpoint inhibitors and other novel immunotherapies for advanced renal cell carcinoma

(2016) Maria I. Carlo et al.   Nature Reviews Urology

Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints

(2016) Shohei Koyama et al.   Nature Communications

Core-shell nanoscale coordination polymers combine chemotherapy and photodynamic therapy to potentiate checkpoint blockade cancer immunotherapy

(2016) Chunbai He et al.   Nature Communications

Enhanced Anti-Tumor Efficacy through a Combination of Integrin αvβ6-Targeted Photodynamic Therapy and Immune Checkpoint Inhibition

(2016) Liquan Gao et al.   Theranostics

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Immunogenic cell death

(2015) Abhishek D. Garg et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Therapeutic cancer vaccine survives biotech bust

(2015) Heidi Ledford   NATURE

Functions of Heat Shock Proteins in Pathways of the Innate and Adaptive Immune System

(2014) Robert Julian Binder   JOURNAL OF IMMUNOLOGY

Rose Bengal Acetate PhotoDynamic Therapy (RBAc-PDT) Induces Exposure and Release of Damage-Associated Molecular Patterns (DAMPs) in Human HeLa Cells

(2014) Elisa Panzarini et al.   PLoS One

Trial watch: IDO inhibitors in cancer therapy

(2014) Erika Vacchelli et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Cell-Death-Associated Molecular Patterns As Determinants of Cancer Immunogenicity

(2013) Sylvain Ladoire et al.   ANTIOXIDANTS & REDOX SIGNALING

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Tryptophan Catabolism in Cancer: Beyond IDO and Tryptophan Depletion

(2012) M. Platten et al.   CANCER RESEARCH

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

(2012) Abhishek D Garg et al.   EMBO JOURNAL

Novel Immunotherapeutic Strategies in Development for Renal Cell Carcinoma

(2012) Brant A. Inman et al.   EUROPEAN UROLOGY

Cancer immunotherapy: a paradigm shift for prostate cancer treatment

(2012) Dev Karan et al.   Nature Reviews Urology

IDO inhibits a tryptophan sufficiency signal that stimulates mTOR: A novel IDO effector pathway targeted by D-1-methyl-tryptophan

(2012) Richard Metz et al.   OncoImmunology

The convergence of radiation and immunogenic cell death signaling pathways

(2012) Encouse B. Golden et al.   Frontiers in Oncology

Metronomic cyclophosphamide treatment in metastasized breast cancer patients: immunological effects and clinical outcome

(2011) Yingzi Ge et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

TIM-3: A Novel Regulatory Molecule of Alloimmune Activation

(2010) O. Boenisch et al.   JOURNAL OF IMMUNOLOGY

Signaling Through OX40 Enhances Antitumor Immunity

(2010) Shawn M. Jensen et al.   SEMINARS IN ONCOLOGY

Immunogenic cell death modalities and their impact on cancer treatment

(2009) Oliver Kepp et al.   APOPTOSIS

OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis

(2009) Daniel Hirschhorn-Cymerman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-OX40 monoclonal antibody therapy in combination with radiotherapy results in therapeutic antitumor immunity to murine lung cancer

(2008) Hiroshi Yokouchi et al.   CANCER SCIENCE

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

(2008) T Panaretakis et al.   CELL DEATH AND DIFFERENTIATION

Koninginins, phospholipase A2 inhibitors from endophytic fungus Trichoderma koningii

(2007) Afonso D.L. Souza et al.   TOXICON