Creating a customized intracellular niche: subversion of host cell signaling by Legionella type IV secretion system effectors

Soluble NSF attachment protein receptor molecular mimicry by aLegionella pneumophila Dot/Icm effector

(2015) Nathan P. King et al.   CELLULAR MICROBIOLOGY

Current and Emerging Legionella Diagnostics for Laboratory and Outbreak Investigations

(2015) Jeffrey W. Mercante et al.   CLINICAL MICROBIOLOGY REVIEWS

Diverse protist grazers select for virulence-related traits in Legionella

(2015) Francisco Amaro et al.   ISME Journal

Host–Pathogen Interaction Profiling Using Self-Assembling Human Protein Arrays

(2015) Xiaobo Yu et al.   JOURNAL OF PROTEOME RESEARCH

Novel export control of aLegionella Dot/Icm substrate is mediated by dual, independent signal sequences

(2015) Kwang Cheol Jeong et al.   MOLECULAR MICROBIOLOGY

Spatiotemporal Regulation of a Legionella pneumophila T4SS Substrate by the Metaeffector SidJ

(2015) Kwang Cheol Jeong et al.   PLoS Pathogens

The Legionella pneumophila Effector Protein, LegC7, Alters Yeast Endosomal Trafficking

(2015) Kevin M. O’Brien et al.   PLoS One

Lpg0393 of Legionella pneumophila Is a Guanine-Nucleotide Exchange Factor for Rab5, Rab21 and Rab22

(2015) Young-Sik Sohn et al.   PLoS One

Icm/Dot-dependent inhibition of phagocyte migration byLegionellais antagonized by a translocated Ran GTPase activator

(2014) Sylvia Simon et al.   CELLULAR MICROBIOLOGY

IroT/mavN, a new iron-regulated gene involved inLegionella pneumophilavirulence against amoebae and macrophages

(2014) Emilie Portier et al.   ENVIRONMENTAL MICROBIOLOGY

The Legionella longbeachae Icm/Dot Substrate SidC Selectively Binds Phosphatidylinositol 4-Phosphate with Nanomolar Affinity and Promotes Pathogen Vacuole-Endoplasmic Reticulum Interactions

(2014) Stephanie Dolinsky et al.   INFECTION AND IMMUNITY

A Type IV TranslocatedLegionellaCysteine Phytase Counteracts Intracellular Growth Restriction by Phytate

(2014) Stephen Weber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amino Acid Uptake and Metabolism ofLegionella pneumophilaHosted byAcanthamoeba castellanii

(2014) Eva Schunder et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Complete and Ubiquitinated Proteome of the Legionella-Containing Vacuole within Human Macrophages

(2014) William M. Bruckert et al.   JOURNAL OF PROTEOME RESEARCH

Epidemiology and clinical management of Legionnaires' disease

(2014) Nick Phin et al.   LANCET INFECTIOUS DISEASES

Bacteria–autophagy interplay: a battle for survival

(2014) Ju Huang et al.   NATURE REVIEWS MICROBIOLOGY

The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling

(2014) F. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the recruitment and activation of the Legionella phospholipase VipD by the host GTPase Rab5

(2014) M. Lucas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VipD is a Rab5-activated phospholipase A1 that protects Legionella pneumophila from endosomal fusion

(2014) A. H. Gaspar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal Structure of the Human, FIC-Domain Containing Protein HYPE and Implications for Its Functions

(2014) Tom D. Bunney et al.   STRUCTURE

Structural Basis for PI(4)P-Specific Membrane Recruitment of the Legionella pneumophila Effector DrrA/SidM

(2014) Claudia M. Del Campo et al.   STRUCTURE

Legionella pneumophilaSubversion of Host Vesicular Transport by SidC Effector Proteins

(2014) Florian A. Horenkamp et al.   TRAFFIC

Live-Cell Imaging of Phosphoinositide Dynamics and Membrane Architecture during Legionella Infection

(2014) S. Weber et al.   mBio

A New Method To Determine In Vivo Interactomes Reveals Binding of the Legionella pneumophila Effector PieE to Multiple Rab GTPases

