Mitochondrial-derived damage-associated molecular patterns amplify neuroinflammation in neurodegenerative diseases

Extracellular cardiolipin modulates microglial phagocytosis and cytokine secretion in a toll-like receptor (TLR) 4-dependent manner

(2021) Tyler J. Wenzel et al.   JOURNAL OF NEUROIMMUNOLOGY

miR‑335 promotes ferroptosis by targeting ferritin heavy chain 1 in in vivo and in vitro models of Parkinson's disease

(2021) Xinrong Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Interleukin-1β mediates alterations in mitochondrial fusion/fission proteins and memory impairment induced by amyloid-β oligomers

(2021) Andre F. Batista et al.   Journal of Neuroinflammation

NADPH and Mito-Apocynin Treatment Protects Against KA-Induced Excitotoxic Injury Through Autophagy Pathway

(2021) Na Liu et al.   Frontiers in Cell and Developmental Biology

Mild mitochondrial impairment enhances innate immunity and longevity through ATFS‐1 and p38 signaling

(2021) Juliane C Campos et al.   EMBO REPORTS

Activation of mitochondrial unfolded protein response protects against multiple exogenous stressors

(2021) Sonja K Soo et al.   Life Science Alliance

Interpretation of risk loci from genome-wide association studies of Alzheimer's disease

(2020) Shea J Andrews et al.   LANCET NEUROLOGY

Reduction of AMPA receptor activity on mature oligodendrocytes attenuates loss of myelinated axons in autoimmune neuroinflammation

(2020) Kirsten S. Evonuk et al.   Science Advances

NADPH protects against kainic acid-induced excitotoxicity via autophagy-lysosome pathway in rat striatum and primary cortical neurons

(2020) Zi-Qi Liu et al.   TOXICOLOGY

P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases

(2020) Peter Illes   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

How Do Sensory Neurons Sense Danger Signals?

(2020) Christopher R. Donnelly et al.   TRENDS IN NEUROSCIENCES

Mitochondrial Dynamics and Bioenergetic Alteration During Inflammatory Activation of Astrocytes

(2020) Md Habibur Rahman et al.   Frontiers in Aging Neuroscience

The Potential Role of the NLRP3 Inflammasome Activation as a Link Between Mitochondria ROS Generation and Neuroinflammation in Postoperative Cognitive Dysfunction

(2019) Penghui Wei et al.   Frontiers in Cellular Neuroscience

Mitochondrial dysfunction in neurodegenerative diseases and the potential countermeasure

(2019) Yan Wang et al.   CNS Neuroscience & Therapeutics

Extracellular cardiolipin regulates select immune functions of microglia and microglia-like cells

(2019) Caitlin B. Pointer et al.   BRAIN RESEARCH BULLETIN

Mitochondrial DNA in liver inflammation and oxidative stress

(2019) Xufei Zhang et al.   LIFE SCIENCES

Microglia-mediated neuroinflammation in neurodegenerative diseases

(2019) Charannya Sozheesvari Subhramanyam et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Cytochrome c can be released into extracellular space and modulate functions of human astrocytes in a toll-like receptor 4-dependent manner

(2019) Tyler J. Wenzel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

TNF-alpha driven inflammation and mitochondrial dysfunction define the platelet hyperreactivity of aging

(2019) Pavel Davizon-Castillo et al.   BLOOD

Extracellular ATP activates P2X7R-NF-κB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice

(2019) Ying Yu et al.   CYTOKINE

ccf-mtDNA as a Potential Link Between the Brain and Immune System in Neuro-Immunological Disorders

(2019) Stefano Gambardella et al.   Frontiers in Immunology

Mitochondria in Health and Disease

(2019) Sarah J. Annesley et al.   Cells

Purinergic receptors and the inflammatory response mediated by lipids

(2019) Cristina Alarcón-Vila et al.   CURRENT OPINION IN PHARMACOLOGY

PINK1-parkin pathway of mitophagy protects against contrast-induced acute kidney injury via decreasing mitochondrial ROS and NLRP3 inflammasome activation

(2019) Qisheng Lin et al.   Redox Biology

Emerging Role of Mitochondrial DNA as a Major Driver of Inflammation and Disease Progression

(2019) Fei Zhong et al.   TRENDS IN IMMUNOLOGY

Repairing Mitochondrial Dysfunction in Disease

(2018) Vincenzo Sorrentino et al.   Annual Review of Pharmacology and Toxicology

Hydrogen sulfide inhibits ATP-induced neuroinflammation and Aβ 1–42 synthesis by suppressing the activation of STAT3 and cathepsin S

(2018) Lei Cao et al.   BRAIN BEHAVIOR AND IMMUNITY

Ubiquitination of ABCE1 by NOT4 in Response to Mitochondrial Damage Links Co-translational Quality Control to PINK1-Directed Mitophagy

(2018) Zhihao Wu et al.   Cell Metabolism

The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

(2018) Inhae Kang et al.   FEBS LETTERS

Trovafloxacin attenuates neuroinflammation and improves outcome after traumatic brain injury in mice

(2018) Charu Garg et al.   Journal of Neuroinflammation

Innate immunity and tolerance toward mitochondria

(2018) Anthony Rongvaux   MITOCHONDRION

Pattern recognition receptors mediate pro-inflammatory effects of extracellular mitochondrial transcription factor A (TFAM)

(2018) Stephanie M. Schindler et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

DOR agonist (SNC-80) exhibits anti-parkinsonian effect via downregulating UPR/oxidative stress signals and inflammatory response in vivo

