Resveratrol sensitizes breast cancer to PARP inhibitor, talazoparib through dual inhibition of AKT and autophagy flux

Targeting autophagy reverses de novo resistance in homologous recombination repair proficient breast cancers to PARP inhibition

(2021) Ganesh Pai Bellare et al.   BRITISH JOURNAL OF CANCER

Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitro and in Vivo

(2021) Saikat Chakraborty et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pharmacological targeting of differential DNA repair, radio-sensitizes WRN-deficient cancer cells in vitro and in vivo

(2021) Pooja Gupta et al.   BIOCHEMICAL PHARMACOLOGY

Arsenic compound sensitizes homologous recombination proficient ovarian cancer to PARP inhibitors

(2021) Junfen Xu et al.   Cell Death Discovery

Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells

(2020) Hongge Wang et al.   ONCOGENE

Autophagic Inhibition via Lysosomal Integrity Dysfunction Leads to Antitumor Activity in Glioma Treatment

(2020) Hui-Yun Hwang et al.   Cancers

Role of autophagy in regulation of cancer cell death/apoptosis during anti-cancer therapy: focus on autophagy flux blockade

(2020) Nirmala Tilija Pun et al.   ARCHIVES OF PHARMACAL RESEARCH

Genome-Wide Screens Reveal that Resveratrol Induces Replicative Stress in Human Cells

(2020) Yahya Benslimane et al.   MOLECULAR CELL

Olaparib and α-specific PI3K inhibitor alpelisib for patients with epithelial ovarian cancer: a dose-escalation and dose-expansion phase 1b trial

(2019) Panagiotis A Konstantinopoulos et al.   LANCET ONCOLOGY

Targeting PARP and autophagy evoked synergistic lethality in hepatocellular carcinoma

(2019) Wenjing Zai et al.   CARCINOGENESIS

PI3K/Akt/mTOR inhibitors in cancer: At the bench and bedside

(2019) Ali S. Alzahrani   SEMINARS IN CANCER BIOLOGY

Breast cancer

(2019) Nadia Harbeck et al.   Nature Reviews Disease Primers

Poly(adenosine diphosphate ribose) polymerase inhibitors induce autophagy‐mediated drug resistance in ovarian cancer cells, xenografts, and patient‐derived xenograft models

(2019) Janice M. Santiago‐O’Farrill et al.   CANCER

Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer

(2019) Yuanyuan Tian et al.   OncoTargets and Therapy

PARP Inhibitor Drugs in the Treatment of Breast, Ovarian, Prostate and Pancreatic Cancers: An Update of Clinical Trials

(2018) Dalia Kamel et al.   CURRENT DRUG TARGETS

Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles

(2018) Fengjuan Wang et al.   Open Biology

Resveratrol analogue, trans-4,4′-dihydroxystilbene (DHS), inhibits melanoma tumor growth and suppresses its metastatic colonization in lungs

(2018) Bhaskar Saha et al.   BIOMEDICINE & PHARMACOTHERAPY

High speed of fork progression induces DNA replication stress and genomic instability

(2018) Apolinar Maya-Mendoza et al.   NATURE

PARP1 Trapping by PARP Inhibitors Drives Cytotoxicity in Both Cancer Cells and Healthy Bone Marrow

(2018) Todd A. Hopkins et al.   MOLECULAR CANCER RESEARCH

Resveratrol, an activator of SIRT1, induces protective autophagy in non-small-cell lung cancer via inhibiting Akt/mTOR and activating p38-MAPK

(2018) Jing Wang et al.   OncoTargets and Therapy

The multifaceted roles of PARP1 in DNA repair and chromatin remodelling

(2017) Arnab Ray Chaudhuri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Resveratrol inactivates PI3K/Akt signaling through upregulating BMP7 in human colon cancer cells

(2017) Yu-Hua Zeng et al.   ONCOLOGY REPORTS

PARP inhibitors: Synthetic lethality in the clinic

(2017) Christopher J. Lord et al.   SCIENCE

Berberine induces oxidative DNA damage and impairs homologous recombination repair in ovarian cancer cells to confer increased sensitivity to PARP inhibition

(2017) Dong Hou et al.   Cell Death & Disease

Progression through mitosis promotes PARP inhibitor-induced cytotoxicity in homologous recombination-deficient cancer cells

(2017) Pepijn M. Schoonen et al.   Nature Communications

trans-4,4’-Dihydroxystilbene (DHS) inhibits human neuroblastoma tumor growth and induces mitochondrial and lysosomal damages in neuroblastoma cell lines

(2017) Bhaskar Saha et al.   Oncotarget

BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer

(2017) Sergey Karakashev et al.   Cell Reports

Combenefit: an interactive platform for the analysis and visualization of drug combinations

(2016) Giovanni Y. Di Veroli et al.   BIOINFORMATICS

CDK12 Inhibition Reverses De Novo and Acquired PARP Inhibitor Resistance in BRCA Wild-Type and Mutated Models of Triple-Negative Breast Cancer

(2016) Shawn F. Johnson et al.   Cell Reports

Resveratrol induces autophagy by directly inhibiting mTOR through ATP competition

(2016) Dohyun Park et al.   Scientific Reports

Resveratrol induces apoptosis of human chronic myelogenous leukemia cells in vitro through p38 and JNK-regulated H2AX phosphorylation

(2015) Xin-pin Wu et al.   ACTA PHARMACOLOGICA SINICA

Replication-induced DNA damage after PARP inhibition causes G2delay, and cell line-dependent apoptosis, necrosis and multinucleation

(2015) Idun Dale Rein et al.   CELL CYCLE

The Combination of Rapamycin and Resveratrol Blocks Autophagy and Induces Apoptosis in Breast Cancer Cells

(2015) Anya Alayev et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Apoptotic Cell Death Induced by Resveratrol Is Partially Mediated by the Autophagy Pathway in Human Ovarian Cancer Cells

(2015) Fangfang Lang et al.   PLoS One

Poly(ADP-Ribose) Polymerase 1 (PARP1) Overexpression in Human Breast Cancer Stem Cells and Resistance to Olaparib

(2014) Marine Gilabert et al.   PLoS One

Resveratrol Inhibits Breast Cancer Stem-Like Cells and Induces Autophagy via Suppressing Wnt/β-Catenin Signaling Pathway

(2014) Yujie Fu et al.   PLoS One

Vulnerabilities of PTEN-TP53-Deficient Prostate Cancers to Compound PARP-PI3K Inhibition

(2014) E. Gonzalez-Billalabeitia et al.   Cancer Discovery

Resveratrol-based combinatorial strategies for cancer management

(2013) Chandra K. Singh et al.   Annals of the New York Academy of Sciences

Resveratrol abrogates the Temozolomide-induced G2 arrest leading to mitotic catastrophe and reinforces the Temozolomide-induced senescence in glioma cells

(2013) Eduardo C Filippi-Chiela et al.   BMC CANCER

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

(2013) J. Gao et al.   Science Signaling

HER2 Overexpression Renders Human Breast Cancers Sensitive to PARP Inhibition Independently of Any Defect in Homologous Recombination DNA Repair

(2012) S. Nowsheen et al.   CANCER RESEARCH

Trapping of PARP1 and PARP2 by Clinical PARP Inhibitors

(2012) J. Murai et al.   CANCER RESEARCH

PI3K-independent AKT activation in cancers: A treasure trove for novel therapeutics

(2012) Kiran Mahajan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

PARP-1 Modulation of mTOR Signaling in Response to a DNA Alkylating Agent

(2012) Chantal Éthier et al.   PLoS One

PI3K Inhibition Impairs BRCA1/2 Expression and Sensitizes BRCA-Proficient Triple-Negative Breast Cancer to PARP Inhibition

(2012) Yasir H. Ibrahim et al.   Cancer Discovery

Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer

(2012) Ashish Juvekar et al.   Cancer Discovery

Chemosensitization of tumors by resveratrol

(2011) Subash C. Gupta et al.   Annals of the New York Academy of Sciences

MRE11 promotes AKT phosphorylation in direct response to DNA double-strand breaks

(2011) Michael Fraser et al.   CELL CYCLE

Mitochondrial Protection by Resveratrol

(2011) Zoltan Ungvari et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition

(2011) Neil Johnson et al.   NATURE MEDICINE

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Methods in Mammalian Autophagy Research

(2010) Noboru Mizushima et al.   CELL

Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

(2008) F Scarlatti et al.   CELL DEATH AND DIFFERENTIATION