(2014) A. Mousnier et al.   mBio

AMPylation Is Critical for Rab1 Localization to Vacuoles Containing Legionella pneumophila

(2014) C. A. Hardiman et al.   mBio

Global profiling of co- and post-translationally N-myristoylated proteomes in human cells

(2014) Emmanuelle Thinon et al.   Nature Communications

The Frustrated Host Response to Legionella pneumophila Is Bypassed by MyD88-Dependent Translation of Pro-inflammatory Cytokines

(2014) Seblewongel Asrat et al.   PLoS Pathogens

The Machinery at Endoplasmic Reticulum-Plasma Membrane Contact Sites Contributes to Spatial Regulation of Multiple Legionella Effector Proteins

(2014) Andree Hubber et al.   PLoS Pathogens

Structure of the N-terminal domain of the effector protein LegC3 fromLegionella pneumophila

(2014) Deqiang Yao et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Legionella pneumophila Effector RomA Uniquely Modifies Host Chromatin to Repress Gene Expression and Promote Intracellular Bacterial Replication

(2013) Monica Rolando et al.   Cell Host & Microbe

The Legionella Effector RidL Inhibits Retrograde Trafficking to Promote Intracellular Replication

(2013) Ivo Finsel et al.   Cell Host & Microbe

Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP

(2013) Qin Yu et al.   CELL RESEARCH

Functional analysis of novel Rab GTPases identified in the proteome of purifiedLegionella-containing vacuoles from macrophages

(2013) Christine Hoffmann et al.   CELLULAR MICROBIOLOGY

Structure of the Legionella effector AnkX reveals the mechanism of phosphocholine transfer by the FIC domain

(2013) Valérie Campanacci et al.   EMBO JOURNAL

SET-domain bacterial effectors target heterochromatin protein 1 to activate host rDNA transcription

(2013) Ting Li et al.   EMBO REPORTS

A bacterial protein promotes the recognition of theLegionella pneumophilavacuole by autophagy

(2013) Arwa A. Khweek et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Dot/Icm Effector SdhA Is Necessary for Virulence of Legionella pneumophila in Galleria mellonella and A/J Mice

(2013) Clare R. Harding et al.   INFECTION AND IMMUNITY

Targeting of the Small GTPase Rab6A′ by the Legionella pneumophila Effector LidA

(2013) Yang Chen et al.   INFECTION AND IMMUNITY

LtpD Is a Novel Legionella pneumophila Effector That Binds Phosphatidylinositol 3-Phosphate and Inositol Monophosphatase IMPA1

(2013) Clare R. Harding et al.   INFECTION AND IMMUNITY

Biofilms: The Stronghold of Legionella pneumophila

(2013) Mena Abdel-Nour et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

TheLegionella pneumophilaDot/Icm-secreted Effector PlcC/CegC1 Together with PlcA and PlcB Promotes Virulence and Belongs to a Novel Zinc Metallophospholipase C Family Present in Bacteria and Fungi

(2013) Philipp Aurass et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and Structural Characterization of aLegionellaPhosphoinositide Phosphatase

(2013) Leila Toulabi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Legionella pneumophila GTPase Activating Protein LepB Accelerates Rab1 Deactivation by a Non-canonical Hydrolytic Mechanism

(2013) Ashwini K. Mishra et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

(2013) Megan H. Wright et al.   Nature Chemistry

Pathogen signatures activate a ubiquitination pathway that modulates the function of the metabolic checkpoint kinase mTOR

(2013) Stanimir S Ivanov et al.   NATURE IMMUNOLOGY

LegC3, an Effector Protein from Legionella pneumophila, Inhibits Homotypic Yeast Vacuole Fusion In Vivo and In Vitro

(2013) Terry L. Bennett et al.   PLoS One

Computational modeling and experimental validation of the Legionella and Coxiella virulence-related type-IVB secretion signal

(2013) Z. Lifshitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for Rab1 De-AMPylation by the Legionella pneumophila Effector SidD

(2013) Yang Chen et al.   PLoS Pathogens

Activation of Ran GTPase by a Legionella Effector Promotes Microtubule Polymerization, Pathogen Vacuole Motility and Infection

(2013) Eva Rothmeier et al.   PLoS Pathogens

The crystal structure of LidA, a translocated substrate of the Legionella pneumophila type IV secretion system

(2013) Geng Meng et al.   Protein & Cell

The Legionella pneumophila Effector DrrA Is Sufficient to Stimulate SNARE-Dependent Membrane Fusion

(2012) Kohei Arasaki et al.   Cell Host & Microbe

Mechanism of invasion of lung epithelial cells by filamentousLegionella pneumophila

(2012) Akriti Prashar et al.   CELLULAR MICROBIOLOGY

Domain organization of Legionella effector SetA

(2012) Thomas Jank et al.   CELLULAR MICROBIOLOGY

Reversible phosphocholination of Rab proteins byLegionella pneumophilaeffector proteins

(2012) Philip R Goody et al.   EMBO JOURNAL

Legionella pneumophila LidA Affects Nucleotide Binding and Activity of the Host GTPase Rab1

(2012) M. R. Neunuebel et al.   JOURNAL OF BACTERIOLOGY

BAG6/BAT3: emerging roles in quality control for nascent polypeptides

(2012) H. Kawahara et al.   JOURNAL OF BIOCHEMISTRY

The protein SdhA maintains the integrity of the Legionella-containing vacuole

(2012) E. A. Creasey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for substrate recognition by a unique Legionella phosphoinositide phosphatase

(2012) F. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking

(2012) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggravating Genetic Interactions Allow a Solution to Redundancy in a Bacterial Pathogen

(2012) T. J. O'Connor et al.   SCIENCE

The Legionella Effector RavZ Inhibits Host Autophagy Through Irreversible Atg8 Deconjugation

(2012) A. Choy et al.   SCIENCE

Bacterial Pathogens Commandeer Rab GTPases to Establish Intracellular Niches

(2012) Mary-Pat Stein et al.   TRAFFIC

The Legionella pneumophila Effector VipA Is an Actin Nucleator That Alters Host Cell Organelle Trafficking

(2012) Irina Saraiva Franco et al.   PLoS Pathogens

Structural Insights into a Unique Legionella pneumophila Effector LidA Recognizing Both GDP and GTP Bound Rab1 in Their Active State

(2012) Wei Cheng et al.   PLoS Pathogens

Legionella pneumophila Secretes a Mitochondrial Carrier Protein during Infection

(2012) Pavel Dolezal et al.   PLoS Pathogens

VipD of Legionella pneumophila Targets Activated Rab5 and Rab22 to Interfere with Endosomal Trafficking in Macrophages

(2012) Bonsu Ku et al.   PLoS Pathogens

The Capping Domain in RalF Regulates Effector Functions

(2012) Eric Alix et al.   PLoS Pathogens

Identification of Two Legionella pneumophila Effectors that Manipulate Host Phospholipids Biosynthesis

(2012) Ram Viner et al.   PLoS Pathogens

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes

(2011) Mikael Altun et al.   CHEMISTRY & BIOLOGY

Protein Kinase LegK2 Is a Type IV Secretion System Effector Involved in Endoplasmic Reticulum Recruitment and Intracellular Replication of Legionella pneumophila

(2011) Eva Hervet et al.   INFECTION AND IMMUNITY

A Chemical Reporter for Protein AMPylation

(2011) Markus Grammel et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Legionella pneumophila SidD is a deAMPylase that modifies Rab1

(2011) Yunhao Tan et al.   NATURE

Modulation of Rab GTPase function by a protein phosphocholine transferase

(2011) Shaeri Mukherjee et al.   NATURE

Comprehensive Identification of Protein Substrates of the Dot/Icm Type IV Transporter of Legionella pneumophila

(2011) Wenhan Zhu et al.   PLoS One

Minimization of the Legionella pneumophila genome reveals chromosomal regions involved in host range expansion

(2011) T. J. O'Connor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein LidA from Legionella is a Rab GTPase supereffector

(2011) S. Schoebel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Legionella pneumophila regulates the small GTPase Rab1 activity by reversible phosphorylcholination

(2011) Y. Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Proteasomal Degradation Generates Amino Acids Essential for Intracellular Bacterial Growth

(2011) C. T. D. Price et al.   SCIENCE

De-AMPylation of the Small GTPase Rab1 by the Pathogen Legionella pneumophila

(2011) M. R. Neunuebel et al.   SCIENCE

Retrograde Transport: Two (or More) Roads Diverged in an Endosomal Tree?

