Chronic cerebral aspects of long COVID, post‐stroke syndromes and similar states share their pathogenesis and perispinal etanercept treatment logic

Post-COVID syndrome and suicide risk

(2021) Leo Sher   QJM-AN INTERNATIONAL JOURNAL OF MEDICINE

Delirium is common in patients hospitalized with COVID-19

(2021) Leiv Otto Watne et al.   Internal and Emergency Medicine

Lyme disease: “End of the debate?”

(2021) Guillaume Coiffier et al.   JOINT BONE SPINE

Elevated plasma levels of galectin-3 binding protein are associated with post-stroke delirium – A pilot study

(2021) Elzbieta Klimiec-Moskal et al.   JOURNAL OF NEUROIMMUNOLOGY

Factors associated with multiple suicide attempts in a nationally representative study of U.S. military veterans

(2021) Brandon Nichter et al.   JOURNAL OF PSYCHIATRIC RESEARCH

Dysregulation of brain and choroid plexus cell types in severe COVID-19

(2021) Andrew C. Yang et al.   NATURE

Implications of Innate Immunity in Post-Acute Sequelae of Non-Persistent Viral Infections

(2021) Maximilian Hirschenberger et al.   Cells

Refining “Long-COVID” by a Prospective Multimodal Evaluation of Patients with Long-Term Symptoms Attributed to SARS-CoV-2 Infection

(2021) Marc Scherlinger et al.   Infectious Diseases and Therapy

How diseases caused by parasites allowed a wider understanding of disease in general: my encounters with parasitology in Australia and elsewhere over the last 50 years

(2021) Ian A. Clark   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Immune-mediated inflammation across disease boundaries: breaking down research silos

(2021) Christopher D. Buckley et al.   NATURE IMMUNOLOGY

Assessment of Cognitive Function in Patients After COVID-19 Infection

(2021) Jacqueline H. Becker et al.   JAMA Network Open

Phase I/II parallel double-blind randomized controlled clinical trial of perispinal etanercept for chronic stroke: improved mobility and pain alleviation

(2020) Stephen J. Ralph et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Randomized controlled trial validating the use of perispinal etanercept to reduce post-stroke disability has wide-ranging implications

(2020) Ian A Clark   Expert Review of Neurotherapeutics

The many faces of the anti-COVID immune response

(2020) Santosha A. Vardhana et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Extracellular HMGB1: a therapeutic target in severe pulmonary inflammation including COVID-19?

(2020) Ulf Andersson et al.   MOLECULAR MEDICINE

Neurologic Features in Severe SARS-CoV-2 Infection

(2020) Julie Helms et al.   NEW ENGLAND JOURNAL OF MEDICINE

The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings

(2020) Ross W Paterson et al.   BRAIN

Brain TNF drives post-inflammation depression-like behavior and persistent pain in experimental arthritis

(2020) Fernando Lopes et al.   BRAIN BEHAVIOR AND IMMUNITY

Revisiting the Vertebral Venous Plexus–A Comprehensive Review of the Literature

(2020) Kennedy Carpenter et al.   World Neurosurgery

Traumatic Brain Injury and Suicidal Behavior: A Review

(2019) Abhishek Wadhawan et al.   JOURNAL OF ALZHEIMERS DISEASE

Dissemination of brain inflammation in traumatic brain injury

(2019) Kaibin Shi et al.   Cellular & Molecular Immunology

Perispinal injection of a TNF blocker directed to the brain of rats alleviates the sensory and affective components of chronic constriction injury-induced neuropathic pain

(2019) Zach M. LaMacchia et al.   BRAIN BEHAVIOR AND IMMUNITY

Global brain inflammation in stroke

(2019) Kaibin Shi et al.   LANCET NEUROLOGY

Human cerebral malaria: 2019 mini review

(2019) F. Bruneel   REVUE NEUROLOGIQUE

Beyond Host Defense: Emerging Functions of the Immune System in Regulating Complex Tissue Physiology

(2018) Lucille C. Rankin et al.   CELL

Expression analysis of HMGB1 in histological samples of malignant pleural mesothelioma

(2018) Eltjona Rrapaj et al.   HISTOPATHOLOGY

Assessment of HMGB-1 concentration in tick-borne encephalitis and neuroborreliosis

(2018) Anna Moniuszko-Malinowska et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Inflammation arising from obesity reduces taste bud abundance and inhibits renewal

(2018) Andrew Kaufman et al.   PLOS BIOLOGY

The Inflammatory Nature of Post-surgical Delirium Predicts Benefit of Agents With Anti-TNF Effects, Such as Dexmedetomidine

(2018) Ian A. Clark et al.   Frontiers in Neuroscience

An unsound AAN Practice Advisory on poststroke etanercept

(2017) Ian A. Clark   Expert Review of Neurotherapeutics

Alarmins: Feel the Stress

(2017) Peleg Rider et al.   JOURNAL OF IMMUNOLOGY

Elevated cerebrospinal fluid tumour necrosis factor is associated with acute and long-term neurocognitive impairment in cerebral malaria

(2017) E. Shabani et al.   PARASITE IMMUNOLOGY

An unsound AAN Practice Advisory on poststroke etanercept

(2017) Ian A. Clark   Expert Review of Neurotherapeutics

The danger zone: Systematic review of the role of HMGB1 danger signalling in traumatic brain injury

(2016) Taylor M. Parker et al.   BRAIN INJURY

Perispinal Delivery of CNS Drugs

(2016) Edward Lewis Tobinick   CNS DRUGS

Protective role of dexmedetomidine in unmethylated CpG-induced inflammation responses in BV2 microglia cells

(2016) Chen Chen et al.   FOLIA NEUROPATHOLOGICA

Inhibiting High-Mobility Group Box 1 (HMGB1) Attenuates Inflammatory Cytokine Expression and Neurological Deficit in Ischemic Brain Injury Following Cardiac Arrest in Rats

(2016) Mei Xu et al.   INFLAMMATION

Excess cerebral TNF causing glutamate excitotoxicity rationalizes treatment of neurodegenerative diseases and neurogenic pain by anti-TNF agents

(2016) Ian A. Clark et al.   Journal of Neuroinflammation

Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial

(2016) Xian Su et al.   LANCET

Modulatory Effects of Antidepressant Classes on the Innate and Adaptive Immune System in Depression

(2016) H. Eyre et al.   PHARMACOPSYCHIATRY

Systemic HMGB1 Neutralization Prevents Postoperative Neurocognitive Dysfunction in Aged Rats

(2016) Niccolò Terrando et al.   Frontiers in Immunology

Tumor necrosis factor alpha and its receptors in behaviour and neurobiology of adult mice, in the absence of an immune challenge

(2015) Marie Lou Camara et al.   BEHAVIOURAL BRAIN RESEARCH

Regulation of bitter taste responses by tumor necrosis factor

(2015) Pu Feng et al.   BRAIN BEHAVIOR AND IMMUNITY

Amyloid β: one of three danger-associated molecules that are secondary inducers of the proinflammatory cytokines that mediate Alzheimer's disease

(2015) I A Clark et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neurological sequelae induced by alphavirus infection of the CNS are attenuated by treatment with the glutamine antagonist 6-diazo-5-oxo-l-norleucine

(2015) Michelle C. Potter et al.   JOURNAL OF NEUROVIROLOGY

Chronic constriction injury-induced nociception is relieved by nanomedicine-mediated decrease of rat hippocampal tumor necrosis factor

(2015) Elizabeth Gerard et al.   PAIN

Exploratory Cohort Study of Associations between Serum C - Reactive Protein and Fatigue after Stroke

(2015) Simiao Wu et al.   PLoS One

Proinflammatory milieu in combat-related PTSD is independent of depression and early life stress

(2014) Daniel Lindqvist et al.   BRAIN BEHAVIOR AND IMMUNITY

Positive Feedback Loop of Autocrine BDNF from Microglia Causes Prolonged Microglia Activation

(2014) Xin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

A high mobility group box 1 (HMGB1) gene from Chlamys farreri and the DNA-binding ability and pro-inflammatory activity of its recombinant protein

(2014) Mengqiang Wang et al.   FISH & SHELLFISH IMMUNOLOGY

Gabapentin, a Synthetic Analogue of Gamma Aminobutyric Acid, Reverses Systemic Acute Inflammation and Oxidative Stress in Mice

(2014) Jordana Maia Dias et al.   INFLAMMATION

Systemic Release of High Mobility Group Box 1 Protein during Severe Murine Influenza

(2014) L. M. Alleva et al.   JOURNAL OF IMMUNOLOGY

Gabapentin Enhances the Morphine Anti-Nociceptive Effect in Neuropathic Pain via the Interleukin-10-Heme Oxygenase-1 Signalling Pathway in Rats

(2014) Yu-Hua Bao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Inflammation-sleep interface in brain disease: TNF, insulin, orexin

(2014) Ian A Clark et al.   Journal of Neuroinflammation

Respiratory Viral Infection in Neonatal Piglets Causes Marked Microglia Activation in the Hippocampus and Deficits in Spatial Learning

(2014) M. R. P. Elmore et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Patients with Chronic Fatigue Syndrome/Myalgic Encephalomyelitis: An 11C-(R)-PK11195 PET Study

(2014) Y. Nakatomi et al.   JOURNAL OF NUCLEAR MEDICINE

TNF-α/TNFR1 Signaling Is Required for the Development and Function of Primary Nociceptors

(2014) Michael A. Wheeler et al.   NEURON

Long-Term Functional Consequences and Ongoing Cerebral Inflammation after Subarachnoid Hemorrhage in the Rat

(2014) Elke Kooijman et al.   PLoS One

Evolution of TNF-induced apoptosis reveals 550 My of functional conservation

(2014) Steven D. Quistad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Two Types of TNF-  Exist in Teleost Fish: Phylogeny, Expression, and Bioactivity Analysis of Type-II TNF- 3 in Rainbow Trout Oncorhynchus mykiss

(2013) S. Hong et al.   JOURNAL OF IMMUNOLOGY

IL-1β and TNF-α induce neurotoxicity through glutamate production: a potential role for neuronal glutaminase

(2013) Ling Ye et al.   JOURNAL OF NEUROCHEMISTRY

Learning and memory ... and the immune system

(2013) I. Marin et al.   LEARNING & MEMORY

Maternal hematopoietic TNF, via milk chemokines, programs hippocampal development and memory

(2013) Bingfang Liu et al.   NATURE NEUROSCIENCE

TNF-Α May Mediate Inflammasome Activation in the Absence of Bacterial Infection in More than One Way

(2013) Susana Álvarez et al.   PLoS One

Congestive heart failure as a determinant of postoperative delirium

(2013) Daniela Parente et al.   Revista Portuguesa de Cardiologia

Discrepancies between patients and physicians in their perceptions of rheumatoid arthritis disease activity

(2012) Paul Studenic et al.   ARTHRITIS AND RHEUMATISM

At the extreme end of the psychoneuroimmunological spectrum: Delirium as a maladaptive sickness behaviour response

(2012) Colm Cunningham et al.   BRAIN BEHAVIOR AND IMMUNITY

Selective TNF Inhibition for Chronic Stroke and Traumatic Brain Injury

(2012) Edward Tobinick et al.   CNS DRUGS

Surgery Upregulates High Mobility Group Box-1 and Disrupts the Blood-Brain Barrier causing Cognitive Dysfunction in Aged Rats

(2012) Hui-Juan He et al.   CNS Neuroscience & Therapeutics

Long-term impact of systemic bacterial infection on the cerebral vasculature and microglia

(2012) Ursula Püntener et al.   Journal of Neuroinflammation

Influenza Infection Induces Neuroinflammation, Alters Hippocampal Neuron Morphology, and Impairs Cognition in Adult Mice

(2012) H. A. Jurgens et al.   JOURNAL OF NEUROSCIENCE

Direct venous spinal reabsorption of cerebrospinal fluid: a new concept with serial magnetic resonance cisternography in rabbits

(2012) Huseyin Biceroglu et al.   JOURNAL OF NEUROSURGERY-SPINE

Institutionalized Stroke Patients: Status of Functioning of an Under Researched Population

(2012) Suzanne van Almenkerk et al.   Journal of the American Medical Directors Association

Severe Stroke Induces Long-Lasting Alterations of High-Mobility Group Box 1

(2012) Juliane Schulze et al.   STROKE

Distinguishing malaria and influenza: Early clinical features in controlled human experimental infection studies

(2012) Patrick J. Lillie et al.   Travel Medicine and Infectious Disease

Inflammation after trauma: Microglial activation and traumatic brain injury

(2011) Anil F. Ramlackhansingh et al.   ANNALS OF NEUROLOGY

Rapid Improvement of Chronic Stroke Deficits after Perispinal Etanercept

(2011) Edward Tobinick   CNS DRUGS

TNF-α induced secretion of HMGB1 from non-immune canine mammary epithelial cells (MTH53A)

(2011) Saskia Willenbrock et al.   CYTOKINE

The role of TNF-α in inflammatory olfactory loss

(2011) Babar Sultan et al.   LARYNGOSCOPE

Tumor necrosis factor-alpha regulates the Hypocretin system via mRNA degradation and ubiquitination

(2010) Shuqin Zhan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Immune modulation of learning, memory, neural plasticity and neurogenesis

(2010) Raz Yirmiya et al.   BRAIN BEHAVIOR AND IMMUNITY

Perispinal etanercept: a new therapeutic paradigm in neurology

(2010) Edward Tobinick   Expert Review of Neurotherapeutics

The expression of two novel orange-spotted grouper (Epinephelus coioides) TNF genes in peripheral blood leukocytes, various organs, and fish larvae

(2010) Freda Wai-San Lam et al.   FISH & SHELLFISH IMMUNOLOGY

Therapeutic evaluation of etanercept in a model of traumatic brain injury

(2010) Chung-Ching Chio et al.   JOURNAL OF NEUROCHEMISTRY

Outcomes of Children Treated for Lyme Arthritis: Results of a Large Pediatric Cohort

(2010) H. O. TORY et al.   JOURNAL OF RHEUMATOLOGY

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

The roles of TNF in brain dysfunction and disease

(2010) Ian A. Clark et al.   PHARMACOLOGY & THERAPEUTICS

The alarmin HMGB1 acts in synergy with endogenous and exogenous danger signals to promote inflammation

(2009) Hulda Sigridur Hreggvidsdottir et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Developmental Regulation of Sensory Neurite Growth by the Tumor Necrosis Factor Superfamily Member LIGHT

(2009) N. Gavalda et al.   JOURNAL OF NEUROSCIENCE

Central post-stroke pain: clinical characteristics, pathophysiology, and management

(2009) Henriette Klit et al.   LANCET NEUROLOGY

Neuropsychiatric Problems After Traumatic Brain Injury: Unraveling the Silent Epidemic

(2009) Sandeep Vaishnavi et al.   PSYCHOSOMATICS

Cognitive dysfunction in mice deficient for TNF- and its receptors

(2008) Bernhard T. Baune et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Tumor Necrosis Factor-α Potentiates Intraneuronal Ca2+Signaling via Regulation of the Inositol 1,4,5-Trisphosphate Receptor

(2008) Keigan M. Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cell Death after Spinal Cord Injury Is Exacerbated by Rapid TNF -Induced Trafficking of GluR2-Lacking AMPARs to the Plasma Membrane

(2008) A. R. Ferguson et al.   JOURNAL OF NEUROSCIENCE

Tumor Necrosis Factor-α Modulates Survival, Proliferation, and Neuronal Differentiation in Neonatal Subventricular Zone Cell Cultures

(2008) Liliana Bernardino et al.   STEM CELLS