The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC

Translational inhibition by deadenylation-independent mechanisms is central to microRNA-mediated silencing in zebrafish

(2012) Y. Mishima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

miRNA-Mediated Gene Silencing by Translational Repression Followed by mRNA Deadenylation and Decay

(2012) S. Djuranovic et al.   SCIENCE

Ribosome Profiling Shows That miR-430 Reduces Translation Before Causing mRNA Decay in Zebrafish

(2012) A. A. Bazzini et al.   SCIENCE

HuR-dependent loading of miRNA RISC to the mRNA encoding the Ras-related small GTPase RhoB controls its translation during UV-induced apoptosis

(2011) V Glorian et al.   CELL DEATH AND DIFFERENTIATION

PABP is not essential for microRNA-mediated translational repression and deadenylationin vitro

(2011) Takashi Fukaya et al.   EMBO JOURNAL

Structural analysis of 5′-mRNA–cap interactions with the human AGO2 MID domain

(2011) Filipp Frank et al.   EMBO REPORTS

Competitive Regulation of Nucleolin Expression by HuR and miR-494

(2011) K. Tominaga et al.   MOLECULAR AND CELLULAR BIOLOGY

The mRNA Stability Factor HuR Inhibits MicroRNA-16 Targeting of COX-2

(2011) L. E. Young et al.   MOLECULAR CANCER RESEARCH

GW182 Proteins Directly Recruit Cytoplasmic Deadenylase Complexes to miRNA Targets

(2011) Joerg E. Braun et al.   MOLECULAR CELL

Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing

(2011) Hong Su et al.   MOLECULAR CELL

Integrative Regulatory Mapping Indicates that the RNA-Binding Protein HuR Couples Pre-mRNA Processing and mRNA Stability

(2011) Neelanjan Mukherjee et al.   MOLECULAR CELL

Transcriptome-wide Analysis of Regulatory Interactions of the RNA-Binding Protein HuR

(2011) Svetlana Lebedeva et al.   MOLECULAR CELL

miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4–NOT

(2011) Marc R Fabian et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

miRNA repression involves GW182-mediated recruitment of CCR4–NOT through conserved W-containing motifs

(2011) Marina Chekulaeva et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Ataxin-2 protein is required for microRNA function and synapse-specific long-term olfactory habituation

(2011) C. McCann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Parsimonious Model for Gene Regulation by miRNAs

(2011) S. Djuranovic et al.   SCIENCE

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Two PABPC1-binding sites in GW182 proteins promote miRNA-mediated gene silencing

(2010) Eric Huntzinger et al.   EMBO JOURNAL

Translational Repression by Deadenylases

(2010) Amy Cooke et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Basis of Binding of P-body-associated Proteins GW182 and Ataxin-2 by the Mlle Domain of Poly(A)-binding Protein

(2010) Guennadi Kozlov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CCR4-NOT Deadenylates mRNA Associated with RNA-Induced Silencing Complexes in Human Cells

(2010) X. Piao et al.   MOLECULAR AND CELLULAR BIOLOGY

Identifying targets of miR-143 using a SILAC-based proteomic approach

(2010) Yi Yang et al.   Molecular BioSystems

Pervasive and Cooperative Deadenylation of 3′UTRs by Embryonic MicroRNA Families

(2010) Edlyn Wu et al.   MOLECULAR CELL

Mammalian microRNAs predominantly act to decrease target mRNA levels

(2010) Huili Guo et al.   NATURE

A Pumilio-induced RNA structure switch in p27-3′ UTR controls miR-221 and miR-222 accessibility

(2010) Martijn Kedde et al.   NATURE CELL BIOLOGY

Allosteric regulation of Argonaute proteins by miRNAs

(2010) Sergej Djuranovic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation

(2010) Martin Jinek et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The GW/WG repeats of Drosophila GW182 function as effector motifs for miRNA-mediated repression

