Lkb1 controls brown adipose tissue growth and thermogenesis by regulating the intracellular localization of CRTC3

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

(2015) Aaron M. Cypess et al.   Cell Metabolism

Cold-Inducible Zfp516 Activates UCP1 Transcription to Promote Browning of White Fat and Development of Brown Fat

(2015) Jon Dempersmier et al.   MOLECULAR CELL

Genetic and functional characterization of clonally derived adult human brown adipocytes

(2015) Kosaku Shinoda et al.   NATURE MEDICINE

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

(2015) Lucie Geurts et al.   Nature Communications

Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements

(2015) Thomas S. Morley et al.   Nature Communications

What We Talk About When We Talk About Fat

(2014) Evan D. Rosen et al.   CELL

Ablation of PRDM16 and Beige Adipose Causes Metabolic Dysfunction and a Subcutaneous to Visceral Fat Switch

(2014) Paul Cohen et al.   CELL

The Browning of White Adipose Tissue: Some Burning Issues

(2014) Jan Nedergaard et al.   Cell Metabolism

Endothelial Cell–Specific Liver Kinase B1 Deletion Causes Endothelial Dysfunction and Hypertension in Mice In Vivo

(2014) Wencheng Zhang et al.   CIRCULATION

Coupling of lipolysis and de novo lipogenesis in brown, beige, and white adipose tissues during chronic β3-adrenergic receptor activation

(2014) Emilio P. Mottillo et al.   JOURNAL OF LIPID RESEARCH

White-to-brown metabolic conversion of human adipocytes by JAK inhibition

(2014) Annie Moisan et al.   NATURE CELL BIOLOGY

Inhibition of Notch signaling promotes browning of white adipose tissue and ameliorates obesity

(2014) Pengpeng Bi et al.   NATURE MEDICINE

Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis

(2014) Justin D Crane et al.   NATURE MEDICINE

Lkb1 Is Indispensable for Skeletal Muscle Development, Regeneration, and Satellite Cell Homeostasis

(2014) Tizhong Shan et al.   STEM CELLS

MitoNEET-mediated effects on browning of white adipose tissue

(2014) Christine M. Kusminski et al.   Nature Communications

A Classical Brown Adipose Tissue mRNA Signature Partly Overlaps with Brite in the Supraclavicular Region of Adult Humans

(2013) Naja Zenius Jespersen et al.   Cell Metabolism

LKB1 Regulates Lipid Oxidation During Exercise Independently of AMPK

(2013) J. Jeppesen et al.   DIABETES

Lessons on Conditional Gene Targeting in Mouse Adipose Tissue

(2013) K. Y. Lee et al.   DIABETES

Liver Kinase B1 Is Required for White Adipose Tissue Growth and Differentiation

(2013) W. Zhang et al.   DIABETES

Adaptive thermogenesis in adipocytes: Is beige the new brown?

(2013) J. Wu et al.   GENES & DEVELOPMENT

Recruited brown adipose tissue as an antiobesity agent in humans

(2013) Takeshi Yoneshiro et al.   JOURNAL OF CLINICAL INVESTIGATION

White to brite adipocyte transition and back again

(2013) Youn-Kyoung Lee et al.   NATURE CELL BIOLOGY

Ablation of LGR4 promotes energy expenditure by driving white-to-brown fat switch

(2013) Jiqiu Wang et al.   NATURE CELL BIOLOGY

Bi-directional interconversion of brite and white adipocytes

(2013) Matthias Rosenwald et al.   NATURE CELL BIOLOGY

Evidence for two types of brown adipose tissue in humans

(2013) Martin E Lidell et al.   NATURE MEDICINE

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Fatty acid binding protein 4 expression marks a population of adipocyte progenitors in white and brown adipose tissues

(2012) Tizhong Shan et al.   FASEB JOURNAL

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

(2012) Kristin I. Stanford et al.   JOURNAL OF CLINICAL INVESTIGATION

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

White to Brown Fat Phenotypic Switch Induced by Genetic and Environmental Activation of a Hypothalamic-Adipocyte Axis

(2011) Lei Cao et al.   Cell Metabolism

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

(2011) Janne Orava et al.   Cell Metabolism

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

Role of cAMP-responsive Element-binding Protein (CREB)-regulated Transcription Coactivator 3 (CRTC3) in the Initiation of Mitochondrial Biogenesis and Stress Response in Liver Cells

(2011) Tin Aung Than et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

(2011) William Mair et al.   NATURE

A guide to analysis of mouse energy metabolism

(2011) Matthias H Tschöp et al.   NATURE METHODS

CREB and the CRTC co-activators: sensors for hormonal and metabolic signals

(2011) Judith Y. Altarejos et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Changed Metabolic World with Human Brown Adipose Tissue: Therapeutic Visions

(2010) Jan Nedergaard et al.   Cell Metabolism

Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice

(2010) Patrick Seale et al.   JOURNAL OF CLINICAL INVESTIGATION

Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

(2010) Daisuke Nakada et al.   NATURE

CRTC3 links catecholamine signalling to energy balance

(2010) Youngsup Song et al.   NATURE

LKB1 Regulates Pancreatic β Cell Size, Polarity, and Function

(2009) Zvi Granot et al.   Cell Metabolism

Loss of Lkb1 in Adult β Cells Increases β Cell Mass and Enhances Glucose Tolerance in Mice

(2009) Accalia Fu et al.   Cell Metabolism

Adipocyte CREB Promotes Insulin Resistance in Obesity

(2009) Ling Qi et al.   Cell Metabolism

Cardiac-specific Deletion of LKB1 Leads to Hypertrophy and Dysfunction

(2009) Yasumasa Ikeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Brown Adipose Tissue in Healthy Adults

(2009) Kirsi A. Virtanen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cold-Activated Brown Adipose Tissue in Healthy Men

(2009) Wouter D. van Marken Lichtenbelt et al.   NEW ENGLAND JOURNAL OF MEDICINE

Identification and Importance of Brown Adipose Tissue in Adult Humans

(2009) Aaron M. Cypess et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adipose-Specific Knockout of raptor Results in Lean Mice with Enhanced Mitochondrial Respiration

(2008) Pazit Polak et al.   Cell Metabolism

LKB1 in endothelial cells is required for angiogenesis and TGF -mediated vascular smooth muscle cell recruitment

(2008) A. Londesborough et al.   DEVELOPMENT