Ganoderma: A Cancer Immunotherapy Review

Induction of Cbl-dependent epidermal growth factor receptor degradation in Ling Zhi-8 suppressed lung cancer

(2017) Tung-Yi Lin et al.   INTERNATIONAL JOURNAL OF CANCER

Isolation and varietal characterization of Ganoderma resinaceum from areas of Ganoderma lucidum production in China

(2017) Bingzhi Chen et al.   SCIENTIA HORTICULTURAE

Anticancer and Anti-Inflammatory Properties of Ganoderma lucidum Extract Effects on Melanoma and Triple-Negative Breast Cancer Treatment

(2017) Antonio Barbieri et al.   Nutrients

Randomized, double-blind and placebo-controlled study of the immunomodulatory effects of Lingzhi in children with cancers

(2017) M. K. Shing et al.   JOURNAL OF CLINICAL ONCOLOGY

Nutraceuticals: Evidence of Benefit in Clinical Practice?

(2016) Qin M. Chen et al.   AMERICAN JOURNAL OF MEDICINE

Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation

(2016) Tung-Yi Lin et al.   CANCER LETTERS

Ganoderma atrum polysaccharide modulates TNF-α secretion and mRNA expression in macrophages of S-180 tumor-bearing mice

(2016) Jianqin Huang et al.   FOOD HYDROCOLLOIDS

Toxicology and immunology of Ganoderma lucidum polysaccharides in Kunming mice and Wistar rats

(2016) Jianjun Zhang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Recombinant FIP-gat, a Fungal Immunomodulatory Protein from Ganoderma atrum, Induces Growth Inhibition and Cell Death in Breast Cancer Cells

(2016) Hui Xu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

The State of Lung Cancer Research: A Global Analysis

(2016) Ajay Aggarwal et al.   Journal of Thoracic Oncology

Distinguishing commercially grown Ganoderma lucidum from Ganoderma lingzhi from Europe and East Asia on the basis of morphology, molecular phylogeny, and triterpenic acid profiles

(2016) Florian Hennicke et al.   PHYTOCHEMISTRY

Toll-like Receptor 4 Mediates the Antitumor Host Response Induced by Ganoderma atrum Polysaccharide

(2015) Qiang Yu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b

(2015) Aimei Li et al.   Journal of Translational Medicine

Effects of extracellular polysaccharides of Ganoderma lucidum supplementation on the growth performance, blood profile, and meat quality in finisher pigs

(2015) X.L. Li et al.   Livestock Science

GMI, an Immunomodulatory Protein from Ganoderma microsporum, Potentiates Cisplatin-Induced Apoptosis via Autophagy in Lung Cancer Cells

(2015) I-Lun Hsin et al.   MOLECULAR PHARMACEUTICS

Immunomodulatory Protein from Ganoderma microsporum Induces Pro-Death Autophagy through Akt-mTOR-p70S6K Pathway Inhibition in Multidrug Resistant Lung Cancer Cells

(2015) Ling-Yen Chiu et al.   PLoS One

Molecular mechanism underlying chemoprotective effects of Ganoderma atrum polysaccharide in cyclophosphamide-induced immunosuppressed mice

(2015) Qiang Yu et al.   Journal of Functional Foods

Activation of antitumor immune responses by Ganoderma formosanum polysaccharides in tumor-bearing mice

(2014) Cheng-Li Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Clinical Characteristics of Gynecologic Cancer Patients who Respond to Salvage Treatment with Lingzhi

(2014) Prapaporn Suprasert et al.   Asian Pacific Journal of Cancer Prevention

Protection Against Lung Cancer Patient Plasma-Induced Lymphocyte Suppression byGanoderma LucidumPolysaccharides

(2014) Li-Xin Sun et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Emerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014)

(2014) Chaomei Chen et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Toll-like receptor 4-mediated ROS signaling pathway involved in Ganoderma atrum polysaccharide-induced tumor necrosis factor-α secretion during macrophage activation

(2014) Qiang Yu et al.   FOOD AND CHEMICAL TOXICOLOGY

Ganoderic acid Me induces the apoptosis of competent T cells and increases the proportion of Treg cells through enhancing the expression and activation of indoleamine 2,3-dioxygenase in mouse lewis lung cancer cells

(2014) Zujun Que et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

A Novel Polysaccharide from Ganoderma atrum Exerts Antitumor Activity by Activating Mitochondria-Mediated Apoptotic Pathway and Boosting the Immune System

(2014) Shenshen Zhang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

A Comparative Study on Immunomodulatory Activity of Polysaccharides from Two Official Species ofGanoderma (Lingzhi)

(2014) Lan-Zhen Meng et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The polysaccharides from fermented Ganoderma lucidum mycelia induced miRNAs regulation in suppressed HepG2 cells

(2013) Jie Shen et al.   CARBOHYDRATE POLYMERS

Ganoderma lucidum stimulates NK cell cytotoxicity by inducing NKG2D/NCR activation and secretion of perforin and granulysin

(2013) Chih-Jung Chang et al.   Innate Immunity

Anticonvulsant and Neuroprotective Effects of Oligosaccharides from Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes)

(2013) Isaac Tello et al.   INTERNATIONAL JOURNAL OF MEDICINAL MUSHROOMS

Anti-Lung Cancer Activity through Enhancement of Immunomodulation and Induction of Cell Apoptosis of Total Triterpenes Extracted from Ganoderma luncidum (Leyss. ex Fr.) Karst.

