Nuts and bolts of the salt-inducible kinases (SIKs)

The Selective SIK2 Inhibitor ARN-3236 Produces Strong Antidepressant-Like Efficacy in Mice via the Hippocampal CRTC1-CREB-BDNF Pathway

(2021) Yue Liu et al.   Frontiers in Pharmacology

Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells

(2021) Nicola J. Darling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of the conserved PKA sites of SIK1 and SIK2 increases sleep need

(2020) Minjeong Park et al.   Scientific Reports

A salt-induced kinase is required for the metabolic regulation of sleep

(2020) Jeremy J. Grubbs et al.   PLOS BIOLOGY

Cellular and Molecular Mechanisms of Metformin Action

(2020) Traci E LaMoia et al.   ENDOCRINE REVIEWS

An Lkb1-Sik axis suppresses lung tumor growth and controls differentiation

(2019) Christopher W Murray et al.   Cancer Discovery

The AMPK-related kinases SIK1 and SIK3 mediate key tumor suppressive effects of LKB1 in NSCLC

(2019) Pablo E Hollstein et al.   Cancer Discovery

Circadian Clock Genes and the Transcriptional Architecture of the Clock Mechanism

(2019) Kimberly H. Cox et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Salt-Inducible Kinase inhibition suppresses acute myeloid leukemia progression in vivo

(2019) Yusuke Tarumoto et al.   BLOOD

Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling

(2019) Shigeki Nishimori et al.   JOURNAL OF CLINICAL INVESTIGATION

14-3-3 proteins mediate inhibitory effects of cAMP on salt-inducible kinases (SIKs)

(2018) Tim Sonntag et al.   FEBS Journal

Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism

(2018) Krushna C. Patra et al.   NATURE CELL BIOLOGY

Quantitative phosphoproteomic analysis of the molecular substrates of sleep need

(2018) Zhiqiang Wang et al.   NATURE

A single phosphorylation site of SIK3 regulates daily sleep amounts and sleep need in mice

(2018) Takato Honda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The PTH/PTHrP-SIK3 pathway affects skeletogenesis through altered mTOR signaling

(2018) Fabiana Csukasi et al.   Science Translational Medicine

Hippocampal Salt-Inducible Kinase 2 Plays a Role in Depression via the CREB-Regulated Transcription Coactivator 1–cAMP Response Element Binding–Brain-Derived Neurotrophic Factor Pathway

(2018) Bo Jiang et al.   BIOLOGICAL PSYCHIATRY

The Salt-Inducible Kinases: Emerging Metabolic Regulators

(2018) Kei Sakamoto et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

SIK3–HDAC4 signaling regulatesDrosophilacircadian male sex drive rhythm via modulating the DN1 clock neurons

(2017) Shinsuke Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin

(2017) Nisma Mujahid et al.   Cell Reports

Salt-inducible kinase 3 regulates the mammalian circadian clock by destabilizing PER2 protein

(2017) Naoto Hayasaka et al.   eLife

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members

(2017) Tim Sonntag et al.   PLoS One

Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo

(2016) Thomas B. Sundberg et al.   ACS Chemical Biology

Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages

(2016) Nicola J. Darling et al.   BIOCHEMICAL JOURNAL

A Novel Compound ARN-3236 Inhibits Salt-Inducible Kinase 2 and Sensitizes Ovarian Cancer Cell Lines and Xenografts to Paclitaxel

(2016) Jinhua Zhou et al.   CLINICAL CANCER RESEARCH

Salt-inducible kinase 2 and -3 are downregulated in adipose tissue from obese or insulin-resistant individuals: implications for insulin signalling and glucose uptake in human adipocytes

(2016) Johanna Säll et al.   DIABETOLOGIA

Epilepsy-causing sequence variations in SIK1 disrupt synaptic activity response gene expression and affect neuronal morphology

(2016) Christoph Pröschel et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

The two-process model of sleep regulation: a reappraisal

(2016) Alexander A. Borbély et al.   JOURNAL OF SLEEP RESEARCH

Forward-genetics analysis of sleep in randomly mutagenized mice

(2016) Hiromasa Funato et al.   NATURE

SIKs control osteocyte responses to parathyroid hormone

(2016) Marc N. Wein et al.   Nature Communications

Pterosin B prevents chondrocyte hypertrophy and osteoarthritis in mice by inhibiting Sik3

(2016) Yasuhito Yahara et al.   Nature Communications

Skeletal muscle salt inducible kinase 1 promotes insulin resistance in obesity

(2016) Mark Nixon et al.   Molecular Metabolism

De Novo Mutations in SIK1 Cause a Spectrum of Developmental Epilepsies

(2015) Jeanne Hansen et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

(2015) James Ozanne et al.   BIOCHEMICAL JOURNAL

Identification of AMPK Phosphorylation Sites Reveals a Network of Proteins Involved in Cell Invasion and Facilitates Large-Scale Substrate Prediction

(2015) Bethany E. Schaffer et al.   Cell Metabolism

Salt-inducible Kinase 3 Signaling Is Important for the Gluconeogenic Programs in Mouse Hepatocytes

(2015) Yumi Itoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype

(2015) Maria Stella Lombardi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CREB phosphorylation at Ser133regulates transcription via distinct mechanisms downstream of cAMP and MAPK signalling

(2014) Shaista Naqvi et al.   BIOCHEMICAL JOURNAL

Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4

(2014) Bing Luan et al.   Cell Metabolism

SIK2 Is Critical in the Regulation of Lipid Homeostasis and Adipogenesis In Vivo

(2014) Jinyoung Park et al.   DIABETES

Class IIa HDACs - new insights into their functions in physiology and pathology

(2014) Maribel Parra   FEBS Journal

Interaction between Salt-inducible Kinase 2 and Protein Phosphatase 2A Regulates the Activity of Calcium/Calmodulin-dependent Protein Kinase I and Protein Phosphatase Methylesterase-1

(2014) Chia-Wei Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIK2 regulates CRTCs, HDAC4 and glucose uptake in adipocytes

(2014) E. Henriksson et al.   JOURNAL OF CELL SCIENCE

AMP-activated protein kinase: a key regulator of energy balance with many roles in human disease

(2014) D. Grahame Hardie   JOURNAL OF INTERNAL MEDICINE

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

(2014) T. B. Sundberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver

(2014) Kashyap Patel et al.   Nature Communications

The CRTC1-SIK1 Pathway Regulates Entrainment of the Circadian Clock

(2013) Aarti Jagannath et al.   CELL

Molecular mechanism of action of metformin: old or new insights?

(2013) Graham Rena et al.   DIABETOLOGIA

The AMPK-related kinase SIK2 is regulated by cAMP via phosphorylation at Ser358in adipocytes

(2012) Emma Henriksson et al.   BIOCHEMICAL JOURNAL

cAMP-elevation mediated by β-adrenergic stimulation inhibits salt-inducible kinase (SIK) 3 activity in adipocytes

(2012) Christine Berggreen et al.   CELLULAR SIGNALLING

SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

(2012) S. Sasagawa et al.   DEVELOPMENT

Osteocyte RANKL: New insights into the control of bone remodeling

(2012) Jinhu Xiong et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

(2012) K. F. MacKenzie et al.   JOURNAL OF IMMUNOLOGY

Toward a Comprehensive Characterization of a Human Cancer Cell Phosphoproteome

(2012) Houjiang Zhou et al.   JOURNAL OF PROTEOME RESEARCH

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Involvement of SIK3 in Glucose and Lipid Homeostasis in Mice

(2012) Tatsuya Uebi et al.   PLoS One

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism of CREB recognition and coactivation by the CREB-regulated transcriptional coactivator CRTC2

(2012) Q. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel cross-talk within the IKK family controls innate immunity

(2011) Kristopher Clark et al.   BIOCHEMICAL JOURNAL

A Hormone-Dependent Module Regulating Energy Balance

(2011) Biao Wang et al.   CELL

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

(2011) Maria M. Mihaylova et al.   CELL

Regulatory macrophages: Setting the Threshold for Therapy

(2011) Bryan D. Fleming et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

SIK2 Is a Key Regulator for Neuronal Survival after Ischemia via TORC1-CREB

(2011) Tsutomu Sasaki et al.   NEURON

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

FoxOs Function Synergistically to Promote Glucose Production

(2010) Rebecca A. Haeusler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Metformin inhibits hepatic gluconeogenesis in mice independently of the LKB1/AMPK pathway via a decrease in hepatic energy state

(2010) Marc Foretz et al.   JOURNAL OF CLINICAL INVESTIGATION

Averting inflammation by targeting the cytokine environment

(2010) Manfred Kopf et al.   NATURE REVIEWS DRUG DISCOVERY

Downregulation of SIK2 expression promotes the melanogenic program in mice

(2010) Nanao Horike et al.   Pigment Cell & Melanoma Research

Involvement of SIK2/TORC2 signaling cascade in the regulation of insulin-induced PGC-1α and UCP-1 gene expression in brown adipocytes

(2009) Masaaki Muraoka et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Calmodulin-dependent protein kinase kinase-β activates AMPK without forming a stable complex: synergistic effects of Ca2+and AMP

(2009) Sarah Fogarty et al.   BIOCHEMICAL JOURNAL

Large-scale Proteomics Analysis of the Human Kinome

(2009) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS

The EGL-4 PKG Acts With KIN-29 Salt-Inducible Kinase and Protein Kinase A to Regulate Chemoreceptor Gene Expression and Sensory Behaviors in Caenorhabditis elegans

(2008) Alexander M. van der Linden et al.   GENETICS

Importance of autophosphorylation at Ser186 in the A-loop of salt inducible kinase 1 for its sustained kinase activity

(2008) Yoshiko Katoh Hashimoto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The molecular neurobiology of depression

(2008) Vaishnav Krishnan et al.   NATURE

SIK2 Can be Activated by Deprivation of Nutrition and It Inhibits Expression of Lipogenic Genes in Adipocytes

(2008) Jing Du et al.   Obesity