(2010) Marina Chekulaeva et al.   NUCLEIC ACIDS RESEARCH

The Structural and Functional Diversity of Metabolite-Binding Riboswitches

(2009) Adam Roth et al.   Annual Review of Biochemistry

The human Ago2 MC region does not contain an eIF4E-like mRNA cap binding motif

(2009) Lisa N Kinch et al.   Biology Direct

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Repression of C. elegans microRNA targets at the initiation level of translation requires GW182 proteins

(2009) Xavier C Ding et al.   EMBO JOURNAL

HuR recruits let-7/RISC to repress c-Myc expression

(2009) H. H. Kim et al.   GENES & DEVELOPMENT

The Silencing Domain of GW182 Interacts with PABPC1 To Promote Translational Repression and Degradation of MicroRNA Targets and Is Required for Target Release

(2009) L. Zekri et al.   MOLECULAR AND CELLULAR BIOLOGY

Drosophila miR2 Primarily Targets the m7GpppN Cap Structure for Translational Repression

(2009) Agnieszka Zdanowicz et al.   MOLECULAR CELL

Mammalian miRNA RISC Recruits CAF1 and PABP to Affect PABP-Dependent Deadenylation

(2009) Marc R. Fabian et al.   MOLECULAR CELL

Ago–TNRC6 triggers microRNA-mediated decay by promoting two deadenylation steps

(2009) Chyi-Ying A Chen et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A Coordinated Local Translational Control Point at the Synapse Involving Relief from Silencing and MOV10 Degradation

(2009) Sourav Banerjee et al.   NEURON

The RRM domain in GW182 proteins contributes to miRNA-mediated gene silencing

(2009) Ana Eulalio et al.   NUCLEIC ACIDS RESEARCH

Importance of the C-terminal domain of the human GW182 protein TNRC6C for translational repression

(2009) J. T. Zipprich et al.   RNA

Multiple independent domains of dGW182 function in miRNA-mediated repression in Drosophila

(2009) M. Chekulaeva et al.   RNA

Mammalian GW182 contains multiple Argonaute-binding sites and functions in microRNA-mediated translational repression

(2009) K. Takimoto et al.   RNA

The GW182 protein family in animal cells: New insights into domains required for miRNA-mediated gene silencing

(2009) A. Eulalio et al.   RNA

The C-terminal half of human Ago2 binds to multiple GW-rich regions of GW182 and requires GW182 to mediate silencing

(2009) S. L. Lian et al.   RNA

A C-terminal silencing domain in GW182 is essential for miRNA function

(2009) A. Eulalio et al.   RNA

Poly(A)-binding protein modulates mRNA susceptibility to cap-dependent miRNA-mediated repression

(2009) R. W. Walters et al.   RNA

BTG/TOB factors impact deadenylases

(2009) Fabienne Mauxion et al.   TRENDS IN BIOCHEMICAL SCIENCES

Concordant Regulation of Translation and mRNA Abundance for Hundreds of Targets of a Human microRNA

(2009) David G. Hendrickson et al.   PLOS BIOLOGY

Getting to the Root of miRNA-Mediated Gene Silencing

(2008) Ana Eulalio et al.   CELL

Spinocerebellar ataxia 2 (SCA2)

(2008) Isabel Lastres-Becker et al.   CEREBELLUM

Riboswitch RNAs: using RNA to sense cellular metabolism

(2008) T. M. Henkin   GENES & DEVELOPMENT

The impact of microRNAs on protein output

(2008) Daehyun Baek et al.   NATURE

Widespread changes in protein synthesis induced by microRNAs

(2008) Matthias Selbach et al.   NATURE

GW182 interaction with Argonaute is essential for miRNA-mediated translational repression and mRNA decay

(2008) Ana Eulalio et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative Analysis of mRNA Targets for Human PUF-Family Proteins Suggests Extensive Interaction with the miRNA Regulatory System

(2008) Alessia Galgano et al.   PLoS One

MicroRNA-repressed mRNAs contain 40S but not 60S components

(2008) B. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deadenylation is a widespread effect of miRNA regulation

(2008) A. Eulalio et al.   RNA