Editorial Material
Biology
Matthieu Le Hars, Luis Jaime Castro-Vega, Fatemeh Rajabi, David Tabatadze, Martha Romero, Marina Pinskaya, Irina Groisman
Summary: This study identified a novel potential competing endogenous lncRNA, lnc-ZNF30-3, which is highly expressed in prostate cancer and associated with poor prognosis. It was found that lnc-ZNF30-3 can interact with miR-145-5p and inhibit its function, leading to increased migration and metastasis in prostate cancer.
Article
Biotechnology & Applied Microbiology
Yidong Cheng, Hao Yu, Kai Li, Jiancheng Lv, Juntao Zhuang, Kexin Bai, Qikai Wu, Xiao Yang, Haiwei Yang, Qiang Lu
Summary: Accumulating evidence has shown that hsa_circ_0003098 plays a vital role in bladder cancer (BCa). The overexpression of hsa_circ_0003098 is associated with poor prognosis and promotes BCa cell proliferation, migration, invasion, and tumor growth. Mechanistically, hsa_circ_0003098 acts as a sponge for miR-377-5p, promoting the upregulation of ACAT2 expression and inducing cholesteryl ester accumulation. Therefore, hsa_circ_0003098 could serve as a potential biomarker and therapeutic target for BCa.
Article
Oncology
Yi Du, Xudong Zhang, Hongwei Zhang, Yiding Chen, Shuying Zhu, Jinjun Shu, Hui Pan
Summary: Propofol has been found to significantly suppress the proliferation, migration, and invasion of bladder cancer cells in vitro, largely through the upregulation of miR-145-5p expression. Silencing the direct target of miR-145-5p, TOP2A, reversed the effects of propofol treatment in bladder cancer cells. Additionally, propofol was shown to suppress tumor xenograft growth, with partial attenuation by miR-145-5p knockdown.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Huyan Ting, Lina Gao, Na Gao, Chaochao Wang, Wuli Guo, Xiaojie Zhou, Qi Li
Summary: Bladder cancer impairs NK cell function and immune surveillance through exosomes. Specific miRNAs in exosomes may interfere with gene stability in NK cells and can be potential targets for BC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Dheeran Rajarajan, Bhavjot Kaur, Dhanamjai Penta, Jagadish Natesh, Syed Musthapa Meeran
Summary: In this study, miR-145-5p was identified as a common miRNA targeting stemness markers in breast cancer, with lower expression in patients compared to healthy individuals. The combination of low miR-145-5p and high SOX2 expression was associated with a poor overall survival rate. Pathway enrichment analysis revealed that SOX2 is highly enriched with transcription factors and upregulated in axillary metastatic lymph nodules.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Cell Biology
Yuan Chen, Shiben Ji, Jianxin Ying, Yongchang Sun, Jun Liu, Guohong Yin
Summary: This study identifies a novel biomarker, KRT6A, for early diagnosis of bladder tumors and reveals its role in promoting bladder tumor progression. Additionally, it uncovers the regulatory axis of KRT6A/miR-31-5p in bladder tumor growth.
Article
Biochemistry & Molecular Biology
Eduarda O. Z. Minin, Layde R. Paim, Elisangela C. P. Lopes, Larissa C. M. Bueno, Luis F. R. S. Carvalho-Romano, Edmilson R. Marques, Camila F. L. Vegian, Jose A. Pio-Magalhaes, Otavio R. Coelho-Filho, Andrei C. Sposito, Jose R. Matos-Souza, Wilson Nadruz, Roberto Schreiber
Summary: In this study, hypertensive patients with carotid plaques were found to have increased expression of miR-145-5p and miR-let7c, suggesting a potential role of these miRNAs as biomarkers for subclinical atherosclerosis in hypertensive individuals.
Article
Oncology
Bing Li, Zhi Wang, Fan Yang, Jing Huang, Xingwei Hu, Shiyan Deng, Maobo Tian, Xiaoyun Si
Summary: miR-449a-5p inhibits CM proliferation by targeting CDK6, which provides a potential molecular target for preventing myocardial injury.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Xinxin Zhang, Ling Zai, Ziqi Tao, Daiqian Wu, Mingying Lin, Jing Wan
Summary: This study found that miR-145-5p regulates autophagy in HAVSMCs by targeting CaMKII delta, and plays an important role in the progression of AS.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cell Biology
Shu-Li Liu, Mao-Hua Chen, Xiao-Bo Wang, Rong-Kai You, Xue-Wei An, Qiu Zhao, Ren-Shu Wang
Summary: The study revealed that upregulation of PCGEM1 in glioma tissues and cell lines was associated with poor prognosis. Knockdown of PCGEM1 suppressed cell proliferation, migration, invasion, and tumor growth in vivo by acting as a ceRNA for miR-539-5p to regulate CDK6 expression. This suggests that PCGEM1 may serve as a potential therapeutic target for glioma.
Article
Cell Biology
Yujing Sun, Yuan Tian, Junyi He, Yaru Tian, Guohao Zhang, Ruinan Zhao, Wen-jie Zhu, Peng Gao
Summary: The long non-coding RNA linc01133 is upregulated in gastric cancer tissues and is correlated with tumor size and differentiation. Linc01133 functions as an endogenous competing RNA of miR-145-5p to upregulate the expression of YES1, which promotes gastric cancer cell growth through YES1 and YAP1 pathway.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Wen Chen, Qunjun He, Jingjing Liu, Ni Li, Kai Xiao, Honghui Chen
Summary: This study reveals that PLAGL2 enhances Snail expression and promotes gastric cancer progression and metastasis through the UCA1/miR-145-5p/YTHDF1 axis, suggesting that PLAGL2 may serve as a therapeutic target for gastric cancer treatment.
Article
Oncology
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Summary: Cancer-associated fibroblasts (CAF) promote cancer stemness and chemoresistance in urothelial bladder cancer (UBC) by overexpressing miR-146a-5p. MiR-146a-5p also enhances UBC stemness and chemoresistance by targeting ARID1A and PRKAA2 mRNA in UBC cells. Elevated levels of exosomal miR-146a-5p in UBC patients' serum are associated with tumor stage and relapse risk.
Article
Cell Biology
Guanwen Zhou, Keqiang Yan, Jikai Liu, Lijian Gao, Xianzhou Jiang, Yidong Fan
Summary: This study found that the aberrant expression of FTO in bladder cancer is associated with poor prognosis. FTO overexpression promoted bladder cancer cell proliferation through the FTO/miR-576/CDK6 pathways. FTO could serve as a potential diagnostic or prognostic biomarker for bladder cancer.
CELL DEATH DISCOVERY
(2021)
Article
Biotechnology & Applied Microbiology
Yongfeng Su, Ting Yu, Yaqi Wang, Xianming Huang, Xiaoyong Wei
Summary: The study revealed that circDNM3OS promotes CCA growth and glutamine metabolism by regulating the miR-145-5p/MORC2 pathway, with experimental evidence supporting this conclusion.
ONCOTARGETS AND THERAPY
(2021)