What’s Next after Lipid Nanoparticles? A Perspective on Enablers of Nucleic Acid Therapeutics

Hybrid Cell Membrane-Functionalized Biomimetic Nanoparticles for Targeted Therapy of Osteosarcoma

(2022) Jia-Xin Cai et al.   International Journal of Nanomedicine

Disulfide Bridging Strategies in Viral and Nonviral Platforms for Nucleic Acid Delivery

(2021) Kingshuk Dutta et al.   BIOCHEMISTRY

BBB pathophysiology–independent delivery of siRNA in traumatic brain injury

(2021) Wen Li et al.   Science Advances

DNA Nanostructures: Current Challenges and Opportunities for Cellular Delivery

(2021) Aurélie Lacroix et al.   ACS Nano

Immune Cell Membrane‐Coated Biomimetic Nanoparticles for Targeted Cancer Therapy

(2021) Fatemeh Oroojalian et al.   Small

Functionalized lipid nanoparticles for subcutaneous administration of mRNA to achieve systemic exposures of a therapeutic protein

(2021) Nigel Davies et al.   Molecular Therapy-Nucleic Acids

The Role of Nucleases and Nucleic Acid Editing Enzymes in the Regulation of Self-Nucleic Acid Sensing

(2021) Pauline Santa et al.   Frontiers in Immunology

Charge‐Conversion Strategies for Nucleic Acid Delivery

(2021) Kingshuk Dutta et al.   ADVANCED FUNCTIONAL MATERIALS

A single dose of self-transcribing and replicating RNA-based SARS-CoV-2 vaccine produces protective adaptive immunity in mice

(2021) Ruklanthi de Alwis et al.   MOLECULAR THERAPY

Functionalizing DNA nanostructures for therapeutic applications

(2021) Skylar J. W. Henry et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

The development of human serum albumin-based drugs and relevant fusion proteins for cancer therapy

(2021) Hong-yu Tao et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

MTL-CEBPA Combined with Immunotherapy or RFA Enhances Immunological Anti-Tumor Response in Preclinical Models

(2021) Kai-Wen Huang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA

(2021) Dapeng Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipid nanoparticles for mRNA delivery

(2021) Xucheng Hou et al.   Nature Reviews Materials

Virus‐Mimicking Cell Membrane‐Coated Nanoparticles for Cytosolic Delivery of mRNA

(2021) Joon Ho Park et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Optimization of non-coding regions for a non-modified mRNA COVID-19 vaccine

(2021) Makda S. Gebre et al.   NATURE

Cell membrane coating integrity affects the internalization mechanism of biomimetic nanoparticles

(2021) Lizhi Liu et al.   Nature Communications

DNA Nanostructure as an Efficient Drug Delivery Platform for Immunotherapy

(2020) Qingjia Chi et al.   Frontiers in Pharmacology

Amplified Self‐Immolative Release of Small Molecules by Spatial Isolation of Reactive Groups on DNA‐Minimal Architectures

(2020) Alexander L. Prinzen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent Advances of pH‐Induced Charge‐Convertible Polymer‐Mediated Inorganic Nanoparticles for Biomedical Applications

(2020) Hong Yu Yang et al.   MACROMOLECULAR RAPID COMMUNICATIONS

RNA therapeutics on the rise

(2020) Feng Wang et al.   NATURE REVIEWS DRUG DISCOVERY

Biomimetic anisotropic polymeric nanoparticles coated with red blood cell membranes for enhanced circulation and toxin removal

(2020) Elana Ben-Akiva et al.   Science Advances

Lipid nanoparticles for nucleic acid delivery: Current perspectives

(2020) Eleni Samaridou et al.   ADVANCED DRUG DELIVERY REVIEWS

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

Protein-Based Nanoparticles as Drug Delivery Systems

(2020) Seyoung Hong et al.   Pharmaceutics

Long-term storage of lipid-like nanoparticles for mRNA delivery

(2020) Pengxuan Zhao et al.   Bioactive Materials

SARS-CoV-2 vaccines in development

(2020) Florian Krammer   NATURE

Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates

(2020) Edward E. Walsh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

(2020) Lang Rao et al.   Nature Communications

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem cell membrane vesicle-coated nanoparticles for efficient tumor-targeted therapy of orthotopic breast cancer

(2019) Wen Tian et al.   POLYMERS FOR ADVANCED TECHNOLOGIES

Minimalist Design of a Stimuli-Responsive Spherical Nucleic Acid for Conditional Delivery of Oligonucleotide Therapeutics

(2019) Hassan H. Fakih et al.   ACS Applied Materials & Interfaces

Postfunctionalization of Noncationic RNA–Polymer Complexes for RNA Delivery

(2019) Ziwen Jiang et al.   INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH

The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo

(2019) Annabelle Biscans et al.   JOURNAL OF CONTROLLED RELEASE

Biomimetic Nanotherapies: Red Blood Cell Based Core–Shell Structured Nanocomplexes for Atherosclerosis Management

(2019) Yi Wang et al.   Advanced Science

Symbiotic Self-Assembly Strategy toward Lipid-Encased Cross-Linked Polymer Nanoparticles for Efficient Gene Silencing

(2019) Kingshuk Dutta et al.   ACS Applied Materials & Interfaces

Introduction: Nucleic Acid Nanotechnology

(2019) Yamuna Krishnan et al.   CHEMICAL REVIEWS

Systematic review of targeted extracellular vesicles for drug delivery – Considerations on methodological and biological heterogeneity

(2019) Johann Mar Gudbergsson et al.   JOURNAL OF CONTROLLED RELEASE

HPV16 RNA-LPX vaccine mediates complete regression of aggressively growing HPV-positive mouse tumors and establishes protective T cell memory

(2019) Christian Grunwitz et al.   OncoImmunology

Size Dependency of Circulation and Biodistribution of Biomimetic Nanoparticles: Red Blood Cell Membrane-Coated Nanoparticles

(2019) Haichun Li et al.   Cells

Large-scale generation of functional mRNA-encapsulating exosomes via cellular nanoporation

(2019) Zhaogang Yang et al.   Nature Biomedical Engineering

Enzyme-Responsive Charge-Reversal Polymer-Mediated Effective Gene Therapy for Intraperitoneal Tumors

(2018) Nasha Qiu et al.   BIOMACROMOLECULES

Lipid Polymer Hybrid Nanomaterials for mRNA Delivery

(2018) Weiyu Zhao et al.   Cellular and Molecular Bioengineering

DNA Nanotechnology-Enabled Drug Delivery Systems

(2018) Qinqin Hu et al.   CHEMICAL REVIEWS

Chemical modifications of nucleic acid drugs and their delivery systems for gene-based therapy

(2018) Changmai Chen et al.   MEDICINAL RESEARCH REVIEWS

Successful reprogramming of cellular protein production through mRNA delivered by functionalized lipid nanoparticles

(2018) Marianna Yanez Arteta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Influenza Hemagglutinin Protein Stability, Activation, and Pandemic Risk

(2018) Charles J. Russell et al.   TRENDS IN MICROBIOLOGY

Emerging Issues in AAV-Mediated In Vivo Gene Therapy

(2018) Pasqualina Colella et al.   Molecular Therapy-Methods & Clinical Development

Impact of Particle Size and Polydispersity Index on the Clinical Applications of Lipidic Nanocarrier Systems

(2018) M. Danaei et al.   Pharmaceutics

Exosomes produced from three-dimensional cultures of mesenchymal stem cells by tangential flow filtration show higher yield and improved activity

(2018) Reka Agnes Haraszti et al.   MOLECULAR THERAPY

Alnylam launches era of RNAi drugs

(2018) Ken Garber   NATURE BIOTECHNOLOGY

Neutrophil membrane-coated nanoparticles inhibit synovial inflammation and alleviate joint damage in inflammatory arthritis

(2018) Qiangzhe Zhang et al.   Nature Nanotechnology

siRNA delivery with stem cell membrane-coated magnetic nanoparticles for imaging-guided photothermal therapy and gene therapy

(2018) Xupeng Mu et al.   ACS Biomaterials-Science & Engineering

Cell-Membrane Immunotherapy Based on Natural Killer Cell Membrane Coated Nanoparticles for the Effective Inhibition of Primary and Abscopal Tumor Growth

(2018) Guanjun Deng et al.   ACS Nano

Bait-and-Switch Supramolecular Strategy To Generate Noncationic RNA–Polymer Complexes for RNA Delivery

(2018) Ziwen Jiang et al.   BIOMACROMOLECULES

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways

(2018) Maire F Osborn et al.   NUCLEIC ACIDS RESEARCH

SL2B aptamer and folic acid dual-targeting DNA nanostructures for synergic biological effect with chemotherapy to combat colorectal cancer

(2017) Pengchao Sun et al.   International Journal of Nanomedicine

Biodegradable lipid nanoparticles induce a prolonged RNA interference-mediated protein knockdown and show rapid hepatic clearance in mice and nonhuman primates

(2017) Yuta Suzuki et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Lipophilic siRNA targets albumin in situ and promotes bioavailability, tumor penetration, and carrier-free gene silencing

(2017) Samantha M. Sarett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effective in vivo gene delivery with reduced toxicity, achieved by charge and fatty acid -modified cell penetrating peptide

(2017) Kaido Kurrikoff et al.   Scientific Reports

Esterase-Activated Charge-Reversal Polymer for Fibroblast-Exempt Cancer Gene Therapy

(2016) Nasha Qiu et al.   ADVANCED MATERIALS

Polyion complex (PIC) particles: Preparation and biomedical applications

(2016) Ignacio Insua et al.   EUROPEAN POLYMER JOURNAL

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Optimized DNA “Nanosuitcases” for Encapsulation and Conditional Release of siRNA

(2016) Katherine E. Bujold et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fusogenic Reactive Oxygen Species Triggered Charge-Reversal Vector for Effective Gene Delivery

(2015) Xin Liu et al.   ADVANCED MATERIALS

Long-circulating siRNA nanoparticles for validating Prohibitin1-targeted non-small cell lung cancer treatment

(2015) Xi Zhu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multivalent N-Acetylgalactosamine-Conjugated siRNA Localizes in Hepatocytes and Elicits Robust RNAi-Mediated Gene Silencing

(2014) Jayaprakash K. Nair et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery

(2014) Ronnie H. Fang et al.   NANO LETTERS

Hybrid lipid–polymer nanoparticles for sustained siRNA delivery and gene silencing

(2014) Jinjun Shi et al.   Nanomedicine-Nanotechnology Biology and Medicine

Overcoming the challenges in administering biopharmaceuticals: formulation and delivery strategies

(2014) Samir Mitragotri et al.   NATURE REVIEWS DRUG DISCOVERY

Synthesis of Polymer–Lipid Nanoparticles for Image-Guided Delivery of Dual Modality Therapy

(2013) Aneta J. Mieszawska et al.   BIOCONJUGATE CHEMISTRY

Immune responses to AAV vectors: overcoming barriers to successful gene therapy

(2013) F. Mingozzi et al.   BLOOD

Biodegradable Lipids Enabling Rapidly Eliminated Lipid Nanoparticles for Systemic Delivery of RNAi Therapeutics

(2013) Martin A Maier et al.   MOLECULAR THERAPY

‘Marker-of-self’ functionalization of nanoscale particles through a top-down cellular membrane coating approach

(2013) Che-Ming J. Hu et al.   Nanoscale

Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells

(2013) Cosimo Commisso et al.   NATURE

Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape

(2013) Jerome Gilleron et al.   NATURE BIOTECHNOLOGY

Nucleic Acid Delivery: The Missing Pieces of the Puzzle?

(2012) Juliane Nguyen et al.   ACCOUNTS OF CHEMICAL RESEARCH

Virus-based nanocarriers for drug delivery

(2012) Yujie Ma et al.   ADVANCED DRUG DELIVERY REVIEWS

siRNA Delivery: From Lipids to Cell-penetrating Peptides and Their Mimics

(2012) Matt Gooding et al.   Chemical Biology & Drug Design

Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging

(2012) Aneta J. Mieszawska et al.   CHEMICAL COMMUNICATIONS

Spherical Nucleic Acids

(2012) Joshua I. Cutler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mass Production and Size Control of Lipid–Polymer Hybrid Nanoparticles through Controlled Microvortices

(2012) YongTae Kim et al.   NANO LETTERS

Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery

(2012) Hyukjin Lee et al.   Nature Nanotechnology

miR-34 – a microRNA replacement therapy is headed to the clinic

(2012) Andreas G. Bader   Frontiers in Genetics

Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery

(2011) Jinjun Shi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

The Final Conformation of the Complete Ectodomain of the HA2 Subunit of Influenza Hemagglutinin Can by Itself Drive Low pH-dependent Fusion

(2011) Chang Sup Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

(2011) C.-M. J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Self-Assembled Lipid−Polymer Hybrid Nanoparticles: A Robust Drug Delivery Platform

(2008) Liangfang Zhang et al.   ACS Nano

Gene therapy progress and prospects: synthetic polymer-based systems

(2008) D Schaffert et al.   GENE THERAPY

Analysis of residues near the fusion peptide in the influenza hemagglutinin structure for roles in triggering membrane fusion

(2007) Sudha Thoennes et al.   VIROLOGY