Frontline Science: A reduction in DHA-derived mediators in male obesity contributes toward defects in select B cell subsets and circulating antibody

ExacerbatedStaphylococcus aureusFoot Infections in Obese/Diabetic Mice Are Associated with Impaired Germinal Center Reactions, Ig Class Switching, and Humoral Immunity

(2018) Christopher W. Farnsworth et al.   JOURNAL OF IMMUNOLOGY

Specialized Pro-Resolving Lipid Mediators Regulate Ozone-Induced Pulmonary and Systemic Inflammation

(2018) Brita Kilburg-Basnyat et al.   TOXICOLOGICAL SCIENCES

Androgen-mediated sex bias impairs efficiency of leukotriene biosynthesis inhibitors in males

(2017) Simona Pace et al.   JOURNAL OF CLINICAL INVESTIGATION

B Cell Activity Is Impaired in Human and Mouse Obesity and Is Responsive to an Essential Fatty Acid upon Murine Influenza Infection

(2017) Rasagna Kosaraju et al.   JOURNAL OF IMMUNOLOGY

Obesity induces pro-inflammatory B cells and impairs B cell function in old mice

(2017) Daniela Frasca et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Carbon Monoxide Improves Efficacy of Mesenchymal Stromal Cells During Sepsis by Production of Specialized Proresolving Lipid Mediators*

(2016) Konstantin Tsoyi et al.   CRITICAL CARE MEDICINE

Accelerated resolution of inflammation underlies sex differences in inflammatory responses in humans

(2016) Krishnaraj S. Rathod et al.   JOURNAL OF CLINICAL INVESTIGATION

Signaling and Immunoresolving Actions of Resolvin D1 in Inflamed Human Visceral Adipose Tissue

(2016) Esther Titos et al.   JOURNAL OF IMMUNOLOGY

Obesity decreases B cell responses in young and elderly individuals

(2016) Daniela Frasca et al.   Obesity

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

How sex and age affect immune responses, susceptibility to infections, and response to vaccination

(2015) Carmen Giefing-Kröll et al.   AGING CELL

Specialized proresolving mediators (SPMs) inhibit human B-cell IgE production

(2015) Nina Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rapid microwave assisted extraction of meat lipids

(2015) Aline Lisbôa Medina et al.   FOOD RESEARCH INTERNATIONAL

The resolution code of acute inflammation: Novel pro-resolving lipid mediators in resolution

(2015) Charles N. Serhan et al.   SEMINARS IN IMMUNOLOGY

The Specialized Proresolving Mediator 17-HDHA Enhances the Antibody-Mediated Immune Response against Influenza Virus: A New Class of Adjuvant?

(2014) Sesquile Ramon et al.   JOURNAL OF IMMUNOLOGY

Eicosapentaenoic and docosahexaenoic acid ethyl esters differentially enhance B-cell activity in murine obesity

(2014) Heather Teague et al.   JOURNAL OF LIPID RESEARCH

High Fat Diet Rapidly Suppresses B Lymphopoiesis by Disrupting the Supportive Capacity of the Bone Marrow Niche

(2014) Benjamin J. Adler et al.   PLoS One

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men

(2014) Benjamin B. Albert et al.   Scientific Reports

Impaired Local Production of Proresolving Lipid Mediators in Obesity and 17-HDHA as a Potential Treatment for Obesity-Associated Inflammation

(2013) A. Neuhofer et al.   DIABETES

Lipoxin A4modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism

(2013) Sesquile Ramon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype

(2013) Jesmond Dalli et al.   FASEB JOURNAL

n-3 PUFAs enhance the frequency of murine B-cell subsets and restore the impairment of antibody production to a T-independent antigen in obesity

(2013) Heather Teague et al.   JOURNAL OF LIPID RESEARCH

Contribution of B cells to obesity and insulin resistance

(2013) Claire Greenhill   Nature Reviews Endocrinology

B cells promote inflammation in obesity and type 2 diabetes through regulation of T-cell function and an inflammatory cytokine profile

(2013) J. DeFuria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct cellular pathways select germline-encoded and somatically mutated antibodies into immunological memory

(2012) Tomohiro Kaji et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Resolvin D1 and Resolvin D2 Govern Local Inflammatory Tone in Obese Fat

(2012) J. Claria et al.   JOURNAL OF IMMUNOLOGY

Specialized Proresolving Mediators Enhance Human B Cell Differentiation to Antibody-Secreting Cells

(2012) S. Ramon et al.   JOURNAL OF IMMUNOLOGY

Serum levels of polyunsaturated fatty acids are low in Chinese men with metabolic syndrome, whereas serum levels of saturated fatty acids, zinc, and magnesium are high

(2012) Yinghua Yu et al.   NUTRITION RESEARCH

Gender effect on in vitro lymphocyte subset levels of healthy individuals

(2011) Maha Abdullah et al.   CELLULAR IMMUNOLOGY

Obesity is associated with impaired immune response to influenza vaccination in humans

(2011) P A Sheridan et al.   INTERNATIONAL JOURNAL OF OBESITY

Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation

(2011) Sungwhan F. Oh et al.   JOURNAL OF CLINICAL INVESTIGATION

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

High dose of an n-3 polyunsaturated fatty acid diet lowers activity of C57BL/6 mice

(2011) Benjamin Drew Rockett et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Progesterone increases skeletal muscle mitochondrial H2O2 emission in nonmenopausal women

(2010) Daniel A. Kane et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Toll-like receptors regulate B cell cytokine production in patients with diabetes

(2010) M. Jagannathan et al.   DIABETOLOGIA

Estrogen Receptors Bind to and Activate theHOXC4/HoxC4Promoter to Potentiate HoxC4-mediated Activation-induced Cytosine Deaminase Induction, Immunoglobulin Class Switch DNA Recombination, and Somatic Hypermutation

(2010) Thach Mai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

n-3 PUFA improves fatty acid composition, prevents palmitate-induced apoptosis, and differentially modifies B cell cytokine secretion in vitro and ex vivo

(2010) Benjamin Drew Rockett et al.   JOURNAL OF LIPID RESEARCH

Obesity accelerates thymic aging

(2009) H. Yang et al.   BLOOD

Plasma n-3 polyunsaturated fatty acids are negatively associated with obesity

(2009) Michelle Micallef et al.   BRITISH JOURNAL OF NUTRITION

Obesity-induced insulin resistance and hepatic steatosis are alleviated by ω-3 fatty acids: a role for resolvins and protectins

(2009) Ana González-Périz et al.   FASEB JOURNAL

Progesterone Inhibits Activation-Induced Deaminase by Binding to the Promoter

(2009) S. Pauklin et al.   JOURNAL OF IMMUNOLOGY

Preparation of fatty acid methyl esters for gas-liquid chromatography

(2009) Ken'ichi Ichihara et al.   JOURNAL OF LIPID RESEARCH

Multiple layers of B cell memory with different effector functions

(2009) Ismail Dogan et al.   NATURE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

Sexual dimorphism of humoral immunity with human vaccines

(2008) Ian Francis Cook   VACCINE