SIK inhibition in human myeloid cells modulates TLR and IL-1R signaling and induces an anti-inflammatory phenotype

The clinically approved drugs dasatinib and bosutinib induce anti-inflammatory macrophages by inhibiting the salt-inducible kinases

(2015) James Ozanne et al.   BIOCHEMICAL JOURNAL

Salt-inducible kinase 3 deficiency exacerbates lipopolysaccharide-induced endotoxin shock accompanied by increased levels of pro-inflammatory molecules in mice

(2015) Masato Sanosaka et al.   IMMUNOLOGY

Protein kinase networks that limit TLR signalling

(2014) Kristopher Clark   BIOCHEMICAL SOCIETY TRANSACTIONS

Leptin-Mediated Increases in Catecholamine Signaling Reduce Adipose Tissue Inflammation via Activation of Macrophage HDAC4

(2014) Bing Luan et al.   Cell Metabolism

Apremilast is a selective PDE4 inhibitor with regulatory effects on innate immunity

(2014) P.H. Schafer et al.   CELLULAR SIGNALLING

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

The TLR and IL-1 signalling network at a glance

(2014) P. Cohen   JOURNAL OF CELL SCIENCE

Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells

(2014) T. B. Sundberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Polarization profiles of human M-CSF-generated macrophages and comparison of M1-markers in classically activated macrophages from GM-CSF and M-CSF origin

(2013) Marie Jaguin et al.   CELLULAR IMMUNOLOGY

AMPKα1 deficiency amplifies proinflammatory myeloid APC activity and CD40 signaling

(2013) Kelly Casey Carroll et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Salt-Inducible Kinases 1 and 3 Negatively Regulate Toll-Like Receptor 4-Mediated Signal

(2013) So Yong Kim et al.   MOLECULAR ENDOCRINOLOGY

Macrophage plasticity and polarization: in vivo veritas

(2012) Antonio Sica et al.   JOURNAL OF CLINICAL INVESTIGATION

PGE2 Induces Macrophage IL-10 Production and a Regulatory-like Phenotype via a Protein Kinase A-SIK-CRTC3 Pathway

(2012) K. F. MacKenzie et al.   JOURNAL OF IMMUNOLOGY

Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages

(2012) K. Clark et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1 in the pathogenesis and treatment of inflammatory diseases

(2011) C. A. Dinarello   BLOOD

Regulatory macrophages: Setting the Threshold for Therapy

(2011) Bryan D. Fleming et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Systematic validation of specific phenotypic markers for in vitro polarized human macrophages

(2011) C.A. Ambarus et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Altered M1/M2 activation patterns of monocytes in severe relapsing experimental rat model of multiple sclerosis. Amelioration of clinical status by M2 activated monocyte administration

(2010) Joanna Mikita et al.   Multiple Sclerosis Journal

Methotrexate—how does it really work?

(2010) Edwin S. L. Chan et al.   Nature Reviews Rheumatology

IL-1 pathways in inflammation and human diseases

(2010) Cem Gabay et al.   Nature Reviews Rheumatology

Interferon-γ reverses the immunosuppressive and protumoral properties and prevents the generation of human tumor-associated macrophages

(2009) Dorothée Duluc et al.   INTERNATIONAL JOURNAL OF CANCER

Alternatively Activated Macrophages Elicited by Helminth Infection Can Be Reprogrammed to Enable Microbial Killing

(2009) K. J. Mylonas et al.   JOURNAL OF IMMUNOLOGY

Strategies for use of IL-10 or its antagonists in human disease

(2008) Anne O'Garra et al.   IMMUNOLOGICAL REVIEWS