Metalloprotease Adam10 suppresses epilepsy through repression of hippocampal neuroinflammation

Brain expression of inflammatory mediators in Mesial Temporal Lobe Epilepsy patients

(2017) Bárbara Leal et al.   JOURNAL OF NEUROIMMUNOLOGY

Neuronal Nitric Oxide Synthase Contributes to PTZ Kindling Epilepsy-Induced Hippocampal Endoplasmic Reticulum Stress and Oxidative Damage

(2017) Xinjian Zhu et al.   Frontiers in Cellular Neuroscience

NADPH oxidase activation is required for pentylenetetrazole kindling-induced hippocampal autophagy

(2016) Xinjian Zhu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Brain region and epilepsy-associated differences in inflammatory mediator levels in medically refractory mesial temporal lobe epilepsy

(2016) Kenneth I. Strauss et al.   Journal of Neuroinflammation

Fractalkine shedding is mediated by p38 and the ADAM10 protease under pro-inflammatory conditions in human astrocytes

(2016) Sinead A. O’Sullivan et al.   Journal of Neuroinflammation

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

(2016) Alba Jimenez-Pacheco et al.   JOURNAL OF NEUROSCIENCE

NMDA receptor NR2B subunits contribute to PTZ-kindling-induced hippocampal astrocytosis and oxidative stress

(2015) Xinjian Zhu et al.   BRAIN RESEARCH BULLETIN

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline

(2015) Kyung-Ok Cho et al.   Nature Communications

Epilepsies associated with hippocampal sclerosis

(2014) Fernando Cendes et al.   ACTA NEUROPATHOLOGICA

Increased CSF APPs-  levels in patients with Alzheimer disease treated with acitretin

(2014) K. Endres et al.   NEUROLOGY

Repeated exposure to low doses of kainic acid activates nuclear factor kappa B (NF-κB) prior to seizure in transgenic NF-κB/EGFP reporter mice

(2014) James A. Miller et al.   NEUROTOXICOLOGY

Involvement of IRS-1 Interaction With ADAM10 in the Regulation of Neurite Extension

(2013) Jin Ying Wang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hippocampal neuropathology of domoic acid-induced epilepsy in California sea lions (Zalophus californianus)

(2013) Paul S. Buckmaster et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients

(2013) Marcelo Teocchi et al.   Journal of Neuroinflammation

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

Minocycline selectively inhibits M1 polarization of microglia

(2013) K Kobayashi et al.   Cell Death & Disease

Ectodomain shedding and ADAMs in development

(2012) S. Weber et al.   DEVELOPMENT

The role of inflammation in epileptogenesis

(2012) Annamaria Vezzani et al.   NEUROPHARMACOLOGY

Hippocampal tissue of patients with refractory temporal lobe epilepsy is associated with astrocyte activation, inflammation, and altered expression of channels and receptors

(2012) A. Das et al.   NEUROSCIENCE

Inflammatory changes during epileptogenesis and spontaneous seizures in a mouse model of mesiotemporal lobe epilepsy

(2011) Fabien Pernot et al.   EPILEPSIA

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

Decreased CREB levels suppress epilepsy

(2011) Xinjian Zhu et al.   NEUROBIOLOGY OF DISEASE

Interleukin-1β Biosynthesis Inhibition Reduces Acute Seizures and Drug Resistant Chronic Epileptic Activity in Mice

(2011) Mattia Maroso et al.   Neurotherapeutics

ADAM10 is the physiologically relevant, constitutive α-secretase of the amyloid precursor protein in primary neurons

(2010) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Dentate gyrus and hilus transection blocks seizure propagation and granule cell dispersion in a mouse model for mesial temporal lobe epilepsy

(2010) Johan Pallud et al.   HIPPOCAMPUS

The role of inflammation in epilepsy

(2010) Annamaria Vezzani et al.   Nature Reviews Neurology

Inflammation enhances epileptogenesis in the developing rat brain

(2010) Stéphane Auvin et al.   NEUROBIOLOGY OF DISEASE

Levels of IL-1β and IL-1ra in Cerebrospinal Fluid of Human Patients after Single and Prolonged Seizures

(2009) Kai A. Lehtimäki et al.   NEUROIMMUNOMODULATION

Postnatal Inflammation Increases Seizure Susceptibility in Adult Rats

(2008) M. A. Galic et al.   JOURNAL OF NEUROSCIENCE

Effects of neuron-specific ADAM10 modulation in an in vivo model of acute excitotoxic stress

(2008) A.B. Clement et al.   NEUROSCIENCE

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY