Evolutionary History of RNA Modifications at N6-Adenosine Originating from the R-M System in Eukaryotes and Prokaryotes

METTL4 is an snRNA m6Am methyltransferase that regulates RNA splicing

(2020) Hao Chen et al.   CELL RESEARCH

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

(2020) Huilin Huang et al.   CANCER CELL

The 18S ribosomal RNA m 6 A methyltransferase Mettl5 is required for normal walking behavior in Drosophila

(2020) Jessica Leismann et al.   EMBO REPORTS

The emerging role of RNA modifications in the regulation of mRNA stability

(2020) Sung Ho Boo et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences

(2020) Clayton B Woodcock et al.   NUCLEIC ACIDS RESEARCH

Mapping the epigenetic modifications of DNA and RNA

(2020) Lin-Yong Zhao et al.   Protein & Cell

Recurrent sequence evolution after independent gene duplication

(2020) Samuel H. A. von der Dunk et al.   BMC EVOLUTIONARY BIOLOGY

Multi-substrate selectivity based on key loops and non-homologous domains: new insight into ALKBH family

(2020) Baofang Xu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA

(2020) Clayton B Woodcock et al.   NUCLEIC ACIDS RESEARCH

A birds'‐eye view of the activity and specificity of the mRNA m 6 A methyltransferase complex

(2020) David Garcias Morales et al.   Wiley Interdisciplinary Reviews-RNA

CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila

(2020) Lei Gu et al.   Cell Discovery

Mechanisms of epitranscriptomic gene regulation

(2020) Kyung W. Seo et al.   BIOPOLYMERS

METTL4 catalyzes m6Am methylation in U2 snRNA to regulate pre-mRNA splicing

(2020) Yeek Teck Goh et al.   NUCLEIC ACIDS RESEARCH

The Mammalian Cap-Specific m6Am RNA Methyltransferase PCIF1 Regulates Transcript Levels in Mouse Tissues

(2020) Radha Raman Pandey et al.   Cell Reports

An Overview of Duplicated Gene Detection Methods: Why the Duplication Mechanism Has to Be Accounted for in Their Choice

(2020) Tanguy Lallemand et al.   Genes

Structural determinants of nucleobase modification recognition in the AlkB family of dioxygenases

(2020) V. Van Deuren et al.   DNA REPAIR

Ribosome 18S m6A Methyltransferase METTL5 Promotes Translation Initiation and Breast Cancer Cell Growth

(2020) Bowen Rong et al.   Cell Reports

Prediction of the molecular boundary and functionality of novel viral AlkB domains using homology modelling and principal component analysis

(2019) Clayton Moore et al.   JOURNAL OF GENERAL VIROLOGY

Where, When, and How: Context-Dependent Functions of RNA Methylation Writers, Readers, and Erasers

(2019) Hailing Shi et al.   MOLECULAR CELL

PCIF1 Catalyzes m6Am mRNA Methylation to Regulate Gene Expression

(2019) Erdem Sendinc et al.   MOLECULAR CELL

The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112

(2019) Nhan van Tran et al.   NUCLEIC ACIDS RESEARCH

Reading, writing and erasing mRNA methylation

(2019) Sara Zaccara et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genes lost during the transition from land to water in cetaceans highlight genomic changes associated with aquatic adaptations

(2019) Matthias Huelsmann et al.   Science Advances

Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112

(2019) Clayton B. Woodcock et al.   Cell Discovery

Structural insight into human N6amt1–Trm112 complex functioning as a protein methyltransferase

(2019) Wenjing Li et al.   Cell Discovery

Gene gain and loss push prokaryotes beyond the homologous recombination barrier and accelerate genome sequence divergence

(2019) Jaime Iranzo et al.   Nature Communications

The human methyltransferase ZCCHC4 catalyses N6-methyladenosine modification of 28S ribosomal RNA

(2019) Rita Pinto et al.   NUCLEIC ACIDS RESEARCH

Human MettL3–MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro

(2019) Clayton B. Woodcock et al.   Cell Discovery

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

YTH Domain: A Family of N 6 -methyladenosine (m 6 A) Readers

(2018) Shanhui Liao et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

DNA methylation on N6-adenine in lepidopteran Bombyx mori

(2018) Xiaoyan Wang et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm

(2018) Jiangbo Wei et al.   MOLECULAR CELL

Differential m6A methylomes between two major life stages allows potential regulations in Trypanosoma brucei

(2018) Luogen Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The m6A Writer: Rise of a Machine for Growing Tasks

