High-Throughput Screening for Extracellular Inhibitors of the FLT3 Receptor Tyrosine Kinase Reveals Chemically Diverse and Druggable Negative Allosteric Modulators

Pondering the mechanism of receptor tyrosine kinase activation: The case for ligand-specific dimer microstate ensembles

(2021) Kelly Karl et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Receptor tyrosine kinase activation: From the ligand perspective

(2020) Raphael Trenker et al.   CURRENT OPINION IN CELL BIOLOGY

Animal Models of Peripheral Pain: Biology Review and Application for Drug Discovery

(2019) Saravanan Kaliyaperumal et al.   TOXICOLOGIC PATHOLOGY

Structural Characterization of the Interaction of the Fibroblast Growth Factor Receptor with a Small Molecule Allosteric Inhibitor

(2018) Franziska Kappert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Kinase-targeted cancer therapies: progress, challenges and future directions

(2018) Khushwant S. Bhullar et al.   Molecular Cancer

Inhibition of neuronal FLT3 receptor tyrosine kinase alleviates peripheral neuropathic pain in mice

(2018) Cyril Rivat et al.   Nature Communications

Inhibition of tumor–microenvironment interaction and tumor invasion by small-molecule allosteric inhibitor of DDR2 extracellular domain

(2018) Whitney R. Grither et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Receptor Tyrosine Kinase-Targeted Cancer Therapy

(2018) Toshimitsu Yamaoka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Cyanamide-Based Janus Kinase 3 (JAK3) Covalent Inhibitors

(2018) Agustin Casimiro-Garcia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rule of five in 2015 and beyond: Target and ligand structural limitations, ligand chemistry structure and drug discovery project decisions

(2016) Christopher A. Lipinski   ADVANCED DRUG DELIVERY REVIEWS

Chimiothèque Nationale

(2015) Florence Mahuteau-Betzer   M S-MEDECINE SCIENCES

Kinase inhibitors and monoclonal antibodies in oncology: clinical implications

(2015) Helen Gharwan et al.   Nature Reviews Clinical Oncology

Allosteric targeting of receptor tyrosine kinases

(2014) Frederik De Smet et al.   NATURE BIOTECHNOLOGY

CaMKK-CaMK1a, a New Post-Traumatic Signalling Pathway Induced in Mouse Somatosensory Neurons

(2014) Lucie Elzière et al.   PLoS One

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

Small-molecule modulation of neurotrophin receptors: a strategy for the treatment of neurological disease

(2013) Frank M. Longo et al.   NATURE REVIEWS DRUG DISCOVERY

Identification of a low–molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

(2011) Maxime Cazorla et al.   JOURNAL OF CLINICAL INVESTIGATION

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

AC220 is a uniquely potent and selective inhibitor of FLT3 for the treatment of acute myeloid leukemia (AML)

(2009) P. P. Zarrinkar et al.   BLOOD

Tyrosine Kinase Inhibitors – A Review on Pharmacology, Metabolism and Side Effects

(2009) Jorg Hartmann et al.   CURRENT DRUG METABOLISM

Efficient Production of Bioactive Recombinant Human Flt3 Ligand in E. coli

(2009) Kenneth Verstraete et al.   PROTEIN JOURNAL