(2013) Liang Feng et al.   MOLECULES

Immunization of fucose-containing polysaccharides from Reishi mushroom induces antibodies to tumor-associated Globo H-series epitopes

(2013) Shih-Fen Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of lysosome degradation on autophagosome formation and responses to GMI, an immunomodulatory protein fromGanoderma microsporum

(2012) I-Lun Hsin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective effect of ganodermanondiol isolated from the Lingzhi mushroom against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2-mediated antioxidant enzymes

(2012) Bin Li et al.   FOOD AND CHEMICAL TOXICOLOGY

Immunomodulatory effect of Ganoderma atrum polysaccharide on CT26 tumor-bearing mice

(2012) Shenshen Zhang et al.   FOOD CHEMISTRY

Enhanced MHC class I and costimulatory molecules on B16F10 cells byGanoderma lucidumpolysaccharides

(2012) Li-Xin Sun et al.   JOURNAL OF DRUG TARGETING

Trends in Ginseng Research in 2010

(2012) Si-Kwan Kim et al.   Journal of Ginseng Research

Antitumor and Immunomodulatory Effects of Polysaccharides from Broken-Spore of Ganoderma lucidum

(2012) Peng-Yun Wang et al.   Frontiers in Pharmacology

Ganoderma lucidum Polysaccharides: Immunomodulation and Potential Anti-Tumor Activities

(2011) Zengtao Xu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

GMI, an immunomodulatory protein fromGanoderma microsporum, induces autophagy in non-small cell lung cancer cells

(2011) I-Lun Hsin et al.   Autophagy

Polysaccharides purified from the submerged culture of Ganoderma formosanum stimulate macrophage activation and protect mice against Listeria monocytogenes infection

(2011) Cheng-Li Wang et al.   BIOTECHNOLOGY LETTERS

A novel adjuvant Ling Zhi-8 enhances the efficacy of DNA cancer vaccine by activating dendritic cells

(2011) Chi-Chen Lin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Spore Powder ofGanoderma lucidumImproves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial

(2011) Hong Zhao et al.   Evidence-based Complementary and Alternative Medicine

Analysis of maturation of murine dendritic cells (DCs) induced by purified Ganoderma lucidum polysaccharides (GLPs)

(2011) Jingjuan Meng et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Ergosterol from the soilborne fungusGanoderma boninense

(2011) R. L. Toh Choon et al.   JOURNAL OF BASIC MICROBIOLOGY

Ganoderma lucidumpolysaccharides antagonize the suppression on lymphocytes induced by culture supernatants of B16F10 melanoma cells

(2011) Li-Xin Sun et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Recombinant Lz-8 from Ganoderma lucidum induces endoplasmic reticulum stress-mediated autophagic cell death in SGC-7901 human gastric cancer cells

(2011) CHONGYANG LIANG et al.   ONCOLOGY REPORTS

Ganoderma lucidum polysaccharides eradicates the blocking effect of fibrinogen on NK cytotoxicity against melanoma cells

(2011) SHENG ZHENG et al.   Oncology Letters

Promoting Effects of Ganoderma lucidum Polysaccharides on B16F10 Cells to Activate Lymphocytes

(2010) Li-Xin Sun et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Ganoderma atrum polysaccharide induces anti-tumor activity via the mitochondrial apoptotic pathway related to activation of host immune response

(2010) Wen-Juan Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A new immunomodulatory protein from Ganoderma microsporum inhibits epidermal growth factor mediated migration and invasion in A549 lung cancer cells

(2010) Ching-Hsiung Lin et al.   PROCESS BIOCHEMISTRY

Free radical scavenging of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes and immunity activities in cervical carcinoma rats

(2009) Chen XiaoPing et al.   CARBOHYDRATE POLYMERS

Lipid extract from completely sporoderm-broken germinatingGanoderma sinensisspores elicits potent antitumor immune responses in human macrophages

(2009) Jing-Ping Zhang et al.   PHYTOTHERAPY RESEARCH

Induction of premature senescence in human lung cancer by fungal immunomodulatory protein from Ganoderma tsugae

(2008) Chien-Huang Liao et al.   FOOD AND CHEMICAL TOXICOLOGY

Reishi immuno-modulation protein induces interleukin-2 expression via protein kinase-dependent signaling pathways within human T cells

(2008) Hsien-Yeh Hsu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ganoderma lucidum polysaccharides can induce human monocytic leukemia cells into dendritic cells with immuno-stimulatory function

(2008) Wing Chan et al.   Journal of Hematology & Oncology

Ganoderma applanatum: a promising mushroom for antitumor and immunomodulating activity

(2008) Yong-Tae Jeong et al.   PHYTOTHERAPY RESEARCH

In vivo immunomodulatory effects of Antrodia camphorata polysaccharides in a T1/T2 doubly transgenic mouse model for inhibiting infection of Schistosoma mansoni

(2007) Po-Ching Cheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY