Pondering the mechanism of receptor tyrosine kinase activation: The case for ligand-specific dimer microstate ensembles

G-protein activation by a metabotropic glutamate receptor

(2021) Alpay B. Seven et al.   NATURE

Molecular basis for receptor tyrosine kinase A-loop tyrosine transphosphorylation

(2020) Lingfeng Chen et al.   Nature Chemical Biology

Receptor tyrosine kinase activation: From the ligand perspective

(2020) Raphael Trenker et al.   CURRENT OPINION IN CELL BIOLOGY

Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding

(2020) Suvrajit Maji et al.   Journal of Chemical Information and Modeling

Visualization of Ligand-Bound Ectodomain Assembly in the Full-Length Human IGF-1 Receptor by Cryo-EM Single-Particle Analysis

(2020) Xi Zhang et al.   STRUCTURE

EGFR forms ligand-independent oligomers that are distinct from the active state

(2020) Patrick O. Byrne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of human GABAB receptor in an inactive state

(2020) Jinseo Park et al.   NATURE

The biophysical basis of receptor tyrosine kinase ligand functional selectivity: Trk-B case study

(2020) Fozia Ahmed et al.   BIOCHEMICAL JOURNAL

Retrieving functional pathways of biomolecules from single-particle snapshots

(2020) Ali Dashti et al.   Nature Communications

Direct measurements of VEGF:VEGFR2 binding affinities reveal the coupling between ligand binding and receptor dimerization

(2019) Christopher King et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The transition model of RTK activation: A quantitative framework for understanding RTK signaling and RTK modulator activity

(2019) Michael D. Paul et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Structural basis of the activation of type 1 insulin-like growth factor receptor

(2019) Jie Li et al.   Nature Communications

Dimerization of the Trk receptors in the plasma membrane: effects of their cognate ligands

(2018) Fozia Ahmed et al.   BIOCHEMICAL JOURNAL

The RTK Interactome: Overview and Perspective on RTK Heterointeractions

(2018) Michael D. Paul et al.   CHEMICAL REVIEWS

Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV

(2017) Yi Zheng et al.   IMMUNITY

Two FGF Receptor Kinase Molecules Act in Concert to Recruit and Transphosphorylate Phospholipase Cγ

(2016) Zhifeng Huang et al.   MOLECULAR CELL

Crystal structures of the M1 and M4 muscarinic acetylcholine receptors

(2016) David M. Thal et al.   NATURE

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

(2016) Jie Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors

(2016) Jie Yin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of Membrane Protein Interactions in Plasma Membrane Derived Vesicles with Quantitative Imaging Förster Resonance Energy Transfer

(2015) Sarvenaz Sarabipour et al.   ACCOUNTS OF CHEMICAL RESEARCH

Structural analysis of the mechanism of phosphorylation of a critical autoregulatory tyrosine residue in FGFR1 kinase domain

(2015) Yoshihiro Kobashigawa et al.   GENES TO CELLS

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

(2015) Qifang Xu et al.   Science Signaling

Identifying three-dimensional structures of autophosphorylation complexes in crystals of protein kinases

(2015) Qifang Xu et al.   Science Signaling

Structure, domain organization, and different conformational states of stem cell factor-induced intact KIT dimers

(2014) Yarden Opatowsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Feedback and redundancy in receptor tyrosine kinase signaling: relevance to cancer therapies

(2014) Chong Sun et al.   TRENDS IN BIOCHEMICAL SCIENCES

Molecular Mechanism of SSR128129E, an Extracellularly Acting, Small-Molecule, Allosteric Inhibitor of FGF Receptor Signaling

(2013) Corentin Herbert et al.   CANCER CELL

Inhibition of Tumor Angiogenesis and Growth by a Small-Molecule Multi-FGF Receptor Blocker with Allosteric Properties

(2013) Françoise Bono et al.   CANCER CELL

Functional Proteomics Defines the Molecular Switch Underlying FGF Receptor Trafficking and Cellular Outputs

(2013) Chiara Francavilla et al.   MOLECULAR CELL

Exploring mechanisms of FGF signalling through the lens of structural biology

(2013) Regina Goetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state

(2013) Jianyun Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural Features for Functional Selectivity at Serotonin Receptors

(2013) D. Wacker et al.   SCIENCE

Inhibition of Basal FGF Receptor Signaling by Dimeric Grb2

(2012) Chi-Chuan Lin et al.   CELL

Mechanisms for Kinase-mediated Dimerization of the Epidermal Growth Factor Receptor

(2012) Chafen Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biased Signaling Pathways in  2-Adrenergic Receptor Characterized by 19F-NMR

(2012) J. J. Liu et al.   SCIENCE

Multiple ligand-specific conformations of the β2-adrenergic receptor

(2011) Alem W Kahsai et al.   Nature Chemical Biology

Simultaneous visualization of the extracellular and cytoplasmic domains of the epidermal growth factor receptor

(2011) Li-Zhi Mi et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

FGFR1 Amplification Drives Endocrine Therapy Resistance and Is a Therapeutic Target in Breast Cancer

(2010) N. Turner et al.   CANCER RESEARCH

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Emerging strategies for EphA2 receptor targeting for cancer therapeutics

(2010) Manish Tandon et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Measuring the Energetics of Membrane Protein Dimerization in Mammalian Membranes

(2010) Lirong Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric receptor contact is required for tyrosine autophosphorylation of fibroblast growth factor receptor in living cells

(2010) J. H. Bae et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

All EGF(ErbB) receptors have preformed homo- and heterodimeric structures in living cells

(2008) R.-H. Tao et al.   JOURNAL OF CELL SCIENCE

A crystallographic snapshot of tyrosine trans-phosphorylation in action

(2008) H. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA