High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators
Authors
Keywords
-
Journal
ACS Chemical Biology
Volume 17, Issue 3, Pages 709-722
Publisher
American Chemical Society (ACS)
Online
2022-03-01
DOI
10.1021/acschembio.2c00048
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Pondering the mechanism of receptor tyrosine kinase activation: The case for ligand-specific dimer microstate ensembles
- (2021) Kelly Karl et al. CURRENT OPINION IN STRUCTURAL BIOLOGY
- Receptor tyrosine kinase activation: From the ligand perspective
- (2020) Raphael Trenker et al. CURRENT OPINION IN CELL BIOLOGY
- Animal Models of Peripheral Pain: Biology Review and Application for Drug Discovery
- (2019) Saravanan Kaliyaperumal et al. TOXICOLOGIC PATHOLOGY
- Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor
- (2018) Franziska Kappert et al. CHEMISTRY-A EUROPEAN JOURNAL
- Kinase-targeted cancer therapies: progress, challenges and future directions
- (2018) Khushwant S. Bhullar et al. Molecular Cancer
- Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice
- (2018) Cyril Rivat et al. Nature Communications
- Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain
- (2018) Whitney R. Grither et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Receptor Tyrosine Kinase-Targeted Cancer Therapy
- (2018) Toshimitsu Yamaoka et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors
- (2018) Agustin Casimiro-Garcia et al. JOURNAL OF MEDICINAL CHEMISTRY
- Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions
- (2016) Christopher A. Lipinski ADVANCED DRUG DELIVERY REVIEWS
- Chimiothèque Nationale
- (2015) Florence Mahuteau-Betzer M S-MEDECINE SCIENCES
- Kinase inhibitors and monoclonal antibodies in oncology: clinical implications
- (2015) Helen Gharwan et al. Nature Reviews Clinical Oncology
- Allosteric targeting of receptor tyrosine kinases
- (2014) Frederik De Smet et al. NATURE BIOTECHNOLOGY
- CaMKK-CaMK1a, a New Post-Traumatic Signalling Pathway Induced in Mouse Somatosensory Neurons
- (2014) Lucie Elzière et al. PLoS One
- Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties
- (2013) Françoise Bono et al. CANCER CELL
- Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease
- (2013) Frank M. Longo et al. NATURE REVIEWS DRUG DISCOVERY
- Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice
- (2011) Maxime Cazorla et al. JOURNAL OF CLINICAL INVESTIGATION
- Cell Signaling by Receptor Tyrosine Kinases
- (2010) Mark A. Lemmon et al. CELL
- AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)
- (2009) P. P. Zarrinkar et al. BLOOD
- Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects
- (2009) Jorg Hartmann et al. CURRENT DRUG METABOLISM
- Efficient Production of Bioactive Recombinant Human Flt3 Ligand in E. coli
- (2009) Kenneth Verstraete et al. PROTEIN JOURNAL
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search