Essential Role of Endocytosis of the Type II Transmembrane Serine Protease TMPRSS6 in Regulating Its Functionality

Modulation of Na+-K+-ATPase cell surface abundance through structural determinants on the α1-subunit

(2010) Sandrine V. Pierre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA

(2010) Sandro Altamura et al.   BIOCHEMICAL JOURNAL

Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface

(2010) Marit Stirnberg et al.   BIOCHEMICAL JOURNAL

Peptide aptamers as new tools to modulate clathrin-mediated internalisation — inhibition of MT1-MMP internalisation

(2010) Rochana D Wickramasinghe et al.   BMC CELL BIOLOGY

Matriptase-2- and Proprotein Convertase-cleaved Forms of Hemojuvelin Have Different Roles in the Down-regulation of Hepcidin Expression

(2010) Julia E. Maxson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transport via the Transcytotic Pathway Makes Prostasin Available as a Substrate for Matriptase

(2010) Stine Friis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Screen for Endocytic Motifs

(2010) Patrycja Kozik et al.   TRAFFIC

The Role of Hepcidin in Iron Metabolism

(2009) Elizabeta Nemeth et al.   ACTA HAEMATOLOGICA

Molecular mechanisms of the defective hepcidin inhibition in TMPRSS6 mutations associated with iron-refractory iron deficiency anemia

(2009) L. Silvestri et al.   BLOOD

Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides

(2009) François Béliveau et al.   FEBS Journal

Matriptase-2 mutations in iron-refractory iron deficiency anemia patients provide new insights into protease activation mechanisms

(2009) Andrew J. Ramsay et al.   HUMAN MOLECULAR GENETICS

Type II Transmembrane Serine Proteases

(2009) Thomas H. Bugge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MEROPS: the peptidase database

(2009) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Calnuc Binds to LRP9 and Affects its Endosomal Sorting

(2009) Julie Brodeur et al.   TRAFFIC

Processing of hemojuvelin requires retrograde trafficking to the Golgi in HepG2 cells

(2008) J. E. Maxson et al.   BLOOD

Two nonsense mutations in the TMPRSS6 gene in a patient with microcytic anemia and iron deficiency

(2008) F. Guillem et al.   BLOOD

The Serine Protease Matriptase-2 (TMPRSS6) Inhibits Hepcidin Activation by Cleaving Membrane Hemojuvelin

(2008) Laura Silvestri et al.   Cell Metabolism

A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron

(2008) M. A. Melis et al.   HAEMATOLOGICA

Genetic upregulation of matriptase‐2 reduces the aggressiveness of prostate cancer cells in vitro and in vivo and affects FAK and paxillin localisation

(2008) Andrew J. Sanders et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Mutations in TMPRSS6 cause iron-refractory iron deficiency anemia (IRIDA)

(2008) Karin E Finberg et al.   NATURE GENETICS

Human Protein Reference Database--2009 update

(2008) T. S. Keshava Prasad et al.   NUCLEIC ACIDS RESEARCH

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

The type II transmembrane serine protease Matriptase-2 - identification, structural features, enzymology, expression pattern and potential roles

(2007) Andrew et al.   Frontiers in Bioscience-Landmark