MAPK15 protects from oxidative stress‐dependent cellular senescence by inducing the mitophagic process

MAPK15-ULK1 signaling regulates mitophagy of airway epithelial cell in chronic obstructive pulmonary disease

(2021) Ming Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

The Cancer SENESCopedia: A delineation of cancer cell senescence

(2021) Fleur Jochems et al.   Cell Reports

Mitophagy: Molecular Mechanisms, New Concepts on Parkin Activation and the Emerging Role of AMPK/ULK1 Axis

(2021) Roberto Iorio et al.   Cells

Mammalian Mitophagosome Formation: A Focus on the Early Signals and Steps

(2020) Maria Zachari et al.   Frontiers in Cell and Developmental Biology

A guide to assessing cellular senescence in vitro and in vivo

(2020) Estela González‐Gualda et al.   FEBS Journal

Cellular senescence in ageing: from mechanisms to therapeutic opportunities

(2020) Raffaella Di Micco et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson’s Disease

(2018) Shankar J. Chinta et al.   Cell Reports

Mitochondrial dysfunction in fibroblasts of Multiple System Atrophy

(2018) Giacomo Monzio Compagnoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

MAPK15 is part of the ULK complex and controls its activity to regulate early phases of the autophagic process

(2018) David Colecchia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of human mitogen-activated protein kinase 15 (extracellular signal-regulated kinase 7/8) and its functions: A recent update

(2018) Andy T. Y. Lau et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Role of Mitochondria in Reactive Oxygen Species Generation and Its Implications for Neurodegenerative Diseases

(2018) Saima Kausar et al.   Cells

Quantitative Proteomic Analysis Identifies MAPK15 as a Potential Regulator of Radioresistance in Nasopharyngeal Carcinoma Cells

(2018) Zhanzhan Li et al.   Frontiers in Oncology

Mitochondrial diseases: the contribution of organelle stress responses to pathology

(2017) Anu Suomalainen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

MAPK15 upregulation promotes cell proliferation and prevents DNA damage in male germ cell tumors

(2016) Matteo Rossi et al.   Oncotarget

MAPK15 mediates BCR-ABL1-induced autophagy and regulates oncogene-dependent cell proliferation and tumor formation

(2015) David Colecchia et al.   Autophagy

Measuring In Vivo Mitophagy

(2015) Nuo Sun et al.   MOLECULAR CELL

AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1

(2014) F Strappazzon et al.   CELL DEATH AND DIFFERENTIATION

A Mitochondrial Switch Promotes Tumor Metastasis

(2014) Paolo E. Porporato et al.   Cell Reports

MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins

(2012) David Colecchia et al.   Autophagy

Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation

(2012) Marzia Fumagalli et al.   NATURE CELL BIOLOGY

Telomeres are favoured targets of a persistent DNA damage response in ageing and stress-induced senescence

(2012) Graeme Hewitt et al.   Nature Communications

High-Throughput RNAi Screening Reveals Novel Regulators of Telomerase

(2011) M. A. Cerone et al.   CANCER RESEARCH

Parkin Interacts with Ambra1 to Induce Mitophagy

(2011) C. Van Humbeeck et al.   JOURNAL OF NEUROSCIENCE

Extracellular Signal-regulated Kinase 8 (ERK8) Controls Estrogen-related Receptor α (ERRα) Cellular Localization and Inhibits Its Transcriptional Activity

(2010) Matteo Rossi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A chromatin-bound kinase, ERK8, protects genomic integrity by inhibiting HDM2-mediated degradation of the DNA clamp PCNA

(2010) Angela L. Groehler et al.   JOURNAL OF CELL BIOLOGY

Feedback between p21 and reactive oxygen production is necessary for cell senescence

(2010) João F Passos et al.   Molecular Systems Biology

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction

(2009) Ji Luo et al.   CELL

Regulation of the activity and expression of ERK8 by DNA damage

(2009) Iva V. Klevernic et al.   FEBS LETTERS

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

(2009) C. Vives-Bauza et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA