Identification of Novel Oxindole Compounds That Suppress ER Stress-Induced Cell Death as Chemical Chaperones

Novel oxindole compounds inhibit the aggregation of amyloidogenic proteins associated with neurodegenerative diseases

(2022) Shintaro Kimura et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Artepillin C, a major component of Brazilian green propolis, inhibits endoplasmic reticulum stress and protein aggregation

(2021) Yoko Hirata et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Identification of novel neuroprotective N,N-dimethylaniline derivatives that prevent oxytosis/ferroptosis and localize to late endosomes and lysosomes

(2021) Yoko Hirata et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferroptosis and its potential role in the physiopathology of Parkinson’s Disease

(2020) Laura Mahoney-Sánchez et al.   PROGRESS IN NEUROBIOLOGY

Trial of Sodium Phenylbutyrate–Taurursodiol for Amyotrophic Lateral Sclerosis

(2020) Sabrina Paganoni et al.   NEW ENGLAND JOURNAL OF MEDICINE

Treating Alzheimer's disease by targeting iron

(2019) Sara Nikseresht et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of double-stranded RNA-dependent protein kinase prevents oxytosis and ferroptosis in mouse hippocampal HT22 cells

(2019) Yoko Hirata et al.   TOXICOLOGY

Oxidative stress in vagal neurons promotes parkinsonian pathology and intercellular α-synuclein transfer

(2019) Ruth E. Musgrove et al.   JOURNAL OF CLINICAL INVESTIGATION

The lipophilic 4‐phenylbutyric acid derivative prevents aggregation and retention of misfolded proteins

(2019) Salome Azoulay-Ginsburg et al.   CHEMISTRY-A EUROPEAN JOURNAL

Novel Oxindole–Curcumin Hybrid Compound for Antioxidative Stress and Neuroprotection

(2019) Yoko Hirata et al.   ACS Chemical Neuroscience

Cell-based HTS identifies a chemical chaperone for preventing ER protein aggregation and proteotoxicity

(2019) Keisuke Kitakaze et al.   eLife

Increased Oxidative Stress Exacerbates α-Synuclein Aggregation In Vivo

(2018) Owen Scudamore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Novel oxindole derivatives prevent oxidative stress-induced cell death in mouse hippocampal HT22 cells

(2018) Yoko Hirata et al.   NEUROPHARMACOLOGY

ER stress and the unfolded protein response in neurodegeneration

(2017) Claudio Hetz et al.   Nature Reviews Neurology

Activation of SK2 channels preserves ER Ca2+ homeostasis and protects against ER stress-induced cell death

(2015) M Richter et al.   CELL DEATH AND DIFFERENTIATION

The therapeutic potential of chemical chaperones in protein folding diseases

(2014) Leonardo Cortez et al.   Prion

ER stress-induced cell death mechanisms

(2013) Renata Sano et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Selective, potent blockade of the IRE1 and ATF6 pathways by 4-phenylbutyric acid analogues

(2013) Hui Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Protective Effects of 4-Phenylbutyrate Derivatives on the Neuronal Cell Death and Endoplasmic Reticulum Stress

(2012) Seisuke Mimori et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Principles and Applications of Halogen Bonding in Medicinal Chemistry and Chemical Biology

(2012) Rainer Wilcken et al.   JOURNAL OF MEDICINAL CHEMISTRY

TUDCA, a Bile Acid, Attenuates Amyloid Precursor Protein Processing and Amyloid-β Deposition in APP/PS1 Mice

(2012) Ana F. Nunes et al.   MOLECULAR NEUROBIOLOGY

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Phenylbutyrate Up-regulates the DJ-1 Protein and Protects Neurons in Cell Culture and in Animal Models of Parkinson Disease

(2011) Wenbo Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unfolded proteins and endoplasmic reticulum stress in neurodegenerative disorders

(2011) Karen M. Doyle et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Chemical and Pharmacological Chaperones: Application for Recombinant Protein Production and Protein Folding Diseases

(2010) Rahul S. Rajan et al.   CURRENT MEDICINAL CHEMISTRY

Restoring endoplasmic reticulum function by chemical chaperones: an emerging therapeutic approach for metabolic diseases

(2010) F. Engin et al.   DIABETES OBESITY & METABOLISM

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS