Secretases Related to Amyloid Precursor Protein Processing

Amyloid Beta-Peptide Increases BACE1 Translation through the Phosphorylation of the Eukaryotic Initiation Factor-2α

(2020) Pol Picón-Pagès et al.   Oxidative Medicine and Cellular Longevity

Mutation profile of APP, PSEN1, and PSEN2 in Chinese familial Alzheimer's disease

(2019) Ying Gao et al.   NEUROBIOLOGY OF AGING

Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 Inhibition Impairs Synaptic Plasticity via Seizure Protein 6

(2018) Kaichuan Zhu et al.   BIOLOGICAL PSYCHIATRY

Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

(2018) Xinjian Zhu et al.   Journal of Neuroinflammation

Host immune defence, amyloid-β peptide and Alzheimer disease

(2016) Todd E. Golde   Nature Reviews Neurology

Metalloprotease meprin β is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding

(2015) Felix Jäckle et al.   BIOCHEMICAL JOURNAL

MT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer’s disease

(2015) Kévin Baranger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Alzheimer's disease

(2015) Colin L. Masters et al.   Nature Reviews Disease Primers

Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

(2014) A. J. Groot et al.   MOLECULAR AND CELLULAR BIOLOGY

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

(2014) Virginie Buggia-Prévot et al.   Molecular Neurodegeneration

Trafficking regulation of proteins in Alzheimer’s disease

(2014) Shangtong Jiang et al.   Molecular Neurodegeneration

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Presenilins and  -Secretase: Structure, Function, and Role in Alzheimer Disease

(2013) B. De Strooper et al.   Cold Spring Harbor Perspectives in Medicine

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

MT5-MMP, ADAM-10, and N-Cadherin Act in Concert To Facilitate Synapse Reorganization after Traumatic Brain Injury

(2012) Kelly M. Warren et al.   JOURNAL OF NEUROTRAUMA

Adaptor protein 2–mediated endocytosis of the β-secretase BACE1 is dispensable for amyloid precursor protein processing

(2012) Yogikala Prabhu et al.   MOLECULAR BIOLOGY OF THE CELL

Endoplasmic Reticulum Enrollment in Alzheimer’s Disease

(2012) Ricardo J. S. Viana et al.   MOLECULAR NEUROBIOLOGY

Soluble amyloid precursor protein-α modulates β-secretase activity and amyloid-β generation

(2012) Demian Obregon et al.   Nature Communications

APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoforms

(2011) Simone Isbert et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Essential Role of Endocytosis of the Type II Transmembrane Serine Protease TMPRSS6 in Regulating Its Functionality

(2011) François Béliveau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

β-Site APP-cleaving enzyme 1 trafficking and Alzheimer’s disease pathogenesis

(2011) Jiangli Tan et al.   JOURNAL OF NEUROCHEMISTRY

The amyloid cascade hypothesis for Alzheimer's disease: an appraisal for the development of therapeutics

(2011) Eric Karran et al.   NATURE REVIEWS DRUG DISCOVERY

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

BACE: Therapeutic target and potential biomarker for Alzheimer's disease

(2010) Geneviève Evin et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

ADAM proteases: ligand processing and modulation of the Notch pathway

(2008) A. Zolkiewska   CELLULAR AND MOLECULAR LIFE SCIENCES

Assembly, Maturation, and Trafficking of the γ-Secretase Complex in Alzheimers Disease

(2008) Daniel Dries et al.   Current Alzheimer Research

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteases: Multifunctional Enzymes in Life and Disease

(2008) Carlos López-Otín et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Flotillin-Dependent Clustering of the Amyloid Precursor Protein Regulates Its Endocytosis and Amyloidogenic Processing in Neurons

(2008) A. Schneider et al.   JOURNAL OF NEUROSCIENCE

The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles

(2007) Andrew et al.   Frontiers in Bioscience-Landmark