(2018) Dario L. Balacco et al.   BIOCHEMISTRY

Proteins, transcripts, and genetic architecture of seminal fluid and sperm in the mosquito Aedes aegypti

(2018) Ethan C Degner et al.   MOLECULAR & CELLULAR PROTEOMICS

Cap-specific terminal N6-methylation of RNA by an RNA polymerase II–associated methyltransferase

(2018) Shinichiro Akichika et al.   SCIENCE

Functional horizontal gene transfer from bacteria to eukaryotes

(2017) Filip Husnik et al.   NATURE REVIEWS MICROBIOLOGY

The non-specific adenine DNA methyltransferase M.EcoGII

(2017) Iain A Murray et al.   NUCLEIC ACIDS RESEARCH

MODOMICS: a database of RNA modification pathways. 2017 update

(2017) Pietro Boccaletto et al.   NUCLEIC ACIDS RESEARCH

A fly view on the roles and mechanisms of the m6A mRNA modification and its players

(2017) Tina Lence et al.   RNA Biology

The RNA modification landscape in human disease

(2017) Nicky Jonkhout et al.   RNA

ALKBHs-facilitated RNA modifications and de-modifications

(2016) Endalkachew A. Alemu et al.   DNA REPAIR

Evolution by gene loss

(2016) Ricard Albalat et al.   NATURE REVIEWS GENETICS

W-IQ-TREE: a fast online phylogenetic tool for maximum likelihood analysis

(2016) Jana Trifinopoulos et al.   NUCLEIC ACIDS RESEARCH

Regulation of genetic flux between bacteria by restriction–modification systems

(2016) Pedro H. Oliveira et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The emerging biology of RNA post-transcriptional modifications

(2016) Sigrid Nachtergaele et al.   RNA Biology

Messenger RNA modifications: Form, distribution, and function

(2016) W. V. Gilbert et al.   SCIENCE

Horizontal Gene Transfer and the History of Life

(2016) Vincent Daubin et al.   Cold Spring Harbor Perspectives in Biology

Recent advances in dynamic m6A RNA modification

(2016) Guangchao Cao et al.   Open Biology

Adenine methylation in eukaryotes: Apprehending the complex evolutionary history and functional potential of an epigenetic modification

(2015) Lakshminarayan M. Iyer et al.   BIOESSAYS

DNA Methylation on N6-Adenine in C. elegans

(2015) Eric Lieberman Greer et al.   CELL

Structural Basis for the Discriminative Recognition ofN6-Methyladenosine RNA by the Human YT521-B Homology Domain Family of Proteins

(2015) Chao Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

(2015) Bogdan I. Fedeles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Widespread occurrence ofN6-methyladenosine in bacterial mRNA

(2015) Xin Deng et al.   NUCLEIC ACIDS RESEARCH

The Atomic Resolution Structure of Human AlkB Homolog 7 (ALKBH7), a Key Protein for Programmed Necrosis and Fat Metabolism

(2014) Guoqiang Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of the β-barrel–type RNA methyltransferase responsible forN6-methylation ofN6-threonylcarbamoyladenosine in tRNAs

(2014) Satoshi Kimura et al.   NUCLEIC ACIDS RESEARCH

Diverse Functions of Restriction-Modification Systems in Addition to Cellular Defense

(2013) K. Vasu et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

A METTL3–METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation

(2013) Jianzhao Liu et al.   Nature Chemical Biology

ALKBH4-dependent demethylation of actin regulates actomyosin dynamics

(2013) Ming-Ming Li et al.   Nature Communications

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

ALKBH8-mediated formation of a novel diastereomeric pair of wobble nucleosides in mammalian tRNA

(2011) Erwin van den Born et al.   Nature Communications

TreeGraph 2: Combining and visualizing evidence from different phylogenetic analyses

(2010) Ben C Stöver et al.   BMC BIOINFORMATICS

The YTH Domain Is a Novel RNA Binding Domain

(2010) Zhaiyi Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A three-dimensional view of the molecular machinery of RNA interference

(2009) Martin Jinek et al.   NATURE

Genome duplication and gene-family evolution: The case of three OXPHOS gene families

(2008) Anna De Grassi et al.   GENE

Gene Family Evolution by Duplication, Speciation, and Loss

(2008) Cedric Chauve et al.   JOURNAL OF COMPUTATIONAL BIOLOGY

PROMALS3D: a tool for multiple protein sequence and structure alignments

(2008) Jimin Pei et al.   NUCLEIC ACIDS RESEARCH