(2011) Ludger Johannes et al.   TRAFFIC

Secreted Bacterial Effectors That Inhibit Host Protein Synthesis Are Critical for Induction of the Innate Immune Response to Virulent Legionella pneumophila

(2011) Mary F. Fontana et al.   PLoS Pathogens

Comparative and Functional Genomics of Legionella Identified Eukaryotic Like Proteins as Key Players in Host?Pathogen Interactions

(2011) Laura Gomez-Valero et al.   Frontiers in Microbiology

Chemical Probes of Surface Layer Biogenesis inClostridium difficile

(2010) T. H. Tam Dang et al.   ACS Chemical Biology

Bacterial Contact-Dependent Delivery Systems

(2010) Christopher S. Hayes et al.   Annual Review of Genetics

The Legionella pneumophila F-box protein Lpp2082 (AnkB) modulates ubiquitination of the host protein parvin B and promotes intracellular replication

(2010) M. Lomma et al.   CELLULAR MICROBIOLOGY

LnaB: a Legionella pneumophila activator of NF-κB

(2010) Vicki P. Losick et al.   CELLULAR MICROBIOLOGY

The E Block motif is associated with Legionella pneumophila translocated substrates

(2010) Li Huang et al.   CELLULAR MICROBIOLOGY

The Versatility of Helicobacter pylori CagA Effector Protein Functions: The Master Key Hypothesis

(2010) Steffen Backert et al.   HELICOBACTER

E3 Ubiquitin Ligase Activity and Targeting of BAT3 by Multiple Legionella pneumophila Translocated Substrates

(2010) A. W. Ensminger et al.   INFECTION AND IMMUNITY

The origins of eukaryotic-like proteins in Legionella pneumophila

(2010) Mor N. Lurie-Weinberger et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Glucose Metabolism in Legionella pneumophila: Dependence on the Entner-Doudoroff Pathway and Connection with Intracellular Bacterial Growth

(2010) E. Harada et al.   JOURNAL OF BACTERIOLOGY

Legionella pneumophila Strain 130b Possesses a Unique Combination of Type IV Secretion Systems and Novel Dot/Icm Secretion System Effector Proteins

(2010) G. N. Schroeder et al.   JOURNAL OF BACTERIOLOGY

Lipidation by the Host Prenyltransferase Machinery Facilitates Membrane Localization ofLegionella pneumophilaEffector Proteins

(2010) Stanimir S. Ivanov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exploitation of conserved eukaryotic host cell farnesylation machinery by an F-box effector ofLegionella pneumophila

(2010) Christopher T.D. Price et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The Legionella Effector Protein DrrA AMPylates the Membrane Traffic Regulator Rab1b

(2010) M. P. Muller et al.   SCIENCE

Inhibition of Host Vacuolar H+-ATPase Activity by a Legionella pneumophila Effector

(2010) Li Xu et al.   PLoS Pathogens

Legionella Metaeffector Exploits Host Proteasome to Temporally Regulate Cognate Effector

(2010) Tomoko Kubori et al.   PLoS Pathogens

Molecular mechanism of elongation factor 1A inhibition by aLegionella pneumophilaglycosyltransferase

(2009) Ramon Hurtado-Guerrero et al.   BIOCHEMICAL JOURNAL

Temporal resolution of two-tracked NF-κB activation byLegionella pneumophila

(2009) Sina Bartfeld et al.   CELLULAR MICROBIOLOGY

Targeting eEF1A by aLegionella pneumophilaeffector leads to inhibition of protein synthesis and induction of host stress response

