TGF-βRII regulates glucose metabolism in oral cancer-associated fibroblasts via promoting PKM2 nuclear translocation

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway

(2021) Jin Yang et al.   International Journal of Oral Science

The Reverse Warburg Effect Is Associated with Fbp2-Dependent Hif1α Regulation in Cancer Cells Stimulated by Fibroblasts

(2020) Przemysław Duda et al.   Cells

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

(2020) Lisa M. Becker et al.   Cell Reports

Hypoxia, angiogenesis, and metabolism in the hereditary kidney cancers

(2019) John C. Chappell et al.   JOURNAL OF CLINICAL INVESTIGATION

TGFβ/BMP immune signaling affects abundance and function of C. elegans gut commensals

(2019) Maureen Berg et al.   Nature Communications

Macrophages Promote Growth of Squamous Cancer Independent of T cells

(2019) F.L. Wu et al.   JOURNAL OF DENTAL RESEARCH

Digoxin Suppresses Pyruvate Kinase M2-Promoted HIF-1α Transactivation in Steatohepatitis

(2018) Xinshou Ouyang et al.   Cell Metabolism

Pyruvate kinase M2 fuels multiple aspects of cancer cells: from cellular metabolism, transcriptional regulation to extracellular signaling

(2018) Ming-Chuan Hsu et al.   Molecular Cancer

PAK2–c-Myc–PKM2 axis plays an essential role in head and neck oncogenesis via regulating Warburg effect

(2018) Amit Gupta et al.   Cell Death & Disease

Effects of PKM2 on global metabolic changes and prognosis in hepatocellular carcinoma: from gene expression to drug discovery

(2018) Wen-Wen Lv et al.   BMC CANCER

Ovarian cancer cell-derived lysophosphatidic acid induces glycolytic shift and cancer-associated fibroblast-phenotype in normal and peritumoral fibroblasts

(2018) Rangasudhagar Radhakrishnan et al.   CANCER LETTERS

miR-361-5p modulates metabolism and autophagy via the Sp1-mediated regulation of PKM2 in prostate cancer

(2017) Zhixin Ling et al.   ONCOLOGY REPORTS

Pyruvate kinase M2 overexpression and poor prognosis in solid tumors of digestive system: evidence from 16 cohort studies

(2016) Jiayuan Wu et al.   OncoTargets and Therapy

Tumor microenvironment derived exosomes pleiotropically modulate cancer cell metabolism

(2016) Hongyun Zhao et al.   eLife

PKM2 contributes to cancer metabolism

(2015) Nicholas Wong et al.   CANCER LETTERS

Metabolic Reprogramming of Cancer-Associated Fibroblasts by IDH3α Downregulation

(2015) Daoxiang Zhang et al.   Cell Reports

A Systems Biology Approach Identifies Effective Tumor–Stroma Common Targets for Oral Squamous Cell Carcinoma

(2014) Wenxia Meng et al.   CANCER RESEARCH

Regulation and function of pyruvate kinase M2 in cancer

(2013) Weiwei Yang et al.   CANCER LETTERS

Reciprocal Metabolic Reprogramming through Lactate Shuttle Coordinately Influences Tumor-Stroma Interplay

(2012) T. Fiaschi et al.   CANCER RESEARCH

PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

(2012) Weiwei Yang et al.   CELL

Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with “Warburg-like” cancer metabolism and L-lactate production

(2012) Carmela Guido et al.   CELL CYCLE

Pyruvate Kinase M2 Is a PHD3-Stimulated Coactivator for Hypoxia-Inducible Factor 1

(2011) Weibo Luo et al.   CELL

The reverse Warburg effect: Aerobic glycolysis in cancer associated fibroblasts and the tumor stroma

(2011) Stephanos Pavlides et al.   CELL CYCLE

Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

(2011) Q. Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The role of Sp1 and Sp3 in normal and cancer cell biology

(2010) Lin Li et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Essential Role of TGF-β Signaling in Glucose-Induced Cell Hypertrophy

(2009) Liyu Wu et al.   DEVELOPMENTAL CELL

A Robust Automated Measure of Average Antibody Staining in Immunohistochemistry Images

(2009) Kingshuk Roy Choudhury et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE