Drug Repurposing: Escitalopram attenuates acute lung injury by inhibiting the SIK2/ HDAC4/ NF-κB signaling cascade

The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

(2021) Yue Liu et al.   Frontiers in Pharmacology

Myostatin inhibitor YK11 as a preventative health supplement for bacterial sepsis

(2021) Su Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Association between antidepressant use and reduced risk of intubation or death in hospitalized patients with COVID-19: results from an observational study

(2021) Nicolas Hoertel et al.   MOLECULAR PSYCHIATRY

Nuts and bolts of the salt-inducible kinases (SIKs)

(2021) Nicola J. Darling et al.   BIOCHEMICAL JOURNAL

Drug repurposing of selective serotonin reuptake inhibitors: Could these drugs help fight COVID-19 and save lives?

(2021) Yaser Pashaei   JOURNAL OF CLINICAL NEUROSCIENCE

HDAC4 induces the development of asthma by increasing Slug-upregulated CXCL12 expression through KLF5 deacetylation

(2021) Wendi Wei et al.   Journal of Translational Medicine

Palmitoylethanolamide (PEA) reduces postoperative adhesions after experimental strabismus surgery in rabbits by suppressing canonical and non-canonical TGFβ signaling through PPARα

(2020) Yitian Li et al.   BIOCHEMICAL PHARMACOLOGY

N-Acylethanolamine acid amidase (NAAA) inhibitor F215 as a novel therapeutic agent for osteoarthritis

(2019) Pan Zhou et al.   PHARMACOLOGICAL RESEARCH

A New Use for an Old Drug: Carmofur Attenuates Lipopolysaccharide (LPS)-Induced Acute Lung Injury via Inhibition of FAAH and NAAA Activities

(2019) Kangni Wu et al.   Frontiers in Pharmacology

Inventing new therapies without reinventing the wheel: the power of drug repurposing

(2018) Andreas Papapetropoulos et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inflammation-restricted anti-inflammatory activities of a N -acylethanolamine acid amidase (NAAA) inhibitor F215

(2018) Yuhang Li et al.   PHARMACOLOGICAL RESEARCH

Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1–cAMP Response Element Binding–Brain-Derived Neurotrophic Factor Pathway

(2018) Bo Jiang et al.   BIOLOGICAL PSYCHIATRY

Identification of highly potent N -acylethanolamine acid amidase (NAAA) inhibitors: Optimization of the terminal phenyl moiety of oxazolidone derivatives

(2017) Yuhang Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Fluoxetine protects against methamphetamine-induced lung inflammation by suppressing oxidative stress through the SERT/p38 MAPK/Nrf2 pathway in rats

(2016) Yun Wang et al.   Molecular Medicine Reports

Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

(2016) Tizhong Shan et al.   Nature Communications

SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype

(2015) Maria Stella Lombardi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4

(2014) Bing Luan et al.   Cell Metabolism

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Higher vs Lower Positive End-Expiratory Pressure in Patients With Acute Lung Injury and Acute Respiratory Distress Syndrome

(2010) Matthias Briel et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Escitalopram

(2010) Lily P.H. Yang et al.   PEDIATRIC DRUGS