(2009) Xihui Shen et al.   CELLULAR MICROBIOLOGY

ALegionellaeffector acquired from protozoa is involved in sphingolipids metabolism and is targeted to the host cell mitochondria

(2009) Elena Degtyar et al.   CELLULAR MICROBIOLOGY

Proteomic analysis of Legionella-containing phagosomes isolated from Dictyostelium

(2009) Olga Shevchuk et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

RabGDI Displacement by DrrA from Legionella Is a Consequence of Its Guanine Nucleotide Exchange Activity

(2009) Stefan Schoebel et al.   MOLECULAR CELL

A Legionella type IV effector activates the NF- B pathway by phosphorylating the I B family of inhibitors

(2009) J. Ge et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteome Analysis of Legionella Vacuoles Purified by Magnetic Immunoseparation Reveals Secretory and Endosomal GTPases

(2009) Simon Urwyler et al.   TRAFFIC

Genome-Scale Identification of Legionella pneumophila Effectors Using a Machine Learning Approach

(2009) David Burstein et al.   PLoS Pathogens

Molecular Mimicry by an F-Box Effector of Legionella pneumophila Hijacks a Conserved Polyubiquitination Machinery within Macrophages and Protozoa

(2009) Christopher T. Price et al.   PLoS Pathogens

Identification of Host Cytosolic Sensors and Bacterial Factors Regulating the Type I Interferon Response to Legionella pneumophila

(2009) Kathryn M. Monroe et al.   PLoS Pathogens

TheLegionella pneumophilaphosphatidylinositol-4 phosphate-binding type IV substrate SidC recruits endoplasmic reticulum vesicles to a replication-permissive vacuole

(2008) Curdin Ragaz et al.   CELLULAR MICROBIOLOGY

Modulation of ubiquitin dynamics and suppression of DALIS formation by theLegionella pneumophilaDot/Icm system

(2008) Stanimir S. Ivanov et al.   CELLULAR MICROBIOLOGY

Large-scale identification ofLegionella pneumophilaDot/Icm substrates that modulate host cell vesicle trafficking pathways

(2008) Matthew Heidtman et al.   CELLULAR MICROBIOLOGY

The inositol polyphosphate 5-phosphatase OCRL1 restricts intracellular growth ofLegionella, localizes to the replicative vacuole and binds to the bacterial effector LpnE

(2008) Stefan S. Weber et al.   CELLULAR MICROBIOLOGY

Editorial Commentary:Community‐Acquired Legionnaires Disease: Implications for Underdiagnosis and Laboratory Testing

(2008) Victor L. Yu et al.   CLINICAL INFECTIOUS DISEASES

Community‐AcquiredLegionellaPneumonia: New Insights from the German Competence Network for Community Acquired Pneumonia

(2008) Heike von Baum et al.   CLINICAL INFECTIOUS DISEASES

Lgt: a Family of Cytotoxic Glucosyltransferases Produced by Legionella pneumophila

(2008) Y. Belyi et al.   JOURNAL OF BACTERIOLOGY

Rab1 Guanine Nucleotide Exchange Factor SidM Is a Major Phosphatidylinositol 4-Phosphate-binding Effector Protein ofLegionella pneumophila

(2008) Eva Brombacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Legionella translocates an E3 ubiquitin ligase that has multiple U-boxes with distinct functions

(2008) Tomoko Kubori et al.   MOLECULAR MICROBIOLOGY

Ankyrin Repeat Proteins Comprise a Diverse Family of Bacterial Type IV Effectors

(2008) X. Pan et al.   SCIENCE

Legionella Eukaryotic-Like Type IV Substrates Interfere with Organelle Trafficking

(2008) Karim Suwwan de Felipe et al.   PLoS Pathogens

Type IV Secretion-Dependent Activation of Host MAP Kinases Induces an Increased Proinflammatory Cytokine Response to Legionella pneumophila

(2008) Sunny Shin et al.   PLoS Pathogens

Icm/Dot-dependent upregulation of phagocytosis by Legionella pneumophila

(2003) Hubert Hilbi et al.   MOLECULAR MICROBIOLOGY