(2018) Erfath Thanjeem Begum M et al.   NEUROSCIENCE LETTERS

BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis

(2018) Kate McArthur et al.   SCIENCE

Iron overloaded polarizes macrophage to proinflammation phenotype through ROS/acetyl-p53 pathway

(2018) Yun Zhou et al.   Cancer Medicine

Mitochondrial inner membrane permeabilisation enables mtDNA release during apoptosis

(2018) Joel S Riley et al.   EMBO JOURNAL

The role of mitochondria in NLRP3 inflammasome activation

(2018) Qiuyun Liu et al.   MOLECULAR IMMUNOLOGY

Microglia in neurodegeneration

(2018) Suzanne Hickman et al.   NATURE NEUROSCIENCE

Mortal engines: Mitochondrial bioenergetics and dysfunction in neurodegenerative diseases

(2018) Amit U. Joshi et al.   PHARMACOLOGICAL RESEARCH

Targeting Mitochondrial Metabolism in Neuroinflammation: Towards a Therapy for Progressive Multiple Sclerosis

(2018) Luca Peruzzotti-Jametti et al.   TRENDS IN MOLECULAR MEDICINE

Inflammation and mitochondrial dysfunction: A vicious circle in neurodegenerative disorders?

(2017) Jack van Horssen et al.   NEUROSCIENCE LETTERS

DsbA-L prevents obesity-induced inflammation and insulin resistance by suppressing the mtDNA release-activated cGAS-cGAMP-STING pathway

(2017) Juli Bai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial dysfunction in glial cells: Implications for neuronal homeostasis and survival

(2017) Jordan Rose et al.   TOXICOLOGY

Neuroinflammation in Alzheimer's disease: Current evidence and future directions

(2016) Valeria Calsolaro et al.   Alzheimers & Dementia

Maintenance and propagation of a deleterious mitochondrial genome by the mitochondrial unfolded protein response

(2016) Yi-Fan Lin et al.   NATURE

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Mitochondrial UPR: A Double-Edged Sword

(2016) Ye Tian et al.   TRENDS IN CELL BIOLOGY

How microglia kill neurons

(2015) Guy C. Brown et al.   BRAIN RESEARCH

Mitochondrial ROS Signaling in Organismal Homeostasis

(2015) Gerald S. Shadel et al.   CELL

Relationships Between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease

(2015) Heather M. Wilkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Polydatin protects hepatocytes against mitochondrial injury in acute severe hemorrhagic shock via SIRT1-SOD2pathway

(2015) Pengyun Li et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Mitochondria-targeted antioxidants

(2015) Anne O. Oyewole et al.   FASEB JOURNAL

Mitochondrial and Nuclear Accumulation of the Transcription Factor ATFS-1 Promotes OXPHOS Recovery during the UPRmt

(2015) Amrita M. Nargund et al.   MOLECULAR CELL

Mitochondrial DNA stress primes the antiviral innate immune response

(2015) A. Phillip West et al.   NATURE

The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

(2015) James B. Stewart et al.   NATURE REVIEWS GENETICS

Energy crisis: The role of oxidative phosphorylation in acute inflammation and sepsis

(2014) Icksoo Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial UPR-regulated innate immunity provides resistance to pathogen infection

(2014) Mark W. Pellegrino et al.   NATURE

Metabolism and function of mitochondrial cardiolipin

(2014) Mindong Ren et al.   PROGRESS IN LIPID RESEARCH

Role of mitochondria ROS generation in ethanol-induced NLRP3 inflammasome activation and cell death in astroglial cells

(2014) Silvia Alfonso-Loeches et al.   Frontiers in Cellular Neuroscience

Bioenergetic Dysfunction and Inflammation in Alzheimer’s Disease: A Possible Connection

(2014) Heather M. Wilkins et al.   Frontiers in Aging Neuroscience

The interplay between iron accumulation, mitochondrial dysfunction, and inflammation during the execution step of neurodegenerative disorders

(2014) Pamela J. Urrutia et al.   Frontiers in Pharmacology

Calcium dysregulation and neuroinflammation: Discrete and integrated mechanisms for age-related synaptic dysfunction

(2013) Diana M. Sama et al.   AGEING RESEARCH REVIEWS

Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance

(2013) Elisa Motori et al.   Cell Metabolism

Mitochondrial Cardiolipin Is Required for Nlrp3 Inflammasome Activation

(2013) Shankar S. Iyer et al.   IMMUNITY

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Neuroinflammation: The role and consequences

(2013) Monty Lyman et al.   NEUROSCIENCE RESEARCH

Mitochondrial transcription factor A regulates mitochondrial transcription initiation, DNA packaging, and genome copy number

(2012) Christopher T. Campbell et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Signaling the mitochondrial unfolded protein response

(2012) Mark W. Pellegrino et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Mitochondria: In Sickness and in Health

(2012) Jodi Nunnari et al.   CELL

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cerebrospinal Fluid Levels of High-Mobility Group Box 1 and Cytochrome C Predict Outcome after Pediatric Traumatic Brain Injury

(2012) Alicia K. Au et al.   JOURNAL OF NEUROTRAUMA

Mitochondrial Import Efficiency of ATFS-1 Regulates Mitochondrial UPR Activation

(2012) A. M. Nargund et al.   SCIENCE

The Mitochondrial Proteome and Human Disease

(2010) Sarah E. Calvo et al.   Annual Review of Genomics and Human Genetics

Molecular and cellular mechanisms of excitotoxic neuronal death

(2010) Yan Wang et al.   APOPTOSIS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

(2009) Xiao-xia Dong et al.   ACTA PHARMACOLOGICA SINICA

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA