FTO promotes tumour proliferation in bladder cancer via the FTO/miR-576/CDK6 axis in an m6A-dependent manner

Down-regulation of FTO promotes proliferation and migration, and protects bladder cancer cells from cisplatin-induced cytotoxicity

(2020) Lijie Wen et al.   BMC Urology

FTO inhibition enhances the anti-tumor effect of temozolomide by targeting MYC-miR-155/23a cluster-MXI1 feedback circuit in glioma

(2020) Li Xiao et al.   CANCER RESEARCH

The FTO/miR‐181b‐3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer

(2020) Yuanyuan Xu et al.   Cancer Communications

miR‑576‑5p promotes epithelial‑to‑mesenchymal transition in colorectal cancer by targeting the Wnt5a‑mediated Wnt/β‑catenin signaling pathway

(2020) Jialin Luo et al.   Molecular Medicine Reports

lncRNA PSTAR Promotes p53 Signaling by Inhibiting hnRNP K deSUMOylation and Suppresses Hepatocellular Carcinoma

(2019) Geng Qin et al.   HEPATOLOGY

NEAT1 promotes colon cancer progression through sponging miR‐495‐3p and activating CDK6 in vitro and in vivo

(2019) Zhiyun He et al.   JOURNAL OF CELLULAR PHYSIOLOGY

METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent manner

(2019) Jie Han et al.   Molecular Cancer

Linc‐PINT acted as a tumor suppressor by sponging miR‐543 and miR‐576‐5p in esophageal cancer

(2019) Lingmin Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation

(2018) Shun Zhou et al.   MOLECULAR CARCINOGENESIS

Dual regulatory role of CCNA2 in modulating CDK6 and MET-mediated cell-cycle pathway and EMT progression is blocked by miR-381-3p in bladder cancer

(2018) Jiangfeng Li et al.   FASEB JOURNAL

miR-193b and miR-30c-1* inhibit, whereas miR-576-5p enhances melanoma cell invasion in vitro

(2018) Theresa Kordaß et al.   Oncotarget

Critical Enzymatic Functions of FTO in Obesity and Cancer

(2018) Xiaolan Deng et al.   Frontiers in Endocrinology

YAP1-mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the combination of YAP1 and CDK4/6 inhibitors in Esophageal Cancer

(2018) Fan Li et al.   CLINICAL CANCER RESEARCH

Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR-145-5p

(2018) Ming Sun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

LinkedOmics: analyzing multi-omics data within and across 32 cancer types

(2017) Suhas V Vasaikar et al.   NUCLEIC ACIDS RESEARCH

FTO Gene Affects Obesity and Breast Cancer Through Similar Mechanisms: A New Insight into the Molecular Therapeutic Targets

(2017) M. E. Akbari et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

FTO expression is associated with the occurrence of gastric cancer and prognosis

(2017) Dong Xu et al.   ONCOLOGY REPORTS

The m 6 A Methyltransferase METTL3 Promotes Translation in Human Cancer Cells

(2016) Shuibin Lin et al.   MOLECULAR CELL

Efficacy and Safety of Abemaciclib, an Inhibitor of CDK4 and CDK6, for Patients with Breast Cancer, Non-Small Cell Lung Cancer, and Other Solid Tumors

(2016) A. Patnaik et al.   Cancer Discovery

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

miR-211 suppresses epithelial ovarian cancer proliferation and cell-cycle progression by targeting Cyclin D1 and CDK6

(2015) Bairong Xia et al.   Molecular Cancer

N6-methyladenosine marks primary microRNAs for processing

(2015) Claudio R. Alarcón et al.   NATURE

Definition of PKC-α, CDK6, and MET as Therapeutic Targets in Triple-Negative Breast Cancer

(2014) Yi-Hsin Hsu et al.   CANCER RESEARCH

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

Mapping and significance of the mRNA methylome

(2013) Tennille Sibbritt et al.   Wiley Interdisciplinary Reviews-RNA

Epidemiology and Risk Factors of Urothelial Bladder Cancer

(2012) Maximilian Burger et al.   EUROPEAN UROLOGY

N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO

(2011) Guifang Jia et al.   Nature Chemical Biology

Overexpression of Fto leads to increased food intake and results in obesity

(2010) Chris Church et al.   NATURE GENETICS