Osteoarthritis endotype discovery via clustering of biochemical marker data

A low cartilage formation and repair endotype predicts radiographic progression of symptomatic knee osteoarthritis

(2021) Yunyun Luo et al.   Journal of Orthopaedics and Traumatology

Serum C-reactive protein metabolite (CRPM) is associated with incidence of contralateral knee osteoarthritis

(2021) Anne-Christine Bay-Jensen et al.   Scientific Reports

Hypertension meets osteoarthritis — revisiting the vascular aetiology hypothesis

(2021) Karen Ching et al.   Nature Reviews Rheumatology

The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date

(2021) Win Min Oo et al.   Drug Design Development and Therapy

Blood and urine biomarkers in osteoarthritis – an update on cartilage associated type II collagen and aggrecan markers

(2021) Anne C. Bay-Jensen et al.   CURRENT OPINION IN RHEUMATOLOGY

Low levels of type II collagen formation (PRO-C2) are associated with response to sprifermin: a pre-defined, exploratory biomarker analysis from the FORWARD study

(2021) A.C. Bay-Jensen et al.   OSTEOARTHRITIS AND CARTILAGE

Safety, Pharmacokinetics, and Pharmacodynamics of the ADAMTS‐5 Inhibitor GLPG1972/S201086 in Healthy Volunteers and Participants With Osteoarthritis of the Knee or Hip

(2021) Ellen Aar et al.   Clinical Pharmacology in Drug Development

Prospects for Therapies in Osteoarthritis

(2020) Asim Ghouri et al.   CALCIFIED TISSUE INTERNATIONAL

Global, regional and national burden of osteoarthritis 1990-2017: a systematic analysis of the Global Burden of Disease Study 2017

(2020) Saeid Safiri et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis: Current Molecular Biomarkers and the Way Forward

(2020) Virginia Byers Kraus et al.   CALCIFIED TISSUE INTERNATIONAL

Multi-classifier prediction of knee osteoarthritis progression from incomplete imbalanced longitudinal data

(2020) Paweł Widera et al.   Scientific Reports

Cohort profile: The Applied Public-Private Research enabling OsteoArthritis Clinical Headway (IMI-APPROACH) study: a 2-year, European, cohort study to describe, validate and predict phenotypes of osteoarthritis using clinical, imaging and biochemical markers

(2020) Eefje M van Helvoort et al.   BMJ Open

Bone phenotypes in rheumatology – there is more to bone than just bone

(2020) Christian S. Thudium et al.   BMC MUSCULOSKELETAL DISORDERS

Concept Endpoints Informing Design Considerations for Confirmatory Clinical Trials in Osteoarthritis

(2020) Yura Kim et al.   ARTHRITIS CARE & RESEARCH

Potential diagnostic value of a type X collagen neo-epitope biomarker for knee osteoarthritis

(2019) Yi He et al.   OSTEOARTHRITIS AND CARTILAGE

Incurred Sample Reanalysis: Time to Change the Sample Size Calculation?

(2019) Piotr J. Rudzki et al.   AAPS Journal

Osteoarthritis

(2019) David J Hunter et al.   LANCET

Coll2-1 and Coll2-1NO2 as exemplars of collagen extracellular matrix turnover - biomarkers to assist the treatment of osteoarthritis?

(2019) Ali Mobasheri et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Multimodal Machine Learning-based Knee Osteoarthritis Progression Prediction from Plain Radiographs and Clinical Data

(2019) Aleksei Tiulpin et al.   Scientific Reports

Automatic Knee Osteoarthritis Diagnosis from Plain Radiographs: A Deep Learning-Based Approach

(2018) Aleksei Tiulpin et al.   Scientific Reports

Molecular taxonomy of osteoarthritis for patient stratification, disease management and drug development

(2018) Ali Mobasheri et al.   CURRENT OPINION IN RHEUMATOLOGY

Effects of dietary weight loss with and without exercise on interstitial matrix turnover and tissue inflammation biomarkers in adults with knee osteoarthritis: the Intensive Diet and Exercise for Arthritis trial (IDEA)

(2017) R.F. Loeser et al.   OSTEOARTHRITIS AND CARTILAGE

Safety, tolerability, and pharmacodynamics of an anti-interleukin-1α/β dual variable domain immunoglobulin in patients with osteoarthritis of the knee: a randomized phase 1 study

(2017) S.X. Wang et al.   OSTEOARTHRITIS AND CARTILAGE

Biomarker of extracellular matrix remodelling C1M and proinflammatory cytokine interleukin 6 are related to synovitis and pain in end-stage knee osteoarthritis patients

(2017) Maja R. Radojčić et al.   PAIN

Is osteoarthritis one disease or a collection of many?

(2017) Leticia A Deveza et al.   RHEUMATOLOGY

Predictive Validity of Radiographic Trabecular Bone Texture in Knee Osteoarthritis

(2017) Virginia Byers Kraus et al.   Arthritis & Rheumatology

Predictive validity of biochemical biomarkers in knee osteoarthritis: data from the FNIH OA Biomarkers Consortium

(2016) Virginia Byers Kraus et al.   ANNALS OF THE RHEUMATIC DISEASES

Osteoarthritis

(2016) Johanne Martel-Pelletier et al.   Nature Reviews Disease Primers

Serum cartilage oligomeric matrix protein and development of radiographic and painful knee osteoarthritis. A community-based cohort of middle-aged women

(2015) Stefan Kluzek et al.   BIOMARKERS

Treatment of symptomatic knee osteoarthritis with oral salmon calcitonin: results from two phase 3 trials

(2015) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

Repeat Analysis and Incurred Sample Reanalysis: Recommendation for Best Practices and Harmonization from the Global Bioanalysis Consortium Harmonization Team

(2014) Eric Fluhler et al.   AAPS Journal

The global burden of hip and knee osteoarthritis: estimates from the Global Burden of Disease 2010 study

(2014) Marita Cross et al.   ANNALS OF THE RHEUMATIC DISEASES

Detecting Rhythms in Time Series with RAIN

(2014) Paul F. Thaben et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Alpha C-Telopeptide of Type I Collagen Is Associated With Subchondral Bone Turnover and Predicts Progression of Joint Space Narrowing and Osteophytes in Osteoarthritis

(2014) Janet L. Huebner et al.   Arthritis & Rheumatology

Osteoarthritis – a case for personalized health care?

(2013) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

An ARGS-aggrecan assay for analysis in blood and synovial fluid

(2013) S. Larsson et al.   OSTEOARTHRITIS AND CARTILAGE

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Enzyme-linked immunosorbent assay (ELISAs) for metalloproteinase derived type II collagen neoepitope, CIIM—Increased serum CIIM in subjects with severe radiographic osteoarthritis

(2011) Anne-Christine Bay-Jensen et al.   CLINICAL BIOCHEMISTRY

Is osteoarthritis a heterogeneous disease that can be stratified into subsets?

(2009) Jeffrey B. Driban et al.   CLINICAL RHEUMATOLOGY